An integrative multivariate approach for predicting functional recovery using magnetic resonance imaging parameters in a translational pig ischemic stroke model

作     者：Erin E.Kaiser J.C.Poythress Kelly M.Scheulin Brian J.Jurgielewicz Nicole A.Lazar Cheolwoo Park Steven L.Stice Jeongyoun Ahn Franklin D.West Erin E. Kaiser;J.C. Poythress;Kelly M. Scheulin;Brian J. Jurgielewicz;Nicole A. Lazar;Cheolwoo Park;Steven L. Stice;Jeongyoun Ahn;Franklin D. West

作者机构：Regenerative Bioscience CenterUniversity of GeorgiaAthensGAUSA NeuroscienceBiomedical and Health Sciences InstituteUniversity of GeorgiaAthensGAUSA Department of Animal and Dairy ScienceCollege of Agricultural and Environmental SciencesUniversity of GeorgiaAthensGAUSA Department of StatisticsFranklin College of Arts and SciencesUniversity of GeorgiaAthensGAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第5期

页      面：842-850页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：This work was supported by the National Institutes of Health National Institute of Neurological Disorders and Stroke grant R01NS093314 as well as Small Business Innovation Research grant 1R43NS103596-01 

主　　题：behavior testing canonical correlation analysis gait analysis Gaussian graphical models ischemic stroke magnetic resonance imaging pig model principal component analysis 

摘      要：Magnetic resonance imaging(MRI)is a clinically relevant,real-time imaging modality that is frequently utilized to assess stroke type and ***,specific MRI biomarkers that can be used to predict long-term functional recovery are still a critical ***,the present study sought to examine the prognostic value of commonly utilized MRI parameters to predict functional outcomes in a porcine model of ischemic *** was induced via permanent middle cerebral artery *** 24 hours post-stroke,MRI analysis revealed focal ischemic lesions,decreased diffusivity,hemispheric swelling,and white matter *** deficits including behavioral abnormalities in open field and novel object exploration as well as spatiotemporal gait impairments were observed at 4 weeks *** graphical models identified specific MRI outputs and functional recovery variables,including white matter integrity and gait performance,that exhibited strong conditional *** correlation analysis revealed a prognostic relationship between lesion volume and white matter integrity and novel object exploration and gait ***,these analyses may also have the potential of predicting patient recovery at chronic time points as pigs and humans share many anatomical similarities(e.g.,white matter composition)that have proven to be critical in ischemic stroke *** study was approved by the University of Georgia(UGA)Institutional Animal Care and Use Committee(IACUC;Protocol Number:A2014-07-021-Y3-A11 and 2018-01-029-Y1-A5)on November 22,2017.