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Chinese Journal of Polymer Science 2021年第2期39卷 147-153,I0005页

作者： Wei Yang Hao-Guo Yue Dong Zhao Hui Yan kang-li cao Jin-Sheng Zhao Qing Zhang Shanghai Key Laboratory of Electrical Insulation and Thermal Aging School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240China Shanghai Space Environment Simulation and Verification Engineering Technology Research Center Shanghai Institute of Spacecraft EquipmentShanghai 200240China College of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252059China

Direct arylation methods have been used to polymerize thienylmethylene oxindoles(TEIs)and 3,3-bis[[(2-ethylhexyl)oxy]methyl]-3,4-dihydro-2 H-thieno-[3,4-b][1,4]dioxepin(ProDOT)for new donor-acceptor conjugated *** polymers exhibited blue hues in neutralstate with distinct color-to-transmissive reversible electrochromic switching under applied potentials from 0 V to+1.5 V,and showed high coloration efficiencies(436-438 cm^(2)·C^(-1))in near-infrared regions with high switching speeds around 1-2 s under ambient conditions.

关键词： Electrochromic Direct arylation Donor-acceptor polymers Isoindigo Near-infrared

A Hybrid Model for the Mid-Long Term Runoff Forecasting by Evolutionary Computation Techniques

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Wuhan University Journal of Natural Sciences 2003年第S1期8卷 234-238页

作者： Zou Xiu-fen. kang li-shan. cao Hong-qing, Wu Zhi-jianSchool of Mathematics and Statistics, Wuhan University, Wuhan 430072,Hubei, ChinaState Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, Hubei, China Wuhan University School of Mathematics and Statistics Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) Wuhan University State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) Wuhan University State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

The mid-long term hydrology forecasting is one of most challenging problems in hydrological studies. This paper proposes an efficient dynamical system prediction model using evolutionary computation techniques. The new model overcomes some disadvantages of conventional hydrology forecasting ones. The observed data is divided into two parts; the slow 'smooth and steady' data, and the fast 'coarse and fluctuation' data. Under the divide and conquer strategy, the behavior of smooth data is modeled by ordinary differential equations based on evolutionary modeling, and that of the coarse data is modeled using gray correlative forecasting method. Our model is verified on the test data of the mid-long term hydrology forecast in the northeast region of China. The experimental results show that the model is superior to gray system prediction model (GSPM).

关键词： hydrology forecasting evolutionary modeling gray correlative

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei liu Dai li Xiaoqi Pang Fanglian Chen Hailong cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong cao Chengjun li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Enhanced ultrasonic total focusing imaging of CFRP corner with ray theory-based homogenization technique

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Chinese Journal of Aeronautics 2023年第1期36卷 434-443页

作者： Zhongbing LUO Jinli kang Huanqing cao li liN NDT&E Laboratory Dalian University of TechnologyDalian 116024China Shenzhen Key Laboratory of Smart Sensing and Intelligent Systems Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Ultrasonic testing is effective in defect characterization and quality assurance of Carbon Fiber Reinforced Plastic(CFRP) components in the aerospace industry. Due to the coupling between complex shape and elastic anisotropy, the Phased Array Ultrasonic Testing(PAUT) and time-based Total Focusing Method(TFM) face significant challenges in the calculation of wave propagation. A wave velocity distribution model is established for a multidirectional convex corner of CFRP based on a homogenization theory and the above coupling effects are also incorporated. A ray-tracing method is proposed based on Dijkstra’s shortest path search algorithm. The predicted time of flight ensures that this technique, the homogenized TFM, could synthesize a high-quality focused image by post-processing on the full matrix capture data. Experiments on a laminate with three φ1.5 mm Side-Drilled Holes(SDHs) in different circumferential directions confirm a successful homogenized TFM imaging that all SDHs can be effectively detected. As compared to the isotropic scenario, the maximum positioning error is reduced to 0.12, 0.08, and 0.38 mm, and the Signal-to-Noise Ratios(SNRs) are increased by 2.1, 1.1, and 11.8 dB, respectively. It is suggested that the ray-tracing assisted TFM technique can effectively improve the imaging of corners in CFRP components.

关键词： Carbon fiber reinforced plastic Complex shape Homogenization Imaging Time of Flight(TOF)

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Removal of Cd^(2+) from water by Friedel's salt (FS:3cao·A1_2O_3 ·CaCl_2 ·10H_2O): Sorption characteristics and mechanisms

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Journal of Environmental Sciences 2013年第9期25卷 1719-1725页

作者： Juanjuan Zhang He Zhao Hongbin cao Heping li Zhibao li Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Sciences College of Chemical and Biologic Engineering Changsha University of Science and Technology National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology

The development of low-cost and efficient new mineral adsorbents has been a hot topic in recent years. In this study, Friedel＇s salt （FS：3cao·A12O3 ·CaCl2 ·10H2O）, a hexagonal layered inorganic absorbent, was synthesized to remove Cd2＋ from water. The adsorption process was simulated by Langmuir and Freundlich models. The adsorption mechanism was further analyzed with TEM, XRD, FT-IR analysis and monitoring of metal cations released and solution pH variation. The results indicated the adsorbent FS had an outstanding ability for Cd（Ⅱ） adsorption. The maximum adsorption capacity of the FS for Cd（Ⅱ） removal can reach up to 671.14 mg/g. The nearly equal numbers of Cd2＋ adsorbed and Ca2＋ released demonstrated that ion-exchange （both surface and inner） of the FS for Cd（Ⅱ） played an important role during the adsorption process. Furthermore, the surface of the FS after adsorption was microscopically disintegrated while the inner lamellar structure was almost unchanged. The behavior of Cd（Ⅱ） adsorption by FS was significantly affected by surface reactions. The mechanisms of Cd2＋ adsorption by the FS mainly included surface complexation and surface precipitation. In the present study, the adsorption process was fitted better by the Langmuir isotherm model （R2 = 0.9999） than the Freundlich isotherm model （R2 = 0.8122）. Finally, due to the high capacity for ion-exchange on the FS surface, FS is a promising layered inorganic adsorbent for the removal of Cd（Ⅱ） from water.

关键词： Friedel’s salt cadmium adsorption isotherm mechanism

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-Bo cao Sai-Jun Mo Zhi-Yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

Review of condition monitoring and defect inspection methods for composited cable terminals

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High Voltage 2023年第3期8卷 431-444页

作者： Shuaibing li Binglei cao Jin li Yi Cui Yongqiang kang Guangning Wu School of New Energy and Power Engineering Lanzhou Jiaotong UniversityLanzhouChina School of Electrical Engineering and Automation Tianjin UniversityTianjinChina School of Engineering University of Southern QueenslandBrisbaneAustralia School of Electrical Engineering Southwest Jiaotong UniversityChengduChina

Composited cable terminals are critical for reliable power delivery of traditional and traction power supply *** its operation,the cable terminal continually undergoes complex circumstances where humidity,temperature,field strength,mechanical stress and other factors continuously change at different *** extreme cases,defects or even failures may occur in the cable terminals,leading to catastrophic *** makes the condition monitoring and defect detection of composited cable terminals become an imperative need for the power ***“state-of-the-art”technology of cable terminal condition assessment is focussed and a systematic review of the current research progress of cable terminal condition assessment from the operation circumstances to failure mechanisms is *** covers both online/offline condition monitoring methods and defects detection *** addition,challenges and future research directions for cable terminal condition assessment are also *** is concluded that the non-destructive and non-intrusive methods like terahertz imaging and ultrasonic testing,and multi-source information fusion methods as well as the digital twin technology have been gaining popularity for cable terminal defect *** is expected the presented work can provide a global field of vision for further advancement of both scholars and industrial engineers in this field.

关键词： defect condition composite

Deep amended COPERT model for regional vehicle emission prediction

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Science China(Information Sciences) 2021年第3期64卷 238-240页

作者： Zhenyi XU Yu kang Yang cao Zerui li Department of Automation University of Science and Technology of China Key Laboratory of Technology in Geo Spatial Information Processing and Application System Chinese Academy of Sciences

Dear editor,The existing methods for regional vehicle emission prediction can be roughly categorized into the classes of classical dispersion models and satellite remote sensing *** plume models, operational street ca...

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