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Petroleum Research 2017年第1期2卷 77-89页

作者： Jianzhang Tian Ran Tian kaiyan chen Shuguang chen Zengqiang Guo Geophysical Exploration Research Institute PetroChina Huabei Oilfield CompanyHebei 062552China Exploration and Development Research Institute PetroChina Huabei Oilfield CompanyHebei 062552China

Tight oil in the redeposited carbonates was mainly distributed in the Lower Submember of Member 3 of Shahejie Formation in Shulu sag of Jizhong depression,North *** high-resolution 3D seismic data,well logging data and drilling data,the Lower Submember of Member 3 of Shahejie Formation was divided into 5 third-order sequences and 15 parasequence *** redeposited marl and rudstone were major reserving horizons of tight oil,and ten reserving space types were developed and could be classified into two main categories,i.e.,pores and *** types of tight oil reservoirs were established,i.e.,the marl hydrocarbon reservoir of the source-reservoir integration and the rudstone hydrocarbon reservoirs of the source-reservoir *** assemblage relationship among the high-quality source rocks,system tracts with the source-reservoir configuration was the major control factor for tight oil accumulation in the redeposited *** lacustrine transgressive system tracts and highstand systems tracts in SQ1 to SQ5 were the favorable horizons for development of the marl hydrocarbon reservoir,the lowstand system tracts in SQ1 to SQ3 were the favorable horizons for development of the rudstone hydrocarbon reservoir.

关键词： Member 3 of Shahejie Formation Tight oil Re-deposited carbonate Marl Rudstone Third-order sequence Hydrocarbon reservoir

Optimization of air quantity regulation in mine ventilation networks using the improved differential evolution algorithm and critical path method

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International Journal of Mining Science and Technology 2015年第1期25卷 79-84页

作者： chen kaiyan Si Junhong Zhou Fubao Zhang Renwei Shao He Zhao Hongmei Faculty of Safety Engineering China University of Mining & Technology Shaanxi Coal and Chemical Technology Institute Co. Ltd.

In mine ventilation networks, the reasonable airflow distribution is very important for the production safety and economy. Three basic problems of the natural, full-controlled and semi-controlled splitting were reviewed in the paper. Aiming at the high difficulty semi-controlled splitting problem, the general nonlinear multi-objectives optimization mathematical model with constraints was established based on the theory of mine ventilation networks. A new algorithm, which combined the improved differential evaluation and the critical path method （CPM） based on the multivariable separate solution strategy, was put forward to search for the global optimal solution more efficiently. In each step of evolution, the feasible solutions of air quantity distribution are firstly produced by the improved differential evolu- tion algorithm, and then the optimal solutions of regulator pressure drop are obtained by the CPM. Through finite steps iterations, the optimal solution can be given. In this new algorithm, the population of feasible solutions were sorted and grouped for enhancing the global search ability and the individuals in general group were randomly initialized for keeping diversity. Meanwhile, the individual neighbor- hood in the fine group which may be closely to the optimal solutions were searched locally and slightly for achieving a balance between global searching and local searching, thus improving the convergence rate. The computer program was developed based on this method. Finally, the two ventilation networks with single-fan and multi-fans were solved. The results show that this algorithm has advantages of high effectiveness, fast convergence, good robustness and flexibility. This computer program could be used to solve lar^e-scale ~eneralized ventilation networks o^timization problem in the future.

关键词： Mine ventilation networkDifferential evolution algorithmCritical path methodPopulation group and neighborhood searchMultivariable separate solution

Complete response of a locally advanced pulmonary hepatoid adenocarcinoma patient to perioperative XELOX-containing chemoimmunotherapy

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Genes & Diseases 2024年第1期11卷 1-3页

作者： kaiyan chen Ying Yu Zhiyu Huang Lei Gong Yun Fan The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) HangzhouZhejiang 310022China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesHangzhouZhejiang 310022China Department of Thoracic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiang 310022China Department of Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China

With morphological features resembling hepatocellular carcinoma,hepatoid adenocarcinoma of the lung(HAL)is a rare and aggressive subtype of lung cancer with a 5-year survival of only 8%.1 Most HAL patients present increased serum alpha-fetoprotein(AFP)levels that are commonly related to poor *** insights into HAL have come from case series or reports,and TP53 is frequently mutated in *** heterogeneity of HAL complicates the *** no established standard,the management of HAL is modeled on that of classical lung adenocarcinoma,although with dismal outcomes.2 Herein,we reported the effective management of a stage IIIb HAL patient with perioperative chemoimmunotherapy and curative-intent *** patient remained disease-free and minimal residual disease(MRD)-negative for more than one year after surgery.

关键词： adenocarcinoma patient lung

Research on Microarchitectural Cache Attacks

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Research on Microarchitectural Cache Attacks

作者： Yao Lu kaiyan chen Yinlong Wang Simulation Center of Ordnance Engineering College Army Engineering University

This paper summarizes the basic concepts and development process of cache sidechannel attack,analyses three basic methods（Evict and Time,Prime and Probe,Flush and Reload） from four aspects:Attack conditions,realization process,applicability,and characteristics,then I expound how to apply side-channel attack methods on CPU vulnerability.

关键词： Side-channel attacks Cache CPU vulnerability Microarchitecture

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基于V2G技术的电动汽车实时调度策略

电力系统保护与控制 2019年第14期47卷 1-9页

作者：陈凯炎牛玉刚华东理工大学化工过程先进控制和优化技术教育部重点实验室

随着电动汽车逐渐普及,其对电网的影响也不断扩大。为加强电动汽车与电网间协作,充分利用电动汽车在电网能量调度中的高度灵活性,提出一种基于 V2G 技术的电动汽车实时调度策略。首先以降低充电成本和网损成本为目标,建立电动汽车调度... 详细信息

随着电动汽车逐渐普及,其对电网的影响也不断扩大。为加强电动汽车与电网间协作,充分利用电动汽车在电网能量调度中的高度灵活性,提出一种基于 V2G 技术的电动汽车实时调度策略。首先以降低充电成本和网损成本为目标,建立电动汽车调度模型。然后通过构建网损灵敏度指标分析电网节点性能,基于电网负荷制定分时电价,通过潮流计算和凸优化算法实时求解得到电动汽车充放电策略。最后以 IEEE 33 节点配电网为例验证了所提策略可以有效降低充电成本与网损成本,同时分析了电动汽车渗透率、V2G 占比对车网协作效果的影响。

关键词：电动汽车 V2G 网损实时优化

基于曲面拟合的NDIR单通道CO_(2)气体传感器快速标定算法

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传感技术学报 2021年第1期34卷 103-108页

作者：陈凯彦朱斌成毛科技浙江工业大学土木工程学院浙江杭州310023 浙江工业大学计算机科学与技术学院浙江杭州310023

为了提高非色散红外(NDIR,Non-Dispersion Infrared)二氧化碳(CO_(2))气体传感器的标定效率,提出一种针对NDIR单通道CO_(2)气体传感器的高效快速标定算法。首先采集m个传感器节点在不同温度、不同浓度下对应的电压值;然后对于每个节点,... 详细信息

为了提高非色散红外(NDIR,Non-Dispersion Infrared)二氧化碳(CO_(2))气体传感器的标定效率,提出一种针对NDIR单通道CO_(2)气体传感器的高效快速标定算法。首先采集m个传感器节点在不同温度、不同浓度下对应的电压值;然后对于每个节点,将它的数据点(温度,浓度,输出电压)进行曲面拟合,拟合后的曲面作为候选曲面;测量待标定传感器的6个在不同温度、不同浓度下对应的输出电压数据点,选择一个与这6个数据点最优匹配的曲面,以此作为待标定传感器的标定曲面。实验结果表明,算法标定准确性和可靠性高,按照5%+50×10^(-6)的精度,算法标定的数据合格率达到99%。

关键词： CO_(2) 气体传感器 NDIR 标定算法曲面拟合

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多目标约束的电动汽车实时调度策略

华东理工大学学报（自然科学版） 2021年第4期47卷 465-474页

作者：常硕牛玉刚陈凯炎华东理工大学能源化工过程智能制造教育部重点实验室上海200237

随着电动汽车并网数量的增多及电池容量的不断增大,不协调的充电会给电网带来巨大压力,甚至会影响电网的稳定运行。相反,合理的电动汽车调度会给电网带来额外的效益。提出了一种滑窗变速优化充电方法对电动汽车进行实时调度,结合实时电... 详细信息

随着电动汽车并网数量的增多及电池容量的不断增大,不协调的充电会给电网带来巨大压力,甚至会影响电网的稳定运行。相反,合理的电动汽车调度会给电网带来额外的效益。提出了一种滑窗变速优化充电方法对电动汽车进行实时调度,结合实时电价计算充电成本,通过离线网损灵敏度快速求解网损量,采用充电功率波动法量化电池老化成本。以电池老化成本、充电成本和网损成本最小化为目标函数,构建一个多目标优化问题,利用凸优化算法求解得到车网互动(V2G)实时调度策略。在改进的IEEE 33节点配电网上对平均分配、自然充电、全局优化和滑窗变速优化充电方案进行了对比实验,验证了滑窗变速优化充电方案在减缓电池老化、降低充电成本、减少网损、平衡负载等方面的有效性。

关键词：电动汽车实时调度多目标约束滑窗变速优化

Reg4 regulates 5-fluorouracil sensitivity in gastric cancer through MAPK/Erk/Bim signaling pathway

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Reg4 regulates 5-fluorouracil sensitivity in gastric cancer ...

Gene Transfection Mediated by Ultrasound and Pluronic P85 in HepG2 Cells

浙江省免疫学会第十次学术大会

作者： Jiaoyue Jin Fanrong Zhang kaiyan chen Nan Zhang Junzhou Wu Lisha Ying Dan Su Cancer Research Institute Zhejiang Cancer Hospital and Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province

Aim:Reg4 is a member of the Reg multigene family,and is highly up-regulated in many gastrointestinal *** cancer cells with high Reg4 expression is resistant to 5-fluorouracil(5-FU),but the mechanism is not very *** the present study,we aimed to comfirm the role of Reg4 in GC cells once again,and further investigate the mechanism by which Reg4 regulates the 5-FU response in GC ***:Protein expression of Reg4 in gastric cancer cells was analyzed by western *** on over-expression and siRNA knockdown of Reg4 were conducted for 5-FU sensitivity and apoptosis analyses.5-FU metabolism and intracellular signaling were examined by real time PCR and western ***:Western blot showed Reg4 expression was low or null in SGC-7901,BGC-823 gastric cancer cell lines,and high in AGS,MKN28,MKN45 gastric cancer cell *** overexpression and knockdown of Reg4 demonstrated that low Reg4 expression promoted the sensitivity to 5-FU,and 5-FU-induced *** were no significant influences on the mRNA levels of thymidylate synthase,orotate phosphoribosyltransferase and dihydropyrimidine *** investigation showed enhanced Reg4 expression activated the P42/P44 phosphorylation,and regulated 5-FU sensitivity through MAPK/Erk/Bim signaling ***:The results indicate that Reg4 may play an important role in5-FU-induced cell ***,upregulation of Reg4 in response to 5-FU may represent an intrinsic mechanism of resistance to this anticancer drug.

关键词： Reg4 5-fluorouracil apoptosis gastric cancer

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第6期27卷 700-702页

作者：王芬李开艳陈云超邓远洪恺 Department of Medical Ultrasound Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

In order to assess whether gene transfection could be mediated by ultrasound in association with P85 and find the appropriate parameters of ultrasound irradiation, the effects of ultrasound with or without P85 on gene transfection of HepG2 cells were examined. The HepG2 cells were irra- diated by ultrasound at 1 MHz, 0.4-2.0 W/cm2 and 50% duty cycle with plasmid encoding enhanced green fluorescent protein （EGFP） as a report gene. Forty-eight h later, the expression of EGFP was detected under the fluorescence microscopy. Transfection efficacy was quantitatively assessed by flow cytometry, and cell viability was evaluated by trypan blue exclusion. The results showed that the transfection efficacy was increased with the increases in ultrasound output power and the ideal transfection efficacy was achieved in HepG2 cells irradiated by ultrasound at 0.8 W/cm2 for 30 s. The transfection efficacy in ulstrasound＋P85 group was three times higher than in single ultrasound group [（17.63±1.07）% vs （5.57±0.56）%, P〈0.05]. The cell viability was about 81% and 62% in ultrasound group and ultrasound＋P85 group respectively. It was concluded that ultrasound in combination with P85 could mediate the gene transfection of HepG2 cells, ideal transfection efficacy was achieved by ultrasound irradiation at 0.8 W/cm2 for 30 s, and P85 could somewhat increase the damage to cells caused by ultrasound.

关键词： ultrasound P85 gene transfection HepG2

基于空气状态参数与风量耦合迭代的风网解算方法

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中国矿业大学学报 2021年第4期50卷 613-623页

作者：陈开岩周福宝夏同强魏连江中国矿业大学安全工程学院江苏徐州221116 中国矿业大学电气与动力工程学院江苏徐州221116

矿井通风网络是一个复杂动态非线性系统,受地面空气状态参数和井下热湿源以及采矿活动的影响,井下风流状态参数将随时间发生变化.因此,必须对矿井通风网络进行实时解算和日常维护调控.根据风流与井巷围岩之间不稳定对流换热、井巷围岩... 详细信息

矿井通风网络是一个复杂动态非线性系统,受地面空气状态参数和井下热湿源以及采矿活动的影响,井下风流状态参数将随时间发生变化.因此,必须对矿井通风网络进行实时解算和日常维护调控.根据风流与井巷围岩之间不稳定对流换热、井巷围岩氧化放热和热水沟散热等模型,结合节点风量平衡方程、回路风压平衡方程和多股风流混合的热湿平衡方程,提出基于空气状态参数与风量耦合迭代的通风网络风量调控决策的方法,编制了计算机程序.举例计算结果表明:在一定条件下空气状态参数随风量调控的变化而变化,并获得风量调控方案,为矿井通风网络实时解算和风量调控决策提供一种技术手段.

关键词：矿井通风风网解算风量调节控制决策耦合迭代法