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Depositional condition of Paleoproterozoic Francevillian carbonate rocks revisited from rare earth element contents

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Geoscience Frontiers 2024年第3期15卷 31-49页

作者： Satoshi Yoshida karen Bakakas Mayika Yuki Ishihara Mathieu Moussavou Hisashi Asanuma Tomohiko Sato Takafumi Hirata cédric Ligna Yusuke Sawaki Amboise Edou-Minko Department of Earth Science and Astronomy The University of Tokyo3-8-1 Komaba Meguro-kuTokyo 153-8902Japan center for Northeast Asian Studies Tohoku University41 KawauchiAoba-kuSendai 980-8576Japan Department of Geology Universitédes Sciences et Techniques de MasukuBP:90190025 FrancevilleGabon Department of Earth and Planetary Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Geochemical Research center The University of Tokyo7-3-1HongoBunkyo-kuTokyo 113-0033Japan Graduate School of Human and Environmental Studies Kyoto UniversityYoshida-nihonmatsuSakyo-kuKyoto 606-8501Japan center for Fundamental Education Okayama University of Science1-1Ridai-choKita-kuOkayama CityOkayama 700-0005Japan

The Paleoproterozoic Francevillian Group in the eastern Gabonese Republic has been recently attracting increasing attention because it includes distinctive macroscopic structures interpreted as eukaryotic ***,its depositional setting and associated redox conditions need to be clearly *** clarify these,petrological studies and rare earth element(REE)abundances of carbonate rocks of the Francevillian Group in the Lastoursville basin were determined with IcP-MS coupled with a laser ablation sampling *** microscopic observations indicate that dolostones in this basin underwent the complicated diagenetic history,including sparitization,decomposition of organic matter,reduction of ferromanganese oxides,silicification,and later *** dolostones of lower Francevillian B(FB)Formation show heterogeneous textures formed by alterations during *** the alterations,changes of REE abundances and degrees of positive Y anomalies appear to have *** indicates that REE signatures in carbonate rocks can vary during *** high Mn contents in the dolostones of upper FB Formation were derived from the reduction of ferromanganese oxides in *** signatures of REE abundance in dolostones can be explained by the mixing of seawater and ferromanganese oxide *** that sense,the dolostones inherited the trace element characteristics of precursor ferromanganese oxides even after the diagenesis.Y/Ho values of the most primary parts of each sample exceed 33,the newly determined threshold value for marine carbonate rocks based on our *** magnitude of the La anomaly values also falls within the range of that of Holocene reefal *** indicate that a precursor of the dolostone of the Francevillian Group was deposited in a marine *** addition,presence of ce anomalies in the upper FB Formation suggests that the Paleoproterozoic ocean was oxidized to such an ex

关键词： carbonate diagenesis Francevillian Group LA-IcP-MS Seawater composition Y/Ho fractionation

chemical degradation of platinum oncolytics in urine and speciation of the inorganic contaminants cisplatin and carboplatin relevant in waste water

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Emerging contaminants 2024年第1期10卷 47-53页

作者： Karel Folens Janis Baeten karen couvreur Gijs Du Laing Laboratory of Analytical chemistry and Applied Ecochemistry(EcOcHEM) Department of Green Chemistry and TechnologyGhent UniversityFrieda Saeystraat 19052ZwijnaardeBelgium center for Microbial Ecology and Technology(cMET) Department of BiotechnologyGhent UniversityCoupure Links 6539000GentBelgium Medical Oncology AZ GlorieuxGlorieuxlaan 559600RonseBelgium

Understanding the prevalent form of platinum(Pt)based antineoplastic agents,used in chemotherapy,is of importance to develop a remediation strategy that restricts aquatic *** speciation of Pt-based compounds was measured in actual patients’urine using hydrophobic interaction liquid chromatography(HILIc)equipped with an IcP-MS *** showed poor metabolization and intact excretion 11 h after administration,whereas cisplatin underwent a rapid aquation in the first 7 *** compare,the in vitro degradation rate of cisplatin,carboplatin and oxaliplatin was determined in synthetic human urine,mimicking true environmental *** fraction of intact molecules was measured at regular intervals following incubation at 37°c,resulting in degradation rate *** chemical stability was highest for carboplatin(k=0.0143±0.0012 min−1),versus faster degradation of oxaliplatin and cisplatin by exponential decay with k1 of 0.0026±0.0001 min−1 and k_(2)=5.59±0.46×10^(−6) min−1,*** kinetic parameters can serve as input to further expand modelling databases and improve the predictive power of speciation software to estimate eco-toxicity *** the strong residual cytotoxicity of the platinum antineoplastic molecules following renal clearance and human excretion,the contaminants are of high environmental concern and offer potential for metal recovery using advanced treatment *** such water treatment processes,especially carboplatin,above all cancerostatic platinum compounds,should be addressed since it is more persistent in the aquatic environment.

关键词： Pharmaceuticals Inorganic contaminants Speciation analysis Ecotoxicity

Are there sex-based disparities in cataract surgery?

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 137-143页

作者： Matthew D.Geiger Anne M.Lynch Alan G.Palestine Nathan c.Grove karen L.christopher Richard S.Davidson Michael J.Taravella Naresh Mandava Jennifer L.Patnaik Department of Ophthalmology University of Colorado School of MedicineAuroraCO 80045USA

AIM:To investigate sex-based differences in the occurrence of intra-operative and post-operative complications and associated visual outcomes following cataract ***:This was a retrospective study of patients who had phacoemulsification cataract surgery at the University of colorado School of *** collected included the patient’s health history,ocular comorbidities,operative and post-operative complications,and the post-operative best corrected visual acuity(BcVA).The data were analyzed using univariate and multivariable logistic regression with generalized estimating equations to account for the correlation of some patients having two eyes included in the ***:A total of 11977 eyes from 7253 patients were included in the *** comorbidities differed by sex,with males having significantly higher percentages of traumatic cataracts(males 0.7%vs females 0.1%),prior ocular surgery(6.7%vs 5.5%),and mature cataracts(2.8%vs 1.9%).conversely,females had significantly higher rates of pseudoexfoliation(2.0%vs 3.2%).In unadjusted analysis,males had higher rates of posterior capsular rupture(0.8%vs 0.4%)and vitreous loss(1.0%vs 0.6%),but this difference was not significant after adjustment for *** had a significantly increased risk of post-operative retinal detachment,but in multivariable analysis this was no longer *** were significantly less likely to undergo post-operative neodymium-doped yttrium aluminum garnet(Nd:YAG)laser capsulotomy for posterior capsule opacification(OR=0.8,95%cI=0.7-0.9,P=0.0005).The BcVA was slightly worse for males pre-operatively;but post-operatively,both sexes exhibited similar visual acuity of Snellen equivalent 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative comorbidities and surgical characteristics that contribute to higher rates of some complications for ***,observed surgical complicatio

关键词： cataract surgery sex-based disparity phacoemulsification outcomes

Optimal transcorneal electrical stimulation parameters for preserving photoreceptors in a mouse model of retinitis pigmentosa

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Neural Regeneration Research 2024年第11期19卷 2543-2552页

作者： Sam Enayati karen chang Anton Lennikov Menglu Yang cherin Lee Ajay Ashok Farris Elzaridi christina Yen Kasim Gunes Jia Xie Kin-Sang cho Tor Paaske Utheim Dong Feng chen Schepens Eye Research Institute of Massachusetts Eye and Ear Department of OphthalmologyHarvard Medical SchoolBostonMAUSA Institute of clinical medicine Faculty of MedicineUniversity of OsloOsloNorway Department of Medical Biochemistry Oslo University HospitalUniversity of OsloOsloNorway Department of Ophthalmology Drammen HospitalVestre Viken Hospital TrustDrammenNorway Department of Histology and Embryology School of MedicineMarmara UniversityIstanbulTurkiye

Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors,leading to progressive photoreceptor *** research supports the beneficial effect of electrical stimulation on photoreceptor *** study aims to identify the most effective electrical stimulation parameters and functional advantages of transcorneal electrical stimulation(tcES)in mice affected by inherited retinal ***,the study seeked to analyze the electric field that reaches the retina in both eyes in mice and post-mortem *** this study,we recorded waveforms and voltages directed to the retina during transcorneal electrical stimulation in c57BL/6J mice using an intraocular needle probe with rectangular,sine,and ramp *** investigate the functional effects of electrical stimulation on photoreceptors,we used human retinal explant cultures and rhodopsin knockout(Rho^(-/-))mice,demonstrating progressive photoreceptor degeneration with *** retinal explants isolated from the donors’eyes were then subjected to electrical stimulation and cultured for 48 hours to simulate the neurodegenerative environment in *** density was evaluated by rhodopsin *** vivo Rho^(-/-)mice were subjected to two 5-day series of daily transcorneal electrical stimulation using rectangular and ramp *** function and visual perception of mice were evaluated by electroretinography and optomotor response(OMR),*** was used to assess the morphological and biochemical changes of the photoreceptor and bipolar cells in mouse *** recordings indicated effective delivery of rectangular,sine,and ramp waveforms to the retina by transcorneal electrical stimulation,of which the ramp waveform required the lowest *** of the total conductive resistance of the post-mortem human compared to the mouse eyes indicated higher cornea-to-retina resistance in human *** tem

关键词： bipolar cells electrical stimulation neuroprotection photoreceptor degeneration retina retinal explants retinitis pigmentosa transcorneal electrical stimulation waveform

Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression

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World Journal of clinical Oncology 2024年第2期15卷 195-207页

作者： Angeles c Tecalco-cruz karen H Medina-Abreu Enrique Oropeza-Martínez Jesus Zepeda-cervantes AleidaVázquez-Macías Marina Macías-Silva Posgrado en ciencias Genómicas Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico colegio de ciencias y Humanidades Universidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Instituo de Fisiología celular Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of *** deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer *** particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γ*** this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in ***,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus *** addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.

关键词： Interferon-gamma IFNGR1 JAK1 Antiviral Anti-tumor Lung adenocarcinoma

clinical and demographic features of patients undergoing videocapsule endoscopy management:A descriptive study

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World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 424-431页

作者： María c Mejía Luis G Piñeros Luis M Pombo Laura A León Jenny A Velásquez Aníbal A Teherán karen P Ayala Research center Fundación Universitaria Juan N.CorpasBogotá111321Colombia Fundación Universitaria Juan N.corpas Bogotá111321Colombia Department of Gastroenterology Universidad Militar Nueva GranadaBogotá111711Colombia Department of Gastroenterology Hospital Universitario Clínica San RafaelBogotá111711Colombia

BAcKGROUND Video-capsule endoscopy(VcE)is an efficient tool that has proven to be highly useful in approaching several gastrointestinal *** was implemented in colombia in 2003,however current characterization of patients undergoing VcE in colombia is limited,and mainly comes from two investigations conducted before the SARS-coV-2 pandemic *** To describe the characteristics of patients undergoing VcEs and establish the main indications,findings,technical limitations,and other outstanding *** A descriptive study was carried out using data from reports of VcE(Pillcam SB3 system)use in a Gastroenterology Unit in Bogotá,colombia between September 2019 and January *** and clinical variables such as indication for the VcE,gastric and small bowel transit times(GTT,SBTT),endoscopic preparation quality,and limitations were described[n(%),median(IQR)].RESULTS A total of 133 VcE reports were *** were in men with a median age of 70 *** majority had good preparation(96.2%),and there were technical limitations in 15.8%of *** main indications were unexplained anemia(91%)or occult bleeding(23.3%).The median GTT and SBTT were 14 and 30 minutes,*** frequencies of bleeding stigma(3.79%)and active bleeding(9.09%)were low,and the most frequent abnormal findings were red spots(28.3%),erosions(17.6%),and vascular ectasias(12.5%).cONcLUSION VcE showed high-level *** main indication was unexplained *** bleeding was the most frequent *** with artificial intelligence,VcE can improve diagnostic precision and targeted therapeutic interventions.

关键词： Endoscopy Video-capsule endoscopy capsule endoscopy Gastrointestinal diseases Observational study Gastrointestinal bleeding

Application of Image Analysis Based on SEM and chemical Mapping on Pc Mortars under Sulfate Attack

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Journal of Wuhan University of Technology(Materials Science) 2014年第3期29卷 534-539页

作者：于诚孙伟 Scrivener karen School of Materials Science and Engineering Southeast University Jiangsu Key Lab of construction Material Laboratory of construction Materials Swiss Federal Institute of Technology (EPFL)Ecublens 1015 LausanneSwitzerland

The degradation mechanisms of cementitious materials exposed to sulfate solutions have been controversial, despite considerable research. In this paper, two methodologies of image analysis based on scanning electron microscope and chemical mapping are used to analyse Portland cement mortars exposed to sodium sulfate solution. The effects of sulfate concentration in solution and water to cement ratio of mortar, which are considered as the most sensitive factors to sulfate attack, are investigated respectively by comparing the macro expansion with microstructure analysis. It is found that the sulfate concentration in pore solution, expressed as sulfate content in c-S-H, plays a critical role on the supersaturation with respect to ettringite and so on the expansion force generated.

关键词： image analysis mapping sulfate attack pore solution

Square wave manoeuvre for apogeotropic variant of horizontal canal benign paroxysmal positional vertigo in neck restricted patients

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Journal of Otology 2021年第2期16卷 65-70页

作者： Dario A.Yacovino Estefania Zanotti karen Roman Timothy c.Hain Department of Neurology Dr.Cesar Milstein HospitalBuenos AiresArgentina Memory and Balance clinic Buenos AiresArgentina Northwestern University ChicagoILUSA

Objective:We aimed to describe the clinical features of the apogeotropic variant of horizontal canal benign paroxysmal positional vertigo(Hc BPPV-AG)in a cluster of patients with restrictive neck movement disorders and a new therapeutic manoeuvre for its ***:In a retrospective review of cases from an ambulatory tertiary referral center,patients with Hc BPPV-AG in combination with neck movement restriction that prevented any classical manual repositioning procedure or who were refractory to canalith repositioning manoeuvres,were treated with a new manoeuvre comprised of sequential square-wave pattern of head and body supine rotations while nystagmus was being monitored,until either an apogeotropic to geotropic conversion or resolution of the nystagmus was ***:Fifteen patients were *** but one[14/15 cases]showed a positive therapeutic response to the repositioning procedure in a single *** two cases,a direct relief of vertigo and elimination of nystagmus was observed without an intermediate geotropic *** in three patients the affected ear was not initially identified,it was ultimately identified and successfully treated by the square wave manoeuvre in all of ***:The square-wave manoeuvre is an alternative for Hc BPPV-AG treatment in either cases with neck restriction,where the affected side is not well identified at the bedside or when other manoeuvres fail to resolve the Hc BPPV-AG.

关键词： Benign paroxysmal positional vertigo Horizontal canal cupulolithiasis treatment

The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies

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Neural Regeneration Research 2021年第9期16卷 1774-1775页

作者： Peng Liu karen H.Ashe Department of Neurology University of MinnesotaMinneapolisMNUSA Department of Neuroscience University of MinnesotaMinneapolisMNUSA N.Bud Grossman center for Memory Research and care University of MinnesotaMinneapolisMNUSA Geriatric Research Educationand Clinical CentersVeterans Affairs Medical CenterMinneapolisMNUSA

A major focus of current experimental therapies for neurodegenerative diseases is on modulating post-translational modifications(PTMs)of the microtubule-associated protein *** is a highly soluble,neuronal protein that is comprised of four domains–the N-terminal projection domain,the proline-rich region,the microtubule-binding domain,and the c-terminal *** a scaffold protein,tau dynamically interacts with numerous structural and functional biomolecules,such as cytoskeleton and motor proteins,chaperones,enzymes,DNA,RNA,and *** a dozen types of PTMs,combined with alternative splicing,confer upon tau its enormous structural heterogeneity,which subserves its many(patho-)physiological functions.

关键词： tau structural cleavage