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Effect of the traditional Chinese medicine fumigation combined with the meibomian gland squeezer for treatment of dry eye associated with meibomian gland dysfunction

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Integrative Medicine Discovery

Integrative Medicine Discovery 2024年第15期8卷 1-5页

作者： Da-Hu Wang Lin Mu Xiao-Yu Wu yin-Jian Zhang Xin-quan Liu Department of Ophthalmology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200031China

Background:To observe the effect of traditional Chinese medicine fumigation combined with the meibomian gland squeezer for the treatment of dry eye associated with meibomian gland dysfunction(MGD).Methods:This is a randomized,controlled,non-masked,single-center study.Seventy-four cases(74 eyes)of dry eye associated with MGD were randomly divided into two groups.Thirty-seven patients were chosen as the treatment group was treated by the traditional Chinese medicine fumigation 3 times a week combined with the meibomian gland squeezer once a week for one month.The other 37 cases were sorted as the control group and only treated with the meibomian gland squeezer once a week for one month.Both groups received the primary treatment for 1 month,including Tobradex eye ointment once a day and 0.1%sodium hyaluronate eye drops 4-6 times daily.Patients were evaluated at baseline and 2-week and 1-month visits for the ocular symptom scores,international ocular surface disease index(OSDI),fluorescein tear break-up time(TBUT),corneal fluorescein staining test(CFS),Schirmer I test,meibum quality and meibum expressibility.Results:Sixty-seven patients were followed in the study,and the mean age was 57(±12.6)years.Thirty-three patients(11 males)in the treatment group and 34 patients(8 males)in the control group were followed in the study,and the mean age of the two groups was 45.36±15.02 years and 43.68±13.43 years,respectively.Before treatment,there was no significant difference between the two groups in gender,age,ocular symptom scores,OSDI,TBUT,CFS,Schirmer I test,meibum quality,and meibum expressibility(P>0.05).Compared with baseline,the 2 groups had different degrees of improvement in the ocular symptom scores,OSDI,TBUT,CFS,meibum quality,and meibum expressibility at the 2-week and 1-month visits(P<0.05),and the treatment group showed a more significant improvement in the ocular symptom scores,OSDI,TBUT,CFS,meibum quality and meibum expressibility compared with the control group(P<0.05).In addition,no serious adverse events wer

关键词： meibomian gland squeezer traditional Chinese medicine dry eye disease meibomian gland dysfunction

Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimot

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

Artificial cavernosa-like tissue based on multibubble Matrigel and a human corpus cavernous fibroblast scaffold

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Asian Journal of Andrology 2024年第3期26卷 260-267页

作者： Yu-Zhuo Chen Yi-Hong Zhou Min-Bo Yan Ming Xiao Biao Liu ying-Hao yin Xiao-Li Tan Yong-quan Huang Yu-Hong Lin Ting Xie Jia-Li Tian Qi Wang Jian-ying Li Zi-Zhou Meng Zheng Li Emily Xing Yu-Xin Tang Ya-Wei Li Zhong-Zhen Su Liang-Yu Zhao Department of Ultrasound The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Interventional Medicine Guangdong ProvincialKey Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Andrology the Center for Men’s HealthUrologic Medical CenterShanghai Key Laboratory of ReproductiveMedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Cedars-Sinai Medical Center Los AngelesCA 90024USA

Ex vivo tissue culture of the human corpus cavernosum(cc)can be used to explore the tissue structural changes and complex signaling networks.At present,artificial Cc-like tissues based on acellular or three-dimensional(3D)-printed scaffolds are used to solve the scarcity of primary penis tissue samples.However,inconvenience and high costs limit the wide application of such methods.Here,we describe a simple,fast,and economical method of constructing artificial CC-like tissue.Human Cc fibroblasts(FBs),endothelial cells(ECs),and smooth muscle cells(SMCs)were expanded in vitro and mixed with Matrigel in specific proportions.A large number of bubbles were formed in the mixture by vortexing combined with pipette blowing,creating a porous,spongy,and spatial structure.The Cc FBs produced a variety of signaling factors,showed multidirectional differentiation potential,and grew in a 3D grid in Matrigel,which is necessary for CC-like tissue to maintain a porous structure as a cell scaffold.Within the C-like tissue,ECs covered the surface of the lumen,and SMCs were located inside the trabeculae,similar to the structure of the primary Cc.Various cell components remained stable for 3 days in vitro,but the EC content decreased on the 7th day.Wingless/integrated(WNT)signaling activation led to lumen atrophy and increased tissue fibrosis in CC-like tissue,inducing the same changes in characteristics as in the primary Cc.This study describes a preparation method for human artificial cC-like tissue that may provide an improved experimental platform for exploring the function and structure of the cC and conducting drug screening for erectile dysfunction therapy.

关键词： artificial tissue corpus cavernosum ex vivo fibroblasts|

Recent advances in photothermal effects for hydrogen evolution

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Chinese Chemical Letters 2024年第1期35卷 129-139页

作者： Pengcheng Fan Yuhao He Junan Pan Ning Sun Qiyu Zhang Chen Gu kang Chen Weinan yin Longlu Wang College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NUPT)Nanjing 210023China

Photothermal effect has been widely employed in the H2 evolution process at the advantage of using clean energy sources to produce another one of higher benefits.The solar-to-heat conversion have various forms and heat can facilitate reactions in a variety of dimensions.Hence,summarizing the sources and destinations of heat is important for constructing hydrogen production systems of higher efficiency.This view mainly focuses on the recent state-of-art progress of hydrogen evolution reaction(HER)based on photothermal effect.First,we introduce the main pathways of photothermal conversions applied in H2 evolution.Then,the functions of the photothermal effect are clearly summarized.Furthermore,we go beyond the catalytic reaction and introduce a method to improve the catalytic system by changing the catalytic bulk phase through thermal means.In the end,we sort out the challenges and outlook to offer some noble insights for this promising area.

关键词： Photothermal effect H_(2)evolution reaction Photothermal catalysis Water vapor splitting Environmental restoration

基于改进YOLOv5l的轻量化鸭蛋裂纹检测算法

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农业工程学报 2024年第5期40卷 216-223页

作者：殷建军康俊琪肖德琴华南农业大学数学与信息学院广州510642 农业农村部华南热带智慧农业技术重点实验室广州510642

鸭蛋裂纹检测技术对于禽蛋加工工厂实现智能化蛋品检测、分级具有重要意义。该研究针对鸭蛋裂纹检测流程复杂、计算量大、模型尺寸大等问题,提出了一种基于改进YOLOv5l(you only look once version5 large)的轻量裂纹检测算法,通过在黑... 详细信息

鸭蛋裂纹检测技术对于禽蛋加工工厂实现智能化蛋品检测、分级具有重要意义。该研究针对鸭蛋裂纹检测流程复杂、计算量大、模型尺寸大等问题,提出了一种基于改进YOLOv5l(you only look once version5 large)的轻量裂纹检测算法,通过在黑暗条件下使用LED灯照射鸭蛋,根据裂纹蛋壳与完好蛋壳透光性不同产生的图像差异进行检测。通过在YOLOv5中引入Ghost_conv模块,大大减少了模型的浮点计算量和参数量,并在模型的骨干网络中加入ECA(efficient channel attention)注意力机制以及使用多尺度特征融合方法 BIFPN(bi-directional feature pyramid network),增加模型对有效信息的关注度,以提高算法检测精度。同时使用CIoU与α-IoU损失函数融合后替代YOLOv5原始GIoU函数加速回归预测。利用自建的鸭蛋裂纹数据集验证改进后模型的性能,结果表明,本研究提出的改进YOLOv5l网络模型检测精准率为93.8%,与原始YOLOv5l模型相比,检测精度提高了6.3个百分点,参数量和浮点计算量分别减少了30.6%、39.4%。检测帧速率为28.954帧/s,较原始YOLOv5l模型仅下降3.824帧/s。与其他的目标检测常用网络SSD(single shot multibox detector)、YOLOv4、Faster-RCNN(faster region convolutional neural networks)相比,精度分别提高了13.1、12.5、8.2个百分点。本研究提出的方法能够在低硬件资源条件下进行高精度检测,可为实际场景应用提供解决方案和技术支持。

关键词：计算机视觉图像识别裂纹检测注意力机制鸭蛋

土壤活性组分界面重金属同位素分馏行为研究进展

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核农学报 2024年第3期38卷 603-611页

作者：殷辉殷明严欣然全越洋涂书新华中农业大学资源与环境学院湖北武汉430070 湖北省生态环境厅十堰生态环境监测中心湖北十堰442000

近年来,多接收电感耦合等离子体质谱仪(MC-ICP-MS)及分离纯化技术的发展使得精确测量重金属稳定同位素组成成为可能,大大促进了其在重金属污染物来源识别、土壤-植物系统重金属迁移和纳米颗粒环境行为示踪等方面的应用。但是,许多表生... 详细信息

近年来,多接收电感耦合等离子体质谱仪(MC-ICP-MS)及分离纯化技术的发展使得精确测量重金属稳定同位素组成成为可能,大大促进了其在重金属污染物来源识别、土壤-植物系统重金属迁移和纳米颗粒环境行为示踪等方面的应用。但是,许多表生环境地球化学过程会引起不同程度的同位素分馏,从而模糊不同重金属储库的同位素指纹特征,使得对环境样品同位素组成的理解变得复杂,被称为“同位素分馏黑箱”。揭示同位素分馏黑箱对于重金属非传统稳定同位素的应用具有重大意义。尽管重金属在各种土壤活性组分界面反应过程中的重金属同位素分馏已有一些研究,但有关矿物结构发生同晶替代过程中的分馏机制尚不清楚,且存在许多不一致或矛盾的地方。本综述系统总结了典型重金属污染物Cd、Zn、Ni在土壤活性组分界面,尤其是铁锰氧化物矿物界面的同位素分馏行为和机制,并指出未来应关注的方向。相关研究的深入将加深对重金属污染物环境地球化学行为的理解,推进对土壤同位素分馏黑箱的理解和非传统稳定同位素在土壤重金属污染物溯源、示踪等过程中的应用,为土壤重金属污染的治理、修复和安全利用等提供科学依据和理论支撑。

关键词：土壤界面反应重金属稳定同位素吸附同晶替代

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和厚朴酚的生物学功能及其饲用化前景的研究

动物营养学报 2024年第4期36卷 2163-2174页

作者：杨康余苗尹福泉马现永广东海洋大学滨海农业学院湛江524088 广东省农业科学院动物科学研究所农业农村部华南动物营养与饲料重点实验室猪禽种业全国重点实验室广东省畜禽育种与营养研究重点实验室广东省畜禽肉品质量安全控制与评定工程技术研究中心广州510640

和厚朴酚是一种天然的中药提取物,具有抗菌、抗肿瘤、抗应激和抗炎等生物学功能,是中药厚朴发挥药理作用的主要成分。在动物生产中的应用表明其具有改善生产性能、增强免疫力和抗镉中毒等作用。因此,和厚朴酚作为一种新型的饲粮添加剂,... 详细信息

和厚朴酚是一种天然的中药提取物,具有抗菌、抗肿瘤、抗应激和抗炎等生物学功能,是中药厚朴发挥药理作用的主要成分。在动物生产中的应用表明其具有改善生产性能、增强免疫力和抗镉中毒等作用。因此,和厚朴酚作为一种新型的饲粮添加剂,具有广泛的应用前景。本文综述了和厚朴酚在机体内的吸收与代谢、生物学功能及其在畜禽生产中的应用,旨在为和厚朴酚在畜禽生产中的高效应用提供参考。

关键词：和厚朴酚生物学功能吸收与代谢作用机理

俯冲带榴辉岩中水的赋存机制及其溶解度的控制因素

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高校地质学报 2024年第2期30卷 142-156页

作者：殷常鑫康磊刘良西北大学地质学系大陆动力学国家重点实验室西安710069

榴辉岩是俯冲带重要的高压—超高压变质岩石类型之一,其主要组成矿物为石榴子石和绿辉石,是名义上无水矿物(NAMs)。随着板片俯冲过程中温度压力的升高,富水流体被释放,但榴辉岩中的石榴子石和绿辉石仍然可以携带一定量的水,成为水向地... 详细信息

榴辉岩是俯冲带重要的高压—超高压变质岩石类型之一,其主要组成矿物为石榴子石和绿辉石,是名义上无水矿物(NAMs)。随着板片俯冲过程中温度压力的升高,富水流体被释放,但榴辉岩中的石榴子石和绿辉石仍然可以携带一定量的水,成为水向地球内部传输的重要载体。在超高压岩石折返过程中,由于压力的降低,石榴子石和绿辉石中的水以羟基出溶的方式释放,能够引起高压变质岩石的退变质甚至同折返岩浆等一系列重要地球动力学过程。文章论述了矿物含水性的研究方法、石榴子石和绿辉石中水的赋存机制、水溶解度的控制因素(例如化学组成、压力、温度、水逸度、氧逸度等)以及板片俯冲/折返过程中榴辉岩水的行为,在此基础上凝炼当前研究中面临的科学问题展望了未来的研究方向。

关键词：俯冲带榴辉岩名义上无水矿物矿物含水量

Adipose-derived stem cells in diabetic foot care:Bridging clinical trials and practical application

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World Journal of Diabetes 2024年第6期15卷 1162-1177页

作者： Song-Lu Tseng Lin kang Zhu-Jun Li Li-quan Wang Zi-Ming Li Tian-Hao Li Jie-Yu Xiang Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences BeijingBeijing 100021China

Diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of patients.Adipose-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improving wound healing in DFUs.Despite extensive exploration of the mechanical aspects of ADSC therapy against DFU,its clinical applications remain elusive.In this review,we aimed to bridge this gap by evaluating the use and advancements of ADSCs in the clinical management of DFUs.The review begins with a discussion of the classification and clinical management of diabetic foot conditions.It then discusses the current landscape of clinical trials,focusing on their geographic distribution,reported efficacy,safety profiles,treatment timing,administration techniques,and dosing considerations.Finally,the review discusses the preclinical strategies to enhance ADSC efficacy.This review shows that many trials exhibit biases in study design,unclear inclusion criteria,and intervention protocols.In conclusion,this review underscores the potential of ADSCs in DFU treatment and emphasizes the critical need for further research and refinement of therapeutic approaches,with a focus on improving the quality of future clinical trials to enhance treatment outcomes and advance the field of diabetic wound care.

关键词： Adipose-derived stem cells Diabetic foot ulcers Wound healing Clinical