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Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis

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Stroke & Vascular Neurology 2022年第1期7卷 77-85页

作者： Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau kam wa chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu Hong Kong Chinese Medicine Clinical Study Centre School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Department of Medicine and Therapeutics and Hong Kong Institute of Integrative Medicine Prince of Wales HospitalFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonOntarioCanada Clinical Laboratory Shanghai Traditional Chinese Medicine Integrated Institute of Vascular AbnomaliesShanghaiChina Institute of Medical Research Northwestern Polytechnical UniversityXi'anShanxiChina Evidence Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina School of Chinese medicine Hong Kong Baptist UniversityHong Kong SARChina Brain Center Guangdong Procincial Hospital of Traditional Chinese MedicineGuangdong University of Chinese MedicineGuangzhouChina The Nethersole School of Nuring Faculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Department of Medicine Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SARChina Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong SARChina Hong Kong Association for Integration of Chinese-Western Medicine Limited Hong Kong SARChina

Background Stroke is a major cause of death or long-term disability *** patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal ***,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke *** The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM *** The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were ***,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were *** included outcomes were dependency,motor function,depression and swallowing *** analysis was performed,and publication bias was assessed using funnel *** of review 58 studies and 6339 patients were included in the *** analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy *** superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also *** Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy ***,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn ***,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined.

关键词： acupuncture routine alone

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TRANSFECTION AND CELL FUSION BY FEMTOSECOND LASERS

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 113-125页

作者： HAO HE SIU KAI KONG kam TAI chan Department of Electronic Engineering The Chinese University of Hong Kong ShatinN.T.Hong Kong Department of Biochemistry The Chinese University of Hong Kong ShatinN.T.Hong Kong

Biophotonics is an exciting and fast-expanding frontier which involves the fusion of advanced photonics and *** has not only created many novel methodologies for biomedical research,but also achieved many significant results as an *** to femtosecond(fs)laser technologies,important progresses have been made regarding the manipulation,imaging,and engineering of biological samples ranging from single molecules to tissues in the last 20 *** ultrashort pulses at near-infrared band provide many advantages:high nonlinear efficiency,low absorption by biological samples,high spatial and temporal resolution and confinement,and low *** are noninvasive and easy to *** the mechanism of how fs laser pulses interact with cells remains unclear,experimental results have shown that they could open up the cell membrane and hence made optical transfection and optical cell fusion *** this review,some of the seminal works on transfection and cell fusion by fs lasers are *** ideas behind and the experimental details will be described together with a highlight on their ***,the thermal effect is analyzed based on multiphoton excitation and plasma formation in an aqueous environment to explain the nontoxic characteristic of fs laser ***,some applications of fs laser induced transfection and cellcell fusion with potential major impact in biomedical sciences are proposed.

关键词： Biophotonics transfection cell fusion femtosecond laser

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Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?

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Regenerative Biomaterials 2016年第2期3卷 87-98页

作者： Hon Fai chan Siying Ma kam W.Leong Department of Biomedical Engineering Department of Systems BiologyColumbia UniversityNew YorkNY 10032USA

Translation of any inventions into products requires *** of drug/gene/cell delivery systems will eventually face manufacturing challenges,which require the establishment of standardized processes to produce biologically-relevant products of high quality without incurring prohibitive *** technologies present many advantages to improve the quality of drug/gene/cell delivery *** also offer the benefits of *** remains unclear is whether they can meet the scale-up *** this perspective,we discuss the advantages of microfluidic-assisted synthesis of nanoscale drug/gene delivery systems,formation of microscale drug/cell-encapsulated particles,generation of genetically engineered cells and fabrication of macroscale drug/cell-loaded micro-/*** also highlight the scale-up challenges one would face in adopting microfluidic technologies for the manufacturing of these therapeutic delivery systems.

关键词： microfluidics biomanufacturing nanoparticle microencapsulation microfiber

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Mini-review on initiatives to interfere with the propagation and clearance of alphasynuclein in Parkinson’s disease

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Translational Neurodegeneration 2017年第1期6卷 333-337页

作者： Daniel kam Yin chan Ying Hua Xu Luke Kar Man chan Nady Braidy George D.Mellick Department of Aged Care and Rehabilitation Bankstown HospitalBankstownNSW 2200Australia Ingham Institute LiverpoolNSW 2170Australia University of New South wales Faculty of MedicineSydneyAustralia Faculty of Medical Science Griffith UniversityNathanQLDAustralia Griffith Institute for Drug Discovery Griffith UniversityNathanQLDAustralia

In this mini-review,we summarize recent findings relating to the prion-like propagation ofα-synuclein(α-syn)and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s disease(PD).We link the Braak’s staging hypothesis of PD with the recent evidence from in-vivo and in-vitro studies for the prion-like cell-to-cell propagation ofα-syn(via exocytosis and endocytosis).The classical accumulation of aggregatedα-syn in PD may result from an increased production or a failure in the mechanisms of clearance ofα-*** discuss novel agents,currently in clinical trial for PD including the ones that impact the aggregation ofα-syn and others that interfere withα-syn endocytosis as a means to target the progression of the disease.

关键词： Parkinson’s disease α-synuclein Endocytosis Aggregation

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Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain

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Cellular & Molecular Immunology 2014年第2期11卷 141-149页

作者： kam-Leung Siu Chi-Ping chan Kin-Hang Kok Patrick Chiu-Yat Woo Dong-Yan Jin Department of Biochemistry The University of Hong Kong Pokfulam Hong Kong Department of Microbiology The University of Hong KongPokfulam Hong Kong

Coronaviruses have developed various measures to evade innate immunity, We have previously shown that severe acute respiratory syndrome （SARS） coronavirus M protein suppresses type I interferon （IFN） production by impeding the formation of functional TRAF3-containing complex. In this study, we demonstrate that the IFN-antagonizing activity is specific to SARS coronavirus M protein and is mediated through its first transmembrane domain （TM 1） located at the N terminus. M protein from human coronavirus HKU 1 does not inhibit IFN production. Whereas N-linked glycosylation of SARS coronavirus M protein has no influence on IFN antagonism, TM1 is indispensable for the suppression of IFN production. TM 1 targets SARS coronavirus M protein and heterologous proteins to the Golgi apparatus, yet Golgi localization is required but not sufficient for IFN antagonism. Mechanistically, TM 1 is capable of binding with RIG-I, TRAF3, TBK1 and IKK~, and preventing the interaction of TRAF3 with its downstream effectors. Our work defines the molecular architecture of SARS coronavirus M orotein reouired for suooression of innate antiviral re^nnn^e.

关键词： human coronavirus HKU1 innate antiviral response SARS coronavirus TRAF3 type I interferons

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Effect of Money Supply on Real Output and Price in China

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China & World Economy 2009年第2期17卷 35-44页

作者： Chih-Hsiang chang kam C.chan Hung-Gay Fung College of Management National University of Kaohsiung Gordon Ford College of Business Western Kentucky University College of Business Administration and Center for International Studies University of Missouri-St.Louis

Over the past 30 years, China has achieved remarkable long-term economic growth. Using quarterly data, we study the effects of money supply on real output and inflation in China between 1993 and 2008. To this end, we use money supply shocks afler filtering out the expected component of the money supply. Our findings provide evidence supporting the asymmetric effect of positive and negative money supply shocks on real output and inflation in China. That is, real GDP growth in China responds to negative money supply shocks but not positive money supply shocks. In addition, inflation responds to positive money supply shocks but not negative money supply shocks. We conclude that the People＇s Bank of China＇ s policy of steady monetary growth appears to be appropriate. Our study offers important policy implications for China.

关键词： inflation money supply real output

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Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong

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World Journal of Gastroenterology 2006年第14期12卷 2223-2228页

作者： kam Hoi chan Chun Wing chan wai Hung Chow wai Keung Kwan Chi Kwan Kong Ka Fung Mak Miu Yi Leung Lin Kiu Lau Department of Medicine Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Surgery Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Radiology Yah Chai Hospital Tsuen Wan Hong Kong SAR Chin Department of Pathology Yah Chai Hospital Tsuen Wan Hong Kong SAR China

AIM： To investigate the prevalence and clinical pattern of gastrointestinal stromal tumors （GISTs） in Hong Kong Chinese, and to assess the impact of introduction of CD117 on the disease incidence. METHODS： From the database of the Department of Pathology of Yan Chai Hospital, 47 patients, with GISTs from September 1995 to December 2003 were included in this study. Ten GISTs were diagnosed before the introduction of CD117. The clinical features, tumor characteristics, and treatment were analyzed. Factors predicting tumor related death or recurrence were studied with Cox proportional hazard model. RESULTS： The patients included 26 males and 21 females, with a mean age of 66.6 years （SD 13.1, range 29-87 years）. The estimated prevalence of GISTs was 13.4-15.6 per 100 000 people, with an annual inddence of 1.68-1.96 per 100 000 people. The annual incidence of GISTs before and after the introduction of CD117 was 1.1 per 100 000 people and 2.1 per 100 000 people respectively. Stomach （34 patients, 72.3%） was the most common location for the tumor, followed by the small intestine （8 patients, 17.0%）, esophagus （2 patients, 4.3%）, omentum （2 patients, 4.3%） and colon （1 patient, 2.1%）. Thirty-one patients （66%） had complete tumor resection. Eleven out of 16 deaths （23%） were tumor-related. The median survival time was 26 too. Five-year survival rate was 61.3%. The significant factors associated with tumor-related death or recurrence were incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis, CONCLUSION： The incidence of GIST in Hong Kong is comparable to that in the United States but lower than that in Finland. The true incidence of GISTs could be underestimated before the introduction of CD117. Incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis are factors predicting tumor-related death or recurrence.

关键词： Gastrointestinal tumor GIST Prognostic factors, Clinical features Incidence

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Efficient estimation of smoothing spline with exact shape constraints

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Statistical Theory and Related Fields 2021年第1期5卷 55-69页

作者： Vincent chan kam-wah Tsui Yanran Wei Zhiyang Zhang Xinwei Deng Department of Statistics University of Wisconsin-MadisonMadisonWIUSA Department of Statistics Virginia TechBlacksburgVAUSA

Smoothing spline is a popular method in non-parametric function *** the analysis of data from real applications,specific shapes on the estimated function are often required to ensure the estimated function undeviating from the domain *** this work,we focus on constructing the exact shape constrained smoothing spline with efficient ***‘exact’here is referred as to impose the shape constraint on an infinite set such as an interval in one-dimensional *** the estimation becomes a so-called semi-infinite optimisation problem with an infinite number of *** proposed method is able to establish a sufficient and necessary condition for transforming the exact shape constraints to a finite number of constraints,leading to efficient estimation of the shape constrained *** performance of the proposed methods is evaluated by both simulation and real case studies.

关键词： Monotonicity non-linear constraint non-parametric regression

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Federated Learning with Privacy-preserving and Model IP-right-protection

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Machine Intelligence Research 2023年第1期20卷 19-37页

作者： Qiang Yang Anbu Huang Lixin Fan Chee Seng chan Jian Han Lim kam Woh Ng Ding Sheng Ong Bowen Li WeBank Shenzhen 518057China Hong Kong University of Science and Technology Hong Kong 999077China University of Malaya Kuala Lumpur 50603Malaysia University of Surrey Guildford GU27XHUK University of Aberystwyth Wales SY233DDUK Shanghai Jiao Tong University Shanghai 200240China

In the past decades,artificial intelligence(AI)has achieved unprecedented success,where statistical models become the central entity in ***,the centralized training and inference paradigm for building and using these models is facing more and more privacy and legal *** bridge the gap between data privacy and the need for data fusion,an emerging AI paradigm feder-ated learning(FL)has emerged as an approach for solving data silos and data privacy *** on secure distributed AI,feder-ated learning emphasizes data security throughout the lifecycle,which includes the following steps:data preprocessing,training,evalu-ation,and *** keeps data security by using methods,such as secure multi-party computation(MPC),differential privacy,and hardware solutions,to build and use distributed multiple-party machine-learning systems and statistical models over different data *** data privacy concerns,we argue that the concept of“model”matters,when developing and deploying federated models,they are easy to expose to various kinds of risks including plagiarism,illegal copy,and *** address these issues,we introduce FedIPR,a novel ownership verification scheme,by embedding watermarks into FL models to verify the ownership of FL models and protect model intellectual property rights(IPR or IP-right for short).While security is at the core of FL,there are still many articles re-ferred to distributed machine learning with no security guarantee as“federated learning”,which are not satisfied with the FL definition supposed to *** this end,in this paper,we reiterate the concept of federated learning and propose secure federated learning(SFL),where the ultimate goal is to build trustworthy and safe AI with strong privacy-preserving and *** provide a com-prehensive overview of existing works,including threats,attacks,and defenses in each phase of SFL from the lifecycle perspective.

关键词： Federated learning privacy-preserving machine learning security decentralized learning intellectual property protection

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Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis

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World Journal of Gastroenterology 2019年第33期25卷 4933-4944页

作者： Marianne Anastasia De Roza Lim Kai Jia Wen kam Yiong Huak chan Andrew Kwek Tiing Leong Ang John Chen Hsiang Department of Gastroenterology and Hepatology Changi General HospitalSinghealth 529889Singapore Clinical Trials and Research Unit Changi General HospitalSinghealth 529889Singapore Biostatistics Unit Yong Loo Lin School of MedicineNational University of SingaporeSingapore 160608Singapore

BACKGROUND Proton pump inhibitors(PPIs)are widely prescribed,often without clear *** are conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic ***,PPI users and PPI exposure in some studies have been poorly defined with many confounding *** To examine if PPI use increases mortality and hepatic decompensation and the impact of cumulative PPI dose *** Data from patients with decompensated liver cirrhosis were extracted from a hospital database between 2013 to *** users were defined as cumulative defined daily dose(cDDD)≥28 within a landmark period,after hospitalisation for hepatic *** regression analysis for comparison was done after propensity score *** risk of hepatic decompensation was analysed by Poisson *** Among 295 decompensated cirrhosis patients,238 were PPI users and 57 were *** users had higher mortality compared to non-users[adjusted HR=2.10,(1.20-3.67);P=0.009].Longer PPI use with cDDD>90 was associated with higher mortality,compared to non-users[aHR=2.27,(1.10-5.14);P=0.038].PPI users had a higher incidence of hospitalization for hepatic decompensation[aRR=1.61,(1.30-2.11);P90 increases the risk of mortality.

关键词： Proton pump inhibitor Liver cirrhosis Mortality Hospitalisation Complications Portal hypertension Variceal bleeding Ascites Spontaneous bacterial peritonitis Hepatic encephalopathy

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