检索结果-南通市图书馆

Treatment of immune dysfunction in intrauterine growth restriction piglets via supplementation with dimethylglycine sodium salt during the suckling period

引用

Animal Nutrition 2022年第4期11卷 215-227页

作者： Kaiwen Bai Luyi Jiang Tian Wang Wei Wang School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhouChina Institute of Dairy Science Ministry of Education Key Laboratory of Molecular Animal NutritionCollege of Animal SciencesZhejiang UniversityHangzhouChina College of Animal Science and Technology Nanjing Agricultural UniversityNanjingChina

This study aimed to investigate the mechanism of small intestinal immune dysfunction in intrauterine growth restriction(IUGR)newborn piglets and relieve this dysfunction via dimethylglycine sodium salt(DMG-Na)supplementation during the suckling period.Thirty sows(Duroc×[Landrace×Yorkshire])were selected,and 1 male newborn piglet with normal birth weight(NBW)and 1 male newborn piglet with IUGR were obtained from each sow.Among them,10 NBW and 10 IUGR newborns were euthanized without suckling.The other 20 NBW newborns were allocated to the group named NCON,which means NBW newborns fed a basic milk diet(BMD)(n=10),and the group named ND,which means NBW newborns fed BMD supplemented with 0.1%DMG-Na(n=10);the other 20 IUGR newborns were assigned to the group named ICON,which means IUGR newborns fed BMD(n=10),and the group named ID,which means IUGR newborns fed BMD supplemented with 0.1%DMG-Na(n=10).The newborns were fed BMD from 7 to 21 d of age and euthanized at 21 d of age to collect serum and small intestinal samples.The growth performance,small intestinal histological morphology and sub-organelle ultrastructure,serum immunoglobulin,small intestinal digestive enzyme activity,inflammatory cytokine level,and jejunum mRNA and protein expression of the toll-like receptor 4(TLR4)/nucleotide-binding oligomerization domain protein(NOD)/nuclear factor-k B(NF-k B)network deteriorated in the ICON group compared to that in the NCON group.The small intestinal histological morphology and suborganelle ultrastructure,serum immunoglobulin,small intestinal digestive enzyme activity,and inflammatory cytokine level improved(P<0.05)in the ID group compared to those in the ICON group.The jejunum mRNA and protein expression of the TLR4/NOD/NF-k B network improved(P<0.05)in the ID group compared to that in the ICON group.In conclusion,the activity of the TLR4/NOD/NF-k B pathway was inhibited in the IUGR newborns,which in turn led to their jejunum immune dysfunction and reduced their performance.By ingesting DMG-Na,the IUGR newborns activ

关键词： Intrauterine growth restriction Piglet Small intestine Immune dysfunction Dimethylglycine sodium salt

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dietary dimethylglycine sodium salt supplementation alleviates redox status imbalance and intestinal dysfunction in weaned piglets with intrauterine growth restriction

引用

Animal Nutrition 2022年第3期10卷 188-197页

作者： Kaiwen Bai Luyi Jiang Qiming Li Jingfei Zhang Lili Zhang Tian Wang College of Animal Science and Technology Nanjing Agricultural UniversityNanjingChina College of Animal Science Zhejiang UniversityHangzhouChina

There are few studies on the mechanism of redox status imbalance and intestinal dysfunction in intrauterine growth restricted(IUGR)newborn piglets.Here,we investigated the mechanism of jejunum dysfunction in weaned piglets with IUGR and the mechanism through which dimethylglycine sodium salt(DMG-Na)supplementation improving the imbalance of their redox status.In this work,a total of 10 normal birth weight(NBW)newborn piglets and 20 IUGR newborn piglets were obtained.After weaning at 21 d,they were assigned to 3 groups(n=10/group):NBW weaned piglets fed standard basal diets(NBWC);one IUGR weaned piglets fed standard basal diets(IUGRC);another IUGR weaned piglets from the same litter fed standard basal diets plus 0.1%DMG-Na(IUGRD).The piglets in these 3 groups were sacrificed at 49 d of age,and the blood and jejunum samples were collected immediately.The growth performance values in the IUGRC group were lower(P<0.05)than those in the NBWC group.Jejunum histomorphological parameters,inflammatory cytokines,and digestive enzyme activity as well as serum immunoglobulin were lower(P<0.05)in the IUGRC group than those in the NBWC group.Compared with these in the NBWC group,the redox status of serum,jejunum,and mitochondria and the expression levels of jejunum redox status-related,cell adhesion-related,and mitochondrial function-related genes and proteins were suppressed in the IUGRC group(P<0.05).However,compared with those in the IUGRC group,the growth performance values,jejunum histomorphological parameters,inflammatory cytokines,digestive enzyme activity,serum immunoglobulin,redox status of serum,jejunum,and mitochondria,and the expression levels of jejunum redox status-related,cell adhesion-related,and mitochondrial function-related genes and proteins were improved(P<0.05)in the IUGRD group.In conclusion,dietary DMG-Na supplementation alleviates redox status imbalance and intestinal dysfunction in IUGR weaned piglets mainly by activating the sirtuin 1(SIRT1)/peroxisome proliferatoractivated receptorgcoactivator-1a(PG

关键词： Intrauterine growth restriction Weaned piglet Jejunum Redox status Mitochondrial function Dimethylglycine sodium salt

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Responses of growth performance,antioxidant function,small intestinal morphology and mRNA expression of jejunal tight junction protein to dietary iron in yellow-feathered broilers

引用

Journal of Integrative Agriculture 2024年第4期23卷 1329-1337页

作者： kaiwen Lei Hao Wu Jerry W Spears Xi Lin Xi Wang Xue bai Yanling Huang Key Laboratory of Animal Science of State Ethnic Affairs Commission Southwest Minzu UniversityChengdu 610041China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Southwest Minzu UniversityChengdu 610041China Department of Animal Science North Carolina State UniversityRaleighNC 27695-7621USA

This study aimed to investigate the dose-effect of iron on growth performance,antioxidant function.intestinal morphology,and mRNA expression of jejunal tight junction protein in 1-to21-d-old yellow-feathered broilers.A total of 7201-d-old yellow-feathered maleb roilers were allocated to 9 treatments with 8 replicate cages of 10 birds per cage.The dietary treatments were consisted of a basal diet(contained 79.6 mg Fe kg^(-1))supplemented with 0,20,40,60,80,160,320,640,and 1,280 mg Fe kg^(-1)in the form of FeSO_(4)·7H_(2)O.Compared with the birds in the control group,birds supplemented with 20mg Fe kg^(-1)had higher average daily gain(ADG)(P<0.0001).Adding 640 and 1,280 mg Fe kg^(-1)significantly decreased ADG(P<0.0001)and average daily feed intake(ADFI)(P<0.0001)compared with supplementation of 20mg Fe kg^(-1).Malondialdehyde(MDA)concentration in plasma and duodenum increased linearly(P<0.0001),but MDA concentration in liver and jejunum increased linearly(P<0.05)or quadratically(P<0.05)with increased dietary Fe concentration.The villus height(VH)in duodenum and jejunum,and the ratio of villus height to crypt depth(V/C)in duodenum decreased linearly(P?0.05)as dietary Feincreased.As dietary Fe increased,the jejunal relative mRNA abundance of claudin-1 decreased linearly(P=0.001),but the jejunal relative mRNA abundance of zona occludens-1(ZO-1)and occludin decreased linearly(P?0.05)or quadratically(P?0.05).Compared with the supplementation of 20 mg Fe kg^(-1),the supplementation of640 mg Fe kg^(-1)or higher increased(P?0.05)MDA concentrations in plasma,duodenum,and jejunum,decreased VH in the duodenum and jejunum,and the addition of 1,280 mg Fe kg^(-1)reduced(P?0.05)the jejunal tight junction protein(claudin-1,ZO-1,occludin)mRNA abundance.In summary,640 mg of supplemental Fe kg^(-1)or greater was associated with decreased growth performance,increased oxidative stress,disrupted intestinal morphology,and reduced mRNA expression of jejunal tight junction protein.

关键词： iron yellow-feathered broiler antioxidant function intestinal morphology tight junction protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新能源时代下汽车维修与检测技术的改革

引用

汽车实用技术 2018年第21期44卷 275-276,280页

作者：白凯文云南工程职业学院云南昆明650304

新能源时代的到来,给了传统汽车维修与检测行业带来不小的压力。文章主要分析了汽修行业现状,指出汽车维修行业存在着的问题阻碍了汽车维修行业的发展。要想改善汽车维修行业的现状,跟进新能源时代的发展必须建立完善的法规制度、提高... 详细信息

新能源时代的到来,给了传统汽车维修与检测行业带来不小的压力。文章主要分析了汽修行业现状,指出汽车维修行业存在着的问题阻碍了汽车维修行业的发展。要想改善汽车维修行业的现状,跟进新能源时代的发展必须建立完善的法规制度、提高行业内部技术维修检测人员的水平、纠正行业内的混乱结构的问题。

关键词：新能源汽车维修与检测技术改革

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biomechanical Effects of Tibial Stems with Different Structures on Human Knee Joint after Total Knee Arthroplasty: A Finite Element Analysis

引用

Journal of Bionic Engineering 2022年第1期19卷 197-208页

作者： Meng Zhang kaiwen Zhang He Gong Department of Engineering Mechanics Nanling CampusJilin UniversityChangchun130025China

Porous structure in orthopedic prosthesis may reduce micromotion and increase the service life of implants.The purposes of this study were to compare the influence of the tibial stems with solid and porous structures in Total Knee Arthroplasty(TKA)on knee joint and prostheses,and to improve the mechanical stability of the host bone by seeking favorable structure for the tibial stem.The Finite Element(FE)models of TKA knee with four different structures in the middle segment of the tibial stem(i.e.,solid,cubic,truncated cubic,and octahedral structures)were constructed.The distributions of von Mises stress in the knee joint,tibial prosthesis and proximal tibia,and the compressive stresses of the tibial prosthesis and ultra-high-molecular-weight polyethylene for the four FE models were analyzed.The results showed that the tibial stem filled with the octahedral structure has the best mechanical performance among the above four types of tibial stems.It could effectively reduce the stress concentration and stress shielding effects,and provide an improved mechanical environment for knee joint after TKA.This study would shed some lights on the design and fabrication of porous implants targeted to biomedical applications.

关键词： Total knee arthroplasty Tibial stem Porous structure Finite element analysis Mechanical performance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

饲粮铁添加量对黄羽肉鸡生长性能、抗氧化能力和屠宰性能的影响

引用

动物营养学报 2022年第5期34卷 2961-2969页

作者：雷凯文吴昊王茜柏雪黄艳玲西南民族大学畜牧兽医学院成都610041 青藏高原动物遗传资源保护与利用教育部重点实验室成都610041

本试验旨在探究饲粮铁添加量对黄羽肉鸡生长性能、抗氧化能力和屠宰性能的影响,为黄羽肉鸡生产中合理利用铁制剂提供参考。选用400只1日龄黄羽肉公雏鸡,采用完全随机分组设计分为5个组,每组8个重复,每个重复10只鸡。各组饲粮铁添加量分... 详细信息

本试验旨在探究饲粮铁添加量对黄羽肉鸡生长性能、抗氧化能力和屠宰性能的影响,为黄羽肉鸡生产中合理利用铁制剂提供参考。选用400只1日龄黄羽肉公雏鸡,采用完全随机分组设计分为5个组,每组8个重复,每个重复10只鸡。各组饲粮铁添加量分别为0(对照)、20、80、320和1 280 mg/kg。试验期63 d,分为1~21日龄、22~42日龄和43~63日龄3个阶段。结果表明:1)黄羽肉鸡各阶段平均日增重(ADG)和平均日采食量(ADFI)均随饲粮铁添加量的提高而线性降低(P0.05)。2)63日龄黄羽肉鸡血浆和肝脏谷胱甘肽过氧化物酶(GSH-Px)和总超氧化物歧化酶(T-SOD)活性均未受饲粮铁添加量的影响(P>0.05),但血浆和肝脏丙二醛(MDA)含量均随饲粮铁添加量的提高而线性提高(P0.05);但腹脂率随饲粮铁添加量的提高而线性降低(P<0.05),与对照组相比,当铁添加量提高至80 mg/kg及以上时,腹脂率显著降低(P<0.05)。由此可见,高铁饲粮会降低黄羽肉鸡生长性能和抗氧化能力,并降低腹脂沉积。

关键词：黄羽肉鸡铁生长性能抗氧化能力屠宰性能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical simulation of droplet coalescence based on the SPH method

引用

Theoretical & Applied Mechanics Letters 2022年第3期12卷 189-196页

作者： kaiwen Gu Tieqiang Gang Lijie Chen School of Aerospace Engineering Xiamen UniversityXiamen 361000China

In this paper,the smoothed particle hydrodynamics(SPH)method is employed in modeling and numerical simulation of droplet coalescence.Considering the effect of tangential force on boundary material,besides normal force,tangential force is also introduced in the continuum surface force(CSF)model.The formation of droplet,the coalescence processes of two droplets and three droplets are simulated by the modified CSF model.The validity of the modified model is verified from the aspects of the morphological change of the droplet,the smoothness of free surface and the conservation of the centroid of the system.Compared with finite element method,the results of the modified CSF model show that tangential force plays a crucial role in the CSF model when dealing with model boundary with curves and sharp angles.

关键词： SPH method CSF model Tangential force Droplet

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Application of total keratometry in ten intraocular lens power calculation formulas in highly myopic eyes

引用

Eye and Vision 2024年第2期10卷 22-30页

作者： Ling Wei kaiwen Cheng Wenwen He Xiangjia Zhu Yi Lu Department of Ophthalmology and Eye Institute Eye and ENT Hospital of Fudan UniversityShanghai 200031China Key Laboratory of Myopia(Fudan University)Key Laboratory of MyopiaShanghai Key Laboratory of Visual Impairment and Restoration National Health CommissionChinese Academy of Medical ScienceShanghai 200031China State Key Laboratory of Medical Neurobiology Fudan UniversityShanghai 200031China

Background:The accuracy of using total keratometry(TK)value in recent IOL power calculation formulas in highly myopic eyes remained unknown.Methods:Highly myopic patients who underwent uneventful cataract surgery were prospectively enrolled in this prospective comparative study.At one month postoperatively,standard deviation(SD)of the prediction errors(PEs),mean and median absolute error(MedAE)of 103 highly myopic eyes were back-calculated and compared among ten formulas,including XGboost,RBF 3.0,Kane,Barrett Universal II,Emmetropia Verifying Optical 2.0,Cooke K6,Haigis,SRK/T,and Wang-Koch modifications of Haigis and SRK/T formulas,using either TK or standard keratometry(K)value.Results:In highly myopic eyes,despite good agreement between TK and K(P>0.05),larger differences between the two were associated with smaller central corneal thickness(P0.05),which both presented smaller MedAEs than others(all P0.05),and statistically larger percentages than the other eight formulas(P<0.05).Conclusions:Highly myopic eyes with thinner corneas tend to have larger differences between TK and K.The XGboost enhancement calculator and RBF 3.0 formula using TK showed the most promising outcomes in highly myopic eyes.

关键词： High myopia Total keratometry Cataract surgery IOL power calculation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolution characteristics of the Atlantic Meridional Overturning Circulation and its thermodynamic and dynamic effects on surface air temperature in the Northern Hemisphere

引用

Science China Earth Sciences 2023年第6期66卷 1185-1211页

作者： Huan WANG Zhiyan ZUO kaiwen ZHANG Lulei BU Dong XIAO Department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China College of Geography and Resources Science Sichuan Normal UniversityChengdu 610101China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary Shanghai 202183China Shanghai Frontiers Science Center of Atmosphere-Ocean Interaction Shanghai 200123China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China Key Laboratory of Cites’Mitigation and Adaptation to Climate Change in Shanghai China Meteorological AdministrationShanghai 200030China

Based on modern observations,historical proxy data,and climate model simulations,this paper provides a comprehensive overview of the past,present and future evolution characteristics of the Atlantic Meridional Overturning Circulation(AMOC),as well as its impact on the surface air temperature(SAT)at regional and hemispherical scales.The reconstruction results based on the proxy data indicate that the AMOC has weakened since the late 19th century and experienced overall weakening throughout the 20th century with low confidence.Direct observations show that the AMOC weakened during 2004–2016,but it is not possible to distinguish between its decadal variability and long-term trend.Climate models predict that if greenhouse gas emissions continue to increase,AMOC will weaken in the future,but there will not be a sudden collapse before 2100.For the thermodynamic effects of AMOC,the increased surface heat flux release and meridional heat transport(MHT)over the North Atlantic associated with the strong AMOC cause an increase in the hemispherical SAT.At the millennial scale,climate cooling(warming)periods correspond to a weakened(strengthened)AMOC.The enhanced MHT of a strong AMOC can affect Arctic warming and thus influence regional SAT anomalies and SAT extremes through mutual feedback between Arctic sea ice and AMOC.In terms of dynamic effects,a strong AMOC modulates the Rossby wave trains originating from the North Atlantic and spreading across mid-to-high latitudes in the Northern Hemisphere and causes an increase in the variabilities in the circulation anomalies over the Ural and Siberian regions.Ultimately,a strong AMOC significantly affects the frequencies of extreme cold and warm events in the mid-to-high latitude regions over Eurasia.In addition,AMOC can also influence regional and global SAT anomalies through its dynamic adjustment of planetary-scale circulation.Decadal variation in AMOC is closely related to the Atlantic Multidecadal Oscillation(AMO).During positive phases of AMO and AMOC,enhanced surface heat

关键词： AMOC Evolution Surface air temperature Thermodynamic and dynamic effects Prediction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of rotation angle on surface morphology, microstructure, and mechanical properties of Inconel 718 alloy fabricated by high power laser powder bed fusion

引用

Journal of Materials Science & Technology 2023年第23期154卷 30-42页

作者： Qiao Zhong kaiwen Wei Taoyuan Ouyang Xiangyou Li Xiaoyan Zeng Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China Beijing Research Institute of Telemetry Beijing 100076 China

Rotation angle of the laser scan direction between two adjacent layers is a key controlling parameter during the high-power (≥ 1 kW) laser powder bed fusion (HP-LPBF) process. This study investigates the influences of rotation angles (θ = 0°, 45°, 90°, 105°) on the surface morphology, microstructure, and mechanical properties of Inconel 718 (IN718) alloy produced by HP-LPBF. Results show that adopting low rotation angles (e.g., 0° and 45°) is prone to relatively poor surface finish and lack-of-fusion defects, whereas adopting high rotation angles (e.g., 90° and 105°) induces smaller surface roughness and better relative density. Each case reveals a noticeable edge effect but the maximal heights witness a downward trend with the increase of rotation angle. There are some minor differences in the primary dendrite arm spacing and grain morphology by varying the rotation angles. Moreover, the tensile property is slightly enhanced as the rotation angle increases. The present work suggests that high rotation angles like 90° and 105° would probably be more favorable for the 1 kW HP-LPBF process than rotation angles with relatively low values.

关键词： High-power laser powder bed fusion Rotation angle Surface morphology Microstructure Mechanical properties Inconel 718 alloy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：