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Bone morphogenetic protein-6 suppresses TGF-β_(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 646-652页

作者： Xuan liu Ming liu Meng Ji Bo Ma Yu-Cen Hou Xin-Yue Yao Qiao-Chu Cheng Li Chen Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710000Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Xi’an 710000Shaanxi ProvinceChina Department of Ophthalmology Ankang Hospital of Traditional Chinese MedicineAnkang 725000Shaanxi ProvinceChina

AIM:To evaluate the effect of bone morphogenetic protein-6(BMP-6)on transforming growth factor(TGF)-β_(2)-induced epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE).METHODS:Adult retinal pigment epithelial cell line(ARPE-19)were randomly divided into control,TGF-β_(2)(5μg/L),and BMP-6 small interfering RNA(siRNA)*** cell morphology was observed by microscopy,and the cell migration ability were detected by Transwell *** EMT-related indexes and BMP-6 protein levels were detected by Western ***,a BMP-6 overexpression plasmid was constructed and RPE cells were divided into the control group,TGF-β_(2)+empty plasmid group,BMP-6 overexpression group,and TGF-β_(2)+BMP-6 overexpression *** EMT-related indexes and extracellular regulated protein kinases(ERK)protein levels were ***:Compared with the control group,the migration of RPE cells in the TGF-β_(2) group was significantly ***-β_(2) increased the protein expression levels ofα-smooth muscle actin(α-SMA),fibronectin and vimentin but significantly decreased the protein levels of E-cadherin and BMP-6(P<0.05)in ***,the migration of RPE cells in the BMP-6 siRNA group was also significantly ***-6 siRNA increased the protein expression levels ofα-SMA,fibronectin and vimentin but significantly decreased the protein expression levels of E-cadherin(P<0.05).Overexpression of BMP-6 inhibited the migration of RPE cells induced by TGF-β_(2) and prevented TGF-β_(2) from affecting EMT-related biomarkers(P<0.05).CONCLUSION:BMP-6 prevents the EMT in RPE cells induced by TGF-β_(2),which may provide a theoretical basis for the prevention and treatment of proliferative vitreoretinopathy.

关键词： bone morphogenetic protein-6 epithelialmesenchymal transition transforming growth factor-β_(2) retinal pigment epithelial cells cell migration

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Highly elastic and degradable vitrimeric elastomers using polycondensation

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Chinese Chemical Letters 2024年第3期35卷 434-438页

作者： Yue liu Yongshuang Huang Chao Li Guifu Si Min Chen Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationAnhui UniversityHefei 230601China CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

Introducing covalently crosslinked network to polymer matrix can merge the advantages in reprocessing and durability of *** this contribution,a series of high-performance vitrimeric elastomers were achieved via *** topological structures of polymers were tuned by varying the feeding ratios of bisacetoacetate,hex–substituted bisacetoacetate,bisamine and tris(2-aminoethyl)*** these structural manipulations,the vitrimeric elastomers presented great elastic recovery properties(strain recovery value up to 80%)benefiting from the introduction of long chain ***,the elastomers exhibited excellent reprocessing property,water vapor/oxygen barrier and adhesive ***,the elastomers could be degraded into monomer under acid conditions which enabled the elastomer synthesis again in closed loop recycling *** ease of the polycondensation in this work to prepare highly elastic and recyclable vitrimeric elastomers demonstrated exciting opportunities for the synthesis of sustainable polymers.

关键词： Polycondensation Vitrimeric elastomers Highly elastic Degradable polymers

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Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms:A narrative review

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Animal Nutrition 2024年第1期16卷 251-266页

作者： Pengju Wang Lv-hui Sun Xu Wang Qinghua Wu Aimei liu Hubei Key Laboratory of Diabetes and Angiopathy Medicine Research InstituteXianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Hubei Hongshan Laboratory College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan430070China National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan430070China College of Life Science Yangtze UniversityJingzhou 434025China

T-2 toxin is one of the most widespread and toxic fungal toxins in food and *** can cause gastrointestinal toxicity,hepatotoxicity,immunotoxicity,reproductive toxicity,neurotoxicity,and nephrotoxicity in humans and animals.T-2 toxin is physicochemically stable and does not readily degrade during food and feed ***,suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent *** agents against the organ toxicity of T-2 toxin have been recorded widely in the literature,but these protective agents and their molecular mechanisms of detoxification have not been comprehensively *** this review,we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification *** appropriate targets to antagonize T-2 toxin toxicity is also an important *** review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future.

关键词： T-2 toxin Organ toxicity Protective agent Detoxification mechanism

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In situ Simulation of Thermal Reality

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Research 2024年第2期2023卷 685-690页

作者： Peng Jin Jinrong liu Fubao Yang Fabio Marchesoni Jian-Hua Jiang Jiping Huang Department of Physics State Key Laboratory of Surface Physicsand Key Laboratory of Micro and Nano Photonic Structures(MOE)Fudan UniversityShanghai 200438China Center for Phononics and Thermal Energy Science Shanghai Key Laboratory of Special Artificial Microstructure Materials and TechnologySchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Physics University of CamerinoCamerino 62032Italy Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China

Simulated reality encompasses virtual,augmented,and mixed realities梕ach characterized by different degrees of truthfulness in the visual perception:"all false","coexistence of true and false,"and"difficult distinction between true and false,"*** all these technologies,however,the temperature rendering of virtual objects is still an unsolved ***,the lack of thermal tactile functions substantially reduces the quality of the user's real-experience *** address this challenge,we propose theoretically and realize experimentally a technological platform for the in situ simulation of thermal *** this purpose,we design a thermal metadevice consisting of a reconfigurable array of radiating units,capable of generating the thermal image of any virtual object,and thus rendering it in situ together with its thermal *** is a substantial technological advance,which opens up new possibilities for simulated reality and its applications to human activities.

关键词： false rendering signature

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Recent progress on the functionalization of white phosphorus in China

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National Science Review 2024年第6期11卷 308-320页

作者： Xinlei Huangfu Zhongzhen Wang Yu Chen Junnian Wei Wei liu Wen-Xiong Zhang Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory of Rare-Earth Materials Chemistry and Applications & Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular Engineering Peking University

Direct synthesis of organophosphorus compounds from white phosphorus represents a significant but challenging subject, especially in the context of ongoing efforts to comprehensively improve the phosphorus-derived chemical industry driven by sustainability and safety concerns. China is the world's largest producer of white phosphorus, creating a significant demand for the green transformation of this crucial feedstock. This review provides an overview of advancements in white phosphorus activation by Chinese research teams, focusing on the direct construction of P–C/N/O/S/M bonds from white phosphorus. Additionally, we offer some insights into prospective directions for the activation and transformation of white phosphorus in the future. This review paper aims to attract more researchers to engage in this area, stimulating follow-up exploration and fostering enduring advances.

关键词： white phosphorus organophosphorus compound activation selectivity efficiency

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Clarification of the dispersion mechanism of cathode slurry of lithium-ion battery under effects of both poly vinylidene fluoride/carbon black ratio and mixing time

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Particuology 2024年第5期88卷 116-127页

作者： Zhilong Wang Zhenzhen Zhao Ye Yang An Zhang Xiayi liu Tong Zhao Yahui Cui School of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China

This paper presents the effects of both poly vinylidene fluoride(PVDF)/carbon black(CB)ratio(m PVDF:m CB)and mixing time t on the dispersion mechanism of the cathode slurry of lithium-ion battery(LIB).The dispersion mechanism is deduced from the electrochemical,morphological and rheological properties of the cathode slurry by using electrical impedance spectroscopy(EIS),scanning electron microscopy and rheology methods,*** the perspective of EIS method,static simulation models are established in the COMSOL Multiphysics software;meanwhile,the simulated results are used to verify the correctness of the electrochemical properties of the cathode *** a result,the following conclusions are able to be ***,in the case of the mass ratio m_(PVDF):m_(CB)=5:10,LiCoO_(2) particles are completely coated by the mixture of CB and PVDF to form a stable polymer gel *** or lower m_(PVDF):m_(CB) leads to the larger impedance and worse dispersion status for the cathode ***,when t=6 min,a good gel-like conductive network structure is formed by coating the thinner evenly dispersed CB–PVDF double layer around LiCoO_(2) ***,a strategy regarding to both m_(PVDF):m_(CB) and t in experimental scale is proposed,which has the capability of improving the performance of LIB.

关键词： Cathode slurry Dispersion mechanism Lithium-ion battery(LIB)

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Security and Privacy in Solar Insecticidal Lamps Internet of Things:Requirements and Challenges

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 58-73页

作者： Qingsong Zhao Lei Shu Kailiang Li Mohamed Amine Ferrag Ximeng liu Yanbin Li the College of Artificial Intelligence Nanjing Agricultural UniversityNanjing 210031 the State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023 the State Key Laboratory of Cryptology Beijing 100878China IEEE the School of Engineering University of LincolnLincoln LN67TSUK the Artificial Intelligence and Digital Science Research Center Technology Innovation InstituteMasdar City 9639UAE the College of Computer and Data Science Fuzhou UniversityFuzhou 350108China

Solar insecticidal lamps(SIL) can effectively control pests and reduce the use of pesticides. Combining SIL and Internet of Things(IoT) has formed a new type of agricultural IoT,known as SIL-IoT, which can improve the effectiveness of migratory phototropic pest control. However, since the SIL is connected to the Internet, it is vulnerable to various security *** issues can lead to serious consequences, such as tampering with the parameters of SIL, illegally starting and stopping SIL,etc. In this paper, we describe the overall security requirements of SIL-IoT and present an extensive survey of security and privacy solutions for SIL-IoT. We investigate the background and logical architecture of SIL-IoT, discuss SIL-IoT security scenarios, and analyze potential attacks. Starting from the security requirements of SIL-IoT we divide them into six categories, namely privacy, authentication, confidentiality, access control, availability,and integrity. Next, we describe the SIL-IoT privacy and security solutions, as well as the blockchain-based solutions. Based on the current survey, we finally discuss the challenges and future research directions of SIL-IoT.

关键词： Challenges Internet of Things(IoT) privacy and security security requirements solar insecticidal lamps(SIL)

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基于大场景视频监控的坝面施工机械潜在碰撞风险预警方法

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水利学报 2024年第7期55卷 780-790,801页

作者：曾拓程王佳俊钟登华张雨诺康栋天津大学水利工程智能建设与运维全国重点实验室天津300350 中国农业大学水利与土木工程学院北京100083 雅砻江流域水电开发有限公司四川成都610051

基于大场景视频监控实现坝面施工机械潜在碰撞风险预警对保证大坝施工安全具有重要意义。然而,目前坝面施工机械潜在碰撞风险检测主要依赖人工经验判断,易出现漏判和误判等问题。因此,本研究提出一种基于大场景视频监控的坝面施工机械... 详细信息

基于大场景视频监控实现坝面施工机械潜在碰撞风险预警对保证大坝施工安全具有重要意义。然而,目前坝面施工机械潜在碰撞风险检测主要依赖人工经验判断,易出现漏判和误判等问题。因此,本研究提出一种基于大场景视频监控的坝面施工机械潜在碰撞风险预警方法。首先,基于Trajectron++轨迹预测算法,通过迁移学习,实现对坝面大场景视频监控中数量众多、类型多样的施工机械在未来一段时间内的轨迹预测。其次,提出将行驶接近时间和机械最大拥挤度作为坝面施工机械潜在碰撞风险的量化指标,并基于模糊规则,建立不同行驶速度条件下两个指标与潜在碰撞风险分级预警的模糊隶属度函数。最后,采用证据理论对两个指标的预警结果进行融合,计算最终的预警等级。以两河口大坝施工现场的大场景视频监控为例进行实验验证,结果表明坝面施工机械未来6 s的轨迹预测平均位移误差和最终位移误差分别为1.17和2.36 m,且基于模糊-证据融合的施工机械潜在碰撞风险分级预警结果可为坝面施工安全提供自动化、智能化分析方法。

关键词：施工机械安全大场景视频监控轨迹预测模糊-证据融合分级预警

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Prescribed-Time Nash Equilibrium Seeking for Pursuit-Evasion Game

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1518-1520页

作者： Lei Xue Jianfeng Ye Yongbao Wu Jian liu D.C.Wunsch Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of EducationNanjing 210096 School of Automation Southeast UniversityNanjing 210096China Department of Electrical and Computer Engineering Missouri University of Science and TechnologyRollaMO 65409 USA IEEE

Dear Editor,This letter is concerned with prescribed-time Nash equilibrium(PTNE)seeking problem in a pursuit-evasion game(PEG)involving agents with second-order *** order to achieve the prior-given and user-defined convergence time for the PEG,a PTNE seeking algorithm has been developed to facilitate collaboration among multiple pursuers for capturing the evader without the need for any global ***,it is theoretically proved that the prescribedtime convergence of the designed algorithm for achieving Nash equilibrium of ***,the effectiveness of the PTNE method was validated by numerical simulation results.A PEG consists of two groups of agents:evaders and *** pursuers aim to capture the evaders through cooperative efforts,while the evaders strive to evade *** is a classic noncooperative *** has attracted plenty of attention due to its wide application scenarios,such as smart grids[1],formation control[2],[3],and spacecraft rendezvous[4].It is noteworthy that most previous research on seeking the Nash equilibrium of the game,where no agent has an incentive to change its actions,has focused on asymptotic and exponential convergence[5]-[7].

关键词： seeking prescribed convergence

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Thermal fatigue and wear of compacted graphite iron brake discs with various thermomechanical properties

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China Foundry 2024年第3期21卷 248-256页

作者： Gui-quan Wang Zhuo Xu Zhong-li liu Xiang Chen Yan-xiang Li School of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

The increase in payload capacity of trucks has heightened the demand for cost-effective yet high performance brake *** this work,the thermal fatigue and wear of compacted graphite iron brake discs were investigated,aiming to provide an experimental foundation for achieving a balance between their thermal and mechanical *** graphite iron brake discs with different tensile strengths,macrohardnesses,specific heat capacities and thermal diffusion coefficients were produced by changing the proportion and strength of *** peak temperature,pressure load and friction coefficient of compacted graphite iron brake discs were analyzed through inertia friction *** morphology of thermal cracks and 3D profiles of the worn surfaces were also *** is found that the thermal fatigue of compacted graphite iron discs is determined by their thermal properties.A compacted graphite iron with the highest specific heat capacity and thermal diffusion coefficient exhibits optimal thermal fatigue *** of the matrix at low temperatures significantly weakens the function of alloy strengthening in hindering the propagation of thermal *** the reduced hardness,increasing the ferrite proportion can mitigate wear loss resulting from low disc temperatures and the absence of abrasive wear.

关键词： compacted graphite iron brake disc thermomechanical properties thermal fatigue wear

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