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Versatile Leadership, LVI and Their Application in Skoda Auto a.s.

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Chinese Business Review 2011年第12期10卷 1181-1190页

作者： karel pavlica Robert B. kaiser Eva Jarosova Skoda Auto University Mladai Boleslav Czech Republic kaplan DeVries Inc. Greensboro USA University of Economics prague Prague Czech Republic

The paper starts with a presentation of the versatile leadership model developed by kaplan and kaiser and of their 360 feedback tool Leadership Versatility Index （LVI）. Versatility can be generally defined as a mastery of opposites, as the ability to play multiple roles, even contradictory ones, without emphasizing some at the expense of others. The LVI has been designed to help managers understand their repertoire and how they can become more versatile leaders. It employs an innovative rating scale on which ideal score ＂0＂ is in the middle of it （the right amount）, flanked by underdoing to the left （too little） and overdoing to the right （too much）. The idea is to avoid the ＂more is better＂ design trap by providing a way for raters to indicate when managers go to counterproductive extremes. The LVI works with two-sided view of leadership based on two major pairs of opposites： directive vs. supportive leadership and execution vs. strategy. Interventions based on the LVI results help to overcome traditional behaviorism as they combine the outer work （behavioral change） with the inner work （personal change） of development. Application of the LV1 on a sample of the managers from Skoda Auto a.s. and verification of its practical value represented the core of the SAVS IGA project MM/O7/02. The last part of the paper is devoted to a presentation of the findings from this project. The LVI has been found to be both original and a very useful 360 feedback tool which can be addressed to two general groups of clients：（1） experienced senior managers; and （2） young perspective managers in the beginning of their career.

关键词： versatilty leadership leadership versatility index 360-degree feedback curvilinear scale personaldevelopment

phytopigments, proline, Chlorophyll Index, Yield and Leaf Nitrogen as Impacted by Rootstock, Training System, and Girdling in “Aztec Fuji” Apple

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American Journal of plant Sciences 2019年第9期10卷 1583-1598页

作者： Esmaeil Fallahi Shahla Mahdavi Clive kaiser Bahar Fallahi pomology and Viticulture program Department of Plant Sciences Parma Research and Extension Center University of Ida-ho Parma USA Umatilla County Extension Oregon State University Milton-Freewater OR USA

World overpopulation, scarcity of water and finite arable land mandate a more efficient use of these natural resources. To remain sustainable, modern-day apple (Malus domestica Borkh.) fruit production utilizes high-density orchards on semi-dwarfing, precocious rootstocks. Nonetheless, little attention has been paid to the use of size-controlling practices such as trunk girdling in these modern orchard systems. The impact of two rootstocks, two tree architecture (training) systems, and three levels of girdling (in spring) on chlorophyll index (CI), proline, chlorophyll content (Chl;a, b, a + b), carotenoids, anthocyanin, yield, fruit weight and leaf nitrogen (N) in “Aztec Fuji” were studied in 2015 and 2016. Trees on “Bud 9” had up to 5% higher chlorophyll indices in leaves on side branches than those on “Nic 29” at each sampling time in 2015 and 2016. However, trees on “Nic 29” had up to 5.5% chlorophyll index in terminal branches, 14% higher Chl b, 54% higher leaf proline in 2015, up to 5% higher leaf nitrogen (N) in 2015 and 2016, 82% higher yields in 2015, and up to 7% higher fruit weight in 2015 and 2016 than those on “Bud 9”. Trees trained into a central leader (CL) architecture had up to 6% higher chlorophyll index and 4% higher leaf N in terminal branches 2015 and 2016, 43% more terminal leaf proline content in 2015, but 13% less yield in 2016 than those with a tall spindle training (TS). Terminal leaves from trees receiving a bark girdling in 2015 (BG15) had up to 6.5% lower leaf N, 7% less chlorophyll index, and between 27% to 56% lower proline content than those from the ungirdled check and score girdled treatment in 2015 (SG15). Also, trees with BG15 and a bark girdling in both 2015 and 2016 (BG1516) treatments had significantly less leaf N concentration than all other treatments or the ungirdled check. Trees that were score girdled in 2015 and repeat score girdled in 2016 (SG1516) had 21% higher yield and 12% higher fruit weight than those that were ung

关键词： Canopy Architecture Cambium Ringing Growth Control High Density Orchards Malus x domestica

Hematopoietic stem cell transplantation for Crohn's disease: Gaps, doubts and perspectives

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World Journal of Stem Cells 2018年第10期10卷 134-137页

作者： Milton Artur Ruiz Roberto Luiz kaiser Junior Lilian piron-Ruiz Tatiana pena-Arciniegas priscila Samara Saran Luiz Gustavo De Quadros Bone Marrow Transplant Department Associaaao Portuguesa de BeneficenciaSao Joseo Rio PretoSP 15090 470Brazil

Crohn's disease(CD) is an inflammatory bowel disease that can affect any site of the digestive system. It occurs due to an immunological imbalance and is responsible for intestinal mucosal lesions and complications such as fistulas and stenoses. Treatment aims to stabilize the disease, reducing the symptoms and healing intestinal lesions. Surgical procedures are common in patients. Cell therapy was initially used to treat this disease in patients who also suffered from lymphoma and leukemia and were considered to be good candidates for autologous and allogeneic transplantation. After transplantation, an improvement was also observed in their CD. In 2003, the procedure began to be used to treat the disease itself, and several case series and randomized studies have been published since then; this approach currently comprises a new option in the treatment of CD. However, considerable doubt along with significant gaps in our knowledge continue to exist in relation to cell therapy for CD. Cell therapy is currently restricted to the autologous modality of hematopoietic stem cell transplantation and, experimentally, to mesenchymal stromal cells to directly treat lesions of the anal mucosa. This article presents the supporting claims for transplantation as well as aspects related to the mobilization regime, conditioning and perspectives of cell therapy.

关键词： Stem cell therapy Hematopoietic stem cell transplantation Treatment Crohn's disease

Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time pCR analysis

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World Journal of Gastroenterology 2008年第16期14卷 2501-2510页

作者： Holger G Hass Oliver Nehls Juergen Jobst Andrea Frilling Ulrich Vogel Stephan kaiser Department of Oncology Hematology and Palliative Care Marien Hospital Stuttgart Department of Hematology Oncology and Rheumatology University of Tuebingen Matrigene GmbH Company Reutlingen Department of Abdominal and Transplant Surgery University of Essen Department of pathology University of Tuebingen Department of Gastroenterology Hepatology and Infectious Diseases University of Tuebingen

AIM: To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling. METHODS: Oligonucleotide arrays (Affymetrix U133A) were used to establish a specific gene expression profile of intrahepatic CCC in comparison to corresponding non- malignant liver tissue. To validate the expression values of the most overexpressed genes, RT-pCR experiments were performed. RESULTS: Five hundred and fifty-two statistically differentially expressed genes/ESTs (221 probes significantly up-regulated, 331 probes down-regulated; p 2; ≥ 70%) were identified. Using these data and two-dimensional cluster analysis,a specific gene expression profile was obtained allowing fast and reproducible differentiation of CCC, which was confirmed by supervised neuronal network modelling. The most consistently overexpressed gene (median fold change 33.5, significantly overexpressed in 100%) encoded osteopontin. Furthermore, an association of various genes with the histopathological grading could be demonstrated. CONCLUSION: A highly specific gene expression profile for intrahepatic CCC was identified, allowing for its fast and reproducible discrimination against non- malignant liver tissue and other liver masses. The most overexpressed gene in intrahepatic CCC was the gene encoding osteopontin. These data may lead to a better understanding of human cholangiocarcinogenesis.

关键词： Cholangiocarcinoma Oligonucleotide arrays Osteopontin Cell cycle regulation Gene expression

Different types of edema of breast lesions in MR-Mammography

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Different types of edema of breast lesions in MR-Mammography

An integrative multivariate approach for predicting functional recovery using magnetic resonance imaging parameters in a translational pig ischemic stroke model

中华医学会第十三届全国放射学大会

作者：杨帆冯敢生 W．A．kaiser 武汉协和医院

目的:To assess if there is a significant difference in the incidence of edema in benign vs. malignant breast lesions．方法:This retrospective study included a total of 1010 consecutive patients from 1994 to 2003 with ...

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Neural Regeneration Research 2021年第5期16卷 842-850页

作者： Erin E.kaiser J.C.poythress kelly M.Scheulin Brian J.Jurgielewicz Nicole A.Lazar Cheolwoo park Steven L.Stice Jeongyoun Ahn Franklin D.West Regenerative Bioscience Center University of GeorgiaAthensGAUSA Neuroscience Biomedical and Health Sciences InstituteUniversity of GeorgiaAthensGAUSA Department of Animal and Dairy Science College of Agricultural and Environmental SciencesUniversity of GeorgiaAthensGAUSA Department of Statistics Franklin College of Arts and SciencesUniversity of GeorgiaAthensGAUSA

Magnetic resonance imaging(MRI)is a clinically relevant,real-time imaging modality that is frequently utilized to assess stroke type and ***,specific MRI biomarkers that can be used to predict long-term functional recovery are still a critical ***,the present study sought to examine the prognostic value of commonly utilized MRI parameters to predict functional outcomes in a porcine model of ischemic *** was induced via permanent middle cerebral artery *** 24 hours post-stroke,MRI analysis revealed focal ischemic lesions,decreased diffusivity,hemispheric swelling,and white matter *** deficits including behavioral abnormalities in open field and novel object exploration as well as spatiotemporal gait impairments were observed at 4 weeks *** graphical models identified specific MRI outputs and functional recovery variables,including white matter integrity and gait performance,that exhibited strong conditional *** correlation analysis revealed a prognostic relationship between lesion volume and white matter integrity and novel object exploration and gait ***,these analyses may also have the potential of predicting patient recovery at chronic time points as pigs and humans share many anatomical similarities(e.g.,white matter composition)that have proven to be critical in ischemic stroke *** study was approved by the University of Georgia(UGA)Institutional Animal Care and Use Committee(IACUC;protocol Number:A2014-07-021-Y3-A11 and 2018-01-029-Y1-A5)on November 22,2017.

关键词： behavior testing canonical correlation analysis gait analysis Gaussian graphical models ischemic stroke magnetic resonance imaging pig model principal component analysis

Metabolomics research on Tibetan medicinal substances

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Journal of Traditional Chinese Medical Sciences 2015年第2期2卷 127-131页

作者： Xiaolei Ren kaiser Abdulkerim Xiaorui Fu Xia Liu Shuangshuang Ma Juan Wang Siqi Liu Jiarui Wu Xueyong Wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100102China College of Xinjiang Traditional Uyghur Medicine Xinjiang 833000China

Background:Tibetan medicinal substances(TMS)has a complete theory that is based on five source *** theories of“Liuwei”,“Baxing”,“Shiqi Gongxiao”,and“Sanhuawei”constitute the prominent core components of the five source doctrines with significant Tibetan ***:This review summarizes the existing literature on the metabolomics and its use in TMS and offers recommendations for future ***:Studies on TMS and the application of metabolomics on TMS are reviewed and *** shortcomings of existing studies and recommendations for future studies are ***:The recent researches have studied on the theory of *** will be increasingly applied to the identification of compounds in TMS,and the resultant detection of biomarkers will help elucidate the metabolic pathways of these substances.

关键词： Tibetan medicinal substances Metabolomics Theory

Theplant cytosolic m^(6)A RNA methylome stabilizes photosynthesis in the cold

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plant Communications 2023年第6期4卷 70-84页

作者： Alexandre Magno Vicente Nikolay Manavski paul Torben Rohn Lisa-Marie Schmid Antoni Garcia-Molina Dario Leister Charlotte Seydel Leo Bellin Torsten Möhlmann Gregor Ammann Stefanie kaiser Jörg Meurer plant Molecular Biology Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany plant Development Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany plant physiology Faculty of BiologyUniversity of KaiserslauternErwin-Schröodinger-Street767663 KaiserslauternGermany pharmaceutical Chemistry Goethe University FrankfurtMax-von-Laue-Str.960438 Frankfurt am MainGermany present address:Loewe Biochemica GmbH Möuhlweg 2a82054 SauerlachGermany present address:Center for Research in Agricultural Genomics 08193

The sessile lifestyle of plants requires an immediate response to environmental stressors that affect photosynthesis,growth,and crop ***,we showed that three abiotic perturbations—heat,cold,and high light—triggered considerable changes in the expression signatures of 42 epitranscriptomic factors(writers,erasers,and readers)with putative chloroplast-associated functions that formed clusters of commonly expressed genes in *** expression changes under all conditions were reversible upon deacclimation,identifying epitranscriptomic players as modulators in acclimation *** dysfunctions,particularly those induced by the oxidative stress-inducing norflurazon in a largely GENOME UNCOUpLED-independent manner,triggered retrograde signals to remodel chloroplastassociated epitranscriptomic expression patterns.N6-methyladenosine(m^(6)A)is known as the most prevalent RNA modification and impacts numerous developmental and physiological functions in living *** cold treatment,expression of components of the primary nuclear m^(6)A methyltransferase complex was upregulated,accompanied by a significant increase in cellular m^(6)A mRNA *** the cold,the presence of FIp37,a core component of the writer complex,played an important role in positive regulation of thylakoid structure,photosynthetic functions,and accumulation of photosystemⅠ,the Cytb6f complex,cyclic electron transport proteins,and Curvature Thylakoid1 but not that of photosystemⅡcomponents and the chloroplast ATp *** of FIp37 affected abundance,polysomal loading,and translation of cytosolic transcripts related to photosynthesis in the cold,suggesting m^(6)Adependent translational regulation of chloroplast *** summary,we identified multifaceted roles of the cellular m^(6)A RNA methylome in coping with cold;these were predominantly associated with chloroplasts and served to stabilize photosynthesis.

关键词： m^(6)A RNA methylation cold acclimation stress response Arabidopsis thaliana photosynthesis chloroplast

Degradable magnesium-hydroxyapatite interpenetrating phase composites processed by current assisted metal infiltration in additive-manufactured porous preforms

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Journal of Magnesium and Alloys 2022年第12期10卷 3641-3656页

作者： Mariano Casas-Luna Edgar B.Montufar Norbert Hort Sebastian Díaz-de-la-Torre JoséClaudio Méndez-García Lucie Vištejnová Adam Brínek AlešDanhel karel Dvorak Jozef kaiser Ladislav Celko Central European Institute of Technology Brno University of TechnologyPurkynova 123Brno 61200Czech Republic Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Straße 1Geesthacht 21502Germany Institute of product and process Innovation Leuphana University LüneburgUniversitätsallee 1Lüneburg 21335Germany Centro de Investigación e Innovación Tecnológica Instituto Politécnico NacionalCerrada de Cecati s/nMexico City 02250Mexico Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 1655/76Plzen 32300Czech Republic Institute of Biophysics of the Czech Academy of Sciences Královopolská135Brno 61265Czech Republic Faculty of Civil Engineering Brno University of TechnologyPurkynova 139Brno 61200Czech Republic

This work explores ceramic additive manufacturing in combination with liquid metal infiltration for the production of degradable interpenetrating phase magnesium/hydroxyapatite(Mg/HA) composites. Material extrusion additive manufacturing was used to produce stoichiometric,and calcium deficient HA preforms with a well-controlled open pore network, allowing the customization of the topological relationship of the composite. pure Mg and two different Mg alloys were used to infiltrate the preforms by means of an advanced liquid infiltration method inspired by spark plasma sintering, using a novel die design to avoid the structural collapse of the preform. Complete infiltration was achieved in 8 min, including the time for the Mg melting. The short processing time enabled to restrict the decomposition of HA due to the reducing capacity of liquid Mg. The pure Mg-base composites showed compressive yield strength above pure Mg in cast state. Mg alloy-based composites did not show higher strength than the bare alloys due to grain coarsening, but showed similar mechanical properties than other Mg/HA composites that have significantly higher fraction of metallic phase. The composites showed faster degradation rate under simulated body conditions than the bare metallic component due to the formation of galvanic pairs at microstructural level. Mg dissolved preferentially over HA leaving behind a scaffold after a prolonged degradation period. In turn, the fast production of soluble degradation products caused cell metabolic changes after 24 h of culture with not-diluted material extracts. The topological optimization and reduction of the degradation rate are the topics for future research.

关键词： Interpenetrating phase composite Biodegradable metal Topological relationship Direct ink writing Metal infiltration Computed aided design