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Antibacterial surface design of biomedical titanium materials for orthopedic applications

Journal of Materials Science & Technology 2021年第19期78卷 51-67页

作者： Zhang Yuan Ye He Chuanchuan Lin Peng Liu kaiyong cai Key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityChongqing400044China

Titanium(Ti)and titanium alloys have become widely used as biomedical materials in orthopedics because of their good machinability,corrosion resistance,low elastic modulus and excellent ***,when Ti-based implants are used for bone repair and replacement,they are easy to cause bacteria adhesion and aggregation,which leads to postoperative *** addition,Ti and its alloys,as bio-inert materials,cannot induce desirable tissue responses such as osseointegration after implantation,which will eventually lead to implant *** bacterial infection and lack of osseointegration directly lead to the failure of implantation surgery and are not conductive to the long-term service of titanium-based ***,researchers have made many attempts to focus on the surface modification of multifunctional Ti-based implants to endow them with both antibacterial activity and simultaneous osteoinductive *** this review,we primarily highlighted the recent progresses in the surface design of Ti implants with both antimicrobial and osteoinductive properties for orthopedic ***,the challenges for treating implant-associated infections were briefly introduced such as the emergence of antibiotic resistance,the formation of biofilms,and the construction of cell-selective *** of the essential fundamentals were concisely introduced to address these emerging ***,we intended to elaborate the potential strategies of multifunctional surface design to endow good osseointegration for antibacterial Ti implants and highlighted the recent advances of the *** hope that this review will provide theoretical basis and technical support for the development of new Ti implant with antibacterial and osteogenic functions.

关键词： Titanium implants Implant-associated infections Anti-biofilms Surface modification Osseointegration

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Surface modification of titanium implant for repairing/improving microenvironment of bone injury and promoting osseointegration

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Journal of Materials Science & Technology 2023年第12期143卷 1-11页

作者： Yao Ding Bailong Tao Ruichen Ma Xin Zhao Peng Liu kaiyong cai Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Laboratory Research Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Bone injury and implantation operation are often accompanied by microenvironment damage of bone tis-sue,which seriously affects the process of osseointegration of implants,especially for titanium(Ti)-based bioinert ***,repairing or improving the microenvironment of damaged bone tissue is of great significance for bone rescue,reconstruction,and regeneration,which is still a major medical *** stress(OS)and oxygen(O_(2))deficiency are considered to be specific physiological signals of the bone-injury *** the above background,a coating consisting of manganese dioxide(MnO_(2))nanoenzyme and strontium(Sr)ions was fabricated on the surface of the Ti implant via a one-step hydrothermal ***_(2) nanoenzyme presented in the coating alleviated OS and O_(2) deficiency at the injury site by catalyzing the decomposition of abundant endogenous H_(2)O_(2) around the modified Ti implants into O_(2).In addition,Sr ions were released from the surface of the implant at a certain rate in a body-fluid environment,further promoting the adhesion,growth,and osteogenic differentiation of mesenchymal stem *** importantly,a Sprague Dawley rat femur model demonstrated that the modified Ti implant showed significant potential to accelerate bone tissue reconstruction in *** sum-mary,the present system provides a new idea for the treatment of bone injury and the development of new orthopedic implants.

关键词： Ti and its alloys Osseointegration Microenviroment Nanoenzyme Sr

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Utilization of unmodified gold nanoparticles in colorimetric detection

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Science China(Physics,Mechanics & Astronomy) 2011年第10期54卷 1757-1765页

作者： HE Sha LIU DingBin WANG Zhuo cai kaiyong JIANG XingYu College of Bioengineering Chongqing University Chongqing 400044 China Chinese Academy of Sciences Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for NanoScience and Technology Beijing 100190 China

This review begins with an overview of the appealing properties and various applications of gold nanoparticles, and briefly summarizes recent advances in using unmodified gold nanoparticles to detect different kinds of targets including nucleic acids, proteins, metal ions and small organic molecules. The key point to the unmodified gold nanoparticle-based visual detection assay is to control dispersion and aggregation of colloidal nanoparticles by targets of interest, which usually relies on affinities between gold nanoparticles and targets. The degree of dispersion or aggregation can be visualized through the change of the solution color or the precipitation of nanoparticles from the solution. Thus, the existence of the target molecules can be trans-lated into optical signals and monitored by the naked eye conveniently. Finally, some future prospects of this research field are given.

关键词： gold nanoparticles colorimetric detection biosensor

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Exo/endogenous factors co-activatable nanodevice for spatiotem-porally controlled miRNA imaging and guided tumor ablation

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Nano Research 2022年第2期15卷 845-857页

作者： Zhenqiang Wang Tao Ding Liucan Wang Shuai Wang Meizhen Zhou Jixi Zhang kaiyong cai Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China

Remote activation of biomarker sensing holds a great promise of shifting the success of in vitro diagnostics to spatiotemporally controlled in vivo visualization of tumor,and in turn,imaging guided ***,a"dual-key-one-lock"nanodevice was designed and built by assembling thermo-activatable probe of trimeric DNA hybrids into a mesoporous polydopamine nanoparticle-based multifunctional nanotransducer(probe host,fluorescence quencher,and photothermal conversion agent),enabling precisely switchable theranostic operations under the co-activation of exo/endogenous stimulations(near-infrared(NIR)light and microRNA(miRNA)).By this design,the NIR irradiation-induced local heat through the porous nanotransducer can be transferred to the DNA nanothermometer for triggering the exposure of the miRNA recognition segment,as well as the subsequent fluorescence activation by strand displacement reactions(SDR).A programmable application of short-(3 min)and long-duration(10 min)NIR irradiation was administered sequentially to induce a milder and a stronger hyperthermia,respectively,to activate the localized miRNA imaging,and in turn,tumor thermoablation under the fluorescence guidance in *** reducing nonspecific activation,dual factor co-activatable nanodevices exhibited a high tumor-to-background ratio(TBR)value of 8.9,as well as a significantly lower(6-9-fold)normal tissue fluorescence as compared with those sensing miRNA *** in vivo results show that the tumors were significantly suppressed after the photothermal therapy with the assistance of the accurate miRNA *** rationally integrated nanoplatform may pave a new avenue for advanced theranostic systems with high spatiotemporal precision by activatable designs.

关键词： thermo-activatable probe porous nanotransducer photothermal activation spatiotemporal miRNA imaging imaging-guided therapy

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Design of manganese ion coated Prussian blue nanocarrier for the therapy of refractory diffuse large B-cell lymphoma based on a comprehensive analysis of ferroptosis regulators from clinical cases

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Nano Research 2023年第4期16卷 5265-5278页

作者： Yulu Yang Rui Chen Ke Li Pengfei Gao Yi Gong Weihu Yang kaiyong cai Key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityChongqing 400044China Department of Pathology Chongqing University Cancer HospitalChongqing 400030China Department of Phase I Clinical Trial Ward Chongqing University Cancer HospitalChongqing 400030China

Diffuse large B-cell lymphoma(DLBCL)is a prevalent human malignancy,and understanding its biology will help identify problems in refractory patients and customize alternative therapies for *** found that DLBCL can be stratified into two independent subtypes with different clinical characteristics and outcomes by consensus clustering of expression of ferroptosis regulatory genes,which proves that ferroptosis is effective in treating refractory *** this work,we constructed a novel ferroptosis nanocarrier(PBPMn@PEG)by coating Prussian blue nanoparticles with manganese ions and encapsulating them with poly(ethyleneglycol).The low efficiency of the Fenton reaction of Prussian blue nanoparticles can be improved greatly by manganese coating,and can effectively generate hydroxyl radicals,and induce ferroptosis of lymphoma cells(SU-DHL-10 cells)by down-regulating ferroptosis suppressor genes and up-regulating ferroptosis driver *** also induces effective cell apoptosis,which is synergistic with ferroptosis for DLBCL *** vivo experiments also prove that PBPMn@PEG achieved a better anti-tumor effect by up-regulating COX2,HO-1/hemeoxygenase-1(HMOX1),and NADPH oxidase-4(NOX4),and downregulating FSP1 and GPX4,with lower *** a novel and potential DLBCL drug carrier,our discovery served as a foundation for the treatment of the refractory DLBCL by inducing ferroptosis for DLBCL treatment in addition to the therapeutic effect of drugs.

关键词： diffuse large B-cell lymphoma(DLBCL) ferroptosis Prussian blue nanoparticles manganese ion tumor therapy

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Effects of Y on the Microstructure, Mechanical and Bio-corrosion Properties of Mg-Zn-Ca Bulk Metallic Glass

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Journal of Materials Science & Technology 2014年第12期30卷 1255-1261页

作者： Jingfeng Wang Yang Li Song Huang Yiyun Wei Xingfeng Xi kaiyong cai Fusheng Pan National Engineering Research Center for Magnesium Alloys College of Materials Science and Engineering Chongqing University China Academy of Engineering Physics College of Bioengineering Chongqing University

The micro-alloying effects of Y on the microstructure, mechanical properties, and bio-corrosion behavior of Mg69-xZn27Ca4Yx（x= 0, 1, 2 at.%） alloys were investigated through X-ray diffraction, compressive tests,electrochemical treatments, and immersion tests. The Mg69Zn27Ca4 alloy was found to be absolutely amorphous, and its glass-forming ability decreased with the addition of Y. The Mg68Zn27Ca4Y1 alloy exhibited an ultrahigh compressive strength above 1010 MPa as well as high capacity for plastic strain above 3.1%.Electrochemical and immersion tests revealed that these Y-doped MgeZ neC a alloys had good bio-corrosion resistance in simulated body fluid（SBF） at 37℃. The results of the cytotoxicity test showed high cell viabilities for these alloys, which means good bio-compatibility.

关键词： Mg alloy Microstructure Mechanical properties Bio-corrosion resistance Bio-compatibility

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Stimuli-responsive nano-reserveriors drug delivery systems based on inorganic nanoparticles

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医用生物力学 2013年第S1期28卷 5-6页

作者： kaiyong cai Zhong Luo Yan Hu Key Laboratory of Biorheological Science and Technology of Ministry of Education College of BioengineeringChongqing University

The convergence of nanotechnology,material science,biology and medicine promotes the rapid development of nano-biomedicine,which plays an important role in relieving the pain of patients and improving the health of human,in particular of cancer *** of stimuli-responsive controlled release system for targeted drug delivery to specific cells is essentially important for cancer therapy since most chemotherapeutics are severely toxic[1].During past decades,magnetic nanoparticles（MNPs）and mesoporous silica nanoparticles（MSNs）attracted much attention in the related field,due to their good biocompatibility。

关键词： inorganic nanotechnology responsive silica targeted hollow cyclodextrin probes redox essentially

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Phenylboronic acid-modified hollow silica nanoparticles for dual-responsive delivery of doxorubicin for targeted tumor therapy

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Regenerative Biomaterials 2017年第2期4卷 111-124页

作者： Ling Huang Qingfeng Zhang Liangliang Dai Xinkun Shen Weizhen Chen kaiyong cai Key Laboratory of Biorheological Science and Technology Ministry of Education College of BioengineeringChongqing UniversityChongqing 400044P.R.China

This work reports a multifunctional nanocarrier based on hollow mesoporous silica nanoparticles(HMSNs)for targeting tumor ***(DOX)was loaded into HMSNs and blocked with cytochrome C conjugated lactobionic acid(CytC–LA)via redox-cleavable disulfide bonds and pH-disassociation boronate ester bonds as intermediate *** CytC–LA was used both as sealing agent and targeting motif.A series of characterizations demonstrated the successful construction of the drug delivery *** system demonstrated pH and redox dual-responsive drug release behavior in *** DOX loading HMSNs system displayed a good biocompatibility,which could be specifically endocytosed by HepG2 cells and led to high cytotoxicity against tumor cells by inducing cell *** vivo data(tumor volume,tumor weight,terminal deoxynucleotidyl transferase dUTP nick end labeling and hematoxylin and eosin staining)proved that the system could deliver DOX to tumor site with high efficiency and inhibit tumor growth with minimal toxic side effect.

关键词： hollow mesoporous silica nanoparticles dual-response drug delivery targeted tumor therapy in vivo

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Moderated crevice corrosion susceptibility of Ti6Al4V implant material due to albumin-corrosion interaction

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Journal of Materials Science & Technology 2022年第14期109卷 209-220页

作者： Jing Wu Meng Li Chuanchuan Lin Pengfei Gao Rui Zhang Xuan Li Jixi Zhang kaiyong cai Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China

Localized corrosion of metallic biomaterials is a concerning problem for implant *** the present work,the interaction between localized corrosion of Ti6Al4V implant material and adsorption of bovine serum albumin(BSA)was investigated by electrochemical tests,surface morphological and compositional *** artificial crevice was set up on the Ti6Al4V surface to simulate the crevice corrosion of metallic *** results show that the BSA adsorption is regulated by the heterogeneous metallic ion release resulted from the crevice *** negatively charged BSA prefers to aggregate at the interior of artificial crevice due to electrostatic interaction with the concentrated metallic cations in the *** return,the non-uniform BSA adsorption can decrease the crevice corrosion susceptibility of the Ti6Al4V implant material,even though the presence of BSA accelerates the dissolution of passive *** the Ti6Al4V alloys with artificial crevice,stable localized corrosion occurs after 96 h of immersion in the PBS free of BSA while no stable localized corrosion can be determined in the presence of 4%*** is deduced that the presence of BSA can reduce the surface potential discrepancy between the crevice interior and the crevice *** disclosed mechanism of albumin-corrosion interaction is vital to the localized corrosion control of metallic implants in clinical use.

关键词： Titanium alloy Albumin Electrochemistry Localized corrosion Protein adsorption

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Interaction pathways of implant metal localized corrosion and macrophage inflammatory reactions

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Bioactive Materials 2024年第1期31卷 355-367页

作者： Meng Li Jing Wu Wenbo Geng Pengfei Gao Yulu Yang Xuan Li Kun Xu Qiang Liao kaiyong cai Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing400044PR China Key Laboratory of Low-grade Energy Utilization Technologies and Systems Chongqing UniversityMinistry of EducationSchool of Energy and Power EngineeringChongqing400044PR China

Macrophages play a central role in immunological responses to metallic species associated with the localized corrosion of metallic implants,and mediating in peri-implant ***,the pathways of localized corrosion-macrophage interactions were systematically investigated on 316L stainless steel(SS)implant *** monitoring under macrophage-mediated inflammatory conditions showed a decreased pitting corrosion resistance of 316L SSs in the presence of RAW264.7 cells as the cells would disrupt biomolecule adsorbed layer on the metal *** pitting potentials were furtherly decreased when the RAW264.7 cells were induced to the M1 pro-inflammatory phenotype by the addition of lipopolysaccharide(LPS),and pitting corrosion preferentially initiated at the peripheries of *** overproduction of aggressive ROS under inflammatory conditions would accelerate the localized corrosion of 316L SS around *** pitting corrosion condition,the viability and pro-inflammatory polarization of RAW264.7 cells were region-dependent,lower viability and more remarkable morphology transformation of macrophages in the pitting corrosion region than the pitting-free *** pitting corrosion of 316L SS induced high expression of CD86,TNF-α,IL-6 and high level of intracellular ROS in *** release of metallic species(Fe^(2+),Cr^(3+),Ni^(2+),etc)and uneven distribution of surface overpotential stimulated macrophage inflammatory responses near the corrosion pits.A synergetic effect of localized corrosion and macrophages was revealed,which could furtherly promote localized corrosion of 316L SS and macrophage inflammatory *** results provided direct evidence of corrosion-macrophage interaction in metallic implants and disclosed the pathways of this mutual stimulation effect.

关键词： Metallic implant Macrophage Localized corrosion Inflammatory reaction Material-cell interaction

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