Emerging signals regulating liver tumor initiating cells
作者机构：Department of Pharmacology and Pharmaceutical SciencesSchool of PharmacyUniversity of Southern CaliforniaLos AngelesCAUSA Department of PathologyKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA
出 版 物：《Liver Research》 (肝脏研究（英文）)
年 卷 期：2018年第2卷第2期
页 面：73-80页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Dr.Stiles acknowledges support from National Institute of Health grants R01CA154986-01 and R01DK084241-01 We also acknowledge support from University of Southern California center for Liver Disease(P30DK48522) Norris Comprehensive Cancer Center(P30CA014089)
主 题：Liver cancer Hepatocellular carcinoma(HCC) Tumor initiating cells(TICs) Sex-determining region Y-box 9(SOX9) b-catenin Notch Numb Transforming growth factor(TGF)-b
摘 要：Tumor initiating cells(TICs)have been identified as cells that account for tumor *** studies demonstrated that genes controlling stem cell biology play key roles in maintaining TICs and promote their development into *** this review,we summarize findings from human and animal studies that indicate the presence of TICs during liver cancer *** identified for liver development and regeneration are used to identify liver cancer *** of these markers is often upregulated in human hepatocellular carcinoma(HCC)*** flow cytometry analysis and lineage tracing approaches,the presence of TICs is *** of TIC markers and the presence of TICs are also observed in genetically modified animals that target genes that are frequently altered in human *** presence of these TICs represents a major challenge for therapeutic devel*** signals that can regulate the fate,transformation and growth of liver TICs is an emerging need in liver ***-determining region Y-box 9(SOX9)has recently become an important marker for liver ***,we summarize the role of SOX9 in TICs and its potential interaction with other *** includes the Notch-Numb signal that controls asymmetrical-symmetrical cell division,Wnt-b-catenin signal that maintains cell fate and transforming growth factor(TGF)-b signal that acts as upstream inducers.
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