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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 211-212页

作者： Risako Onodera Tomohiro Hayashi Tatsuo Nakamura kaori aibeb Kohei Tahara Hirofumi Takeuchi Gifu Pharmaceutical University 1-25-4 Daigaku-nishiGifu 501-1196Japan FANCL Corporation 12-13 Kamisinano Totsuka-kuYokohamaKanagawa 244-0806Japan

Oral bioavailability of drug is limited by the factors such as the membrane permeability, the solubility, the dissolution rate and so on (1)In case of a poorly water-soluble drug, its solubility and dissolution rate is a critical factor for its oral *** various techniques for enhancing solubility or dissolution properties, physical modification of drug products such as reducing the particle size is one of common approaches [2].

关键词： PureNano^(■) Silymarin Hydroxypropyl cyclodextrin Crystallization

A novel approach in preventing vascular leakage and angiogenesis in wet age-related macular degeneration

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Neural Regeneration Research 2022年第8期17卷 1751-1752页

作者： kaori H.Yamada Department of Pharmacology and Regenerative Medicine Department of Ophthalmology and Visual SciencesUniversity of Illinois College of MedicineChicagoILUSA

Vascular leakage and angiogenesis in diseases:The vascular system carries blood throughout the body to supply oxygen and nutrients to tissues and remove waste from *** of the vascular system worsens many *** this perspective,vascular function in blinding eye diseases,current therapies,and our developing approach will be *** blood vessels are composed of the monolayer of the endothelial cells,and the outer layer made by pericytes and smooth muscle cells provide structural support and shape to the *** monolayers function as a *** barrier function of endothelial monolayers controls plasma protein uptake and the infiltration of immune cells by regulating adherence of cell-cell *** leakage causes unwanted plasma leak,accumulation of immune cells,and tissue inflammation.

关键词： degeneration approach remove

Toll-like receptor 9 gene mutations and polymorphisms in Japanese ulcerative colitis patients

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World Journal of Gastroenterology 2010年第46期16卷 5815-5821页

作者： kaori Fuse Kyoko Katakura Natsumi Sakamoto Hiromasa Ohira Department of Gastroenterology and Rheumatology School of MedicineFukushima Medical University

Abnormal innate immune responses toward luminal bacteria play an important role in the pathogenesis of inflammatory bowel *** has been demonstrated that bacteria having CpG DNA ameliorate experimental colitis in mice,and Toll-like receptor 9 (TLR9) signaling mediates the anti-inflammatory effects in mouse colonic inflammation.A gene variation in NOD2/CARD15 has been reported in Crohn's disease (CD) patients in Western countries,but this variation has not been identified in Japanese CD ***,we hypothesized that TLR9 is a key factor in the development of ulcerative colitis (UC),and we investigated gene mutations and polymorphisms of TLR9 in Japanese UC *** single nucleotide polymorphisms (SNPs) in TLR9 were identified in healthy controls,and were assessed in 48 UC patients and 47 healthy *** subjects were matched for age,sex and date of blood sampling from among a subgroup of *** found that TLR9-1486CC,1174GG and 2848AA increase the risk of UC [odds ratio (OR) 2.64,95% confidence interval (95% CI):1.73-6.53,P=0.042],and TLR9-1486TT,1174AA and 2848GG decrease the risk of UC (OR 0.30,95% CI:0.10-0.94,P=0.039),although there were no correlations between SNPs and disease phenotype or TLR9 mRNA *** findings suggest that TLR9 polymorphisms are associated with increased susceptibility to UC.

关键词： Toll-like receptor 9 Single nucleotide polymorphism Ulcerative colitis Inflammatory bowel disease Innate immunity

Dirac reduction of binary asteroid systems with symmetry and stability of relative equilibria

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Theoretical & Applied Mechanics Letters 2013年第1期3卷 81-88页

作者： kaori Onozaki Hiroaki Yoshimura Major in Applied Mechanics Graduate School of Fundamental Science and Engineering Waseda University Department of Applied Mechanics and Aerospace Engineering Waseda University

In this paper, we study symmetry reduction for a binary asteroid system modeled by a rigid body and a particle. In particular, we demonstrate how translational and rotational symmetry reduction appeared in the binary asteroid system can be carried out in the context of Dirac reduction by stages and with the associated reduction of implicit Hamiltonian systems. Then we investigate Stability of relative equilibria of the asteroid pair and show stability regions by using the energy-momentum method. Lastly, we illustrate some numerical simulations for stable and unstable orbits near from relative equilibria of the Collinear and T configurations.C 2013 The Chinese Society of Theoretical and Applied Mechanics. [doi：10.1063/2.1301311]

关键词： binary asteroid dirac reduction stability

Simultaneously disrupting AtPrx2,AtPrx25 and AtPrx71 alters lignin content and structure in Arabidopsis stem

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Journal of Integrative Plant Biology 2015年第4期57卷 349-356页

作者： Jun Shigeto Yoshitaka Itoh Sakie Hirao kaori Ohira Koki Fujita Yuji Tsutsumi Faculty of Agriculture Kyushu University

Plant class III heme peroxidases catalyze lignin polymerization. Previous reports have shown that at least three Arabidopsis thaliana peroxidases, AtPrx2, AtPrx25 and AtPrx71, are involved in stem lignification using T-D NA insertion mutants, atprx2, atprx25, and atprx71. Here, we generated three double mutants, atprx2/atprx25, atprx2/atprx71, and atprx25/atprx71, and investigated the impact of the simultaneous deficiency of these peroxidases on lignins and plant growth. Stem tissue analysis using the acetyl bromide method and derivatization followed by reductive cleavage revealed improved lignin characteristics, such as lowered lignin content and increased arylglycerol-β-aryl （β-O-4） linkage type, especially β-O-4 linked syringyl units, in lignin, supporting the roles of these genes in lignin polymerization. In addition, none of the double mutants oexhibited severe growth defects, such as shorter plant stature, dwarfing, or sterility, and their stems had improved ceil wall degradability. This study will contribute to progress in lignin bioengineering to improve iignocellulosic biomass.

关键词： Arabidopsis knockout mutant lignin biosynthesis plantperoxidase

Comparison of imo and Humphrey field analyzer perimeters in glaucomatous eyes

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1882-1887页

作者： Yoshinori Nakai Kyoko Bessho Yuko Shono kaori Taoka Yoshihide Nakai Tokai Eye Clinic 399-Hadokoro-choTsu 514-0009Japan

AIM:To compare the imo perimeter,a new portable head-mounted perimeter unit that enables both eyes to be examined quickly and simultaneously,with the Humphrey field analyzer(HFA)perimeter to investigate correlations and their diagnostic ability in glaucomatous ***:The performance of the equipment in 128 glaucomatous eyes and 40 normal eyes were *** investigated the correlations of mean deviation,pattern standard deviation,visual field index,and the ***:Measurements of mean deviation(r=0.886,P<0.001),pattern standard deviation(r=0.814,P<0.001),and visual field index(r=0.871,P<0.001)in both perimeters were strongly and positively *** sensitivities in the imo perimeter were 80.5%for mean deviation,81.2%for pattern standard deviation,and 80.5%in visual field index;those in the HFA were 63.3%for mean deviation,74.5%for pattern standard deviation,and 80.5%for visual field *** perimeters demonstrated high diagnostic ***:The parameters by the imo and HFA in glaucomatous eyes show strong positive correlations with favorable sensitivity,specificity,and diagnostic ***,the difference between imo and HFA results increases with the increase in visual field disturbance.

关键词： imo perimeter visual field diagnosis diagnostic validation

Combination of genetic analysis and ancient literature survey reveals the diverge nee of traditional Brassica rapa varieties from Kyoto, Japan

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Horticulture Research 2021年第1期8卷 1877-1886页

作者： Yaichi Kawakatsu Tomoaki Sakamoto Hokuto Nakayama kaori Kaminoyama kaori Igarashi Masaki Yasugi Hiroshi Kudoh Atsushi JNagano Kentaro Yano Nakao Kubo Michitaka Notaguchi Seisuke Kimura Faculty of Life Sciences Kyoto Sangyo UniversityKamigamo-motoyamaKita-kuKyoto 603-8555Japan Bioscience and Biotechnology Center Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Center for Plant Sciences Kyoto Sangyo UniversityKamigamo-motoyamaKita-kuKyoto 6038555Japan Graduate School of Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan School of Agriculture Meiji University1-1-1Higashi-MitaTama-kuKawasakiKanagawa 214-8571Japan Faculty of Engineering Utsunomiya University7-1-2 YotoUtsunomiyaTochigi 321-8585Japan Center for Ecological Research Kyoto UniversityHirano 2-509-3OtsuShiga 520-2113Japan Faculty of Agriculture Ryukoku University1-5 YokotaniSeta Oe-choOtsuShiga 520-2194Japan Graduate School of Life and Environmental Sciences Kyoto Prefectural University1-5 Hangi-choShimogamoSakyo-kuKyoto 606-8522Japan Biotechnology Research Department Kyoto Prefectural AgricultureForestry and Fisheries Technology Center74 OjiKitainayazumaSeika-choSoraku-gunKyoto 6190244Japan Graduate School of Bioagricultural Sciences Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Institute of Transformative Bio-Molecules Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

Since ancient times,humans have bred several plants that we rely on ***,little is known about the divergence of most of these *** the present study,we investigated the divergence of Mibuna(Brassica rapa *** ***),a traditional leafy vegetable in Kyoto(Japan),by combining genetic analysis and a survey of ancient *** is considered to have been bred 200 years ago from Mizuna,another traditional leafy vegetable in *** has simple spatulate leaves,whereas Mizuna has characteristic serrated *** quantitative trait loci(QTL)and gene expression analyses suggested that the downregulation of BrTCP15 expression contributed to the change in the leaf shape from serrated to simple ***,the SNP analysis indicated that the genomic region containing the BrTCP15 locus was transferred to Mibuna by ***,we conducted a survey of ancient literature to reveal the divergence of Mibuna and found that hybridization between Mizuna and a simple-leaved turnip might have occurred in the ***,the genomic analysis of multiple turnip cultivars showed that one of the cultivars,Murasakihime,has almost the same sequence in the BrTCP15 region as *** results suggest that the hybridization between Mizuna and turnip has resulted in the establishment of Mibuna.

关键词： cultivar survey analysis

Family empowerment and associated factors in Japanese families raising a child with severe motor and intellectual disabilities

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International Journal of Nursing Sciences 2018年第4期5卷 370-376页

作者： Rie Wakimizu Hiroshi Fujioka kaori Nishigaki Akemi Matsuzawa Department of Child Healthcare Nursing Division of Health Innovation and NursingFaculty of MedicineUniversity of TsukubaIbarakiJapan Department of Nursing Faculty of Health SciencesIbaraki Prefectural University of Health SciencesIbarakiJapan Department of Child Health Nursing Graduate School of Nursing SciencesSt.Luke's International UniversityTokyoJapan Department of Nursing Ibaraki Christian UniversityIbarakiJapan

Objectives:Family caregivers raising children with severe motor and intellectual disabilities(SMID)experience the enormous burden of *** concept of family empowerment is one of the important assessment indexes of family nursing from the perspective of providing comprehensive support for these *** objective of this study was to identify the factors associated with the empowerment of families raising a child with SMID in ***:We conducted a nationwide questionnaire survey involving 1659 primary caregivers raising a child with SMID through 89 special *** assessed the main outcomes using the Family Empowerment Scale(FES).We then conducted a multiple linear regression analysis to reveal the factors associated with family ***:In total,1362 primary caregivers were included in our *** results show that factors contributing to high FES scores are higher age of the primary caregiver,higher education,greater recognition of regional support,lower childcare burden,higher utilization of home visit services,higher usage of a childcare institution,higher household income,and stronger family ***:Healthcare professionals should carefully assess the state of family empowerment of the primary caregivers who are younger and those who have low education,low household income,high childcare burden,and fragile bonding with the ***,they should encourage such families to use regional support resources for *** is,policy makers should consider ways to promote home visits and institutional services for the care of children with SMID,aiming especially for the provision of well-coordinated care and services.

关键词： Caregivers Child care Disabled children Family empowerment Home nursing Intellectual disability Japan Social supports

Specific acupuncture stimulation of Shenshu(BL23)affects sympathetic nervous activity-associated plasma renin concentration changes

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Journal of Traditional Chinese Medicine 2022年第2期42卷 250-255页

作者： Kanae Umemoto Tomoya Hayashi kaori Fukushige Shuichi Hirai Hayato Terayama Kou Sakabe Munekazu Naito Graduate School of Acupuncture and Moxibustion Meiji University of Integrative MedicineNantanKyoto 629-0392Japan Department of Anatomy Division of Basic Medical Sc+ienceTokai University School of MedicineIseharaKanagawa 259-1193Japan Department of Anatomy Aichi Medical University School of MedicineNagakuteAichi 480-1195Japan Graduate School of Acupuncture and Moxibustion Meiji University of Integrative MedicineNantanKyoto629-0392Japan Department of Physiology Meiji University of Integrative MedicineNantanKyoto 629-0392Japan Division of Anatomical Science Department of Functional MorphologyNihon University School of MedicineItabashi-kuTokyo 173-0032Japan Department of Anatomy Division of Basic Medical ScienceTokai University School of MedicineIseharaKanagawa 259-1193Japan

OBJECTIVE:To examine whether specific stimulation of Shenshu(BL23)affects sympathetic nervous activity(SNA)-associated plasma renin concentration(PRC).METHODS:Eight healthy volunteers participated in three pattern conditions in random order:control(Cont),stimulation of Shenshu(BL23),and stimulation of sham point(Sham).All participants were initially in the supine position for>60 min,and then remained in the standing position during the experimental procedure to increase *** electrocardiogram was used to calculate low frequency/high frequency(LF/HF)ratio;blood was collected to analyze ***:The LF/HF ratio was significantly increased in the standing position when compared with the supine position(P<0.01).There was no difference in LF/HF ratio during or after stimulation of Shenshu(BL23)in the standing position when compared with before the stimulation in the supine position;however,the LF/HF ratio was significantly increased in Cont and Sham conditions(P<0.01).There was no difference in PRC after stimulation of Shenshu(BL23)in the standing position when compared with before the stimulation in the supine position;however,there was a significant increase in PRC in the Cont and Sham conditions(Cont P<0.05,Sham P<0.01).CONCLUSION:Our results demonstrated that specific acupuncture stimulation of Shenshu(BL23)in the standing position decreased SNA-associated PRC,which was not observed during acupuncture stimulation of the sham point.

关键词： Acupuncture Point BL23(Shenshu) Sympathetic nervous activity Plasma renin concentration

Magnetic relaxation behavior of a spatially closed dysprosium(Ⅲ) phthalocyaninato double-decker complex

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Science China Chemistry 2012年第6期55卷 918-925,1178-1184页

作者： KATOH Keiichi UMETSU kaori BREEDLOVE BRIAN K. YAMASHITA Masahiro Department of Chemistry Graduate School of Science Tohoku University 6-3 Aramaki-Aza-Aoba Aoba-ku Sendai Miyagi 980-8578 Japan

The SMM properties of the spatially closed Dy（Ⅲ） double-decker Pc complex Dy（obPc）2 （1）, which is equivalent to a pseudo dinuclear complex, are reported. Complex 1 crystallized with ethanol in the crystal lattice in the monoclinic space group P22/n and was isomorphous with Tb（obPc）2 （3）, which is arranged in a dimer structure along the b axis. The intermetallic Dy-Dy distance was determined to be 0.756 nm. ZMT versus T plots for 1 decreased with a decrease in T, which suggests the existence of an antiferromagnetic （AF） interaction between the Dy3＋ ions. The M-H curve for 1 at 1.8 K showed magnetic hysteresis. In ac susceptibility measurements on a powder sample of 1, which were dependent on the applied ac field, indicating that 1 is an single molecule magnet （SMM）, a maximum appeared at 22 K at an ac frequency 09 of 1488 Hz. The shape of the peaks dras- tically changed, and the peaks did not shift when an Hd~ large enough to suppress the quantum tunneling of the magnetization （QTM） was applied. The energy barrier （A/hc） was estimated to be 44 cm-1 with a pre-exponential factor （r0） of 1.6 × 10-5 s from an Arrhenius plot. Our results suggest that the SMM/magnetic properties of 1 significantly change in a dc magnetic field. These relaxation mechanisms are related to the energy gap of the ground state and to QTM.

关键词： single-molecule magnets dysprosium double-decker complex pseudo dinuclear complex magnetic relaxation process