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基于事实——BANCO SALVADOREN(?)O通过ORACLE激励佣金管理软件实现了奖励机制的透明度并提高了销售业绩

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银行家 2004年第3期 167-168页

作者： karen j.BANNAN

Banco Salvadoreo是萨尔瓦多的第三大银行,它清楚完整、集成的信息可以为公司、员工和客户带来很大利益。现在,让我们来了解一下该银行的奖励系统。在几年前,这家有着百年历史的机构还在为销售专业人员发放固定工资。但是由于不同的销... 详细信息

Banco Salvadoreo是萨尔瓦多的第三大银行,它清楚完整、集成的信息可以为公司、员工和客户带来很大利益。现在,让我们来了解一下该银行的奖励系统。在几年前,这家有着百年历史的机构还在为销售专业人员发放固定工资。但是由于不同的销售人员对企业带来的利润不同,因此这种工资模式不能激励员工发挥其全部潜能。

关键词：客户数据佣金销售业绩 BANCO SALVADOREN ORACLE 软件

客户信念——ORACLE数据仓库帮助秘鲁BANCO DE CREDITO银行向客户推销服务和产品

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银行家 2004年第3期 153-154页

作者： karen j.BANNAN

金钱高于一切,特别在秘鲁更是如此。繁多的银行分支机构,以及对金融专业人员的不断需求都证明了这一点。虽然有些在美国的金融机构认为这样做的成本高得令人望而生畏——支付一名专业银行工作人员的工资要比维护一台ATM(自动取款机)昂... 详细信息

金钱高于一切,特别在秘鲁更是如此。繁多的银行分支机构,以及对金融专业人员的不断需求都证明了这一点。虽然有些在美国的金融机构认为这样做的成本高得令人望而生畏——支付一名专业银行工作人员的工资要比维护一台ATM(自动取款机)昂贵得多,但是Banco Crédito de BCP银行的首席信息官Ricardo Guiloermo Bustamante却降这看作是一种机遇。“每次,当一名客户走进一个分支银

关键词：银行金融机构 ORACLE BANCO DE CREDITO 秘鲁南美洲数据仓库

Disturbance increases high tide travel distance of a roosting shorebird but only marginally affects daily energy expenditure

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Avian Research 2019年第3期10卷 294-304页

作者： Hans Linssen Martij. van de Pol Andrew M.Allen Mitzi j.ns Bruno j.Ens karen L.Krij.sveld Magali Frauendorf Henk-j.n van der Kolk Department of Animal Ecology Netherlands Institute of Ecology6708PB WageningenThe Netherlands Resource Ecology Group Wageningen University & Research6708PB WageningenThe Netherlands Centre for Avian Population Studies Droevendaalsesteeg 106708PB WageningenThe Netherlands Department of Animal Ecology and Physiology Radboud University6500GL NijmegenThe Netherlands Sovon-Texel Sovon Dutch Centre for Field Ornithology1790AB Den BurgThe Netherlands Nature Bureau Royal Netherlands Air Force4820BB BredaThe Netherlands

Background:Anthropogenic disturbance can negatively affect an animal's energy budget by evoking movement *** research focuses mainly on immediate displacement as a disturbance effect,since this can be easily observed in the field. However, effects on movement over longer timescales are poorly examined and it is largely unknown if and to what extent they reflect immediate ***-term responses could for example be larger than immediate responses if birds, after disturbance, return to the original location and thereby travel twice the immediate disturbed distance. Methods:We combined GPS tracking data with observational data to quantify the effects of anthropogenic (air force and walkers) and non-anthropogenic disturbances on distances travelled by roosting Eurasian Oystercatchers (Haematopus ostralegus) during the non-breeding season. We compared immediate displacement after a disturbance with distance travelled during the entire high tide period (longer-term response), while accounting for environmental ***,we calculated energy expenditure due to disturbance based on observed disturbance ***:Disturbance resulted in an immediate displacement response of ~200 m (median).Air force disturbances tended to yield larger immediate responses than walker and,especially,than non-anthropogenic ***-term responses and immediate responses were approximately similar,suggesting that,over longer timescales,spatial disturbance effects in the study area remain confined to immediate ***,disturbances were infrequent (0.17 disturbances per bird per hour) and most disturbances were of natural origin (62%).Consequently, anthropogenic disturbance of roosting oystercatchers in the study area on average costs 0.08% of the daily energy expenditure. Conclusions:Our results suggest that immediate spatial responses to disturbance can be a useful proxy for spatial responses over longer *** the non-exha

关键词： Biologging Disturbance Haematopus ostralegus High tide roost Movement ecology Shorebird

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Prescription for Obesity: Eat Less and Move More. Is It Really That Simple?

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Open j.urnal of Nursing 2014年第9期4卷 656-662页

作者： karen M. Deck Beth Haney Camille F. Fitzpatrick Susanne j. Phillips Susan M. Tiso Core Faculty Graduate Nursing Programs University of California Irvine Irvine CA USA

“Obesity is a disease.” This is the declaration by the American Medical Association in j.ne, 2013. The purpose of this article is to provide an overview of options for patients who meet the criteria of obesity. Primary care nurse practitioners are urged to confront obesity head on, with early, individualized intervention to reduce associated morbidity and mortality. Options for weight loss and maintenance are abundant and often confusing or unattractive to the patient. Working with patients to achieve realistic, reasonable, and patient-tailored goals for weight loss and exercise programs are paramount to achieving a healthy weight and lifestyle.

关键词： Obesity Management Options

Sex-specific differences in white matter microvascular integrity after ischaemic stroke

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Stroke & Vascular Neurology 2019年第4期4卷 198-205页

作者： Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark j.R j.Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske karen L Furie Natalia S Rost Department of Neurology Massachusetts General Hospital and Harvard Medical SchoolBostonMassachusettsUSA Martinos Center for Biomedical Imaging Massachusetts General HospitalCharlestownMAUnited States Department of Radiology Massachusetts General Hospital and Harvard Medical SchoolBostonMAUnited States Medical School of Ribeirao Preto University of Sao PauloSao PauloBrazil Department of Human Neurosciences Sapienza University of RomeRomeItaly Institute of Psychology Leiden UniversityLeidenNetherlands Department of Neuroradiology Goethe-Universitat Frankfurt am MainFrankfurtGermany Department of Neurology Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUnited States Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRhode IslandUSA

background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adj.sting for differences in comorbidities and treatment *** matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic *** aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic *** A retrospective analysis of subj.cts with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was *** the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)*** analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were *** 105 men and 79 women met inclusion criteria for *** no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) *** multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not *** In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural *** studies investigating sex-specific differences in white matter microvascular integrity are needed.

关键词： microvascular white coefficient

Reducing parental anxiety using a family based intervention for youth mental health: A randomized controlled trial

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Open j.urnal of Psychiatry 2013年第1期3卷 173-185页

作者： Melanie D. Bertino karen Richens Tess Knight j.hn W. Toumbourou Lina Ricciardelli Andrew j. Lewis Centre for Mental Health and Wellbeing Research School of Psychology Deakin University Burwood Australia

This paper presents findings on parent anxiety and attachment relationship style from the Deakin Family Options (DFO) pilot study, a randomized controlled pilot study comparing a family-based treatment (BEST Plus), versus a youth only treatment (CBT) versus a group who received both of these treatments (COMBINED). Eligible participants were families with a young person (aged 12 - 25 years) with a high prevalence mental health problem. Youth from participating families scored in the clinical or subclinical range for depression, anxiety and/or substance misuse symptoms on standardized measures during the initial assessment. The collected sample was drawn from regional and urban centers in Victoria, Australia and allocated to treatment condition using a simple randomization procedure (parallel design). It was hypothesized that families receiving the BEST Plus would experience greater reductions in youth and parent mental health symptoms, and improved parent-child relationships, compared with those in the CBT condition. This paper describes and discusses changes in parent anxiety and parent attachment, according to whether the parent participated in a treatment (BEST Plus) or did not (NONBEST Plus). Participants were blind to the study hypotheses. In total 71 parent participants returned pre data and were allocated to a treatment group. In this paper, data from parent participants who completed pre and post measures (n = 48) and pre, post, and 6-month follow-up measures (n = 28) on anxiety and attachment were analyzed by group (BEST Plus versus NONBEST Plus). The results of this study suggest that parent anxiety decreased significantly more following parent involvement in a group treatment, than for parents that did not receive treatment. Unexpectedly, avoidant attachment increased in the no treatment group, but remained relatively stable following the BEST Plus group. There were no significant findings in relation to compulsive traits and anxious attachment. These find

关键词： Adolescent Parenting Anxiety Depression Attachment Randomized Controlled Trial

Cholesteryl ester storage disease of clinical and genetic characterisation: A case report and review of literature

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World j.urnal of Clinical Cases 2020年第9期8卷 1642-1650页

作者： Elias Badal Rashu Anders Ellekær j.nker karen Vagner Danielsen Emilie Dahl Ole Hamberg Line Borgwardt Vibeke Brix Christensen Nicolai j.Wewer Albrechtsen Lise L Gluud Gastrounit Copenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Hepatology RigshospitaletCopenhagen UniversityCopenhagen 2100Denmark Centre of Genomic Medicine RigshospitaletCopenhagen UniversityCopenhagen 2100Denmark Department of Paediatrics and Adolescent Medicine RigshospitaletCopenhagen UniversityCopenhagen 2100Denmark Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen 2200Denmark Department for Clinical Biochemistry RigshospitaletUniversity of CopenhagenCopenhagen 2200Denmark

BACKGROUND Cholesteryl ester storage disease(CESD)is a rare genetic *** symptoms and severity are highly *** is a systemic disease that can lead to the accumulation of fat and inflammation in the liver,as well as gastrointestinal and cardiovascular *** maj.rity of patients require liver transplantation due to decompensated *** replacement therapy has been approved based on a randomized *** study aims to clinically and genetically evaluate two siblings with CESD who underwent liver transplantation,as well as their first-degree family *** SUMMARY The siblings were compound heterozygous for the missense variant in LIPA exon 8,c.894G>A,(***298Gln)and a single base pair deletion,c.482del(***161Ilefs*19).Analyses of single nucleotide polymorphisms showed variants with an increased risk of fatty liver disease and fibrosis for both ***,both patients show signs of recurrence of CESD in the liver after transplantation and additional gastrointestinal and cardiovascular signs of *** family members who were LIPA heterozygous had a lysosomal acid lipase activity below the reference *** of these carriers,a seven-year-old boy,was found to have severe dyslipidemia and was subsequently treated with *** Our study underlines that CESD is a multi-organ disease,the progression of which may occur post-liver *** findings underline the need for monitoring of complications and assessment of possible further treatment.

关键词： Lysosomal acid lipase deficiency Lysosomal storage disease Non-alcoholicfatty liver disease Liver transplantation Sebelipase alfa Case report

Disulfiram’s Antineoplastic Effects on Ovarian Cancer

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j.urnal of Cancer Therapy 2015年第14期6卷 1196-1205页

作者： Youssef A. Rezk Kun Yang Shoumei Bai karen Mclean Carolyn j.hnston R. Kevin Reynolds Ronald j. Buckanovich Division of Gynecologic Oncology Department of Obstetrics and Gynecology University of Michigan Ann Arbor MI USA Division of Hematology Oncology Department of Internal Medicine University of Michigan Ann Arbor MI USA

Obj.ctive: Aldehyde dehydrogenase (ALDH) enzymatic activity identifies ovarian cancer stem-like cells. We investigated the antineoplastic activity of the ALDH inhibitor Disulfiram on bulk ovarian cancer cells and CD133+/ALDH+ cancer stem-like cells. Study Design: Ovarian cancer cell lines, human ovarian surface epithelial cells, and mesenchymal stem cells were treated with increasing concentrations of Disulfiram and/or Cisplatin in vitro. Treated cells were assessed for viability or FACS-analyzed for either percentage of ovarian cancer stem-like cells or induction of apoptosis. Disulfiram’s impact on cancer stem-like cells was tested in vitro using tumor sphere formation assays and in vivo using tumor initiation assays with in vitro-treated A2780 cells in NSG mice. Finally, Disulfiram’s in vivo activity was assessed versus CD133+/ALDH+ cell-initiated tumor xenografts. Results: Disulfiram demonstrated antineoplastic activity against multiple ovarian cancer cell lines. While Disulfiram had limited in vitro toxicity against human ovarian surface epithelial cells or mesenchymal stem cells (IC50 of ~15 μM and >30 μM, respectively), its antineoplastic activity against cell lines was comparable to Cisplatin (IC50 ~1.5 μM). Disulfiram-mediated cell death was due, at least in part, to induction of apoptosis. Disulfiram activity was additive with chemotherapy. Disulfiram demonstrated selective depletion of CD44+ cells but not the CD133+ cancer stem-like cells. Disulfiram had no therapeutic impact on tumor initiation studies or in vivo therapy of whole cell line or stem cell-initiated tumor xenografts. Conclusions: In biologically relevant concentrations, Disulfiram has clear antineoplastic activity against ovarian cancer cells in vitro. Disulfiram selectively depleted CD44+ but not CD133+ ovarian cancer stem-like cells in vitro. However, Disulfiram had no significant activity in vivo. Thus, improved and more selective ALDH inhibitors may be required to target ovarian cancer s

关键词： Antineoplastic ALDH Disulfiram NSG Mice Ovarian Cancer Stem Cells

Suitable conditions for natural regeneration in variable retention harvesting of southern Patagonian Nothofagus pumilio forests

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Ecological Processes 2019年第1期8卷 240-251页

作者： Mónica D.R.Toro Manríquez j.an M.Cellini María V.Lencinas Pablo L.Peri karen A.Peña Roj.s Guillermo j.Martínez Pastur Centro Austral de Investigaciones Científicas(CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 200(9410)UshuaiaTierra del FuegoArgentina Laboratorio de Investigaciones en Maderas(LIMAD) Universidad Nacional de la Plata(UNLP)Diagonal 113 n°469(1904)La PlataBuenos AiresArgentina Instituto Nacional de Tecnología Agropecuaria(INTA) Universidad Nacional de la Patagonia Austral(UNPA)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)cc 332(9400)Río GallegosSanta CruzArgentina Departamento de Silvicultura y Conservación de la Naturaleza Facultad de Ciencias Forestales y de Conservación de la NaturalezaUniversidad de Chilecc 9206SantiagoChile.

Background:Variable retention(aggregated and dispersed retention)harvesting proposed for Nothofagus pumilio was designed for timber purposes and biodiversity *** by opening canopy generates different microenvironments and creates contrasting conditions for seedling establishment,growth,and eco-physiology performance due to synergies(positives or negatives)with biotic and abiotic *** study evaluated the regeneration in different microenvironment conditions within managed stands during 5 years after *** forest structure after harvesting and different microenvironments were characterized in managed stands,where 105 regeneration plots were measured(3 stands×7 microenvironments×5 replicas).We characterized the seedling bank,as well as growth and ecophysiology performance of the *** and multivariate analyses were conducted for the ***:Microenvironments offered different environmental conditions for natural regeneration(soil moisture and light availability).Seedling under debris and dicot plants showed better eco-physiological performance,establishment,and growth than plants growing under monocots or located in the dispersed retention without the protection of other understory *** most unfavorable microenvironment conditions were high canopy cover of remnant trees(inside the aggregates or close to trees in the dispersed retention)and heavily impacted areas(skidder extraction roads).Conclusions:Favorable microenvironments in the harvested areas will improve the natural recruitment,growth,and eco-physiology performance of the natural regeneration after *** is necessary to develop new silvicultural practices that decrease the unfavorable microenvironments(e.g.,road density or excessive woody accumulation),to assure the success of the proposed silvicultural method.

关键词： Aggregated retention Dispersed retention Microenvironments Environmental variables Biometric values Biomass allocation Eco-physiology