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Using a Musculoskeletal Mathematical Model to Analyze Fatigue of the Muscles in the Lower Limbs during Different Motions

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Computer Modeling in Engineering & Sciences 2018年第2期114卷 191-207页

作者： kaito Watanabe Masaki Izawa Ayumi Takahashi Kazuhito Misaji College of Industrial Technology Nihon University

Under the aim of finding effective rehabilitation solutions,the difference between the extents of fatigue of each muscle used in different motions are *** research suggested methods for estimating muscle torque and muscle tension on the basis of a musculoskeletal *** a result,it has become possible to quantitatively identify the extent of fatigue in each muscle during ***,to evaluate muscle fatigue more quantitatively,driving power and angular momentum are focused *** on the driving torque of joints and the muscle torque calculated by using a three-dimensional musculoskeletal model,a method for calculating the driving power of joints and the angular momentum of a muscle is *** method is applied to analysis of different ***,fatigue of muscles is quantitatively analyzed on the basis of driving power and angular momentum.

关键词： Angular momentum driving power driving torque musculoskeletal model

Quantifying Roll Feel of a Car by Using a Musculoskeletal Mathematical Model

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Computer Modeling in Engineering & Sciences 2019年第3期118卷 493-507页

作者： Masaki Izawa Ryota Araki Tatsuro Suzuki kaito Watanabe Kazuhito Misaji Showa Corporation 112-1 Haga-daiHaga-machHaga-gunTochigiJapan Ex-Graduate Student Nihon UniversityCollege of Industrial TechnologyDepartment of Mathematical Information EngineeringJapan Nihon University College of Industrial TechnologyDepartment of Mathematical Information EngineeringJapan

Primary purpose of this research is to create a three-dimensional musculoskeletal mathematical model of a driver of a car using a motion capture *** model is then used in an analysis of drive torque around joints and attached muscles as a vehicle travels in different travel modes and damping force settings to examine‘burdens’for the *** studies proposed a method of quantifying the degree of musculoskeletal load in simple human motion from the changes in drive torque around joints and attached ***,examination of the level of burdens for the driver while driving using this method does not seem to *** within the scope of evaluating different travel modes and dampers,there is no other *** of this study are hence a valuable new perspective on quantitative analysis of the burdens for the driver’s joints and muscles depending on the different settings of travel modes and dampers.

关键词： Human engineering biomechanics musculoskeletal mathematical model driving torque motion capture

Reevaluation of the Taxonomic Status of a Poorly Known Gecko, Gekko liboensis(Reptilia: Squamata)

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Asian Herpetological Research 2015年第3期6卷 229-236页

作者： Teppei JONO Li DING Takuma kaito Yezhong TANG Mamoru TODA Chengdu Institute of Biology Chinese Academy of Sciences Department of Chemistry Biology and Marine ScienceGraduate School of Engineering and ScienceUniversity of the Ryukyus Tropical Biosphere Research Center University of the Ryukyus

Gekko liboensis Zhou and Li, 1982 is a poorly known gecko originating from Libo, Guizhou, southern China. Since the original description based on a single female from Libo, only three specimens（two females and one juvenile） have been reported from the type locality. Because of its close morphological resemblance to G. hokouensis Pope, 1927, G. liboensis is required to be reevaluated for its taxonomic status by studies based on additional specimens. Here we report for the first time the morphological features of 31 newly obtained specimens of G. liboensis from type locality and others, including males, and compare them with those of related species, chiefly on the basis of information from the literature. In addition, specimen-based comparisons were also made with G. hokouensis and an undescribed cryptic species known from the Ryukyus Islands, Japan. Results showed that the species is distinguished from its congeners in having a larger body size（60–91 mm）, 0–2 small internasals, 10–13 supralabials, 10–13 infralabials, smooth enlarged tubercles present on the dorsum forming 4–10 irregular rows at the midbody but absent on the four limbs and tail, both fingers and toes without developed interdigital webs, a single cloacal spur on each side, and 10–12 precloacal pores in males. It most resembles G. hokouensis and its cryptic species but is clearly differentiated by having a larger body size, a predominantly absent internasal, fewer number of dorsal tubercle rows, larger number of precloacal pores, and conspicuous white marks on the dorsum and head. Judging from these results, we confirmed the taxonomic validity of G. liboensis. In addition, the geographic distribution of this gecko on the basis of obtained data was briefly discussed.

关键词： China East Asia Gekkonidae Gekko japonicus group taxonomy morphology

LC-MS/MS method for the quantitation of serum tocilizumab in rheumatoid arthritis patients using rapid tryptic digestion without IgG purification

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Journal of Pharmaceutical Analysis 2022年第6期12卷 852-859页

作者： Takashi Mochizuki kaito Shibata Takafumi Naito Kumiko Shimoyama Noriyoshi Ogawa Masato Maekawa Junichi Kawakami Department of Hospital Pharmacy Hamamatsu University School of MedicineHamamatsu431-3192Japan Department of Pharmacy Shinshu University HospitalMatsumotoNagano390-8621Japan Third Division Department of Internal MedicineHamamatsu University School of MedicineHamamatsu431-3192Japan Department of Laboratory Medicine Hamamatsu University School of MedicineHamamatsu431-3192Japan

The quantitation of serum tocilizumab using liquid chromatography tandem-mass spectrometry(LC-MS/MS)method has not been widely applied in clinical settings because of its time-consuming and costly sample *** present study aimed to develop a validated LC-MS/MS method for detecting serum tocilizumab by utilizing immobilized trypsin without an immunoglobulin G purification step and evaluate its applicability in the treatment of rheumatoid arthritis(RA)patients administered intravenously or subcutaneously with *** tocilizumab-derived signature peptide was deciphered using a nano-LC system coupled to a hybrid quadrupole-orbitrap mass *** serum tocilizumab was rapidly digested by immobilized trypsin for 30 *** chromatographic peak of the signature peptide and that of the internal standard were separated from the serum digests for a total run time of 15 *** calibration curve of serum tocilizumab concentration was linear with a range of 2-200 μg/*** intra-and inter-day accuracy and relative standard deviation(RSD)were 90.7%-109.4%and<10%,*** serum tocilizumab concentrations in the RA patients receiving intravenous and subcutaneous injections were 5.8-28.9 and 2.4-63.5 μg/mL,*** serum tocilizumab concentrations using the current method positively correlated with those using the enzyme-linked immunosorbent assay,although a systematic error was observed between these *** conclusion,a validated LC-MS/MS method with minimal sample pretreatments for monitoring serum tocilizumab concentrations in RA patients was developed.

关键词： Tocilizumab LC-MS/MS Immobilized trypsin IgG purification Proteomics Rheumatoid arthritis

Theoretical Study on Direction of Vibrational Transition Dipole Moment of XH Stretching Vibration in HXD

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Chinese Journal of Chemical Physics 2020年第1期33卷 13-22页

作者： kaito Takahashi Institute of Atomic and Molecular Sciences Academia SinicaTaipei 10617

Experimental vibrational spectra of heavy light XH stretching vibrations of simple molecules have been analyzed using the local mode *** addition,the bond dipole approach,which assumes that the transition dipole moment(TDM)of the XH stretching mode is aligned along the XH bond,has helped analyze experimental *** performed theoretical calculations of the XH stretching vibrations of HOD,HND^−,HCD,HSD,HPD^−,and HSiD using local mode model and multi-dimensional normal *** found that consistent with previous notions,a localized 1D picture to treat the XH stretching vibration is valid even for analyzing the TDM tilt *** addition,while the TDM of the OH stretching fundamental transition tilted away from the OH bond in the direction away from the OD bond,that for the XH stretching fundamental of HSD,HND^−,HPD^−,HCD,and HSiD tilted away from the OH bond but toward the OD *** shows that bond dipole approximation may not be a good approximation for the present systems and that the heavy atom X can affect the transition dipole moment *** variation of the dipole moment was analyzed using the atoms-in-molecule method.

关键词： Heavy light stretching vibration Transition dipole moment Vibrational mode coupling Quantum chemistry

HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer

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World Journal of Clinical Cases 2019年第15期7卷 1964-1977页

作者： Akio kaito Takeshi Kuwata Masanori Tokunaga Kohei Shitara Reo Sato Tetsuo Akimoto Takahiro Kinoshita Department of Gastric Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Gastrointestinal Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research&Clinical Trial Center(EPOC) National Cancer Center Hospital EastKashiwa 277-8577Japan Juntendo University Graduate School of Medicine Tokyo 163-8001Japan Department of Radiation Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan

BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based *** To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based *** Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were *** patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were *** A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based ***,HER2 heterogeneity should be considered during the assessment of HER2 expression.

关键词： Human epidermal growth factor receptor 2 Heterogeneity Trastuzumab Gastric cancer Chemotherapy

Electron-Irradiation Induced Nanocrystallization of Pb（ll） in Silica Gels Prepared in High Magnetic Field

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Journal of Chemistry and Chemical Engineering 2015年第1期9卷 61-66页

作者： Takamasa kaito Atsushi Mori Chihiro kaito Graduate School of Engineering Tokushima University Tokushima 770-8506 Japan Institute of Technology and Science Tokushima University Tokushima 770-8506 Japan Department of Nanophysics in Frontier Project Ritsumeikan University Shiga 535-8577 Japan

In a previous study, structure of silica gels prepared in a high magnetic field was investigated. While a direct application of such anisotropic silica gels is for an optical anisotropic medium possessing chemical resistance, we show here their possibility of medium in materials processing. In this direction, for example, silica hydrogels have so far been used as media of crystal growth. In this paper, as opposed to the soft-wet state, dried silica gels have been investigated. We have found that lead （II） nanocrystallites were formed induced by electron irradiation to lead （ll）-doped dried Hydrogels made from a sodium metasilicate solution doped with silica gels prepared in a high magnetic field such as B = 10 T. lead （II） acetate were prepared. The dried specimens were irradiated by electrons in a transmission electron microscope environment. Electron diffraction patterns indicated the crystallinity of lead （II） nanocrystallites depending on B. An advantage of this processing technique is that the crystallinity can be controlled through the strength of magnetic field B applied during gel preparation. Specific skills are not required to control the strength of magnetic field.

关键词： Silica gel magnetic field nanocrystallite electron irradiation.

Effect of branched-chain amino acids in patients receiving intervention for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第10期20卷 2673-2680页

作者： Tomoaki Ishihara Motoh Iwasa Hideaki Tanaka Masahiko kaito Jiro Ikoma Toshiya Shibata Yoshiyuki Takei Department of Gastroenterology and Hepatology Yokkaichi Digestive Disease Center Komono Mie 510-1232 Japan Department of Gastroenterology and Hepatology Mie University Graduate School of Medicine Tsu Mie 514-8507 Japan Department of Gastroenterology and Hepatology Mie Shokakinaika Tsu Mie 514-0062 Japan Department of Diagnostic Imaging and Nuclear Medicine Kyoto University Graduate School of MedicineKyoto 606-8507 Japan

AIM: To investigate the usefulness of branched-chain amino acids (BCAA) before transarterial chemoembolization (TACE) or radiofrequency ablation (RFA).

关键词： Branched-chain amino acids Cirrhosis Hepatocellular carcinoma Transarterial chemoembolization Radiofrequency ablation Hypoalbuminemia

Improvement of regional cerebral blood flow after oral intake of ranched-chain amino acids in patients with cirrhosis

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World Journal of Gastroenterology 2005年第43期11卷 6792-6799页

作者： Mika Yamamoto Motoh Iwasa Kaname Matsumura Yuri Nakagawa Naoki Fujita Yoshinao Kobayashi Masahiko kaito Kan Takeda Yukihiko Adachi Department of Internal Medicine Department of Radiology

AIM： To evaluate the effect of oral intake of branchedchain amino acids （BCAA） on brain perfusion in patients with liver cirrhosis. METHODS： Single photon emission computed tomography scans were performed in 43 patients with cirrhosis and in 15 age-matched healthy subjects. Twenty-nine out of forty-three patients were randomly treated with either BCAA granules or placebo, and single photon emission computed tomography was performed before and after the treatment. We measured the regional cerebral blood flow values using a threedimensional stereotaxic region of interest template. RESULTS： Cirrhotic patients had regions of significant hypoperfusion in the bilateral central （right P = 0.039, P〈0.05; left P = 0.006 P〈0.01）, parietal （right P = 0.028, P〈0.05; left P = 0.009, P〈0.01）, angular （right P = 0.039, P〈0.05; left P = 0.008, P〈0.01）, and left pericallosal segments （P = 0.038 P〈0.05） as compared with healthy subjects. A significant increase in cerebral perfusion was observed 70 min after the oral intake of BCAA in the angular （right P = 0.012, P〈0.05; left P = 0.049, P〈0.05）, temporal （right P = 0.012, P〈0.05; left P=0.038, P〈0.05）, pericallosal segments （right P = 0.025, P〈0.05; left P = 0.049, P〈0.05） and left precentral （P = 0.044, P〈0.05）, parietal （P = 0.040, P〈0.05） and thalamus （P = 0.033, P〈0.05）. No significant change in perfusion was observed in the placebo group. CONCLUSION： Administration of BCAA rapidly improves cerebral perfusion.

关键词： Liver cirrhosis Cerebral blood flow Branchedchain amino acids