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The effects of ultrasonic irradiation in combination with ozone on the reduction of residual ethion of tangerine (<i>Citrus reticulata</i>Blanco cv. Sai Nam Pung) fruit after harvest

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Agricultural Sciences 2013年第5期4卷 7-11页

作者： kanda whangchai Satit Phiyanalinmat Jamnong Uthaibutra Sarunya Pengphol Nakao Nomura 1Postharvest Technology Innovation Center Commission on Higher Education Bangkok Thailand 2Postharvest Technology Research Institute Chiang Mai University Chiang Mai Thailand 3Postharvest Technology Research Institute Chiang Mai University Chiang MaiThailand Department of Industrial Chemistry Faculty of Science Chiang Mai University Chiang Mai Thailand Faculty of Agriculture and Industrial Technology Nakonsawan Rajabhat University Nakonsawan Thailand Graduate School of Life and Environmental Science University of Tsukuba 1-1-1 Tennodai Tsukuba lbaraki Japan

Ethion residue removal efficiency using individual and combined effects of ultrasonication (US), ozonation (O3), ultrasonication and ozonation (US/O3) was investigated. A 1 mg·L-1 standard ethion was subjected to an ultrasonic irradiation (3W input power) device with different frequencies of 108, 400, 700, 1000 kHz, and to an ozone with a concentration of 200 mg· mL-1 with various exposure times (0, 15, 30, 45 and 60 minutes). Reduction of residual ethion was determined by gas chromatography with flame photometric detection (GC-FPD). It was found that 1000 kHz ultrasonic irradiation for 60 minutes was the most effective treatment for reducing ethion concentration. Additionally, ozone could reduce the concentration of standard ethion after 60 minutes of exposure. Ultrasonic irradiation in combination with ozone had a synergistic effect in reducing standard ethion concentration, with the highest rate occurring within the first 15 minutes. Ethion concentration was reduced to 75.43% after ultrasonic irradiation at 1000 kHz and ozone exposure for 60 minutes. The effectiveness of the combined scheme for reducing of ethion residues on tangerine was also determined by GC-FPD. The ethion residue on fresh tangerines after ultrasonic irradiation and ozone washing was reduced by 73.03% after 60 minutes. The present study demonstrates that ultrasonic irradiation and ozone exposure could be used to reduce ethion residues in treated tangerine in order to meet the Standards for Pesticide Residue Limits.

关键词： Tangerine Ethion Pesticide Residue Ozone Ultrasonic Irradiation

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Usefulness of Newly Devised Clomiphene Citrate Administration Method Compared with the Conventional Method in Ovulation and Pregnancy

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 637-649页

作者： Makoto Kawamura Misaki Akiyama Remi Nakajima Eri Satoi Yoko Ogaki Rieko kanda Department of Obstetrics and Gynecology Kohseichuo General Hospital Tokyo Japan

Objective: Since not all women wish to conceive a child through aggressive treatment, we investigated the usefulness of modified repeated intracyclic clomiphene citrate (CC) therapy (repeated CC therapy) as a newly devised administration method. Methods: We evaluated the effects of CC administration on menstrual cycle length and retrospectively compared ovulation and pregnancy in 220 women who received CC at our hospital. Patients in the conventional method group received 50 mg per day for five days, starting on the fifth day of menstruation (withdrawal bleeding). Groups with and without menstrual cycle shortening after conventional CC administration were compared. The repeated CC therapy group was also compared with the non-shortened group. Repeated CC therapy was administered for the first five days as in the conventional method, and a second five-day repeat treatment was administered after an interval of five to seven days. Pregnancy rates, including indirect pregnancies, were evaluated by three different methods. Results: Ovulation and pregnancy rates were significantly better in the shortened group than in the non-shortened group (P < 0.001 and P = 0.010, respectively). Even in the non-shortened group, ovulation and pregnancy rates including indirect pregnancies were significantly improved when ovulation was observed with repeated CC therapy (P < 0.001 and P = 0.022, respectively). Conclusions: For patients whose menstrual cycle was not improved or shortened, repeated CC therapy as the newly devised CC administration method is useful as the next step after the conventional CC administration method.

关键词： Clomiphene Citrate Infertility Menstrual Cycle Ovulation Induction

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云峰山温泉度假村

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城市环境设计 2024年第1期147卷 70-75页

作者：横尾实秋山弘明猿田晓生神田刚隈研吾建筑都市设计事务所

这座温泉度假村坐落在中国云南省腾冲市的山区中。项目用地西面有一座山，名叫云峰山，被誉为道教圣地。于是，我们把这些建筑物布置得像是顺着道教“精神”从山上下来的水流。我们还利用了附近采石场的不同种类的石头，把各种石头像马...

这座温泉度假村坐落在中国云南省腾冲市的山区中。项目用地西面有一座山，名叫云峰山，被誉为道教圣地。于是，我们把这些建筑物布置得像是顺着道教“精神”从山上下来的水流。我们还利用了附近采石场的不同种类的石头，把各种石头像马赛克一样拼在一起。通过使用当地的石头，我们试图在我们设计的建筑中表达“大地的力量”。

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Light is an Important Limiting Factor for the Vertical Distribution of the Largest Extant Benthic Foraminifer Cycloclypeus carpenteri

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Journal of Earth Science 2022年第6期33卷 1460-1468页

作者： Kazuhiko Fujita Yoji kanda Takashi Hosono Department of Physics and Earth Sciences University of the RyukyusOkinawa903-0213Japan Tropical Biosphere Research Center University of the RyukyusOkinawa903-0213Japan Japan Agency for Marine-Earth Science and Technology(JAMSTEC) Global Oceanographic Data Center(GODAC)Kanagawa236-0001Japan

Cycloclypeus carpenteri is the largest extant benthic foraminifer,dwelling in the deep euphotic zone(a water depth between 60 and 130 m)of the warm oligotrophic Indo-West *** foraminifer harbors diatom endosymbionts and the foraminifer-microalgal association acts like a *** verify that light is an important limiting factor controlling the vertical(depth)distribution of living Cycloclypeus holobionts,their physiological responses to light intensity were examined by short-term metabolic measurements and long-term *** oxygen production(OP)rates measured under different light levels using an oxygen microelectrode indicate that Cycloclypeus holobionts are daily net primary producers adapted to low light levels,with slight photoinhibition(reduced net OP rates relative to a light-saturated rate)over 100μmol photons m^(−2)s^(−1).Long-term growth increments of asexually reproduced juveniles incubated for two months at different light levels ranging from 0 to 100μmol photons m^(−2)s^(−1) show that Cycloclypeus holobionts are adapted to a low light level(∼5μmol photons m^(−2)s^(−1)),but can be acclimatized to a certain low light ranges(<50μmol photons m^(−2)s^(−1)).These experimental results confirm that light is an important environmental gradient affecting the vertical distribution of Cycloclypeus holobionts.

关键词： algal symbiosis diatom large benthic foraminifer oxygen production photosynthesis

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Criminal or bystander: imatinib and second primary malignancy in GIST patients

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Chinese Journal of Cancer Research 2013年第5期25卷 490-492页

作者： Tatsuo kanda Sanjo General Hospital

Niigata University Hospital is a regional center institution of cancer therapy where many patients with gastrointestinal stromal tumors （GISTs） are visiting to seek the latest *** the time Ⅰ was treating GIST patients there with imatinib,a tyrosine kinase inhibitor,a small concern was raised：Ⅰ successively encountered patients who were newly diagnosed as having malignant neoplasms during the course of their *** the 70 GIST patients who were enrolled in our prospective study of imatinib therapy,seven suffered from second primary malignancies （SPMs）.One female GIST patient who suffered from advanced esophageal cancer died of the SPM,whereas the remaining six patients continued with their imatinib therapy and their prognoses were not affected by their SPMs.I reported on the risk of SPMs in GIST patients under imatinib therapy to an international journal of clinical oncology （1）.As the patient cohort of our study was so small in number to apply to statistical analysis,our observation was no more than a clinical alert.

关键词： GIST imatinib and second primary malignancy in GIST patients Criminal or bystander

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Experimental and numerical study on hydrodynamics of riparian vegetation

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Journal of Hydrodynamics 2014年第5期26卷 796-806页

作者： UOTANI Takuya kanda Keiichi MICHIOKU Kohji Kobe City Bureau KobeJapan Department of Civil Engineering Akashi National College of TechnologyAkashiJapan Department of Civil and Environmental Engineering Hosei UniversityShinjukuTokyoJapan

Recently, many channelized rivers tend to be heavily vegetated due to regime shifts in hydrological, fluvial and ecological processes. Dense vegetation in a river frequently obstructs a flood flow and reduces conveyance capacity of channels. On the other hand, river vegetation provides various ecological services such as habitats for various species and life, natural cycle of organic and inorganic substances, etc.. It is of engineering importance to understand vegetation hydrodynamics in order to preserve vegetation nature and keep a certain level of flow conveyance capacity. In view that willows tend to be densely vegetated along the shoreline of floodplains or sandbars, a field measurement, a physical model experiment and a numerical analysis were carried out for investigating hydrodynamics in an open channel with riparian vegetation. Discussion was made focusing on flow and shear layer structures developed around the vegetation canopy.

关键词： open channel riparian vegetation drag force velocity profile laboratory experiment hydrodynamic model

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A Switching Controller System for a Wheeled Mobile Robot

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Journal of Bionic Engineering 2007年第4期4卷 281-289页

作者： Masanori Sato Atushi kanda Kazuo Ishii Department of Brain Science and Engineering Kyushu Institute of Technology Kitakyushu 808-0196 Japan

A wheeled mobile mechanism with a passive and/or active linkage mechanism for rough terrain environment is developed and evaluated. The wheeled mobile mechanism which has high mobility in rough terrain needs sophisticated system to adapt various environments. We focus on the development of a switching controller system for wheeled mobile robots in rough terrain. This system consists of two sub-systems： an environment recognition system using link angles and an adaptive control system. In the environment recognition system, we introduce a Self-Organizing Map （SOM） for clustering link angles. In the adaptive controllers, we introduce neural networks to calculate the inverse model of the wheeled mobile robot. The environment recognition system can recognize the environment in which the robot travels, and the adjustable controllers are tuned by experimental results for each environment. The dual sub-system switching controller system is experimentally evaluated. The system recognizes its environment and adapts by switching the adjustable controllers. This system demonstrates superior performance to a well-tuned single PID controller.

关键词： mobile robot rough terrain neural network Self-Organizing Map

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国立竞技场

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城市环境设计 2024年第1期147卷 64-68页

作者：横尾实宫原贤次草谷友则原田爽一朗矢田元辉松长知宏神田刚南雅博 Japan Sport Council

这个大型体育场由一些小直径的木头建成。外立面上覆盖了重叠的多层屋檐，每层屋檐的下面是小直径的木百叶窗，通过这种现代的方式表达了日本传统建筑中的屋檐之美。105毫米的雪松木方是日本最常见的尺寸，这里将其分成三块50毫米的木...

这个大型体育场由一些小直径的木头建成。外立面上覆盖了重叠的多层屋檐，每层屋檐的下面是小直径的木百叶窗，通过这种现代的方式表达了日本传统建筑中的屋檐之美。105毫米的雪松木方是日本最常见的尺寸，这里将其分成三块50毫米的木板来制作百叶窗。百叶窗出现在外立面上的频率和密度是变化的，让屋檐的尺度更加人性化。屋顶采用桁架结构，该结构结合了具有中等横截面的钢梁和层压木材，利用木材的轴向刚度来最大限度地减少屋顶桁架因风或地震而产生的变形。

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Antiviral therapy for ＂difficult-to-treat＂ hepatitis C virus-infected patients

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Chinese Medical Journal 2013年第23期126卷 4568-4574页

作者： Tatsuo kanda Osamu Yokosuka Masao Omata Department of Gastroenterology and Nephrology Chiba UniversityGraduate School of Medicine 1-8-1 Inohana Chuo-ku Chiba Japan Yamanashi Hospitals(Central and Kita)Organization 1-1-1 FujimiKofu-shi Yamanashi Japan University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo Japan

Objective To review the updated research on direct antiviral agents （DAAs）-including regimens for hepatitis C virus （HCV）,and focus on ＂difficult-to-treat＂ HCV-infected *** sources The literature concerning DAAs and hepatitis C cited in this review was collected from PubMed and Google Scholar databases published in English up to July *** selection Data from published articles regarding HCV and DAAs in clinical trials and in clinical use were identified and *** It was recognized that some ＂difficult-to-treat＂ patients would still exist,even though stronger treatments using such as DAAs,including telaprevir and boceprevir,which lead to higher sustained virological response rates,are *** patients include those with advanced fibrosis/cirrhosis,elderly persons,children,HCV-human immunodeficiency virus co-infected patients,HCV-infected recipients,and so *** Certain ＂difficult-to-treat＂ patients would still exist,even though stronger treatment is *** evidence from clinical trials is still lacking,interferon-sparing regimens could have stronger effects for eradicating HCV in such cases.

关键词： advanced cirrhosis direct antiviral agents elderly hepatocellular carcinoma hepatitis C virus interferon-free treatment liver transplant

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Direct-acting antiviral agents against hepatitis C virus and lipid metabolism

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World Journal of Gastroenterology 2017年第31期23卷 5645-5649页

作者： tatsuo kanda mitsuhiko moriyama division of gastro-enterology and hepatology department of medicine nihon university school of medicine

Hepatitis C virus(HCV) infection induces steatosis and is accompanied by multiple metabolic alterations including hyperuricemia, reversible hypocholesterolemia and insulin resistance. Total cholesterol, low-density lipoprotein-cholesterol and triglyceride levels are increased by peginterferon and ribavirin combination therapy when a sustained virologic response(SVR) is achieved in patients with HCV. Steatosis is significantly more common in patients with HCV genotype 3 but interferon-free regimens are not always effective for treating HCV genotype 3 infections. HCV infection increases fatty acid synthase levels, resulting in the accumulation of fatty acids in hepatocytes. Of note, low-density lipoprotein receptor, scavenger receptor class B type Ⅰ and Niemann-Pick C1-like 1 proteins are candidate receptors that may be involved in HCV. They are also required for the uptake of cholesterol from the external environment of hepatocytes. Among HCV-infected patients with or without human immunodeficiency virus infection, changes in serum lipid profiles are observed during interferon-free treatment and after the achievement of an SVR. It is evident that HCV affects cholesterol metabolism during interferon-free regimens. Although higher SVR rates were achieved with interferon-free treatment of HCV, special attention must also be paid to unexpected adverse events based on host metabolic changes including hyperlipidemia.

关键词：胆固醇丙肝病毒没有干扰素类脂化合物新陈代谢

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