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Attributes of cancer patients admitted to the emergency department in one year

World Journal of Emergency Medicine 2014年第2期5卷 85-90页

作者： Muallaoglu Sadik karagün ozlem Mertsoylu Huseyin Besen AliAyberk Sezer Ahmet Ozyilkan Ozgur Department of Medical Oncology School of Medicine Baskent University Department of Emergency School of Medicine Baskent University Department of Medical Oncology Van Training and Research Hospital

BACKGROUnD： Cancer patients frequently visit the emergency department （ED） with various symptoms of cancer. The purpose of this study was to determine the clinical characteristics and 1-year survival rate of cancer patients in the ED of a university hospital. METHODS： We conducted a retrospective review of 408 cancer patients who visited the ED between January 2011 and December 2011. Patient information on demographics, chief complaints, findings, and survival was gathered from the hospital registry and corresponding health administration. RESULTS： The study included 240 （58.8%） males and 168 （41.2%） females with a median age of 57.9 years （range 19-87）. Regarding cancer staging, 266 patients （65.3%） had metastatic disease and 142 （34.7%） had local and Ioco-regional disease. The hospitalization rate was 59.6%. The most common symptoms were shortness of breath （23.2%）, pain （17.8%）, fever （14.2%）, and nausea/vomiting （14.4%）. The most common cancer sites were the lung （32.5%）, gastrointestinal system （25.4%）, and breast （9.3%）. The initial evaluation determined progressive disease （42.4%）, chemotherapy effects （20.7%）, infections （17.2%）, radiotherapy effects （4.7%）, extravasation （1.8%）, anemia （1.4%）, and unknown （11.3%）. During follow up, 191 （46.8%） patients died after admission to the ED. The 1-year overall survival of all patients was 7.3 months. COnCLUSIOnS： Symptom management in cancer patients is a complex multifaceted concern for the emergency physician. Because of the increasing prevalence of cancer patients, emergency physicians should develop consensus algorithms in collaboration with the relevant disciplines to manage the commonly encountered problems.

关键词： Cancer Oncology Emergency department Surviva

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Ionic liquid-based transparent membrane-coupled human lung epithelium-on-a-chip demonstrating PM0.5 pollution effect under breathing mechanostress

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Bio-Design and Manufacturing 2024年第5期7卷 624-636页

作者： Bilgesu Kaya ozlem Yesil-Celiktas Department of Bioengineering Faculty of EngineeringEge UniversityIzmir 35100Türkiye Translational Pulmonary Research Center(EgeSAM) Ege UniversityIzmir 35100Türkiye

The plausibility of human exposure to particulate matter(PM)has witnessed an increase within the last several *** of different sizes has been discovered in the atmosphere given the role of dust transport in weather and climate *** a regulator,the lung epithelium orchestrates the innate response to local ***,we developed a lung epithelium-ona-chip platform consisting of easily moldable polydimethylsiloxane layers along with a thin,flexible,and transparent ionic liquid-based poly(hydroxyethyl)methacrylate gel *** epithelium was formed through the culture of human lung epithelial cells(Calu-3)on this *** mechanical stress at the air–liquid interface during inhalation/exhalation was recapitulated using an Arduino-based servo motor system,which applied a uniaxial tensile strength from the two sides of the chip with 10%strain and a frequency of 0.2 ***,the administration of silica nanoparticles(PM0.5)with an average size of 463 nm to the on-chip platform under static,dynamic,and dynamic+mechanical stress(DMS)conditions demonstrated the effect of environmental pollutants on lung *** viability and release of lactate dehydrogenase were determined along with proinflammatory response through the quantification of tumor necrosis factor-α,which indicated alterations in the epithelium.

关键词： Ionic liquid-based membrane Lung Epithelial barrier Mechanostress Organ-on-chip Silica particles

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Tata-box-binding protein-associated factor 15 as a new potential marker in gastrointestinal tumors

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World Journal of Gastroenterology 2024年第28期30卷 3367-3372页

作者： Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Türkiye

In this editorial,the roles of tata-box-binding protein-associated factor 15(TAF15)in oncogenesis,tumor behavior,and as a therapeutic target in cancers in the context of gastrointestinal(GI)tumors are discussed concerning the publication by Guo et ***15 is a member of the FET protein family with a comprehensive range of cellular ***,evidence has shown that TAF15 is involved in many diseases,including ***15 contributes to carcinogenesis and tumor behavior in many ***,its relationship with the mitogen-activated protein kinases(MAPK)signaling pathway makes TAF15 a new target for ***,the fact that there is few studies investigating the expression of TAF15 constitutes a potential limitation in GI system,the association of TAF15 expression with aggressive tumor behavior and,similar to other organ tumors,the influence of TAF15 on the MAPK signaling pathway emphasize that this protein could serve as a new molecular biomarker to predict tumor behavior and target therapeutic intervention in GI *** conclusion,more studies should be performed to better understand the prognostic and therapeutic role of TAF15 in GI tumors,especially in tumors resistant to therapy.

关键词： Gastrointestinal cancer Tata-box-binding protein-associated factor 15 Cell proliferation Cell migration Prognosis

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Is sarcopenia effective on survival in patients with metastatic gastric cancer?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1861-1868页

作者： ozlem Dogan Hayriye Sahinli Yakup Duzkopru Tuba Akdag Abdulkadir Kocanoglu Department of Medical Oncology Adıyaman University Training and Research HospitalAdiyaman 02100Turkey Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey Department of Radiology University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06000Turkey Department of Medical Oncology Ankara Ataturk Sanatoryum Training and Research HospitalAnkara 06170Turkey

BACKGROUnD Sarcopenia is a progressively diminishing state characterized by the reduction of muscle mass and density,which is frequently observed in malignancies of solid *** To assess how sarcopenia affects the overall survival of individuals who have been diagnosed with metastatic gastric *** The study retrospectively included individuals who had been diagnosed with metastatic gastric cancer between January 2008 and December *** was identified through the calculation of the average Hounsfield units(HUAC)using computed tomography(CT)images taken at the time of diagnosis in *** A total of 118 patients with metastatic gastric cancer were *** was detected in 29 patients(24.6%).The median survival of all patients was 8(1-43)*** median survival of patients with sarcopenia was 2 mo,while it was 10 mo for those without sarcopenia(Pnificant relationship was found between sarcopenia and *** Sarcopenia has been observed to impact survival outcomes in various types of solid tumor *** patients can be identified in a short time,easily and inexpensively,by HUAC measurements from CT images used for diagnosis,and survival could be promoted with nutritional support.

关键词： Hounsfield units Sarcopenia Gastric cancer Survival Psoas muscle mass Muscle density

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Assessment of the potential interactions between favipiravir and radiocontrast agents

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World Journal of Radiology 2024年第5期16卷 128-135页

作者： Sonay Aydin ozlem Celik Aydin Mesut Furkan Yazar Huseyin Aydemir Mecit Kantarci Sureyya Barun Department of Radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24100Türkiye Department of Pharmacology Gazi UniversityFaculty of MedicineErzincan 24100Türkiye Department of Radiology Bilecik Education and Reseach HospitalBilecik 11230Türkiye Department of Radiology Atatürk UniversityFaculty of MedicineErzurum 25030Türkiye

BACKGROUnD In cases of coronavirus disease 2019(COVID-19),favipiravir is commonly included to the therapy *** interactions between favipiravir and other COVID-19 therapy drugs are frequently ***,no research on possible drug interactions between Favipiravir and radiocontrast agents,which have become almost crucial in diagnostic processes while not being part of the treatment,has been *** To determine potential medication interactions between Favipiravir and radiocontrast *** The study comprised patients who were taking Favipiravir for COVID-19 therapy and underwent a contrast-enhanced computed tomography(CT)or magnetic resonance imaging(MRI)test while taking the *** computerized patient files of the cases included in the study,as well as the pharmacovigilance forms in the designated hospital,were evaluated for this *** The study included the evaluation of data from 1046 *** study sample's mean age was 47.23±9.48 *** mean age of cases with drug interactions was statistically significant greater than that of cases with no drug interactions(P=0.003).When evaluated with logistic regression analysis,a 1-year raises in age increases the risk of developing drug interactions by 1.63 times(P=0.023).There was no statistically significant difference in the occurrence of medication interactions between the sexes(P=0.090).Possible medication interactions were discovered in 42 cases(4%).COnCLUSIOn The findings of this study revealed that the most notable findings as a result of the combined use of contrast agents and favipiravir were increased creatinine and transaminase values,as well as an increase in the frequency of nausea and *** majority of drug interactions discovered were modest enough that they were not reflected in the *** interactions become more common as people get older.

关键词： Favipiravir Iohexol Gadoxetic acid Meglumine gadoterate Drug interactions

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Prognostic significance of tumor budding,desmoplastic reaction,and lymphocytic infiltration in patients with gastric adenocarcinoma

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 9-25页

作者： Aysen Yavuz Kubra Simsek Anil Alpsoy Busra Altunay Elif Ocak Gedik Betul Unal Cumhur Ibrahim Bassorgun Ali Murat Tatli Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Türkiye Department of Medical Oncology Akdeniz University Medical SchoolAntalya 07070Türkiye

BACKGROUnD Recent studies have shown that the tumor microenvironment significantly influences the behavior of solid *** this context,Accumulated data suggests that pathological evaluation of tumor budding(TB),desmoplastic reaction(DR),and tumor-infiltrating lymphocytes(TILs)may be crucial in determining tumor behavior in the gastrointestinal *** gastric adenocarcinoma(GAC),although some results suggest that TB and TILs may be effective in determining the course of the disease,the data do not ***,very few studies have investigated the relationship between DR and *** present,the associations between tumor TB,DR and TILs in GAC patients have not been *** To establish the relationships between TB,DR,and TILs in patients with GAC and to assess their influence on *** Our study group comprised 130 patients diagnosed with *** definition of TB was established based on the International TB Consensus *** DR was categorized into three groups according to the level of tumor stroma *** assessment of TILs was conducted using a semiquantitative approach,employing a cutoff value of 5%.The statistical analysis of the whole group and 100 patients with an intestinal subtype of GAC was performed using SPSS version *** A significant correlation between peritumoral budding(PTB)and intratumoral budding(ITB)was noted(r=0.943).Tumors with high PTBs and ITBs had a greater incidence of immature DRs and low TILs(Pnd ITB were associated with histological subtype,lymph node metastasis(LnM),and stage(PnM,DR,and stage were significant risk factors associated with poor *** multivariate Cox regression analysis identified ITB,PTB,and LnM as independent prognostic variables(Pn intestinal-type adenocarcinomas,a positive correlation between PTB and ITB was noted(r=0.972).While univariate analysis revealed that LnM,stage,PTB,ITB,and DR were strong parameters for pred

关键词： Gastric cancer Tumor budding Desmoplastic stroma Tumor-infiltrating lymphocytes Prognosis

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Solutions of Three-Dimensional Separable non-Central Potential

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Chinese Physics Letters 2008年第4期25卷 1172-1174页

作者： ozlem Yesiltas Gazi University Faculty of Arts and Sciences Department of Physics 06500 Ankara Turkey

We show that a wide class of non-central potentials can be analysed via the improved picture of the nikiforov- Uvarov method [Physica Scripta 75 （2007） 686]. It has been shown that using the alternative approach, po... 详细信息

关键词： supernova explosion proto-neutron star shock wave

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Role of natural products and intestinal flora on type 2 diabetes mellitus treatment

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World Journal of Clinical Cases 2023年第1期11卷 65-72页

作者： ozlem Celik Aydin Sonay Aydın Sureyya Barun Department of Medical Pharmacology Erzincan Mengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of Radiology Erzincan Binali Yıldırım UniversityMengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of Medical Pharmacology Gazi University Faculty of MedicineAnkara 06500Turkey

Diabetes mellitus(DM)is a complicated,globally expanding disease that is influenced by hereditary and environmental *** in modern society’s food choices,physical inactivity,and obesity are significant factors in the development of type 2 DM(T2DM).The association between changes in intestinal flora and numerous disorders,including obesity,diabetes,and cardiovascular diseases,has been studied in recent *** purpose of this review is to analyze the mechanisms underlying the alteration of the diabetic patients’intestinal flora,as well as their therapeutic *** included is a summary of the antidiabetic benefits of natural compounds demonstrated by *** short-chain fatty acids theory,the bile acid theory,and the endotoxin theory are all potential methods by which intestinal flora contributes to the establishment and progression of *** to an intestinal flora imbalance,abnormalities in shortchain fatty acids and secondary bile acids have been found in diabetic ***,metabolic endotoxemia with altering flora induces a systemic inflammatory response by stimulating the immune system via bacterial *** agenda for diabetes treatment includes the use of short-chain fatty acids,probiotics,prebiotics in the diet,fecal bacteria transplantation,and *** studies have proven the antidiabetic benefits of numerous bioactive substances,including Flavonoids,Alkaloids,Saponin,and ***,further research is required to contribute to the treatment of diabetes.

关键词： Diabetes mellitus Intestinal flora natural products Endotoxemia Bioactive compounds Probiotics

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A cross-layer fault tolerance management module for wireless sensor networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第9期13卷 660-673页

作者： ozlem KARACA Radosveta SOKULLU Izmir Vocational School Dokuz Eylul UniversityIzmir 35160Turkey Department of Electrical and Electronics Engineering Ege UniversityIzmir 35100Turkey

It is a well-established fact that wireless sensor networks (WSns) are very power constraint networks, but besides this, they are inherently more fault-prone than any other type of wireless network and their protocol design is very application specific. Major reasons for the faults are the unpredictable wireless communication channel, battery depletion, as well as fragility and mobility of the nodes. Furthermore, as traditional protocol design methods have proved inadequate, the cross-layer design (CLD) approach, which allows for interactions between different layers, providing more flexible and energy-efficient functionality, has emerged as a viable solution for WSns. In this study we define a fault tolerance management module suitable to the requirements, limitations, and specifics of WSns, encompassing methods for fault detection, fault prevention, fault management, and recovery. The suggested solution is in line with the CLD approach, which is an important factor in increasing the network performance. Through simulations the functionality of the network is evaluated, based on packet loss, delay, and energy consumption, and is compared with a similar solution not including fault management. The results achieved support the idea that the introduction of a unified approach to fault management improves the network performance as a whole.

关键词： Wireless sensor networks (WSns) Cross-layer frameworks Protocol design Fault management

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Indoor^(222)Rn Levels and Effective Dose Estimation of Academic Staff in izmir-Turkey

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Biomedical and Environmental Sciences 2014年第4期27卷 259-267页

作者： TURKAn ALKAn ozlem KARADEnIZ Department of Medical Physics Institute of Health SciencesDokuz Eyliil University Department of Physics Faculty of SciencesDokuz Eyliil University

Objective To investigate the annual effective doses from indoor radon received by academic staff in the Faculty building. Methods Measurements of indoor radon concentrations were performed in the Arts and Sciences Faculty of Dokuz Eylul University for two surveys of about 1 month duration respectively using the SSnTD （Solid State nuclear Track Detectors） method with LR115 detectors. Time integrated measurements comprised different locations inside the faculty building： classrooms, toilets, canteen and offices. Homes of academic staff were also tested for radon. Results The aritthmetic mean radon concentration is 161 Bq m-3 with a range between 40 and 335 Bq m-3 in the Faculty. Six offices and three classrooms have a radon concentration above 200 Bq m-3. The results show that the radon concentration in classrooms is generally higher than in offices. Based on the measured indoor radon data, the annual effective doses received by staff in the Faculty were estimated to range from 0.79 to 4.27 mSv, according to UnSCEAR methodology. The annual effective doses received by staff ranged from 0.78 to 4.20 mSv in homes. On average, the Faculty contributed 56% to the annual effective dose. Conclusion Reported values for radon concentrations and corresponding doses are within the ICRP recommended limits for workplaces.

关键词： Indoor radon Solid state nuclear track detectors School Annual effective dose

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