检索结果-南通市图书馆

Chinese Journal of Aeronautics 2024年第6期37卷 20-37页

作者： Zhiyu LI kaiyuan zhang Zhigang LI Jun LI Institute of Turbomachinery Xi’an Jiaotong UniversityXi’an 710049China

The mid-passage gap is an inevitable structure in a vane passage due to turbine vanes being manufactured *** coolant from this gap is able to prevent hot mainstream ingression and provide cooling protection for the endwall.A novel idea of enlarging the endwall’s coverage area and reducing the endwall’s thermal load by applying the mid-passage gap with variable surface angles is carried out in this *** endwall’s aerothermal and film cooling performances under four mid-passage gap modes at three typical mass flow ratio conditions are numerically *** indicate that under the traditional mid-passage mode,the coolant flows into the mainstream with a perpendicular incidence angle and can’t stick to the ***,cooling failure occurs,and the endwall’s thermal load is badly *** film cooling level at the suction-side endwall is improved when applying the mid-passage gap of a 45surface angle due to the secondary vortex being *** addition,when applying the mid-passage gap of a 135surface angle,the horseshoe vortex is pushed away,and the coverage area at the pressure-side endwall is enlarged *** best film cooling performance is achieved when the upstream surface angle is 135and the downstream surface angle is 45due to the adiabatic film cooling effectiveness being increased at both the pressure-and suction-side *** the mass flow ratio is 1.5%,the coverage area is enlarged by 43%,and the area-averaged adiabatic film cooling effectiveness is increased by 37%,when compared with those under the traditional mid-passage mode.

关键词： Film cooling Heat transfer Surface angle Mid-passagegap Turbinevane endwall

Physical model test and numerical simulation on the failure mechanism of the roadway in layered soft rocks

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2021年第2期31卷 291-302页

作者： Xiaoming Sun Chengwei Zhao Yong zhang Feng Chen Shangkun zhang kaiyuan zhang State Key Laboratory for GeoMechanics and Deep Underground Engineering China University of Mining and Technology-BeijingBeijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBeijing 100083China School of Civil Engineering Nanyang Institute of TechnologyNanyang 473004China

To explore the failure mechanism of roadway in layered soft rocks,a physical model with the physically finite elemental slab assemblage(PFESA)method was *** thermography and a video camera were employed to capture thermal responses and *** model results showed that layered soft roadway suffered from large deformation.A three-dimensional distinct element code(3 DEC)model with tetrahedral blocks was built to capture the characteristics of roadway deformation,stress,and *** results showed two failure patterns,layer bending fracture and layer slipping after *** layer bending fracture occurred at positions where the normal direction of layers pointed to the inside of the roadway and the layer slipping occurred in the *** schemes were proposed to investigate the effects of layered soft *** results showed that the deformation of ribs was obviously larger than that of the roof and floor when the roadway passed through three types of *** the roadway was completely in a coal seam,the change of deformation in ribs was not obvious,while the deformation in the roof and floor increased *** results can provide guidance for excavation and support design of roadways in layered soft rocks.

关键词： Failure mechanism Physical model test 3DEC Layered soft rocks Large deformation

A polarized^(3)He system based on metastability-exchange optical pumping

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 72-81页

作者： Yuting Wang Liangyong Wu kaiyuan zhang Mei Peng Siyu Chen Haiyang Yan State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200433China Key Laboratory of Neutron Physics Institute of Nuclear Physics and ChemistryChina Academy of Engineering PhysicsMianyang 621900China

Hyperpolarized^(3)He nuclei have emerged as a significantly important approach in quantum precision measurement techniques,with extensive applications in fundamental physics,magnetometry,metrology,and *** this study,we report on the design and implementation of a^(3)He polarization system at the China Mianyang Research Reactor(CMRR),utilizing the metastabilityexchange optical pumping(MEOP)*** employed a Merritt coil system consisting of four square coils to furnish a uniform holding *** deployed a 2 W fiber laser to pump the metastable^(3)He atoms and conducted free induction decay(FID)detection of the polarized^(3)He nuclei using both pickup coil and optical *** the optical method,we used a50 m W linearly polarized distributed Bragg reflector(DBR)laser as the *** applied transverse light absorption polarimetry to measure the absolute nuclear polarization of the ground-state^(3)*** have developed cell fabrication capabilities at the CMRR,and cells at various pressures ranging from 100 to 1000 Pa have been fabricated and *** a typical borosilicate cell with 100 Pa pressure,the absolute polarization is measured as Pn≈70%,and the transverse relaxation time is estimated as T2≈0.5 ***,we constructed a few aluminosilicate cells,each carefully filled with pure^(3)He at a pressure of 100 ***,we conducted a comprehensive evaluation of their performance in the context of MEOP.

关键词： metastability exchange optical pumping polarized^(3)He magnetic resonance

同方期刊数据库

5-Formyluracil targeted biochemical reactions with proteins inhibit DNA replication,induce mutations and interference gene expression in living cells

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2021年第10期32卷 3252-3256页

作者： Guangrong Zou kaiyuan zhang Wei Yang Chaoxing Liu Zhentian Fang Xiang Zhou College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers of Ministry of EducationThe Institute for Advanced StudiesHubei Province Key Laboratory of Allergy and Immunology Wuhan UniversityWuhan 430072China

Covalent DNA–protein cross-links are toxic DNA lesions that interfere with essential biological processes,which can cause serious biological consequences,such as genomic instability and protein misexpression.5-Formyluracil(5 fU) as an important modification in DNA,which is mainly from oxidative damage,exists in a variety of cells and *** have reported that 5 fU mediated DNA–protein conjugates could exist in human cells [Zhou et *** Chem.2(2020) 54–63].We now aimed to explore its potential biological effects in vitro and in *** this paper,we firstly reported that 5 fU intermediated DNA–peptide or DNA–protein conjugates(both were called DPCs) could inhibit different polymerases bypass or cause *** we further investigated the functional impacts caused by 5 fU-mediated DPCs,which appeared in different gene expression components [in the promoter sequence or 50-untranslated regions(UTR)].These results together may contribute to a broader understanding of DNA–protein interactions as well as the biological functions associated with 5 fU.

关键词： 5-Formyluracil Biochemicalreaction DNA replication Mutation Gene expression

Boron-, Sulfur- and Nitrogen-Doped Tridecacyclic Aromatic Emitters with Multiple Resonance Effect for Narrowband Red Emission

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第22期40卷 2671-2677页

作者： Yinuo Wang kaiyuan zhang Fan Chen xingdong Wang Qingqing Yang Shumeng Wang Shiyang Shao Lixiang Wang state Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunJilin130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiAnhui 230026China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikouHainan570228China

Two novel boron(B),sulfur(S),nitrogen(N)-doped polycyclic aromatic hydrocarbon multiple resonance emitters(DBNS and DBNS-tBu)are designed and synthesized for narrowband red emission by embedding two pairs of S and N atoms and two B atoms in para-positions of central benzene rings within a tridecacyclic aromatic skeleton to form donor-π-donor(D-π-D)and acceptor-π-acceptor(A-π-A)structures,which not only exhibit emission maximum at 641 nm with small full width at half maximum of 39 nm,but also combine high photoluminescent quantum efficiency(85%)and rapid reverse intersystem crossing(kRISC=2.2×10^(5) s^(−1)).

关键词： Multipleresonance Polycycles Donor-acceptor systems Sulfur Narrowband

Perspectives on a New Life

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Today 2002年第11期51卷 22-26页

作者： zhang kaiyuan

WHAT does life mean? According to the traditional Chinese mentality, it means to clothe, feed and shelter oneself, and to be mobile. Today, these staples still apply, alongside an additional two: entertainment and education. The acquisition of two more essentials within a definition of the meaning of life indicates, from another perspective,

关键词： In Perspectives on a New Life

Regulable DNA–Protein Interactions in Vitro and Vivo at Epigenetic DNA Marks

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2020年第2期2卷 54-63页

作者： Guangrong Zou Chaoxing Liu Weiwu Zeng Wei Yang kaiyuan zhang Yalun Xie Cong Chen Xiang Zhou College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers of Ministry of EducationThe Institute for Advanced StudiesHubei Province Key Laboratory of Allergy and ImmunologyWuhan UniversityWuhanHubei 430072China

5-Formyluracil(5fU)is a vital DNA marker that is widely distributed in the cells of organisms.A unique feature of 5fU is the possession of a potentially reactive aldehyde group in its structure that could realize addition and condensation ***,the biological functional details of 5fU remain mostly elusive,especially,regarding its relatedness with *** this current study,we show that 5fU bases have a strong affinity toward nucleosome core particles,and that could yield regulable DNA–protein conjugates(DPCs)via chemical interactions between amino and aldehyde groups,and reductants could be applied to stabilize or dissociate the ***,we developed a photocaged method to exploit the relationship between 5fU and ***,by applying a combination of the existence of 5fU–histone interactions in vivo by ChIP analysis of histone H4 with liquid chromatography–mass spectrometry(LC–MS),we probed further,the DPCs’influence on nucleosome and ***,our results showed that the 5fU–protein interactions increase the occupancy and stability of nucleosomes,affect enzyme recognition,and block DNA *** might imply that,in vivo,the DPCs between 5fU and nucleosome core particles might play a key role in 5fU-associated pathways such as DNA repair,transcriptional regulation,or development.

关键词： DNA–protein interactions epigenetic DNA marks regulable photocaged

春江水暖鸭先知,似曾相识燕归来——两岸民国史研究追忆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

华中师范大学学报（人文社会科学版） 2017年第5期56卷 114-119页

作者：章开沅华中师范大学中国近代史研究所湖北武汉430079

作者与"台湾"民国史研究者接触较早,交流甚多,或可算是两岸学术交流的先驱之一。特别是1986年以后,作者与华中师范大学及其历史研究所同仁更成为两岸交流的积极推动者。作者根据30年的亲身经历,认为两岸民国史研究交流可划分为三个阶段:... 详细信息

作者与"台湾"民国史研究者接触较早,交流甚多,或可算是两岸学术交流的先驱之一。特别是1986年以后,作者与华中师范大学及其历史研究所同仁更成为两岸交流的积极推动者。作者根据30年的亲身经历,认为两岸民国史研究交流可划分为三个阶段:(1)神交阶段(1979年以前)、初交阶段(1979—1993)、深交阶段(1993—)。两岸学术交流,顺乎潮流,切合民意。

关键词：民国史研究 “台湾” 大陆华中师范大学

The role of poly-L-ornithine in determining neural stem cell fate

在线全文

学校读者我要写书评

暂无评论

The role of poly-L-ornithine in determining neural stem cell...

第十四届中国医师协会神经外科医师年会

作者： kaiyuan zhang Hua Feng Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalThird Military Medical University

The most attractive strategies to restore an injured brain are cell replacement therapies or stimulation of endogenous stem cells to date. Biomaterial-supported culture methods provide possibilities to investigate the characteristics of neural stem/progenitor cells（NSPCs） in vitro. In this study, we evaluate the suitability of three different substrates（poly-L-lysine, poly-L-ornithine and fibronectin） on the proliferation and differentiation towards young neurons of NSPCs in vitro. Immunocytochemistry analyses showed that cells grown on poly-L-ornithine（PO） present increased proliferation and differentiation toward neural lineages with respect to poly-L-lysine（PLL） control and to fibronectin（Fn） group. Westren Blot analyses confirmed these results by the expression of marker of neuronal subtype. These effects were significantly inhibited with the addition of U0126（an ERK antagonist） and enhanced with addition of Ceramide C6（an ERK agonist）. Our data indicate that poly-L-ornithine might serve as a suitable biomaterial to promote proliferation and enhance neuronal specification of NSPCs in vitro and ERK signalling pathway plays a pivotal role during this process.

关键词： neural stem/progenitor cells poly-L-lysine poly-L-ornithine fibronectin ERK

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

百年以后看同盟会

四川大学学报（哲学社会科学版） 2006年第4期 34-38页

作者：章开沅华中师范大学中国近代史研究所

1905年同盟会成立于日本东京,这是历史的必然。同盟会的成立以及成立以后的革命活动都得到许多日本人士的关切与支持,这是中日友好交流史上的一段佳话。

关键词： 1905年同盟会日本