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Seismic vulnerability evaluation of axially loaded steel built-up laced members II:evaluations

Earthquake Engineering and Engineering Vibration 2008年第2期7卷 125-136页

作者： kangmin lee Michel Bruneau Department of Architectural Engineering Chungnam National University Department of Civil Structuraland Environmental EngineeringUniversity at BuffaloState University of New York

The test results described in Part 1 of this paper （lee and Bruneau, 2008） on twelve steel built-up laced members （BLMs） subjected to quasi-static loading are analyzed to provide better knowledge on their seismic behavior. Strength capacity of the BLM specimens is correlated with the strength predicted by the AISC LRFD Specifications. Assessments of hysteretic properties such as ductility capacity, energy dissipation capacity, and strength degradation after buckling of the specimen are performed. The compressive strength of BLMs is found to be relatively well predicted by the AISC LRFD Specifications. BLMs with smaller kl/r were ductile but failed to reach the target ductility of 3.0 before starting to fracture, while those with larger kl/r could meet the ductility demand in most cases. The normalized energy dissipation ratio, EC/ET and the normalized compressive strength degradation, Cr″/Cr of BLMs typically decrease as normalized displacements δ/δb,exp increase, and the ratios for specimens with larger kl/r dropped more rapidly than for specimens with smaller kl/r; similar trends were observed for the monolithic braces. The BLMs with a smaller slenderness ratio, kl/r, and width-to-thickness ratio, b/t, experienced a larger number of inelastic cycles than those with larger ratios.

关键词： seismic vulnerability built-up compression member strength capacity ductility capacity energy dissipation strength degradation

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Emerging signals regulating liver tumor initiating cells

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Liver Research 2018年第2期2卷 73-80页

作者： Jingyu Chen Chien-Yu Chen Christopher Nguyen Lulu Chen kangmin lee Bangyan L.Stiles Department of Pharmacology and Pharmaceutical Sciences School of PharmacyUniversity of Southern CaliforniaLos AngelesCAUSA Department of Pathology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Tumor initiating cells(TICs)have been identified as cells that account for tumor *** studies demonstrated that genes controlling stem cell biology play key roles in maintaining TICs and promote their development into *** this review,we summarize findings from human and animal studies that indicate the presence of TICs during liver cancer *** identified for liver development and regeneration are used to identify liver cancer *** of these markers is often upregulated in human hepatocellular carcinoma(HCC)*** flow cytometry analysis and lineage tracing approaches,the presence of TICs is *** of TIC markers and the presence of TICs are also observed in genetically modified animals that target genes that are frequently altered in human *** presence of these TICs represents a major challenge for therapeutic devel*** signals that can regulate the fate,transformation and growth of liver TICs is an emerging need in liver ***-determining region Y-box 9(SOX9)has recently become an important marker for liver ***,we summarize the role of SOX9 in TICs and its potential interaction with other *** includes the Notch-Numb signal that controls asymmetrical-symmetrical cell division,Wnt-b-catenin signal that maintains cell fate and transforming growth factor(TGF)-b signal that acts as upstream inducers.

关键词： Liver cancer Hepatocellular carcinoma(HCC) Tumor initiating cells(TICs) Sex-determining region Y-box 9(SOX9) b-catenin Notch Numb Transforming growth factor(TGF)-b

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