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An integrative bioinformatics pipeline shows that honeybee-associated microbiomes are driven primarily by pollen composition

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Insect science 2023年第2期30卷 555-568页

作者： Douglas Chesters Xiuwei Liu karen L.Bell Michael C.Orr Tingting Xie Qingsong Zhou Chaodong Zhu Key Laboratory ofZoological systematics andEvolution Institute ofZoologyChinese Academy of SciencesBejingChina International College University of Chinese Academy of SciencesBejingChina Institute of Agro-Products Processing Yunnan Province Academy of Agricultural ScienceKunmingChina school of Biological sciences University of Western AustraliaCrawleyWAAustralia csIRO Health&Biosecurity FloreatWAAustralia College of Life sciences Anhui Normal UniversityWuhuAnhui ProvinceChina state Key Laboratory of Integrated Pest Management Institute of ZoologyChinese Academy of SciencesBeijingChina College of Biological sciences University of Chinese Academy of SciencesBeijingChina

The microbiomes associated with bee nests influence colony health through various mechanisms,although it is not yet clear how honeybee congeners differ in microbiome assembly processes,in particular the degrees to which floral visitations and the environment contribute to different aspects of *** used DNA metabarcoding to sequence bacterial 16s rRNA from honey and stored pollen from nests of 4 honeybee species(Apis cerana,***,***,and ***)sampled throughout Yunnan,China,a global biodiversity *** developed a computational pipeline integrating multiple databases for quantifying key facets of diversity,including compositional,taxonomic,phylogenetic,and functional ***,we assessed candidate drivers of observed microbiome dissimilarity,particularly differences in floral visitations,habitat disturbance,and other key environmental *** revealed that microbiome alpha diversity was broadly equivalent across the study sites and between bee species,apart from functional diversity which was very low in nests of the reclusive *** in microbiome composition across Yunnan was driven predominantly by pollen *** disturbance negatively impacted both compositional and phylogenetic alpha diversity of nest microbiomes,but did not correlate with microbial *** herein make progress in understanding microbiome diversity associated with key pollinators in a biodiversity hotspot,and provide a model for the use of a comprehensive informatics framework in assessing pattern and drivers of diversity,which enables the inclusion of explanatory variables both subtly and fundamentally different and enables elucidation of emergent or unexpected drivers.

关键词： Apis biodiversity hotspot honeybee informatics metabarcoding microbiome

Direct Observation of Arthrobacter 4-Hydroxybenzoyl-Coenzyme A Thioesterase Catalysis complexes using Electrospray Ionization Mass spectrometry

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Direct Observation of Arthrobacter 4-Hydroxybenzoyl-Coenzyme...

Risk Factors for Abuse in Children with Congenital Heart Disease Presenting at a Pediatric Tertiary Care Hospital

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Debra Dunaway-Mariano karen s. Anderson Department of Chemistry University of New Mexico Department of Pharmacology Yale University School of Medicine

＜正＞Investigating enzymatic reaction in multimeric enzymes is utmost interest to improve our understanding of the mechanism of enzymatic reaction and *** this study,we

关键词： Arthrobacter thioesterase multinary enzyme-ligand complex mass spectrometry

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Congenital Heart Disease 2023年第6期18卷 657-670页

作者： Kristi K.Westphaln karen Kay Imagawa Lorena Espinosa smith Julia srivastava Nancy A.Pike school of Nursing University of CaliforniaLos AngelesCaliforniaUSA Department of Pediatrics Children’s Hospital Los AngelesAudrey Hepburn CARES CenterLos AngelesCaliforniaUSA Keck school of Medicine of the University of southern California Los AngelesCaliforniaUSA Department of Pediatrics Critical Care MedicineChildren’s Hospital Los AngelesLos AngelesCaliforniaUSA Department of Pediatrics Heart Institute Children’s Hospital Los AngelesLos AngelesCaliforniaUSA

Background:Congenital heart disease(CHD)is a chronic medical condition often diagnosed at birth and requires surgical intervention,multiple hospitalizations,and lifelong *** can put signiﬁcant stress on the family,leading to altered maternal mental health,bonding and attachment issues,and the potential for child *** purpose of this study is to explore the characteristics of a sample of young children with CHD who experienced hospitalization with concurrent concern for child abuse in a free-standing pediatric tertiary care ***:Electronic medical records were reviewed for children aged 0–5 years old who were hospitalized with concern for child abuse between 2016 and *** were extracted related to the history of presenta-tion,and sociodemographics including sDOH,admission,and discharge condition/*** statis-tics were used to characterize the sample and correlations to identify an association with abuse ***:Out of 251 hospitalizations involving concern for child abuse,49(19.5%)had a diagnosis of *** majority of cases were neglect(51%),spanic ethnicity(45%),and publicly insured(90%).CHD severity was moderate to severe(71%)with multiple co-occurring medical conditions(genetic syn-drome,failure to thrive(FTT),prematurity,history of a feeding tube,developmental delay,and intrauterine drug exposure).Correlations associated with physical abuse were age,maternal mental health,head injury,and history of Child Protective services(CPs)*** correlated with age,FTT,head injury,history of a feeding tube,previous CPs involvement,and substance *** speciﬁcally related to prenatal substance use included age,maternal mental health status,history of domestic violence,CPs involvement,feeding tube,FTT,lack of housing,employment status,and public ***:Our study highlights the risk for abuse in children with CHD,regardless of defect *** most com

关键词： Child maltreatment intrauterine substance exposure failure to thrive

Which strategy after first-line therapy in advanced colorectal cancer?

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World Journal of Gastroenterology 2014年第27期20卷 8921-8927页

作者： Coinu Andrea Petrelli Fausto Borgonovo karen Francesca Cabiddu Mary Ghilardi Mara Lonati Veronica Barni sandro Medical Oncology Unit Oncology Department Azienda Ospedaliera di Treviglio Treviglio 24047 BG Italy

second-line therapy for advanced colorectal cancer is an integral part of the treatment strategy that needs to be set from the beginning for each patient, bearing in mind the expected toxicities of chosen treatments, the patient's clinical condition, comorbidities, preferences, the aims of the treatment and the molecular status. Furthermore, the distinction between lines of therapy is no longer absolute. The perspective of "continuum of care" includes switching chemotherapy prior to disease progression, maintenance therapy, drug "holidays" if needed, surgical resection of metastases in selected patients, and seems to allow a tailored treatment, in which patients are more likely to benefit from exposure to all active agents, which is known to correlate with overall survival. The scenario of second-line treatment has changed dramatically over the years and could currently benefit from several options including chemotherapy with a single agent or in combination and the addition of molecular-targeted agents developed in the last decade, such as epidermal growth factor receptor antibodies(cetuximab, panitumumab) and vascular endothelial growth factor-targeting agents(bevacizumab, aflibercept), with the possibility of bevacizumab use even beyond first progression. The purpose of this review is to summarize the most important scientific data supporting the use of chemotherapy and the new biologic agents in the second-line setting in advanced colorectal cancer.

关键词： Advanced colorectal cancer second-line Targeted agents Polychemotherapy Overall survival

Impact of androgen deprivation therapy on sexua function： a response

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Asian Journal of Andrology 2012年第5期14卷 793-794页

作者： Erik Wibowo Richard Wassersug karen Warkentin Lauren Walker John Robinson Lori Brotto Thomas Johnson Department of Anatomy&Neurobiology Dalhousie UniversityHalifaxNS B3H 4R2Canada Men's Health Initiative of B.C. Department of Urologic SciencesUniversity of British ColumbiaVancouverBC V5Z 1M9Canada Department of Biology Boston UniversityBostonMA 02215USA Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada Department of Psychosocial Resources Tom Baker Cancer CentreCalgaryAB T2S 3C1Canada UBC sexual Health Lab Gordon&Leslie Diamond Health Care CentreDepartment of Obstetrics/GynecologyDivision of Gynecologic OncologyVancouverBC V5Z 1M9Canada Department of Anthropology California State UniversityFultonCA 95439-0050USA

Dear Editors, We appreciate the growing patients and survivors. Mazzola interest in sexual health for cancer and Mulhall＇s recent paper,a however, creates the impression that rewarding sex is not possible for prostate cancer patients on androgen deprivation therapy （ADT）. This impression, we believe, is not scientifically justified,

关键词： androgen therapy estosterone

Importance of adapted digestion conditions to simulate in vitro lipid digestion of broilers in different life stages

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Animal Nutrition 2023年第1期12卷 151-158页

作者： Daphne Michels sarah H.E.Verkempinck Agnese Panozzo karen Vermeulen Marc E.Hendrickx Liesbet Thijs Tara Grauwet Laboratory of Food Technology and Leuven Food science and Nutrition Research Centre(LFoRCe) Department of Microbial and Molecular Systems(M2S)KU LeuvenLeuven3001Belgium Kemin Animal Nutrition and Health Kemin Europa N.V.Herentals2200Belgium

In vitro digestion studies demonstrate large potential to gain more and quicker insights into the underlying mechanisms of feed additives,allowing the optimization of feed ***,current in vitro digestion models relevant for broiler chickens lack sufficient description in terms of protocols and standardisation ***,no distinction is made between the different life phases of these animals(starter,grower,and finisher).Hence,our research aimed to establish adapted in vitro digestion conditions,corresponding to the 3 life phases in broilers,with specific focus on lipid *** effect of 3 different bile salt concentrations of 2,10,and 20 mM,and 3 different lipase activities of 5,20,and 100 U/mL,on in vitro lipid digestion kinetics were evaluated using a full factorial *** values were selected to represent starter,grower,and finisher birds,*** findings showed that the extent of lipid digestion was mainly influenced by lipase *** rate of lipid digestion was affected by an interplay between bile salt concentration and lipase activity,due to possible lipase inhibition at certain bile salt ***,this work resulted in 3 in vitro lipid digestion models representative for starter,grower,and finisher *** conclusion,this research showed the impact of adapted in vitro digestion conditions on lipid digestion kinetics and thus the need for these conditions relevant for each life phase of broilers.

关键词： Lipolysis Lipase activity Bile salt In vitro digestion Broiler chicken Emulsion

Vulvar sarcomas: A 25 plus-year experience from Queensland

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 37-40页

作者： Ian s. C. Jones Alex Crandon karen sanday Queensland Centre for Gynaecological Cancer University of Queensland Brisbane Australia Queensland Centre for Gynaecological Cancer University of Queensland Brisbane Australia&Women’s and Newborn Services Royal Brisbane and Women’s Hospital Herston Australia

Objective: To review the characteristics of cases of vulvar sarcomas (Vs) referred to the Queensland Centre for Gynaecological Cancer (QCGC) between mid 1984 and mid 2012. Methods: Vs case data from QCGC were reviewed and analysed using the computer software statistical Package for the social sciences (sPss) 11.0. Results: Of the nine cases three died of their disease, one died of ovarian cancer and five are still alive and disease free. The mean age at diagnosis was 54.8 years. Time from onset of symptoms to diagnosis averaged one month. All diagnoses were confirmed histologically. The most common presenting complaint was a lump. Treatment in all but one case involved surgical excision, one case had chemotherapy alone and two cases had surgery followed by radiotherapy. Conclusions: To talk of five year survival for patients with such a rare cancer, so many histological types with variable cell differentiation plus the unknown of when sarcomatous cells metastasize from even early FIGO staged lesions is in our opinion taking generalisation to far. A multidisciplinary approach to management achieves the best results for each individual and pooling multicentre data will improve our understanding of this rare disease and benefit future patients.

关键词： Vulvar sarcoma Diagnosis Management Outcome Follow Up

Bartholin’s Gland Carcinomas: A 20 plus-year experience from Queensland

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Open Journal of Obstetrics and Gynecology 2012年第4期2卷 385-388页

作者： Ian s. C. Jones Alex Crandon karen sanday Queensland Centre for Gynaecological Cancer University of Queensland Brisbane Australia

Objective: To review the records of cases of Bartholin’s Gland Carcinoma referred to the Queensland Centre for Gynaecological Cancer (QCGC) between mid 1993 and mid 2012. Methods: Bartholin’s Gland Carcinoma case data from QCGC were reviewed and analysed using the computer software statistical Package for the social sciences 11.0. Results: Of the 12 cases four died of their disease, seven are still alive and disease free and one is alive with recurrent disease. The mean age at diagnosis was 52.8 years. Time from onset of symptoms to diagnosis averaged 5.8 months. All diagnoses were confirmed histologically. Presenting symptoms included a lump and pain. The most common presenting complaint was a lump. Treatment included surgical excision, occasional biopsy followed by radiotherapy with or without chemotherapy. In some cases radiation and chemotherapy was followed by vulvectomy of various extent. Conclusions: Bartholin’s Gland Carcinoma is a rare condition with outcome dependent on duration of symptoms, including delay in diagnosis, cell-type, cellular differentiation and the International Federation of Gynecology and Obstetrics (FIGO) classification. A Bartholin’s gland mass in a woman aged 40 years or more should be considered malignant until a biopsy proves *** incidence of Bartholin’s Gland Carcinoma in Queensland is less than that reported elsewhere but a higher proportion of squamous cell carcinomas was found in this small series.

关键词： Bartholin’s Gland Carcinomas Cancer Diagnosis Management Outcome Follow Up

Vulvar basal cell carcinoma: A retrospective study of 29 cases from Queensland

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Open Journal of Obstetrics and Gynecology 2012年第2期2卷 136-139页

作者： Ian s. C. Jones Alex Crandon karen sanday Queensland Centre for Gynaecological Cancer Royal Brisbane and Women’s Hospital Brisbane Australia

Objective: Review the clinical features, diagnosis, management and outcomes for 29 cases of Basal Cell Carcinoma (BCC) of the Vulva referred to Queensland Centre for Gynaecological Cancer (QCGC) between 1986 and 2010. Methods: Vulvar BCC cases from QCGC were reviewed and analysed using the computer software statistical Package for the social sciences (sPss) 11.0. Results: BCC of the vulva is uncommon with an incidence from the QCGC vulvar cancer registry of 3.2%. Of the 29 patients one died of their BCC and seven died of unrelated causes. The mean age at diagnosis was 69.5 years (range 40 to 91). All cases were Caucasian. Time from onset of symptoms to diagnosis averaged 22.6 months (range 0 - 120 months). Not until a biopsy was performed was the diagnosis made. The most common presenting complaints were pruritis and a lump. Initial treatment was surgical. Conclusions: The prognosis for vulvar BCC is excellent. Histological diagnosis and long term follow-up are important management issues. The status of disease at the margins of surgical specimens does not reliably equate to patient long term outcomes. Follow up should be supervised via a gynecological oncology register to reduce the risk of patient loss to follow up.

关键词： Vulvar Basal Cell Carcinoma Diagnosis Management Outcome specimen Margins Follow-Up