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Neural Regeneration Research 2024年第12期19卷 2577-2578页

作者： Allison RBalaj Hiroaki kaku Department of Investigative Medicine Western Michigan University Homer Stryker MD School of MedicineKalamazooMIUSA

Parkinson's disease(PD),a prevalent neurodegenerative disorder,is chara cterized by the loss of dopaminergic neurons and the aggregation ofα-synuclein protein into Lewy *** the current standards of therapy have been successful in providing some symptom relief,they fail to address the underlying pathophysiology of PD and as a result,they have no effect on disease progression.

关键词： aggregation death therapeutic

State Estimation of Drive-by-Wire Chassis Vehicle Based on Dual Unscented Particle Filter Algorithm

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 99-113页

作者： Zixu Wang Chaoning Chen Quan Jiang Hongyu Zheng Chuyo kaku State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022China Jiangsu Chaoli Electric Co.Ltd. Zhenjiang 212321China

Accurate vehicle dynamic information plays an important role in vehicle driving ***,due to the characteristics of high mobility and multiple controllable degrees of freedom of drive-by-wire chassis vehicles,the current mature application of traditional vehicle state estimation algorithms can not meet the requirements of drive-by-wire chassis vehicle state *** paper proposes a state estimation method for drive-by-wire chassis vehicle based on the dual unscented particle filter algorithm,which make full use of the known advantages of the four-wheel drive torque and steer angle parameters of the drive-by-wire chassis *** the dual unscented particle filter algorithm,two unscented particle filter transfer information to each other,observe the vehicle state information and the tire force parameter information of the four wheels respectively,which reduce the influence of parameter uncertainty and model parameter changes on the estimation accuracy during *** performance with the dual unscented particle filter algorithm,which is analyzed in terms of the time-average square error,is superior of the unscented Kalman filter *** effectiveness of the algorithm is further verified by driving simulator *** this paper,a vehicle state estimator based on dual unscented particle filter algorithm was proposed for the first time to improve the estimation accuracy of vehicle parameters and states.

关键词： Drive-by-wire chassis vehicle Vehicle state estimation Dual unscented particle filter Tire force estimation Unscented particle filter

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

Newfound physiological function of FAIM protein offers hope of novel disease-modifying therapy for Alzheimer's disease

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Neural Regeneration Research 2023年第12期18卷 2677-2679页

作者： Allison RBalaj Hiroaki kaku Department of Investigative Medicine Western Michigan University Homer Stryker M.D.School of MedicineKalamazooMIUSA

Introduction of Fas apoptosis inhibitory molecule(FAIM): FAIM was originally discovered in FASresistant mouse primary B lymphocytes in 1999, and was thought of as a FAS-apoptosis inhibitor based on overexpression studies(Schneider et al., 1999). FAIM is an approximately 20 k Da intracellular protein, but a subsequent study identified an alternatively spliced form.

关键词： al. Alzheimer lymphocytes

Scale variant vehicle object recognition by CNN module of multipooling- PCA process

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Journal of Intelligent and Connected Vehicles

Journal of Intelligent and Connected Vehicles 2023年第4期6卷 227-236页

作者： Yuxiang Guo Itsuo Kumazawa Chuyo kaku Department of Information and Communications Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan Research and Development Center Jiangsu Chaoli Electric Manufacture Co.Ltd.Shanghai 212321China

The moving vehicles present different scales in the image due to the perspective effect of different viewpoint *** premise of advanced driver assistance system(ADAS)system for safety surveillance and safe driving is early identification of vehicle targets in front of the ego *** recognition of the same vehicle at different scales requires feature learning with scale *** existing feature vector methods,the normalized PCA eigenvalues calculated from feature maps are used to extract scale-invariant *** study proposed a convolutional neural network(CNN)structure embedded with the module of multi-pooling-PCA for scale variant object *** validation of the proposed network structure is verified by scale variant vehicle image *** with scale invariant network algorithms of Scale-invariant feature transform(SIFT)and FSAF as well as miscellaneous networks,the proposed network can achieve the best recognition accuracy tested by the vehicle scale variant *** testify the practicality of this modified network,the testing of public dataset ImageNet is done and the comparable results proved its effectiveness in general purpose of applications.

关键词： object detection scale invariance spatial pyramid pooling multi-pooling convolutional neural network(CNN)

Blind Spot Obstacle Detection from Monocular Camera Images with Depth Cues Extracted by CNN

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Automotive Innovation 2018年第4期1卷 362-373页

作者： Yuxiang Guo Itsuo Kumazawa Chuyo kaku Department of Information and Communication Engineering Tokyo Institute of TechnologyTokyo 152-8550Japan Research and Development Center LBN Corporation Ltd.Shanghai 200233China

The images from a monocular camera can be processed to detect depth information regarding obstacles in the blind spot area captured by the side-view camera of a *** depth information is given as a classification result“near”or“far”when two blocks in the image are compared with respect to their distances and the depth information can be used for the purpose of blind spot area *** this paper,the proposed depth information is inferred from a combination of blur cues and texture *** depth information is estimated by comparing the features of two image blocks selected within a single image.A preliminary experiment demonstrates that a convolutional neural network(CNN)model trained by deep learning with a set of relatively ideal images achieves good *** same CNN model is applied to distinguish near and far obstacles according to a specified threshold in the vehicle blind spot area,and the promising results are *** proposed method uses a standard blind spot camera and can improve safety without other additional sensing ***,the proposed approach has the potential to be applied in vehicular applications for the detection of objects in the driver’s blind spot.

关键词： Coarse-to-fine analysis Convolutional neural network Blind spot detection Principal component analysis Discrete cosine transformation

Distribution and relative activity of matrix metalloproteinase-2 in human coronal dentin

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International Journal of Oral Science 2011年第4期3卷 192-199页

作者： Lee W. Boushell Masaru kaku Yoshiyuki Mochida Mitsuo Yamauchi Department of Operative Dentistry School of Dentistry University of North Carolina Department of Bio-Prosthodontics Medical and Dental Science Niigata University Graduate School Chuo-ku Department of Periodontology and Oral Biology Division of Oral Biology Boston University Henry M. Goldman School of Dental Medicine Center for Advanced Biomedical Research Dental Research Center School of Dentistry University of North Carolina

The presence of matrix metalloproteinase-2 （MMP-2） in dentin has been reported, but its distribution and activity level in mature human coronal dentin are not well understood. The purpose of this study was to determine the MMP-2 distribution and relative activity in demineralized dentin. Crowns of twenty eight human molars were sectioned into inner （ID）, middle （MD）, and outer dentin （OD） regions and demineralized. MMP-2 was extracted with 0.33 mol·L-1 EDTA/2 mol·L-1 guanidine-HCl, pH 7.4, and MMP-2 concentration was estimated with enzyme-linked immunoabsorbant assay （ELISA）. Further characterization was accomplished by Western blotting analysis and gelatin zymography. The mean concentrations of MMP-2 per mg dentin protein in the dentin regions were significantly different （P=0.043）： 0.9 ng （ID）, 0.4 ng （MD）, and 2.2 ng （OD）, respectively. The pattern of MMP-2 concentration was OD〉ID〉MD. Western blotting analysis detected -66 and -72 kDa immunopositive proteins corresponding to pro- and mature MMP-2, respectively, in the ID and MD, and a -66 kDa protein in the OD. Gelatinolytic activity consistent with MMP-2 was detected in all regions. Interestingly, the pattern of levels of Western blot immunodetection and gelatinolytic activity was MD〉ID〉OD. The eoneentration of MMP-2 in human coronal dentin was highest in the region of dentin that contains the dentinoenamel junction and least in the middle region of dentin. However, levels of Western blot immunodetection and gelatinolytic activity did not correlate with the estimated regional concentrations of MMP-2, potentially indicating region specific protein interactions.

关键词： matrix metalloproteinase-2 human coronal dentin distribution gelatinolytic activity

Five Stylized Facts on Belt and Road Countries and Their Trade Patterns

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China & World Economy 2023年第1期31卷 149-181页

作者： kaku Attah Damoah Giorgia Giovannetti Enrico Marvasi Department of Economics and Management University of FlorenceItaly Department of Economics and Management University of FlorenceItalyand European University InstituteItaly Department of Economics Roma Tre UniversityItaly

The Belt and Road Initiative(BRI)offers investment opportunities for several Eurasian countries but not all of them attract investments in the same *** paper investigates the geographical distribution of BRI projects completed between 2013 and *** analysis shows that pre-existing trade patterns are related to the likelihood of a country receiving completed BRI *** single out and provide evidence in support of five stylized ***,BRI countries with completed projects tend to be poorer and ***,projects are more likely to occur in countries with intense intermediate trade with ***,the countries that received projects have more diversified export structures and their sectoral specialization overlaps with that of ***,among middle-high-income countries,the allocation ofprojects tends to favor those with high levels of intra-industry ***,among BRI countries with projects,the complexity or sophistication of the goods traded increases faster with *** findings suggest that fostering trade integration has direct benefits and may also contribute to further BRI investments.

关键词： Belt and Road Initiative China global value chains network trade in intermediates

团队型文化对赛汝(SERU)生产及运营绩效的影响:中国制造业的实证分析

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系统工程理论与实践 2021年第2期41卷 431-441页

作者：刘畅李珍殷勇 Ikou kaku 东北财经大学管理科学与工程学院大连116025 同志社大学商学院日本京都6028580 东京都市大学环境管理与可持续发展系日本东京1588557

SERU生产是以人为中心的、基于社会-技术实践交互作用的复杂生产系统.适配的组织文化可以为SERU生产的成功实施提供重要支持.本文构建了团队型文化、SERU生产与企业运营绩效之间关系的概念模型,并探讨了环境不确定性的调节效应.基于357... 详细信息

SERU生产是以人为中心的、基于社会-技术实践交互作用的复杂生产系统.适配的组织文化可以为SERU生产的成功实施提供重要支持.本文构建了团队型文化、SERU生产与企业运营绩效之间关系的概念模型,并探讨了环境不确定性的调节效应.基于357份来自中国制造企业的调研数据进行实证检验,研究发现团队型文化对SERU生产有显著正向影响,是SERU生产实施的重要前因.环境不确定性对团队型文化与SERU生产之间的关系,以及SERU生产与运营绩效之间的关系有显著调节效应.特别地,环境不确定性强化了团队型文化与SERU生产的多能工运用的关系,以及多能工运用与运营绩效之间的关系.这些结论不仅丰富了SERU生产理论,也为企业实施SERU生产提供了理论指导.

关键词： SERU生产团队型文化运营绩效环境不确定性调节效应

Chemoradiotherapy with twice-weekly administration of low-dose gemcitabine for locally advanced pancreatic cancer

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World Journal of Gastroenterology 2008年第34期14卷 5311-5315页

作者： Hisato Igarashi Tetsuhide Ito Ken Kawabe Terumasa Hisano Yoshiyuki Arita Toyoma kaku Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical ScienceKyushu University

AIM:To evaluate the chemoradiotherapy for locally advanced pancreatic cancer utilizing low dose gemcitabine as a radiation sensitizer administered twice weekly. METHODS: We performed a retrospective analysis of chemoradiotherapy utilizing gemcitabine administered twice weekly at a dose of 40 mg/m2. After that, maintenance systemic chemotherapy with gemcitabine, at a dose of 1000 mg/m2, was administered weekly for 3 wk with 1-wk rest until disease progression or unacceptable toxicity developed. RESULTS: Eighteen patients with locally advanced unresectable pancreatic cancer were enrolled. Three of those patients could not continue with the therapy; one patient had interstitial pneumonia during radiation therapy and two other patients showed liver metastasis or peritoneal metastasis during an early stage of the therapy. The median survival was 15.0 mo and the overall 1-year survival rate was 60%, while the median progression-free survival was 8.0 mo. The subgroup which showed the reduction of tumor development, more than 50% showed a tendency for a better prognosis; however, other parameters including age, gender and performance status did not correlate with survival. The median survival of the groups that died of liver metastasis and peritoneal metastasis were 13.0 mo and 27.7 mo, ***: Chemoradiotherapy with low-dose gemcitabine administered twice weekly could be effective to patients with locally advanced pancreatic cancer; however, patients developing liver metastases had a worse prognosis. Another chemoradiotherapy strategy might be needed for those patients, such as administrating one or two cycles of chemotherapy initially, followed by chemoradiotherapy for the cases with no distant metastases.

关键词： Advanced pancreatic cancer Chemoradio-therapy Gemcitabine Radiosensitizer Tumor marker