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高超声速流场激光测速技术研究进展

力学学报 2024年第4期56卷 890-914页

作者：栗继伟罗凯尚甲豪王业军汪球赵伟中国科学院力学研究所高温气体动力学国家重点实验室北京100190 中国科学院大学工程科学学院北京100049

高超声速气流条件下飞行器内/外部流动中存在强湍流及脉动、边界层转捩、激波-边界层干扰和高温真实气体效应等耦合效应,表征该非定常流动现象对飞行器气动力、气动热以及目标光电特性等产生的影响是高超声速流动研究中的前沿课题.速度... 详细信息

高超声速气流条件下飞行器内/外部流动中存在强湍流及脉动、边界层转捩、激波-边界层干扰和高温真实气体效应等耦合效应,表征该非定常流动现象对飞行器气动力、气动热以及目标光电特性等产生的影响是高超声速流动研究中的前沿课题.速度作为表征流动过程最重要的参数之一,准确的速度测量对于深入理解上述复杂流动-传输机理以及高超声速飞行器设计具有重要指导意义.文章针对高超声速流场速度测量中几种常用的非接触式激光测试技术进行了综述,主要包括基于空间法的粒子图像测速,基于激光吸收光谱、激光诱导荧光和瑞利散射的多普勒测速,基于飞行时间法的分子标记测速,以及基于流场折射率的聚焦激光差分干涉测速技术.首先简要介绍每种激光测速技术的基本原理,然后进一步介绍该技术在高超声速自由流、层/湍流边界层、激波/边界层干扰、尾流或其他复杂流动区域的速度及其脉动度测量等方面的典型应用,分析各种技术环境适用性及面临的局限性和挑战.最后对基于激光技术的高超声速流场速度测量进行了总结及发展趋势展望.

关键词：高超声速流动速度场非接触式测量激光诊断飞秒激光脉冲

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Comprehensive analysis of advanced glycation end-products in commonly consumed foods:presenting a database for dietary AGEs and associated exposure assessment

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Food Science and Human Wellness 2024年第4期13卷 1917-1928页

作者： Qiaozhi Zhang Huatao li Ruixing Zheng lili Cao Shufen Zhang Shuifeng Zhang Huadong Sheng Yuhao jiang Yanbo wang linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Ningbo Academy of Product and Food Quality Inspection(Ningbo Fibre Inspection Institute) Ningbo 315048China National Pre-packaged Food Quality Supervision and Inspection Center(Zhejiang) Zhejiang Fangyuan Test Group Co.Ltd.Hangzhou 310018China

Advanced glycation end-products(AGEs)are a group of heterogeneous compounds formed in heatprocessed foods and are proven to be detrimental to human ***,there is no comprehensive database for AGEs in foods that covers the entire range of food categories,which limits the accurate risk assessment of dietary AGEs in human *** this study,we first established an isotope dilution UHPLCQq Q-MS/MS-based method for simultaneous quantification of 10 major AGEs in *** contents of these AGEs were detected in 334 foods covering all main groups consumed in Western and Chinese populations.Nε-Carboxymethyllysine,methylglyoxal-derived hydroimidazolone isomers,and glyoxal-derived hydroimidazolone-1 are predominant AGEs found in most *** amounts of AGEs were high in processed nuts,bakery products,and certain types of cereals and meats(>150 mg/kg),while low in dairy products,vegetables,fruits,and beverages(lied that the contribution of food groups to daily AGE intake varied a lot under different eating patterns,and selection of high-AGE foods leads to up to a 2.7-fold higher intake of AGEs through daily *** presented AGE database allows accurate assessment of dietary exposure to these glycotoxins to explore their physiological impacts on human health.

关键词： Advanced glycation end-products Maillard reaction Processed foods Dietary database Exposure assessment

Adaptive Optimal Discrete-Time Output-Feedback Using an Internal Model Principle and Adaptive Dynamic Programming

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 131-140页

作者： Zhongyang wang Youqing wang Zdzisław Kowalczuk the College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China IEEE the Department of Robotics and Decision Systems Faculty of ElectronicsTelecommunications and InformaticsGdańsk University of TechnologyGdansk 80-233Poland

In order to address the output feedback issue for linear discrete-time systems, this work suggests a brand-new adaptive dynamic programming(ADP) technique based on the internal model principle(IMP). The proposed method, termed as IMP-ADP, does not require complete state feedback-merely the measurement of input and output data. More specifically, based on the IMP, the output control problem can first be converted into a stabilization problem. We then design an observer to reproduce the full state of the system by measuring the inputs and outputs. Moreover, this technique includes both a policy iteration algorithm and a value iteration algorithm to determine the optimal feedback gain without using a dynamic system model. It is important that with this concept one does not need to solve the regulator equation. Finally, this control method was tested on an inverter system of grid-connected LCLs to demonstrate that the proposed method provides the desired performance in terms of both tracking and disturbance rejection.

关键词： Adaptive dynamic programming(ADP) internal model principle(IMP) output feedback problem policy iteration(PI) value iteration(VI)

Inetetamab combined with pyrotinib and oral vinorelbine for patients with human epidermal growth factor receptor 2 positive advanced breast cancer:A single-arm phase 2 clinical trial

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Cancer Pathogenesis and Therapy 2024年第1期2卷 31-37页

作者： Nan jin yi Xu Siqi wang Chunxiao Sun Xueqi Yan Fan Yang Yan liang Weiwei Chen Xiang Huang Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Radiology Department The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Oncology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210000China

Background Human epidermal growth factor receptor 2(HER2)-targeted agents have significantly improved the outcomes of patients with HER2-positive breast cancer;however,a large proportion of patients still develop resistance to *** this study,we investigated the efficacy and safety of inetetamab,another anti-HER2 antibody,combined with pyrotinib and oral vinorelbine in patients with HER2-positive advanced breast cancer so as to provide new ideas for the *** In this prospective,single-arm,phase 2 trial,patients with HER2-positive advanced breast cancer with disease progression after trastuzumab were *** received a combination of inetetamab(loading dose of 8 mg/kg and subsequent doses of 6 mg/kg intravenously once every 3 weeks),pyrotinib(400 mg orally once daily),and vinorelbine(60 mg/m^(2)orally once weekly)until disease progression or intolerable *** primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),overall survival(OS),disease control rate(DCR),and *** Between February 13,2022 and December 25,2022,30 patients were screened and enrolled in this *** median age of the patients at enrollment was 54 years,12 patients(40.0%)had hormone-receptor-positive disease and 23 patients(76.7%)had visceral *** median PFS was 8.63 months(95%confidence interval[CI]4.15-13.12 months).The median OS was not *** ORR was 53.3%(16/30)and the DCR was 96.7%(29/30).The most common Grade III/IV adverse events were leukopenia(n=5,16.7%),neutropenia(n=4,13.3%),and diarrhea(n=3,10%).No treatment-related serious adverse events or deaths *** The combination regimen of inetetamab,pyrotinib,and oral vinorelbine showed encouraging efficacy and favorable safety in patients with HER2-positive advanced breast cancer and could be considered as an alternative treatment option for the patients.

关键词： Human epidermal growth factor receptor 2 Breast cancer Inetetamab Pyrotinib Vinorelbine

qGW11a/OsCAT8,encoding an amino acid permease,negatively regulates grain size and weight in rice

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The Crop Journal 2024年第4期12卷 1150-1158页

作者： Peng Gao Feifan Chen Haitang liu Shijun Fan jierui Zeng Xue Diao Yang liu Wencheng Song Shifu wang jing li Xiaobo Zhu Bin Tu Weilan Chen Ting li Yuping wang Bingtian Ma Shigui li Hua Yuan Peng Qin State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Rice Research InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina

Grain size is a key factor influencing grain weight in *** this study,a chromosome segment substitution line(CSSL9-17)was identified,that exhibits a significant reduction in both grain size and weight compared to its donor parent *** investigation identified two quantitative trait loci(QTL)on chromosome 11,designated qGW11a and qGW11b,which contribute to 1000-grain weight with an additive ***_Os11g05690,encoding the amino acid permease OsCAT8,is the target gene of *** of OsCAT8 resulted in decreased grain weight,while OsCAT8 knockout mutants exhibited increased grain *** 287-bp located within the OsCAT8 promoter region of 93-11 negatively regulates its activity,which is subsequently correlated with an increase in grain size and *** results suggest that OsCAT8 functions as a negative regulator of grain size and grain weight in rice.

关键词： Rice Grain size Grain weight QTL OsCAT8

Efficient Photolytic Halogenation and Oxidation of Unactivated Alkyl sp^(3) C—H Bonds with Iodine(III)

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Chinese Journal of Chemistry 2024年第5期42卷 505-510页

作者： Hao jia Nan li Chunmei Tang Yajuan wang Yonghao Xi Rongbao liao Wei Xu Fufang Wu Xiaobao Shen Hongbin Zhai Biomass Oligosaccharides Engineering Technology Research Center of Anhui Province Engineering Research Center of Biomass Conversion and Pollution Prevention of Anhui Educational InstitutionsFuyang Normal UniversityFuyangAnhui236037 China Institute of Marine Biomedicine Shenzhen PolytechnicShenzhenGuangdong518055 China State Key Laboratory of Chemical Oncogenomics Shenzhen Engineering Laboratory of Nano Drug Slow-ReleasePeking University Shenzhen Graduate SchoolShenzhenGuangdong518055 China

A metal-free,green,and sustainable functionalization of unactivated alkyl sp^(3) C—H bonds is reported using iodine(III)as a feasible dehydrogenation agent under visible light or KBr,and alkyl chlorides,bromides,alcohols,and ketones could be constructed by addition of different coupling *** and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp^(3) C—H bond in a highly efficient manner,which can construct different alkylation products by adding corresponding coupling reagents.

关键词： Alkyl sp^(3)C—H bonds Chlorination Bromination Oxidation Iodine(III) C—H activation Radical Photocatalysis

南水北调中线工程通水对沿线地区经济增长的影响——基于受水区和水源地的检验

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长江流域资源与环境 2024年第6期33卷 1168-1181页

作者：李祎雯侯瑞雪王莹河海大学商学院江苏南京210000

水资源配置深刻影响着地区经济发展格局。南水北调工程为优化水资源配置、缓解我国北方地区水资源严重短缺问题提供有力支撑,但工程运行通水能否进一步推动受水区和水源地经济增长呢?以南水北调中线工程为例,运用合成控制法,分析工程运... 详细信息

水资源配置深刻影响着地区经济发展格局。南水北调工程为优化水资源配置、缓解我国北方地区水资源严重短缺问题提供有力支撑,但工程运行通水能否进一步推动受水区和水源地经济增长呢?以南水北调中线工程为例,运用合成控制法,分析工程运行通水对受水地区以及水源地区经济增长的影响,并检验其中的作用机制。研究表明:(1)从整体效应来看,中线工程通水显著提高了受水区和水源地的人均GDP和夜间灯光亮度,说明工程通水有效促进了两地区经济增长量和经济活跃度的提升。就动态效应来看,工程通水对受水区经济增长的促进作用存在一定滞后性,通水后的前两年对水源地经济发展产生微弱冲击,此后呈现正向促进作用。(2)中线工程通水运行对受水区和水源地产业结构合理化均产生显著正向影响,产业结构合理化程度的加深进一步促进两地区经济增长。(3)中线工程通水提升了受水区产业结构高级化程度,但对水源区产业结构高级化的影响存在一定滞后性;工程通水运行所带来的产业结构高级化效应能够显著促进两地区经济增长。(4)从经济增长的不同维度来看,受水区和水源区人均经济量的增长主要依赖于工程通水所产生的产业结构合理化效应;而经济活跃度的提升则依赖于产业结构高级化效应。最后,对推进南水北调后续工程高质量发展,充分发挥工程战略性、基础性功能提出政策建议。

关键词：南水北调中线工程区域经济增长合成控制法产业结构升级

On the Identification of N-rich Metal-poor Field Stars with Future Chinese Space Station Telescope

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Research in Astronomy and Astrophysics 2024年第1期24卷 151-164页

作者： jiajun Zhang Baitian Tang jiang Chang Xiangxiang Xue JoséGFernández-Trincado Chengyuan li Long wang Hao Tian Yang Huang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Sun Yat-sen UniversityZhuhai 519082China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China Key Lab of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Instituto de Astronomía Universidad Católica del NorteAv.Angamos 0610AntofagastaChile Key Lab of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

During the long term evolution of globular clusters(GCs), some member stars are lost to the field. The recently found nitrogen-rich(N-rich) metal-poor field stars are promising candidates of these GC escapees, since N enhancement is the fingerprint of chemically enhanced populations in GCs. In this work, we discuss the possibility of identifying N-rich metal-poor field stars with the upcoming Chinese Space Station Telescope(CSST). We focus on the main survey camera with NUV, u, g, r, i, z, y filters and slitless spectrograph with a resolution about *** combination of UV sensitive equipment and prominent N-related molecular lines in the UV band bodes well for the identification: the color–color diagram of(u-g) versus(g-r) is capable of separating N-rich field stars from normal halo stars, if metallicity can be estimated without using the information on u-band ***, the synthetic spectra show that a signal-to-noise ratio of 10 is sufficient to identify N-rich field stars. In the near future, a large sample of N-rich field stars found by CSST, combined with state-of-the-art N-body simulations will be crucial to deciphering GC-Galaxy co-evolution.

关键词： stars:chemically peculiar stars:abundances techniques:photometric techniques:spectroscopic

Facile Surface Engineering of NiCo_(2)O_(4) to Boost Propane Oxidation Activity

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 19-26页

作者： Yang jialei wang Fengyi Lei Yang Zhang Mingchao Sun Shiqiang Xu Wenfan Ke jiaxiang Wu Haojie li Xingyun Qi jian Institute of Materials for Energy and Environment College of Materials Science and EngineeringQingdao UniversityQingdao 266071China School of Chemistry and Chemical Engineering Hubei Key Laboratory of Coal Conversion and New Carbon MaterialsWuhan University of Science and TechnologyWuhan 430081China Department of Burn and Plastic Surgery Qingdao Municipal Hospital Affiliated to Rehabilitation UniversityQingdao 266000China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Spinel oxide(NiCo_(2)O_(4))has demonstrated great potential to replace noble metal catalysts for the oxidation reaction of air *** further boost the oxidation ability of such catalysts,in this study,a facile surface-engineering strategy wherein NiCo_(2)O_(4) was treated with different alkali solvents was *** obtained catalyst(NiCo_(2)O_(4)-OH)showed a higher surface alkalinity and more surface defects compared to the pristine spinel oxide,including enhanced structural distortion as well as promoted oxygen *** propane oxidation ability of NiCo_(2)O_(4)-OH was greatly enhanced,with a propane conversion rate that was approximately 6.4 times higher than that of pristine NiCo_(2)O_(4) at a reaction temperature 193℃.This work sets a valuable paradigm for the surface modulation of spinel oxide via alkali treatment to ensure a high-performance oxidation catalyst.

关键词： NiCo_(2)O_(4) surface defects alkali treatment propane oxidation