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Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway

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World Journal of Gastroenterology 2019年第30期25卷 4222-4234页

作者： Gao-Liang Zou Shi Zuo Shuang Lu Rui-Han Hu Yin-Ying Lu Jing Yang kai-sheng deng Ye-Ting Wu Mao Mu Juan-Juan Zhu Jing-Zhang Zeng Bao-Fang Zhang Xian Wu Xue-Ke Zhao Hai-Yang Li Department of Infectious Diseases Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Comprehensive Liver Cancer Center 302 HospitalBeijing 100039China

BACKGROUND Liver fibrosis is a refractory disease whose persistence can eventually induce cirrhosis or even liver *** liver fibrosis is reversible by *** a member of the transforming growth factor-beta(TGF-β)superfamily,bone morphogenetic protein 7(BMP7)has anti-liver fibrosis ***,little is known about BMP7 expression changes and its potential regulatory mechanism as well as the relationship between BMP7 and TGF-βduring liver *** addition,the mechanism underlying the anti-liver fibrosis function of BMP7 needs to be further *** To investigate changes in the dynamic expression of BMP7 during liver fibrosis,interactions between BMP7 and TGF-β1,and possible mechanisms underlying the anti-liver fibrosis function of *** Changes in BMP7 expression during liver fibrosis and the interaction between BMP7 and TGF-β1 in mice were *** BMP7 was used to treat mouse primary hepatic stellate cells(HSCs)to observe its effect on activation,migration,and proliferation of HSCs and explore the possible mechanism underlying the anti-liver fibrosis function of *** with liver fibrosis received exogenous BMP7 intervention to observe improvement of liver fibrosis by using Masson’s trichrome staining and detecting the expression of the HSC activation indicator alpha-smooth muscle actin(α-SMA)and the collagen formation associated protein type I collagen(Col I).Changes in the dynamic expression of BMP7 during liver fibrosis in the human body were further *** In the process of liver fibrosis induced by carbon tetrachloride(CCl4)in mice,BMP7 protein expression first increased,followed by a decrease;there was a similar trend in the human *** process was accompanied by a sustained increase in TGF-β1 protein *** vitro experiment results showed that TGF-β1 inhibited BMP7 expression in a time-and dose-dependent *** contrast,high doses of exogenous BMP7 inhibited TGF-β1-induced activation

关键词： Liver fibrosis Bone morphogenetic protein Transforming growth factor Hepatic stellate cells

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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang kaiwen Bao kai Qu Xian Qin Kun Zhang Wuquan deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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SYNTHESIS AND CHARACTERIZATION OF COPOLYMERS BASED ON BENZOTHIADIZOLE-THIOPHENE-PHENYLENEVINYLENE

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Chinese Journal of Polymer Science 2010年第6期28卷 931-939页

作者： Zheng Wang kai-ge Meng Wei Zhang Xiao-jing Yang sheng-wei deng Ying Li College of Chemistry Sichuan UniversityChengdu 610064China

Two novel copolymers based on benzothiadizole-thiophene-phenylenevinylene have been synthesized through palladium catalyzed triple-bond polycondensation *** copolymers exhibit good solubility in common organic solvents such as CHCl;,CH;Cl;and *** structures and properties of the two copolymers are characterized by FT-IR,;H-NMR,UV-Vis absorbance（Abs）,gel permeation chromatography（GPC）,thermal gravimetric analysis and cyclic voltammetry（CV）.The copolymers of P;and P;show absorption spectra with maximum peak at 532 nm and 573 nm in solution,*** to their monomers M;and M;,the absorption peaks of P;and P;were red-shifted by 34 nm and 54 nm *** gravimetric analysis demonstrated that the polymers were stable and little weight loss was observed below 300℃.Cyclic voltammetry experiments showed that the band gaps of the copolymers were 1.81 eV and 1.62 eV,respectively,suggesting their potential for applications as organic solar cell materials.

关键词： Benzothiadizole Triple-bond polycondensation Synthesis Organic solar cell materials

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贵阳市居家老年人日常生活能力对生命质量的影响

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中国现代医学杂志 2018年第24期28卷 77-82页

作者：蒋芝月王秀红汪俊华李芳邓开盛戴黎黎贵州医科大学公共卫生学院贵州贵阳550025 贵州医科大学护理学院贵州贵阳550025 贵州医科大学附属医院感染科贵州贵阳550004

目的了解贵阳市居家老人生命质量(QOL)现况,探讨其日常生活能力(ADL)对QOL的影响。方法随机抽取贵阳市1 898名年龄≥60岁的居家老年人进行ADL和QOL调查,ADL对QOL的影响采用多元线性回归分析。结果贵阳市居家老年人QOL总分为(560.47±136... 详细信息

目的了解贵阳市居家老人生命质量(QOL)现况,探讨其日常生活能力(ADL)对QOL的影响。方法随机抽取贵阳市1 898名年龄≥60岁的居家老年人进行ADL和QOL调查,ADL对QOL的影响采用多元线性回归分析。结果贵阳市居家老年人QOL总分为(560.47±136.27)分;QOL维度影响从大到小依次为年龄和是否患慢性病、体育锻炼及文化程度和性别。在控制上述因素后发现,躯体性日常生活能力(PADL)对老年人总体QOL的生理机能(PF)、生理职能(RP)、社会功能(SF)、情感职能(RE)及精神职能(MH)5个维度有影响(P<0.05);工具性日常生活能力(IADL)对老年人总体QOL的PF、躯体疼痛(BP)、总体健康(GH)、活力(VT)及SF 5个维度有影响(P<0.05)。结论不同ADL对QOL及各维度有不同的影响。

关键词：居家养老老年人日常生活能力生命质量

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Effects of sand sedimentation and wind erosion around sand barrier:Numerical simulation and wind tunnel test studies

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Journal of Mountain Science 2023年第4期20卷 962-978页

作者： ZHANG kai ZHANG Hai-long deng Yu-hui QU Jian-jun WANG Zheng-hui LI sheng College of Civil Engineering Lanzhou Jiaotong UniversityLanzhou730000China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China

Based on numerical simulations,this study highlights the sedimentation and erosion problems around a sand barrier through the relationship between the shear stress of the surface around the sand barrier and the critical shear stress of sand *** numerical simulation results were verified using data measured by the wind tunnel *** results showed that when the porosity was the same,the size and position of the vortex on the leeward side of the sand barrier were related to the inlet wind *** the wind speed increased,the vortex volume increased and the positions of the separation and reattachment points moved toward the leeward *** the porosity of the sand barrier was 30%,the strength of the acceleration zone above the sand barrier was the highest,and the strength of the acceleration zone was negatively correlated with the *** erosion and sedimentation distance were related to wind *** an increase in wind speed,the sand grain forward erosion or reverse erosion areas on the leeward side of the sand barrier gradually replaced the sedimentation *** an increase in porosity,the sand sedimentation distance on the leeward side of the sand barrier gradually shortened,and the sand erosion area gradually *** sand sedimentation distance on the leeward side of the sand barrier with 30%porosity was the *** numerical simulation results were in good agreement with the wind tunnel test *** on the sand erosion and sedimentation results of the numerical simulation and wind tunnel test,when the porosity was 30%,the protection effect of the High Density Polyethylene(HDPE)board sand barrier was best.

关键词： Sand sedimentation Wind erosion Numerical simulation Wind tunnel test

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Future Digital Design and Manufacturing: Embracing Industry 4.0 and Beyond

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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1047-1049页

作者： sheng-Feng Qin kai Cheng School of Design Northumbria University College of Engineering Design and Physical SciencesBrunel University London

Digital design and manufacturing have been around for several decades from the numerical control of machine tools and automating engineering design in 1960s, through early Computer Aided Design （CAD）/Computer Aided Engineering analysis （CAE）/Computer Aided Manufacturing （CAM）, to modem digital design and manufacturing [1], and cloud manufacturing [2] converging into product lifecycle management （PLM） [3, 4] and Internet-enabled personalized manufacturing [5].

关键词： Digital design Future manufacturing Industry 4.0

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Metal-Backboned Polymer:Conception,Design and Synthesis

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Chinese Journal of Polymer Science 2023年第1期41卷 3-6页

作者： kai-Wen Zeng Hui-sheng Peng State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science Fudan UniversityShanghai200438China

The backbones of polymers are generally composed of non-metal elements such as C,N,O and *** we propose and synthesize a new class of polymers whose backbones are completely made from metal atoms connected by chemical bonds,and they are thus named metal-backboned *** a demonstration,nickel is selected as the metal to construct the nickel-backboned polymers with varied lengths,which are verified by mass spectrometry and studied by ultraviolet-visible *** metal-bonded polymers open up a new avenue to develop functional polymers in the future.

关键词： Metal-backboned Nickel Functional Polymer

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Neutrophils in liver diseases:pathogenesis and therapeutic targets

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Cellular & Molecular Immunology 2021年第1期18卷 38-44页

作者： kai Liu Fu-sheng Wang Ruonan Xu Peking University 302 Clinical Medical School BeijingChina Treatment and Research Center for Infectious Diseases The Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijingChina

Previously,it was assumed that peripheral neutrophils are a homogeneous population that displays antimicrobial ***,recent data have revealed that neutrophils are heterogeneous and are additionally involved in tissue damage and immune *** phenotypic and functional plasticity of neutrophils has been identified in patients with cancer,inflammatory disorders,infections,and other ***,neutrophils,with their autocrine,paracrine,and immune modulation functions,have been shown to be involved in liver diseases,including viral hepatitis,nonalcoholic steatohepatitis,alcoholic liver disease,liver fibrosis,cirrhosis,liver failure,and liver ***,this review summarizes the role of neutrophils in liver diseases.

关键词： Liver disease Liver injury Neutrophil Innate immunity Immunotherapy

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Probe Knots and Hopf Insulators with Ultracold Atoms

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Chinese Physics Letters 2018年第1期35卷 36-40页

作者： Dong-Ling deng sheng-Tao Wang kai Sun L.-M.Duan Department of Physics University of MichiganAnn ArborMichigan 48109USA Condensed Matter Theory Center and Joint Quantum Institute Department of PhysicsUniversity of MarylandCollege ParkMD 20742-4111USA Center for Quantum Information IIISTsinghua UniversityBeijing 100084 Department of Physics Harvard UniversityCambridgeMassachusetts 02138USA

Knots and links are fascinating and intricate topological *** influence spans from DNA and molecular chemistry to vortices in superfluid helium,defects in liquid crystals and cosmic strings in the early *** we find that knotted structures also exist in a peculiar class of three-dimensional topological insulators—the Hopf *** particular,we demonstrate that the momentum-space spin textures of Hopf insulators are twisted in a nontrivial way,which implies the presence of various knot and link *** further illustrate that the knots and nontrivial spin textures can be probed via standard time-of-flight images in cold atoms as preimage contours of spin orientations in stereographic *** extracted Hopf invariants,knots,and links are validated to be robust to typical experimental *** work establishes the existence of knotted structures in Hopf insulators,which may have potential applications in spintronics and quantum information processing.

关键词： Superfluid helium

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Oxidation behaviour of electron beam physical vapour deposition β-NiAlHf coatings at 1100℃ in dry and humid atmospheres

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Rare Metals 2016年第7期35卷 513-519页

作者： kai Yan Hong-Bo Guo Hui Peng sheng-kai Gong School of Materials Science and Engineering Beihang University Beijing Key Laboratory for Advanced Functional Material and Thin Film Technology Beihang University

NiA1 intermetallic compounds attract increas- ing attention for high-temperature applications due to their combination of excellent properties, especially as metallic protective coatings on superalloys or as bond coats in thermal barrier coatings （TBCs）. Oxidation behaviour of the β-NiA1Hf coatings prepared by electron beam physical vapour deposition （EB-PVD） was investigated at 1100 ℃ for short time and 100h in 20% 02＋Ar and 15 % H20 ＋ Ar, respectively. The results of mass changes re- veal that the addition of minor reactive element Hf sig- nificantly improves the cyclic oxidation resistance of the 13- NiA1 coatings in both dry and humid atmospheres. During the initial oxidation stage, water vapour retards the phase transformation from 0-A1203 to a-A1203. Moreover, com- pared with the case in dry atmosphere, water vapour sig- nificantly reduces the surface roughness of the oxide scales formed on EB-PVD β-NiA1Hf coatings after 100 h cyclic oxidation, which corresponds with the difference of surface morphologies of the oxide scales.

关键词： β-NiA1Hf coatings Water vapour Oxidation Phase transformation Roughness

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