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NECAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane traffick.ng and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, k.y regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is ak.n to atypical heme oxygenases in prok.ryotes but is not wellcharacterized in vertebrates. Prok.ryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is k.own about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

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1例皮质发育不良所致癫痫患者在枕叶皮质切除术后出现复杂幻视

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 15-15页

作者： hoi E.-j. Lee j.-k. kang j.-k. Lee S.-A. 黄卫东 Department of Neurology Univ. of Ulsan College of Medicine Asan Medical Center 388-1 Pungnap-dong Songpa-gu Seoul 138-736 South KoreaDr.

Back.round: Charles Bonnet syndrome is a rare disorder characterized by complex and recurrent visual hallucinations in elderly patients with visual pathway pa thologic defects. To date, to our k.owledge, it has not been described in patien ts undergoing surgical resection for occipital lobe epilepsy due to cortical dys plasia. Obj.ctive: To describe a patient who experienced complex visual hallucin ations following resection of cortical dysplasia on the right occipital lobe and who was diagnosed as having Charles Bonnet syndrome. Patient: A 35-year-old w oman underwent surgical resection for medically intractable epilepsy caused by c ortical dysplasia involving the right occipital lobe. Results: Two months after resection of the epileptogenic zone, complex visual hallucinations in the left v isual field not associated with loss of consciousness or delusion developed in t he patient. Hallucinations persisted for more than 12 months despite treatment w ith anti-epileptic medications. During hallucination, no electrographic seizure s were recorded through long-term video-electroencephalographic monitoring. Co nclusions: Charles Bonnet syndrome may occur in a patient with occipital lobe ep ilepsy following resection of the diseased brain with a developmental malformati on. Charles Bonnet syndrome associated with surgical treatment of occipital lobe epilepsy may have been overlook.d.

关键词：皮质切除发育不良难治性癫痫抗癫痫药物癫痫灶视频脑电图发作期间外科切除 Bonnet 切除术

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Regulation of Power Conversion in Fuel Cells

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Chemical Research in Chinese Universities 2004年第4期20卷 466-469页

作者： ZHANG j. k. Scott School of Chemical Engineering & Advanced Materials University of Newcastle upon Tyne Newcastle upon TyneSchool of Chemical Engineering & Advanced Materials University of Newcastle upon Tyne Newcastle upon Tyne NE1 7RU UK NE1 7RU UK

Here we report a regulation about power conversion in fuel cells. This regulation is expressed as that total power produced by fuel cells is always proportional to the square of the potential difference between the \{equilibrium\} potential and work.potential. With this regulation we deduced fuel cell performance equation which can describe the potential *** current performance curves, namely, polarization curves of fuel cells with three power source parameters: equilibrium potential E_0; internal resistance R; and power conversion coefficient k. The concept of the power conversion coefficient is a new criterion to evaluate and compare the characteristics and capacity of different fuel cells. The calculated values obtained with this equation agree with practical performance of different types of fuel cells.

关键词： Fuel cell Power conversion coefficient Internal resistance Performance Potential

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A low redox potential and long life organic anode material for sodium-ion batteries

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j.urnal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei kang Zhou Xin Huang Xing Zhou j.e Xu Taoyi k.ng j.nwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai k.y Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements lik. C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （k.Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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Three-dimensional simulation for problem of penetrative convection near the maximum density

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j.urnal of Hydrodynamics 2015年第2期27卷 292-303页

作者： HARFASH Ak.l j. ALSHARA Ahmed k. Department of Mathematics College of SciencesUniversity of Basrah Petroleum Department College of EngineeringUniversity of Misan

The problem of penetrative convection with the cubic and fifth-order equations of state proposed by Merk.r, Waas and Grigull is studied. Both linear instability and nonlinear stability analyses are performed to assess the suitability of linear theory to predict destabilisation of the convection. The validity of both the linear instability and global nonlinear energy stability thresholds are tested using three-dimensional simulation. The results show that the linear threshold accurately predicts the onset of instability in the basic steady state solution.

关键词： thermal convection linear instability nonlinear stability finite difference scheme

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Real meromorphic functions and linear differential polynomials

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Science China Mathematics 2010年第3期53卷 739-748页

作者： LANGLEY j. k. School of Mathematical Sciences University of Nottingham

We determine all real meromorphic functions f in the plane such that f has finitely many zeros, the poles of f have bounded multiplicities, and f and F have finitely many non-real zeros, where F is a linear differential polynomial given by F = f (k. +Σk.1j.0aj.(j. , in which k.2 and the coefficients aj.are real numbers with a0≠0.

关键词： non-real zeros meromorphic function linear differential polynomial

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su j.a‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China k.y Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou k.y Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work.demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and k.batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Surface Effects on Wannier Excitons in Superlattices:Monte Carlo Simulation

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Chinese Physics Letters 2002年第8期19卷 1164-1167页

作者： k. Afif, A. Benyoussef and j. Diouri Laboratoire de Magnetisme Faculte des Sciences Groupe d"Electronique et de Physique du Solide Faculte des Science

Using a Monte Carlo quadrature, we calculate by a variational method the binding energy Eb of Wannier excitons in N-period m-CdMnTe/n-CdTe superlattices, including or not including the step discontinuity in the potential barrier at the interface, and with varying N as well as well width. The calculation is performed in the framework.of the effective mass approximation for both heavy-hole and light-hole excitons. The degree of exciton localization dependence on these parameters is accurately illustrated.

关键词： Monte Carlo methods

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Auto-correlation Effects on the sp^3-d Exchange Interaction in Cd1-x MnxTe/CdTe Multilayers

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Chinese Physics Letters 2002年第11期19卷 1679-1682页

作者： k. Afif, A. Benyoussef and j. Diouri Laboratoire de Magnetisme Faculte des Sciences Groupe d"Electronique et de Physique du Solide Faculte des Sciences

Band offsets and total energy of Wannier excitons in multilayers are affected by dimensional and auto-correlation effects, and sp^3-d coupling is consequently modified. Thus, the calculation of the Zeeman splitting in the quantum wells has to tak. into account these effects, especially when the mismatch cannot be disregarded. In this work. the theoretical study of these combined effects has been performed for Cd1-xMnxTe/CdTe multilayers embedded by Cd1-yZnyTe as the substrate (or the buffer) on one side and as a cladding layer on the other side. This sample allows us to highlight the role played by the substrate (buffer) and the growth direction on the Zeeman splitting in such multilayers

关键词： Multilayers

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Large eddy simulation of turbulent diffusion flame combustion using a conserved scalar methodology

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航空动力学报 2007年第7期22卷 1106-1117页

作者： k. Wang Z. Yang j. j. McGuirk Department of Aeronautical and Automotive EngineeringLoughborough University Loughborough Leicestershire LE11 3TU UK

The present paper describes an LES prediction of turbulent diffusion flame combustion in a simplifled axi-symmetric combustor *** calculations are carried out using a well-tested finite volume incompressible LES code which has been modified to handle variable density and reacting *** basic mixture fraction conserved scalar method *** with the chemical state relationships described by fast *** turbulence-chemistry interaction is modelled by a sub-grid PDF method and the PDF is assumed to follow a Beta-function *** LES predictions have been time-averaged over 3.5 flow-through times to generate the mean radial profiles of mixture fraction,product mass fraction,temperature,axial velocity and axial *** agreement of the LES predictions with the experimental data is good for all the above quantities at four different axial positions with largest differences at the first measurement *** LES method also provides information on the unsteady nature of turbulent diffusion *** turbulent reacting flows with large density ratio,it was found necessary to use a relaxation method in order to remove unphysical high-frequency fluctuations and to maintain numerical stability.

关键词：大涡模拟湍流扩散数量方法论弛豫法燃烧理论

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