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Who should be screened for colorectal cancer and how can it be prevented more effectively?

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3741-3746页

作者： You-Xiang wang kai-juan wang College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina College of Public Health Key Laboratory of Tumor Epidemiology of Henan ProvinceState Key Laboratory of Esophageal Cancer Prevention&TreatmentZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

In this editorial,we comment on the article published by Agatsuma et al in a recent issue of the World J Gastroenterol(2024;30:1368-1376).We firmly concur with Agatsuma et al regarding the vital significance of colorectal cancer(CRC)screening as a public health strategy to diminish disease *** exposed to risk factors for CRC,those with comorbid conditions,and those with limited health literacy should undergo ***,we believe that more regular screenings should be accompanied by a greater focus on primary prevention(PP)of *** remains a significant global health challenge,and its incidence is strongly linked to age,lifestyle,and socioeconomic *** is particularly noteworthy that the majority of CRC patients are diagnosed outside of established screening pathways and frequently at an advanced stage of the disease,and the majority of patients possess inadequate or even nonexistent knowledge regarding CRC,which significantly impacts the prognosis and imposes a substantial economic *** study revealed that CRC identified during hospital visits for comorbid conditions was typically diagnosed at an earlier stage than detected via symptomatic ***,early incidental detection of CRC aligns closely with the timing of discovery through routine cancer *** suggests that by adopting more inclusive screening protocols that combine opportunistic testing with traditional screening methods,health care systems can create a more comprehensive safety net for individuals at risk of ***,before maximizing the health benefits of screening programs,it is essential to make additional efforts prior to screening,such as raising awareness via public education,risk assessment,and personalized recommendations,enhancing the knowledge and skills of health care professionals,optimizing the accessibility and convenience of screening processes,ensuring the quality and safety of screening services,strengthening follow-up and su

关键词： Colorectal cancer Primary prevention Screening program Disease burden Health literacy Economic benefits

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Prevention of malignant digestive system tumors should focus on the control of chronic inflammation

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World Journal of Gastrointestinal Oncology 2023年第3期15卷 389-404页

作者： Yue-Hua Zhang Xiao-Lin Chen Yi-Ran wang Yu-Wei Hou Yao-Dong Zhang kai-juan wang College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Henan International Joint Laboratory of Prevention and Treatment of Pediatric Diseases Henan Children's Hospital Zhengzhou Children’s HospitalChildren's Hospital Affiliated to Zhengzhou UniversityZhengzhou 450018Henan ProvinceChina Department of Prenatal Diagnosis Center The Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Henan Children’s Hospital Zhengzhou Children’s Hospital Children’s Hospital Affiliated to Zhengzhou UniversityKey Laboratory of Tumor Epidemiology of Henan ProvinceState Key Laboratory of Esophageal Cancer Prevention&TreatmentZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Chronic inflammation,through a variety of mechanisms,plays a key role in the occurrence and development of digestive system malignant tumors(DSMTs).In this study,we feature and provide a comprehensive understanding of DSMT prevention strategies based on preventing or controlling chronic *** development and evaluation of cancer prevention strategies is a longstanding *** prevention,especially in the early stage of life,should be emphasized throughout the whole life *** such as the time interval for colon cancer screening,the development of direct-acting antiviral drugs for liver cancer,and the Helicobacter pylori vaccine all need to be explored in long-term,large-scale experiments in the future.

关键词： Chronic inflammation Digestive system malignant tumors Prevention Screening Life course Gastrointestinal cancer

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Genetic variant of cyclooxygenase-2 in gastric cancer:More inflammation and susceptibility

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World Journal of Gastroenterology 2021年第28期27卷 4653-4666页

作者： Xuan-Ke Ji Sailaja Vatsalya Madhurapantula Gui He Kun-Yan wang Chun-Hua Song Jian-Ying Zhang kai-juan wang College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Key Laboratory of Tumor Epidemiology of Henan Province Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Gastric cancer accounts for the majority cancer-related deaths *** various methods have considerably improved the screening,diagnosis,and treatment of gastric cancer,its incidence is still high in Asia,and the 5-year survival rate of advanced gastric cancer patients is only 10%-20%.Therefore,more effective drugs and better screening strategies are needed for reducing the incidence and mortality of gastric ***-2(COX-2)is considered to be the key inducible enzyme in prostaglandins(PGs)synthesis,which is involved in multiple pathways in the inflammatory *** example,inflammatory cytokines stimulate innate immune responses via Toll-like receptors and nuclear factor-kappa B to induce COX-2/PGE2 *** these processes,the production of an inflammatory microenvironment promotes the occurrence of gastric *** studies have also indicated that non-steroidal antiinflammatory drugs can reduce the risk of malignant tumors of the digestive system by blocking the effect of ***,clinical use of COX-2 inhibitors to prevent or treat gastric cancer may be limited because of potential side effects,especially in the cardiovascular *** these side effects and low treatment efficacy,new therapeutic approaches and early screening strategies are urgently *** studies have shown that genetic variation in COX-2 also play an important role in ***,the genetic variation analysis in these studies is incomplete and isolated,pointing out only a few single nucleotide polymorphisms(SNPs)and the risk of gastric cancer,and no comprehensive study covering the whole gene region has been carried *** addition,copy number variation(CNV)is not *** this review,we summarize the SNPs in the whole COX-2 gene sequence,including exons,introns,and both the 5’and 3’untranslated *** suggest that COX-2 does not increase its expression through the CNV and the SNPs in COX-2 may serve as the p

关键词： Cyclooxygenase-2 Inflammation Genetic variant Gastric cancer Prostaglandin E2

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Adaptive state-constrained/model-free iterative sliding mode control for aerial robot trajectory tracking

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 603-618页

作者： Chen AN Jiaxi ZHOU kai wang College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong KongChina

This paper develops a novel hierarchical control strategy for improving the trajectory tracking capability of aerial robots under parameter *** hierarchical control strategy is composed of an adaptive sliding mode controller and a model-free iterative sliding mode controller(MFISMC).A position controller is designed based on adaptive sliding mode control(SMC)to safely drive the aerial robot and ensure fast state convergence under external ***,the MFISMC acts as an attitude controller to estimate the unmodeled dynamics without detailed knowledge of aerial ***,the adaption laws are derived with the Lyapunov theory to guarantee the asymptotic tracking of the system ***,to demonstrate the performance and robustness of the proposed control strategy,numerical simulations are carried out,which are also compared with other conventional strategies,such as proportional-integralderivative(PID),backstepping(BS),and *** simulation results indicate that the proposed hierarchical control strategy can fulfill zero steady-state error and achieve faster convergence compared with conventional strategies.

关键词： aerial robot hierarchical control strategy model-free iterative sliding mode controller(MFISMC) trajectory tracking reinforcement learning

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Adaptive learning-based optimal tracking control system design and analysis of a disturbed nonlinear hypersonic vehicle model

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Science China(Technological Sciences) 2024年第6期67卷 1893-1906页

作者： AN kai wang ZhenGuo HUANG Wei Hypersonic Technology Laboratory National University of Defense TechnologyChangsha410073China

We propose an adaptive learning-based optimal control scheme for height-velocity control models considering model uncertainties and external disturbances of hypersonic winged-cone *** longitudinal nonlinear model is first established and transformed into the control-oriented error equations,and the control scheme is organized by a steady-compensation *** overcome and eliminate the impact of model uncertainties and external disturbances,an adaptive radial basis function neural network(RBFNN)is designed by a q-gradient *** the height-velocity error system with estimated uncertainties into account,the adaptive learning-based optimal tracking control(ALOTC)scheme is proposed by combining the critic-only adaptive dynamic programming(ADP)framework and parameter optimization of system settling ***,a novel weight update law is proposed to satisfy the online iteration requirements,and the algorithm convergence and closedloop stability are discussed by the Lyapunov ***,four simulation cases are provided to prove the effectiveness,accuracy,and robustness of the proposed scheme for the hypersonic longitudinal control system.

关键词： optimal tracking control adaptive dynamic programming RBFNN hypersonic vehicle

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Autonomous navigation method of satellite constellation based on adaptive forgetting factors

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Chinese Journal of Aeronautics 2024年第7期37卷 317-332页

作者： Dong wang Jing YANG kai XIONG School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Science and Technology on Space Intelligent Control Laboratory Beijing Institute of Control EngineeringBeijing 100094China

To address the problem that model uncertainty and unknown time-varying system noise hinder the filtering accuracy of the autonomous navigation system of satellite constellation,an autonomous navigation method of satellite constellation based on the Unscented Kalman Filter with Adaptive Forgetting Factors(UKF-AFF)is *** process noise covariance matrix is estimated online with the strategy that combines covariance matching and adaptive adjustment of forgetting *** adaptive adjustment coefficient based on squared Mahalanobis distance of state residual is employed to achieve online regulation of forgetting factors,equipping this method with more *** intersatellite direction vector obtained from photographic observations is introduced to determine the constellation satellite orbit together with the distance measurement to avoid rank deficiency *** that the number of available measurements varies online with intersatellite visibility in practical applications such as time-varying constellation configurations,the smooth covariance matrix of state correction determined by innovation and gain is adopted and constructed *** analysis of the proposed method is also *** effectiveness of the proposed method is verified by the Monte Carlo simulation and comparison *** estimation accuracy of constellation position and velocity of UKF-AFF is improved by 30%and 44%respectively compared to those of the extended Kalman filter,and the method proposed is also better than other several adaptive filtering methods in the presence of significant model uncertainty.

关键词： Constellation autonomous navigation Unscented Kalman filter Adaptive forgetting factor Model uncertainty Stability analysis

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Robustness of the octupole collectivity in 144Ba within the cranking covariant density functional theory in 3D lattice

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Nuclear Science and Techniques 2024年第8期35卷 124-131页

作者： Ze‑kai Li Yuan‑Yuan wang Mathematics and Physics Department North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071000China

The octupole deformation and collectivity in octupole double-magic nucleus 144Ba are investigated using the Cranking covariant density functional theory in a three-dimensional lattice *** reduced B(E3)transition probability is implemented for the first time in semiclassical approximation based on the microscopically calculated electric octupole *** available data,including the I-ωrelation and electric transitional probabilities B(E2)and B(E3)are well ***,it is shown that the ground state of 144Ba exhibits axial octupole and quadrupole deformations that persist up to high spins(I≈24h).

关键词： Octupole collectivity Cranking covariant density functional theory Rotational spectrum Electric transitional probabilities

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A widely used nonionic surfactant with desired functional groups as aqueous electrolyte additives for stabilizing Zn anode

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Rare Metals 2024年第8期43卷 3692-3701页

作者： Yue-Xian Song Xiao-Feng wang Cai-Bin Liu kai-Xuan Guo Xu-Huan Guo Xiao-Bin Zhong Yao-Hui Zhang kai wang Hui-juan Guo Li-Xin Zhang Jun-Fei Liang School of Energy and Power Engineering North University of ChinaTaiyuan 030051China Key Laboratory of Green Chemical Process of Ministry of Education Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical TechnologySchool of Chemical Engineering and PharmacyWuhan Institute of TechnologyWuhan 430073China Shanxi Provincial Key Laboratory for High Performance Battery Materials and Devices Taiyuan 030051China

Aqueous Zn-ion batteries(AZIBs) have emerged as potential candidates for Li-ion batteries due to their intrinsic safety and high ***,metallic Zn anodes encounter dendrite growth and water-induced corrosion,rendering poor stability and severe irreversibility at the electrode/electrolyte interface during *** stabilize the Zn anode,we report a low-cost and effective nonionic surfactant,Tween-20 polymer,as an electrolyte additive for *** Tween-20,sequential oxyethylene groups tended to be preferentially adsorbed on the Zn electrode to form a shielding layer for regulating uniform Zn ***,the hydrophobic hendecyl chains prevented H_(2)O-induced corrosion on the Zn anode *** from the desired functional groups,when only trace amounts of Tween-20(0.050 g·L^(-1)) were used,the Zn anode displayed good cycling stability over 2170 h at10 mA·cm^(-2) and a high average Coulombic efficiency of98.94% over 1000 *** Tween-20 polymer can also be effectively employed in MnO_(2)/Zn full *** their toxicity,price and amount of usage,these surfactant additives provide a promising strategy for realizing the stability and reversibility of high-performance Zn anodes.

关键词： Zn anode Dendrite growth Tween-20 polymer Surfactant additive Aqueous electrolyte

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Full-domain collaborative deployment method of multiple interference sources and evaluation of its deployment effect

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Defence Technology（防务技术） 2024年第2期32卷 572-595页

作者： Yue wang Fuping Sun Xian wang Jinming Hao kai Xiao School of Geospatial Information The PLA Information Engineering UniversityZhengzhou 450001HenanChina

This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation *** evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment *** principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively ***,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to *** evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality.

关键词： Jamming effect Multiple interference sources Collaborative deployment Effect evaluation Defense capability

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Cerebral artery evaluation of dual energy CT angiography with dual source CT

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Chinese Medical Journal 2010年第9期123卷 1139-1144页

作者： MA Rui LIU Cheng DENG kai SONG Shao-juan wang Dao-ping HUANG Ling Shandong Medical Imaging Research Institute Shandong UniversityJinanShandong 250021China

Background Conventional computed tomography angiography （CTA） is time consuming, user-dependent and has poor image quality in skull base region. This study assessed the feasibility of a new method, dual energy CTA for depicting the cerebral *** Phantom scan was done with head CTA sequences on dual source CT and 64 spiral CT for radiation dose calculation. Dual energy CTA was done with dual source CT on 36 patients who were suspected of having cerebral vascular disease. Three series axial images in 0.75 mm thick, 0.4 mm increment were acquired, which were named with 80 kV, 140 kV and merged images; 80 kV and 140 kV images were transferred into dual energy software, and maximum intensity projection （MIP） image was generated quickly by dual energy bone remove （DEBR group）; merged images were transferred into In Space software to acquire MIP image through manual conventional bone remove （CoBR group）. Post processing time and reading time were compared. Image qualities of the two groups were compared, mainly focusing on skull base segments of internal carotid artery and bone subtraction. ANOVA and SNK tests were applied for radiation dose comparison. Student＇s t test and Wilcoxon rank sum test were applied for assessing differences between data for significance. Cohen＇s kappa was used for interobserver agreement. Results Radiation dose of phantom scan showed dual energy CTA was between digital bone subtraction and conventional CTA. The post processing time and reading time were much shorter in DEBR than CoBR, and image quality in skull base was much higher in DEBR than CoBR （P〈0.01）. There was no significant difference for suprasellar vessels between two groups （P〉0.5）. Interobserver agreement for all vessel segments was excellent （kappa=0.97）. Conclusions Dual energy CTA is a reliable, new modality for depicting cerebral artery, overcoming the limitation of conventional CTA in the skull base region. It can save much time in post processing and reading than co

关键词： computed tomography X-ray dual energy X-ray absorptiometry scan cerebral artery angiography subtraction technique

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