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Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice

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Animal Models and Experimental medicine 2020年第2期3卷 160-168页

作者： kare.Kryger Vols Mads Kjelgaard-Hansen Carsten Dan ley Axel Kornerup Hansen Maj Petersen Global Drug Discovery Novo Nordisk A/SMaaloevDenmark veterinary and Animal Sciences University of CopenhagenFrederiksbergDenmark veterinary Clinical Sciences University of CopenhagenFrederiksbergDenmark

Background: Hemophilic arthropathy is a debilitating morbidity of hemophilia caused by recurrent joint bleeds. We investigated if the joint bleed volume, before initiation of treatment, was linked to the subsequent degree of histopathological changes and the development of bone pathology in a mouse model of hemophilic ***: FVIII knock-out(F8-KO) mice were dosed with a micro-CT blood pool agent prior to induction of hemarthrosis. Eight hours after induction, the bleed volume was quantified with micro computed tomography(micro-CT) and recombinant FVIII treatment initiated. On Day 8, inflammation in the knees was characterized by fluorescence molecular tomography. On Day 14, knee pathology was characterized by micro-CT and histopathology. In a second study, contrast agent was injected into the knee of wild-type(WT) mice, followed by histopathological evaluation on Day ***: The average joint bleed volume before treatment was 3.9 mm3. The inflammation-related fluorescent intensities in the injured knees were significantly increased on Day 8. The injured knees had significantly increased synovitis scores, vessel counts, and areas of hemosiderin compared to un-injured knees. However, no cartilage-or bone pathology was observed. The bleed volume before initiation of treatment correlated with the degree of synovitis and was associated with high fluorescent intensity on Day 8. In F8-KO and WT mice, persistence of contrast agent in the joint elicited morphological ***: When applying a delayed on-demand treatment regimen to hemophilic mice subjected to an induced knee hemarthrosis, the degree of histopathological changes on Day 14 reflected the bleed volume prior to initiation of treatment.

关键词： Animal models arthropathy hemarthrosis haemophilia A in vivo imaging micro-CT

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Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients

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World Journal of Diabetes 2017年第3期8卷 112-119页

作者： Neerja Aggarwal Pawan Kumar kare.Parul Varshney Om Prakash Kalra Sri venkata Madhu Basu Dev Banerjee Anil Yadav Alpana Raizada Ashok Kumar Tripathi Department of medicine University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital Department of Biochemistry University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital Pt. B. D. Sharma University of Health Sciences

AIM To investigate the role of genetic variants of angiotensin converting enzyme(ACE) and angiotensinogen(AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy(DN) *** In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor(ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio(ACR) in urine. Genotyping of ACE I/D and AGT M235 T polymorphisms were performed by using primer specific polymerase chain reaction(PCR) and PCR-RFLP techniques, respectively. RESULTS Forty-eight percent of DN patients(responders) benefited with respect to proteinuria from ACE inhibitor therapy at 6 mo follow-up. A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric(≥ 30 and me of enrollment. However, macro-albuminuric patients(55%) showed better response to therapy. A reduction in urinary ACR was found independent of genotypes of ACE I/D and AGT M235 T polymorphisms although macro-albuminuric patients having TT genotype showed statistically insignificant increased response(72%). CONCLUSION ACE inhibitor therapy reduced urinary ACR by ≥ 30% in 50% of DN patients and the response is independent of ACE I/D and AGT M235 T polymorphisms.

关键词： Diabetic nephropathy Angiotensin converting enzyme inhibitor therapy Renin-angiotensin-aldosterone system gene polymorphisms Responder Urinary albumin/creatinine ratio Albuminuria

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On the red fluorescence emission of Aggregatibacter actinomycetemcomitans

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Open Journal of Stomatology 2012年第4期2卷 299-306页

作者： Nadja Bjurshammar Annsofi Johannsen kare.Buhlin Sofia Tran█us Conny Ostman Department of Dental medicine Division of Periodontology and Dental HygieneKarolinska InstitutetHuddingeSweden Department of Dental medicine Division of CariologyKarolinska InstitutetHuddingeSweden The Swedish Council of Health Technology Assessment StockholmSweden Department of Analytical Chemistry Stockholm UniversityStockholmSweden

A number of studies have indicated that bacteria able to emit red fluorescence can be detected by light in-duced fluorescence technique and killed by photodynamic therapy. The objective of this study was to investigate the red fluorescence properties of the single gram negative capnophilic bacterium Aggregatibacter actinomycetemcomitans, ATCC 33384, and to investigate if these properties were related to the growth, morphology and size of the bacterial colonies. Time trend assessment was made with red fluorescence by QLF (Quantitative Light-induced Fluorescence), as well as with white light digital imaging. It was demonstrated that A. actinomycetemcomitans, a single capnophilic bacterium, is able to produce red fluorescence on its own, i.e. in the absence of other bacteria strains, and that blood agar is necessary to obtain red fluorescence from this bacterium on culture plates. This bacterium formed smooth circular, bell/dome like colonies increasing in size with time exhibiting various red fluorescence behaviors. A large variation in the fluorescence behavior points out an inhomogeneous distribution of red fluorescence within and between the colonies, i.e. the size of the investigated colonies did not correlate with the red fluorescence area, suggesting a dependence on the colony morphology such as the colony growth in height. To our knowledge this is the first study that have shown that A. actinomycetemcomitans on its own is able to produce fluorescence in the red spectral region.

关键词： Aggregatibacter actinomycetemcomitans Red Fluorescence Porphyrin Quantitative Light-induced Fluorescence QLF

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Clinical Predictors for Recurrence after Curative Resection for Colorectal Cancer

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Journal of Cancer Therapy 2017年第12期8卷 1107-1124页

作者： Ola Rokke Thomas Heggelund Jurate Saltyte Benth Marianne Steffensen Rokke Kjell kare.Ovrebo Department of Digestive Surgery Akershus University HospitalLorenskogNorway Institute of Clinical medicine Campus AhusUniversity of OsloOsloNorway Institute of Clinical medicine Campus AhusUniversity of OsloHealth Services Research UnitAkershus University HospitalLorenskogNorway Department of Head and Neck Surgery Akershus University HospitalLorenskogNorway Department of Digestive Surgery Haukeland University HospitalBergenNorway

Purpose: To identify clinical predictors of recurrence of colorectal cancer after curative surgical treatment. methods: Retrospective follow-up-study of 925 consecutive patients treated with R0-resection for colorectal cancer Stage I, II and III from 1990 until 2000 with a mean follow-up of 60 ± 37 months. Predictors for cancer recurrence were identified in a pilot-sample of these patients, followed by analyses of the rest of the patients (test-sample), and finally with a concluding analyses of the entire patient group. Data were analyzed with Pearson Chi-square test (χ2), Cox regression analyses and log rank test. Results: Tumor stage (Stage I: HR 0.10 (0.05;0.19), Stage II: HR 0.31 (0.24;0.41)) and postoperative reoperations due to complications due to other causes than anastomotic leakage (HR 2.02 (1.21;3.36)) were significant predictors of cancer recurrence in the multivariate Cox regression model. The association between reoperations and recurrence was strongest for the patients with the best prognosis: Stage I and Stage II-cancers. Long duration of surgery, strongly associated with blood-loss and infusions of liquid and blood-products, reoperation due to anastomotic leakage as well as right colon/transversum localization were significant at a trend-level (10%). Conclusions: Tumor stage and reoperations due to postoperative complications other than anastomotic leakage are significant predictors for recurrence after curative surgery for colorectal cancer.

关键词： Cancer Colon Rectum metastases Predictors Recurrence Reoperation Complication

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Distribution of mercury in a Gadoid Fish Species, Tusk （Brosme brosme）, and Its Implication for Food Safety

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Journal of Food Science and Engineering 2012年第11期2卷 603-615页

作者： Kristine Kvangarsnes Sylvia Frantzen kare.Julshamn leif J. Saethret Kjell Nedreaas Amund Maage National Institute of Nutrition and Seafood Research P.O. Box Bergen 5817 Norway Department of Chemistry University of Bergen Alleg Bergen 5007 Norway Institute of Marine Research Postboks 1870 Nordnes Bergen 5007 Bergen

The tusk （Brosme brosme） is a popular gadoid fish for human consumption, which also is susceptible to mercury accumulation. However, few data of mercury levels in tusk exist, and it is difficult to compare tusk fished from assumed contaminated areas with background levels. The aim of this study was to increase the information of mercury levels observed in tusk from the Northeast Atlantic Ocean. Samples of tusk were collected from seven different localities in open ocean areas, nine along the Norwegian coastal current （NCC）, and from two fjord stations. Determinations of mercury in muscle and liver were carried out using inductive coupled plasma mass spectrometry （ICPMS） after microwave-assisted wet digestion. The highest concentrations of mercury in muscle were found in tusk captured from the fjords Hardangerfjord and Sorfjord, and had mean concentrations of mercury at 1.5 and 1.7 mg kg＂~ wet weight （ww）, respectively, where all of the tusk exceeded EU＇s upper limit of 0.5 mg kg1 ww. The lowest concentrations of mercury were observed in tusk captured from the open ocean areas, and the concentrations ranged from 0.08 to 0.30 mg kg-1 ww. mercury concentrations of tusk captured along the NCC ranged from 0.21 to 0.49 mg kg-1 ww. mercury concentrations increased with the weight of the tusk, and variance analysis （ANOVA） of weight normalized mercury concentrations showed that there were significant differences in mercury concentrations between tusk collected from the open ocean, NCC and fjords, which indicates that differences in mercury concentration between different areas arecaused by other factors.

关键词： Tusk mercury food safety U-864 ICPMS.

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水泥窑协同处置长江漂浮物过程的污染物排放与环境风险

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环境污染与防治 2023年第7期45卷 972-979页

作者：刘美佳崔长颢闫大海陈超李丽 kare.Helge Karstensen 中国环境科学研究院国家环境保护危险废物鉴别与风险控制重点实验室北京100012 中国环境科学研究院固体废物污染控制技术研究所北京100012 Foundation for Scientific and Industrial Research Norway Oslo

长江水面聚集大量漂浮物,对发电和航运安全造成严重影响,也是影响库区环境的重要问题。在水泥窑协同处置长江漂浮物工程现场,分析了水泥窑协同处置长江漂浮物过程中窑尾烟气、水泥熟料和旁路放风粉尘中的污染物排放特征,评估了水泥窑协... 详细信息

长江水面聚集大量漂浮物,对发电和航运安全造成严重影响,也是影响库区环境的重要问题。在水泥窑协同处置长江漂浮物工程现场,分析了水泥窑协同处置长江漂浮物过程中窑尾烟气、水泥熟料和旁路放风粉尘中的污染物排放特征,评估了水泥窑协同处置长江漂浮物的环境风险,也研究了氯和5种典型重金属在水泥窑系统中的分配规律。结果表明,氯主要由入窑生料引入窑系统,由熟料带出,开启旁路放风时约20%的氯进到旁路放风粉尘中。Cr、Co、Ni、Cu和Sb主要来自于入窑生料,长江漂浮物也能引入一定量的重金属,最终超过90%的重金属经熟料带出窑系统,其余重金属主要进入窑灰。水泥窑协同处置长江漂浮物过程中,窑尾烟气、水泥熟料和旁路放风粉尘的大部分污染物均低于相应的标准限值,但需重点关注窑内燃烧状态,减少CO的产生以避免影响脱硝效率,旁路放风粉尘的Se浸出浓度超过《危险废物鉴别标准浸出毒性鉴别》(GB 5085.3—2007)规定的限值,具有一定环境风险。

关键词：长江漂浮物协同处置水泥窑环境风险

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感染性心内膜炎的变迁

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贵州医药 1987年第2期 46-46页

作者： kare.D 熊守仁

感染性心内膜炎已发生变迁。本文试图预计今后10～20年可能出现的某些变化和治疗方法的抉择。病人的年龄心内膜炎病人的年龄有显著增高趋势。1932～1943年统计的103例男病人平均年龄37岁,1944～1960年的107例增至46岁;同期女病人由70例... 详细信息

感染性心内膜炎已发生变迁。本文试图预计今后10～20年可能出现的某些变化和治疗方法的抉择。病人的年龄心内膜炎病人的年龄有显著增高趋势。1932～1943年统计的103例男病人平均年龄37岁,1944～1960年的107例增至46岁;同期女病人由70例的30岁增至93例的40岁。1967～1977年三篇报道的平均年龄分别为44,55,75岁。其主要原因是风湿热发生率显著降低,风心病随之减少,其次是现代内外科治疗使具有高度感染危险性的先心病和风湿性心瓣膜损害的病人生存期延长。此外,老年人口增多,平均寿命延长则退行性心瓣膜病发生率增高,后者也是易感因素。心内膜炎病人的年龄还将随人口年龄的增长而继续增高。但静脉内药物滥用者则例外,这组患者的年龄大概仍将在40以下。

关键词：心内膜炎病原菌药物滥用者杆菌静脉内心内膜疾病葡萄球菌链球菌

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脑膜炎败血黄杆菌：免疫受损病人的潜在致病菌：6例报告及文献回顾

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世界医学杂志 1998年第1期2卷 9-17页

作者： kare.,C. Roha.,N

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Implementing physically active learning:Future directions for research,policy,and practice

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Journal of Sport and Health Science 2020年第1期9卷 41-49,F0003页

作者： Andy Daly-Smith Thomas Quarmby Victoria S.J.Archbold Ash C.Routen Jade L.Morris Catherine Gammon John B.Bartholomew Geir kare.Resaland Bryn Llewellyn Richard Allman Henry Dorling School of Sport Leeds Beckett UniversityLeedsLS63QSUK School of Sport Exercise and Health SciencesLoughborough UniversityE152GZUK School of Health Promotion and Human Performance Eastern Michigan UniversityYpsilantiMI 48197USA Centre for Diet and Activity Research MRC Epidemiology UnitUniversity of CambridgeCambridgeCB21TNUK Department of Kinesiology and Health Education The University of Texas at AustinAustinTX 78705USA Center for Physically Active learning Faculty of EducationArts and SportsWestern Norway University of Applied SciencesSogndal5020 BergenNorway Tagtiv8 Ltd and Move&learn LeedsWF27BSUK School of Sport Health and Social ScienceSolent UniversitySouthamptonSO 14 ORTUK

Purpose:To identify co-produced multi-stakeholder perspectives important for successful widespread physically active learning(PAL) adoption and ***:A total of 35 stakeholders(policymakers n=9;commercial education sector,n=8;teachers,n=3;researchers,n=15) attended a design thinking PAL *** formed 5 multi-disciplinary groups with at least 1 representative from each stakeholder *** group,facilitated by a researcher,undertook 2 tasks:(1) using Post-it Notes,the following question was answered:within the school day,what are the opportunities for learning combined with movement?and(2) structured as a washing-line task,the following question was answered:how can we establish PAL as the norm?All discussions were audio-recorded and *** analyses were conducted by 4 *** the analyses were complete,the main themes and subthemes were assigned to 4 predetermined categories:(1) PAL design and implementation,(2) priorities for practice,(3) priorities for policy,and(4) priorities for ***:The following were the main themes for PAL implementation:opportunities for PAL within the school day,delivery environments,learning approaches,and the intensity of *** main themes for the priorities for practice included teacher confidence and competence,resources to support delivery,and community of *** main themes for the policy for priorities included self-governance,the Office for Standards in Education,Children’s Services,and Skill,policy investment in initial teacher training,and curriculum *** main themes for the research priorities included establishing a strong evidence base,school-based PAL implementation,and a whole-systems ***:The present study is the first to identify PAL implementation factors using a combined multi-stakeholder *** achieve wider PAL adoption and implementation,future interventions should be evidence based and address implementation factors

关键词： Children Physical activity Physically active learning Policy School

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分析哲学与现象学之间的反思均衡——弗莱斯塔教授访谈录

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哲学分析 2019年第5期10卷 164-177页

作者：达格芬·弗莱斯塔[挪威] 刘靖贤李晽国际哲学学院中南大学公共管理学院辽宁大学哲学与公共管理学院

受“北京大学海外名家讲学计划”资助,应北京大学陈波教授邀请,弗莱斯塔教授于2018年11月6日至12日在北京大学作五次学术讲演。弗莱斯塔(Dagfinn kare.Follesdal)是美国斯坦福大学刘易斯(***)讲席荣休教授,挪威奥斯陆大学荣休教授。

关键词：斯塔弗莱分析哲学访谈录现象学美国斯坦福大学北京大学刘易斯

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