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Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 289-306页

作者： Chen Qiu Yu-kai Xiang Xuan-Bo Da Hong-Lei Zhang Xiang-Yu Kong Nian-Zong Hou Cheng Zhang fu-Zhou Tian Yu-Long Yang Center of Gallbladder Disease Shanghai East HospitalInstitute of Gallstone DiseaseSchool of MedicineTongji UniversityShanghai 200092China General Surgery Center Chengdu Military General HospitalChengdu 610083Sichuan ProvinceChina

BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface ***,these enzymes play a significant role in the development of diverse *** To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression *** study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and *** Set Enrichment Analysis was utilized to pinpoint associated ***,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was *** PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy *** expression of PLA2G2A was correlated with poorer overall survival in CCA ***,the study delineated pathways and miRNAs associated with these *** Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for *** increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.

关键词： PLA2G2A PLA2G12B Diagnostic Prognostic biomarkers cholangiocarcinoma

系统性金融风险的联合网络关联度测量及频率研究——基于局部平稳的非参数时变VHAR模型

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中国管理科学 2024年第2期32卷 1-10页

作者：傅强石泽龙重庆大学经济与工商管理学院重庆400030

准确度量系统性金融风险并分析其来源是研究系统性金融风险的重要问题,也是制定风险防范措施的必要保证。本文以金融类股票的高频数据为对象,通过假设向量异质自回归模型(VHAR模型)的参数为时间t/T的函数,建立了高维度局部平稳的非参数... 详细信息

准确度量系统性金融风险并分析其来源是研究系统性金融风险的重要问题,也是制定风险防范措施的必要保证。本文以金融类股票的高频数据为对象,通过假设向量异质自回归模型(VHAR模型)的参数为时间t/T的函数,建立了高维度局部平稳的非参数时变VHAR模型(即tv-VHAR model),并利用拟贝叶斯局部似然(QBLL)估计方法,解决了“维数灾难”下的估计问题。进一步,为更准确度量系统性金融风险,对Baruník和K?ehlík(2018)模型存在的缺陷进行修正,提出了联合网络关联度的频率成分指标,结合2015年股灾和新冠疫情这两次危机事件分析了我国系统性金融风险。结果表明:(1)我国金融系统风险的联合网络关联度比较高且持续性波动。(2)从频率角度来看,正常时期短期成分在风险网络中占据主导地位,其次为中期,最后为长期。(3)危机时期,短期成分迅速下降,而中、长期成分迅速上升,甚至超过了短期成分。(4)相比新冠疫情危机事件,股灾危机对投资者信心影响更大,导致危机持续时间更长。(5)各金融机构在风险网络中的作用差异较大:大型证券公司、股份制银行主要表现为风险净传播者,而大型国有商业银行及其他金融机构主要表现为风险净接受者。

关键词： tv-VHAR模型联合网络关联度的频率分解系统性金融风险已实现波动率

Identification and distribution of 13003 landslides in the northwest margin of Qinghai-Tibet Plateau based on human-computer interaction remote sensing interpretation

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China Geology 2024年第2期7卷 171-187页

作者： Wei Wang Yuan-dong Huang Chong Xu Xiao-yi Shao Lei Li Li-ye Feng Hui-ran Gao Yu-long Cui Shuai Wu Zhi-qiang Yang kai Ma National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of Chin12eijing 100085China School of Emergency Management Science and Engineering University of Chinese Academy of SciencesBeijing 100049China School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China School of Civil Engineering and Architecture Anhui University of Science and TechnologyHuainan 232001China No.3 Bureau of China Metallurgical Geology Bureau Taiyuan 030031China

The periphery of the Qinghai-Tibet Plateau is renowned for its susceptibility to ***,the northwestern margin of this region,characterised by limited human activities and challenging transportation,remains insufficiently explored concerning landslide occurrence and *** the planning and construction of the Xinjiang-Tibet Railway,a comprehensive investigation into disastrous landslides in this area is essential for effective disaster preparedness and mitigation *** using the human-computer interaction interpretation approach,the authors established a landslide database encompassing 13003 landslides,collectively spanning an area of 3351.24 km^(2)(36°N-40°N,73°E-78°E).The database incorporates diverse topographical and environmental parameters,including regional elevation,slope angle,slope aspect,distance to faults,distance to roads,distance to rivers,annual precipitation,and *** statistical characteristics of number and area of landslides,landslide number density(LND),and landslide area percentage(LAP)are *** authors found that a predominant concentration of landslide origins within high slope angle regions,with the highest incidence observed in intervals characterised by average slopes of 20°to 30°,maximum slope angle above 80°,along with orientations towards the north(N),northeast(NE),and southwest(SW).Additionally,elevations above 4.5 km,distance to rivers below 1 km,rainfall between 20-30 mm and 30-40 mm emerge as particularly susceptible to landslide *** study area’s geological composition primarily comprises Mesozoic and Upper Paleozoic *** fault and human engineering activities have different degrees of influence on landslide ***,the significance of the landslide database,the relationship between landslide distribution and environmental factors,and the geometric and morphological characteristics of landslides are *** landslide H/L ratios in the study area are

关键词： Landslides Human-computer interaction interpretation Landslide database Spatial distribution Earthquake Rainfall Human engineering activity Qinghai-Tibet Plateau Geological hazards survey engineering

Analysis on Typical Spatio-temporal Characteristics of Open-cast Mining and Its Countermeasures

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Asian Agricultural Research 2024年第5期16卷 20-24页

作者： Qingyou AO qiang fu Zhihua LIU Yu XUN Lin LIN State Power Investment Corporation Inner Mongolia Energy Co. Ltd.Tongliao 029200China Huolinhe South Surface Mine of Inner Mongolia Power Investment Energy Co. Ltd.Tongliao 029200China Huolinhe North Surface Mine of Inner Mongolia Power Investment Energy Co. Ltd.Tongliao 029200China CCTEG Shenyang Engineering Company Shenyang 110015China

In order to deal with the special spatio-temporal environmental changes encountered in the process of open-cast mining,taking Huolinhe No.1 Open-cast Mine as the research object,this paper studied its typical problems in river reconstruction and cultural relics *** study focused on eight key core aspects,including the design optimization of the spatial layout of the mining area,the accurate estimation of the mineral resources reserves,the scientific theoretical demonstration of the mining scale,the fine analysis and calculation of the stripping ratio,the comprehensive consideration of the transport distance and efficiency,the accurate judgment of the best time for the implementation of the transformation,the analysis and evaluation of the slope stability,and the overall planning of the production *** results show that the extracted problem-solving strategies and scheme system for special mining conditions can not only provide specific and practical guidance for Huolinhe No.1 Open-cast Mine,but also serve as a valuable reference and practical reference for other open-cast mine enterprises facing similar challenges.

关键词： Open-cast mining in the mining area Typical space-time environment River reconstruction Cultural relics protection Spatial layout

Epidemiological and Subtype Characterization of Influenza Viruses Infection in Children in Shenzhen, China during Three Consecutive Seasons (January 2016-December 2018)

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Open Journal of Pediatrics 2024年第5期14卷 851-864页

作者： Yaxian Kuang Ruihong Ma Lei Jia qiang Yao Chenhui Zhang Xiaoying fu Department of Laboratory Medicine Shenzhen Childrens Hospital Affiliated to Shantou University Medical College Shenzhen China The Department of Clinical Laboratory The Sixth Peoples Hospital of Nansha Guangzhou China Guangxi Key Laboratory of Intelligent Precision Medicine Nanning China International Health Medicine Innovation Center Shenzhen University Shenzhen China

Background: Children with seasonal influenza infection cause a significant burden of disease each year in the pediatric clinic. Influenza A and B viruses are the major types responsible for illness. A better understanding of the periodicity facilitates the prevention and control of influenza in children. Objective: This study aims to analyze the epidemiological patterns and subtype characterization of influenza viruses among children in Shenzhen, China. Methods: Influenza samples were collected by nasopharyngeal swabs from influenza like illness patients in Shenzhen Children’s Hospital from January 2016 to December 2018. The positive cases and influenza subtypes were determined by gold labeled antigen detection and reverse transcriptase polymerase chain reaction. The influenza periodicity and age, subtype distribution as well as the association between climate parameters and different influenza subtypes were analyzed by SPSS 22.0. Results: The influenza positive rate during 2016-2018 was 21.0%, with a highest positive rate in the year 2018. The positive rate varied by month, season, and year describing a sequence of peaks presenting primarily in all year including spring, summer and winter. The characteristics of influenza peak were different in each year, with a spring peak in 2016 and a summer plus a winter-spring peaks in 2017 and 2018. In addition, influenza B exhibited a winter-spring seasonal pattern while influenza A displayed a more variable seasonality, highlighting influenza B rather than influenza A which had a negative association with climate parameters. Influenza-positive cases were older than influenza-negative cases (P P Conclusion: Influenza activity in children from Shenzhen typically displays both winter-spring and summer peaks. Influenza A epidemic occurred separately or co-circulated with influenza B, with a winter-spring pattern for influenza B and a much more variable seasonality for influenza A. Influenza B had a negative association with cli

关键词： Influenza Influenza Like Illness Gold Labeled Antigen Detection Reverse Transcriptase Polymerase Chain Reaction Influenza A Influenza B

Leading Pattern of Spring Drought Variability over East Asia and Associated Drivers

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Journal of Tropical Meteorology 2024年第1期30卷 1-10页

作者：赵庆红杨崧田红瑛邓开强 School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)ZhuhaiGuangdong 519082 China Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen UniversityZhuhaiGuangdong 519082 China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000 China

Drought events have become more frequent and intense over East Asia in recent decades,leading to huge socioeconomic *** the droughts have been studied extensively by cases or for individual regions,their leading variability and associated causes remain *** on the Standardized Precipitation Evapotranspiration Index(SPEI)and ERA5 reanalysis product from 1979 to 2020,this study evealuates the severity of spring droughts in East Asia and investigates their variations and associated *** results indicate that North China and Mongolia have experienced remarkable trends toward dryness during spring in recent decades,while southwestern China has witnessed an opposite trend toward *** first Empirical Orthogonal function mode of SPEI variability reveals a similar seesawing pattern,with more severe dryness in northwestern China,Mongolia,North China,South Korea,and Japan but increased wetness in Southwestern China and southeast *** investigation reveals that the anomalously dry(wet)surface in North(Southwestern)China is significantly associated with anomalously high(low)temperature,less(more)precipitation,and reduced(increased)soil moisture during the previous winter and early spring,regulated by an anomalous anticyclone(cyclone)and thus reduced(increased)water vapor *** spring dry-wet pattern in East Asia is also linked to cold sea surface temperature anomalies in the central-eastern *** findings of this study have important implications for improving the prediction of spring drought events in East Asia.

关键词： drought leading pattern East Asia spring drivers

Carbon Storage Dynamics in Lower Shimentan Formation of the Qiantang Sag, East China Sea Shelf Basin: Stratigraphy, Reservoir ‒ Cap Analysis, and Source ‒ Sink Compatibility

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哈尔滨工程大学学报（英文版） 2024年第3期23卷 565-574页

作者： kailong Feng Weilin Zhu kai Zhong qiang fu Weizhen Chen Zengyuan Zhou Guanyu Zhang Ji Teng Zhe Yang State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu 610059China Naval Architecture and Shipping College Guangdong Ocean UniversityZhanjiang 524088China Center for Marine Resources Tongji UniversityShanghai 200092China School of Management Guangdong Ocean UniversityZhanjiang 524088China

Excessive carbon emissions have resulted in the greenhouse effect, causing considerable global climate change. Marine carbon storage has emerged as a crucial approach to addressing climate change. The Qiantang Sag(QTS) in the East China Sea Shelf Basin, characterized by its extensive area, thick sedimentary strata, and optimal depth, presents distinct geological advantages for carbon dioxide(CO_(2)) storage. Focusing on the lower section of the Shimentan Formation in the Upper Cretaceous of the QTS, this study integrates seismic interpretation and drilling data with core and thin-section analysis. We reveal the vertical variation characteristics of the strata by providing a detailed stratigraphic description. We use petrophysical data to reveal the development characteristics of high-quality carbon-storage layers and favorable reservoircaprock combinations, thereby evaluating the geological conditions for CO_(2) storage in various stratigraphic sections. We identify Layer B of the lower Shimentan Formation as the most advantageous stratum for marine CO_(2) storage. furthermore, we analyze the carbon emission trends in the adjacent Yangtze River Delta region. Considering the characteristics of the source and sink areas, we suggest a strong correlation between the carbon emission sources of the Yangtze River Delta and the CO_(2) storage area of the QTS, making the latter a priority area for conducting experiments on marine CO_(2) storage.

关键词： Carbon storage Qiantang Sag Reservoir-cap Source-sink dynamics East China Sea Shelf Basin

Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe WANG Rui Chen LI Yan ZHANG Jun Feng LIU Sheng Hui HU Dan He XU Chong Xiao YIN Jia Yu YIN Qi kai HE Ying LI Fan fu Shi Hong NIE kai LIANG Guo Dong TAO Yong XU Song Tao MA Chao Feng WANG Huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

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Bone Research 2024年第2期12卷 334-348页

作者： Ziqian Xiang Pengfei Zhang Chunwang Jia Rongkun Xu Dingren Cao Zhaoning Xu Tingting Lu Jingwei Liu Xiaoxiong Wang Cheng Qiu Wenyang fu Weiwei Li Lei Cheng qiang Yang Shiqing Feng Lianlei Wang Yunpeng Zhao Xinyu Liu Department of Orthopaedics Qilu Hospital of Shandong UniversityJinan 250012China University of Health and Rehabilitation Sciences Qingdao 226000China Xiangya School of Medicine Central South UniversityChangsha 410013China School of Nursing and Rehabilitation Shandong UniversityJinan 250012China Department of Pediatrics Cangzhou Central HospitalCangzhou 061011China Department of Pediatric Surgery Qilu Hospital of Shandong UniversityJinan 250012China Department of Pathology Qilu Hospital of Shandong UniversityJinan 250012China Department of Spine Surgery Tianjin HospitalTianjin UniversityTianjin 30021China The Second Hospital of Shandong University Cheeloo College of MedicineShandong UniversityJinan 250012China

To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be ***,Piezo1 channel was identified as a key iron transporter in response to mechanical ***1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron ***,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical ***,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.

关键词： stress overload channel