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HBXIP blocks myosin-ⅡA assembly by phosphorylating and interacting with NMHC-ⅡA in breast cancer metastasis

Acta Pharmaceutica Sinica B 2023年第3期13卷 1053-1070页

作者： Lu Zhang Xiaolei Zhou Bowen Liu Xuhe Shi Xianmeng Li Feifei Xu Xueli Fu Xue Wang kai ye Tianzhi Jin Huimin Sun Qianqian Li Weiying Zhang Lihong ye State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Protein SciencesDepartment of Biochemistry and Molecular BiologyCollege of Life SciencesNankai UniversityTianjin 300071China College of Food Science&Biology Hebei University of Science and TechnologyShijiazhuang 050091China Henan Key Laboratory of Immunology and Targeted Drugs School of Laboratory MedicineXinxiang Medical UniversityXinxiang 453003China

Tumor metastasis depends on the dynamic balance of the actomyosin *** a key component of actomyosin filaments,non-muscle myosin-ⅡA disassembly contributes to tumor cell spreading and ***,its regulatory mechanism in tumor migration and invasion is poorly ***,we found that oncoprotein hepatitis B X-interacting protein(HBXIP) blocked the myosin-ⅡA assemble state promoting breast cancer cell ***,mass spectrometry analysis,co-immunoprecipitation assay and GST-pull down assay proved that HBXIP directly interacted with the assembly-competent domain(ACD) of non-muscle heavy chain myosin-ⅡA(NMHC-ⅡA).The interaction was enhanced by NMHC-ⅡA S1916 phosphorylation via HBXIP-recruited protein kinase PKCβⅡ.Moreover,HBXIP induced the transcription of PRKCB,encoding PKCβⅡ,by coactivating Sp1,and triggered PKCβⅡ kinase ***,RNA sequencing and mouse metastasis model indicated that the anti-hyperlipidemic drug bezafibrate(BZF) suppressed breast cancer metastasis via inhibiting PKCβⅡ-mediated NMHC-ⅡA phosphorylation in vitro and in *** reveal a novel mechanism by which HBXIP promotes myosin-ⅡA disassembly via interacting and phosphorylating NMHC-ⅡA,and BZF can serve as an effective anti-metastatic drug in breast cancer.

关键词： Breast cancer metastasis Actomyosin cytoskeleton HBXIP Myosin-IIA NMHC-IIA Phosphorylation PKCβII Bezafibrate

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Laparoscopic resection and endoscopic submucosal dissection for treating gastric ectopic pancreas

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2799-2808页

作者： Hui-Da Zheng Qiao-Yi Huang Yun-Huang Hu kai ye Jian-Hua Xu Department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Gastric ectopic pancreas(GEP)is a rare developmental abnormality that refers to the existence of pancreatic tissue in the stomach with no anatomical relationship with the main *** is usually difficult to diagnose through histological examination,and the choice of treatment method is *** To describe the endoscopic ultrasound characteristics of GEP and evaluate the value of laparoscopic resection(LR)and endoscopic submucosal dissection(ESD).METHODS Forty-nine patients with GEP who underwent ESD and LR in the Second Affiliated Hospital of Fujian Medical University from May 2018 to July 2023 were retrospectively *** on clinical characteristics,endoscopic ultrasonography(EUS),ESD,and LR were collected and *** characteristics of EUS and the efficacy of the two treatments were *** The average age of the patients was 43.31±13.50 years,and the average maximum diameter of the lesions was 1.55±0.70 *** lesion originated from the mucosa in one patient(2.04%),from the submucosa in 42 patients(85.71%),and from the muscularis propria in 6 patients(12.25%).Twenty-nine patients(59.20%)with GEP showed umbilical depression on *** most common initial symptom of GEP was abdominal pain(40.82%).Tumor markers,including carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9),were generally within the normal *** patient(2.04%)with GEP had increased CEA and CA-19-9 ***,no cancer tissue was found on postoperative pathological examination,and tumor markers returned to normal levels after resecting the *** was no significant difference in surgery duration(72.42±23.84 vs 74.17±12.81 min)or hospital stay(3.70±0.91 vs 3.83±0.75 d)between the two *** was more often used for patients with larger tumors and deeper *** amount of bleeding was significantly higher in LR than in ESD(11.28±16.87 vs 16.67±8.76 mL,P<0.05).Surgery was associated with complete resection of the lesion with

关键词： Ectopic pancreas Endoscopic ultrasonography Endoscopic submucosal dissection Laparoscopic resection

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Disturbance failure mechanism of highly stressed rock in deep excavation:Current status and prospects

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 611-627页

作者： Tao Wang Weiwei ye Liyuan Liu kai Liu Naisheng Jiang Xianhui Feng School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

This article reviews the current status on the dynamic behavior of highly stressed rocks under ***,the experimental apparatus,methods,and theories related to the disturbance dynamics of deep,high-stress rock are reviewed,followed by the introduction of scholars’research on deep rock deformation and failure from an energy ***,with a backdrop of highstress phenomena in deep hard rock,such as rock bursts and core disking,we delve into the current state of research on rock microstructure analysis and residual stresses from the perspective of studying the energy storage mechanisms in ***,the current state of research on the mechanical response and the energy dissipation of highly stressed rock formations is briefly ***,the insufficient aspects in the current research on the disturbance and failure mechanisms in deep,highly stressed rock formations are summarized,and prospects for future research are *** work provides new avenues for the research on the mechanical response and damage-fracture mechanisms of rocks under high-stress conditions.

关键词： deep rock with high stress highly stressed rock rock failure residual stress energy release

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基于物联网技术的鼋自然保护区生态监测系统设计

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绿色科技 2024年第4期26卷 34-37,43页

作者：叶锴吴丞昊梁谢恩单程雪黄天来丽水市青田县林业局浙江青田323900 浙江省森林资源监测中心浙江杭州310000 中共青田县委组织部浙江青田323900

开发了一套鼋自然保护区生态监测系统,用于鼋生存环境的动态监测。在传感器技术、信息传输技术等技术的支持下,首次设计了一种鼋自然保护区生态监测系统,在Arduino平台设计制作监测终端,采集保护区水域的水温、pH值、溶解氧、氨氮离子... 详细信息

开发了一套鼋自然保护区生态监测系统,用于鼋生存环境的动态监测。在传感器技术、信息传输技术等技术的支持下,首次设计了一种鼋自然保护区生态监测系统,在Arduino平台设计制作监测终端,采集保护区水域的水温、pH值、溶解氧、氨氮离子等参数,使用4G和云服务器技术将采集到的数据进行整合优化,用户可在Andriod端或Windows端APP实时查看数据。研究结果表明基于物联网技术的鼋自然保护区生态监测系统能实时准确监测保护区生态数据,并能进行实时的智能化分析,使得鼋自然保护区初步拥有了“电子皮肤”,管理者能随时为其生态环境“把脉”。

关键词：鼋自然保护区生态监测物联网

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Advances in the research of plant-derived natural products against retinoblastoma

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1391-1400页

作者： Jing-Chen Liu Chun-Li Zhang kai-ye Dong Ming-Jun Li Shu-Guang Sun Cai-Rui Li Department of Ophthalmology Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicinethe Fourth Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330003Jiangxi ProvinceChina School of Clinical Medicine Dali UniversityDali 671000Yunnan ProvinceChina School of Clinical Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology General Hospital of Southern Theatre CommandGuangzhou 510010Guangdong ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Dali UniversityDali 671000Yunnan ProvinceChina Department of Endocrinology the First Affiliated Hospital of Dali UniversityDali 671000Yunnan ProvinceChina

Retinoblastoma(RB)is a highly aggressive ocular tumor,and due to socioeconomic and medical constraints,many children receive treatment only in the metaphase and advanced clinical stages,resulting in high rates of blindness and *** several approaches exist in the treatment of RB,some children with the disease do not have satisfactory results because of various *** natural products have shown definite therapeutic effects in the treatment of various tumors and are also widely used in the study of *** review plant-derived natural products used in the study of anti-RB to provide ideas for the clinical application of these drugs and the development of new therapeutic drugs.

关键词： plant-derived retinoblastoma apoptosis cell cycle drug resistance

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自然时效对5A06铝合金自冲铆接接头性能的影响

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锻压技术 2024年第4期49卷 125-130页

作者：雷军乐刘高宇赵伦雷乐叶凯卢杰豪李承旺张亚平宋振东鲍丹阳桂林理工大学机械与控制工程学院广西桂林541004 深圳职业技术大学超声技术研究所广东深圳518055

为了研究自然时效对自冲铆接接头的影响,采用5A06铝合金进行自冲铆接,通过拉伸试验,从宏观层面研究自然时效对于5A06铝合金自冲铆接接头性能的影响,从微观层面分析了接头拉脱失效的形式和机理。结果表明:经过一年的自然时效,接头特有的... 详细信息

为了研究自然时效对自冲铆接接头的影响,采用5A06铝合金进行自冲铆接,通过拉伸试验,从宏观层面研究自然时效对于5A06铝合金自冲铆接接头性能的影响,从微观层面分析了接头拉脱失效的形式和机理。结果表明:经过一年的自然时效,接头特有的机械内锁结构由于其应力的释放,畸变程度降低,接头的平均峰值载荷下降了15.28%、平均失效位移上升了58.37%、平均能量吸收提升了55.92%。接头不同应力集中处的应力释放不均匀,上、下板应力的集中释放速率不一致,导致两组试验主要失效的部位不同。在经过一年自然时效处理后,接头失效点处的韧窝分布更加密集,形状更大且更深,接头的脆性降低,塑性增加。

关键词：自冲铆接 5A06铝合金薄板自然时效静力学性能微观分析

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高产酚酸菌株筛选及其在清香型白酒生产中的应用

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酿酒科技 2024年第7期 50-55页

作者：李锐江威吕义俊叶凯许银杨强杨生智陈申习劲牌有限公司劲牌研究院中药保健食品质量与安全湖北省重点实验室湖北黄石435100

为了筛选高产酚酸的功能菌株,对菌种库中保藏的213株菌进行底物平板初筛和产阿魏酸酯酶酶活测定复筛,初步得到4株具有产酚酸潜力的菌株M198、M202、B249和B263。针对4株菌进行实验室固态发酵,结果表明添加菌株M198(分枝横梗霉)酒样中酚... 详细信息

为了筛选高产酚酸的功能菌株,对菌种库中保藏的213株菌进行底物平板初筛和产阿魏酸酯酶酶活测定复筛,初步得到4株具有产酚酸潜力的菌株M198、M202、B249和B263。针对4株菌进行实验室固态发酵,结果表明添加菌株M198(分枝横梗霉)酒样中酚酸含量较高,M198麸皮种与桂花曲以1∶5配比时酒样中酚酸含量最高,达到103.48μg/L。通过产酶发酵实验确定菌株M198最适产酶条件为接种量10^(7)~10^(8)CFU/g、初始pH4.0、培养温度32℃、培养时间6 d。该菌株应用于车间生产时,酒样中酚酸含量与对照相比提高了29.31%,总酯含量提高了37.65%。本研究筛选获得了一株酚酸产量较高的分枝横梗霉,在清香型白酒生产中具有高产酚酸的能力,为提升清香型白酒的健康内涵提供了理论依据。

关键词：清香型白酒阿魏酸酯酶酚酸酿酒生产

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Hydrogen-induced marginal growth model for the synthesis of graphene by arc discharge

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Science China(Technological Sciences) 2021年第5期64卷 1074-1080页

作者： ZHANG Da ye kai LIANG Feng DAI YongNian Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming 650093China

High-quality graphene is prepared by arc discharge with low cost under hydrogen atmosphere. However, the growth mechanism of graphene synthesis by arc discharge remains unclear. In this paper, the hydrogen-induced marginal growth(HIMG) model is deduced to study the growth mechanism of graphene by combining experiment with numerical simulation results. First, the characteristics of thick edges and thin middle and containing hydrogen are verified by transmission electron microscopy and Raman spectroscopy, respectively. In addition, numerical simulation provides the chemical species and temperature range of graphene growth. Second, the marginal growth pattern of hydrogen transfer and carbon addition is introduced because the C–H and C–C reduce configuration energy and island energy, respectively. Meanwhile, the stacking growth at the margin of the graphene island leads to the longitudinal growth of graphene because of the Van der Waals force and the effect of self-assembly,increasing the number of graphene layers. Finally, graphene sheets with a small amount of hydrogen are deposited on the inner wall after annealing. The investigation of the growth mechanism of graphene under hydrogen atmosphere lays a foundation for the large-scale preparation of graphene by arc discharge.

关键词： hydrogen graphene growth mechanism hydrogen-induced marginal growth model arc discharge

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Synthesis and microwave absorption performance of heat-treated RF/SiO_(2)aerogels

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Defence Technology（防务技术） 2024年第4期34卷 177-186页

作者： Xinli ye Hao Yu kai Zheng Shan Li Xiaomin Ma Bangxiao Mao Junxiong Zhang School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072PR China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057PR China Yangtze River Delta Research Institute of Northwestern Polytechnical University Suzhou 215400PR China National Equipment New Material&Technology(Jiangsu)Co. LtdSuzhou 215400PR China Beijing Xinfeng Aerospace Equipment Co. LtdBeijing 100854PR China School of Textile and Clothing Nantong UniversityNantong 226019PR China

The well-designed composite with satisfactory electromagnetic microwave absorption at high temperatures remains a serious ***,we fabricated a resorcinol-formaldehyde/silica dioxide composite aerogel(RF/SiO_(2))with a three-dimensional network structure using sol-gel,atmospheric pressure drying technique as well as heat-treated processes to achieve enhanced microwave absorption capabilities in the low frequency *** pristine RF/SiO_(2)aerogel presented a typical micropores structure with a surface area,porous volume,and density of 146.82 m^(2)/g,62.40%,and 0.28 cm^(3)/g,***,the RF/SiO_(2)aerogel showed an effective absorption bandwidth of 3.56 GHz and a minimum reflection loss value of-46.10 d B at 2.25 mm after being heat-treated at 1500°C,while the maximum effective absorption bandwidth was 3.60 GHz at 2.30 *** intricate three-dimensional networks possessed remarkable impedance matching,multiple attenuation mechanisms,interfacial polarization,and dielectric loss,which were attributed to the exceptional ability to absorb electromagnetic *** offered a fresh approach to creating adaptable and effective microwave absorption materials in military defense.

关键词： RF/SiO_(2) Aerogel Heat-treated Microwave absorption

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JAX-CNV:A Whole-genome Sequencing-based Algorithm for Copy Number Detection at Clinical Grade Level

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1197-1206页

作者： Wan-Ping Lee Qihui Zhu Xiaofei Yang Silvia Liu Eliza Cerveira Mallory Ryan Adam Mil-Homens Lauren Bellfy kai ye Charles Lee Chengsheng Zhang Precision Medicine Center The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China The Jackson Laboratory for Genomic Medicine FarmingtonCT 06032USA School of Cyber Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Pathology and Laboratory Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA School of Computer Science and Technology Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China MOE Key Lab for Intelligent Networks&Networks Security Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China Department of Life Sciences Ewha Womans UniversitySeoul 03760South Korea

We aimed to develop a whole-genome sequencing(WGS)-based copy number variant(CNV)calling algorithm with the potential of replacing chromosomal microarray assay(CMA)for clinical ***-CNV is thus developed for CNV detection from WGS *** performance of this CNV calling algorithm was evaluated in a blinded manner on 31 samples and compared to the 112 CNVs reported by clinically validated CMAs for these 31 *** result showed that JAX-CNV recalled 100%of these ***,JAX-CNV identified an average of 30 CNVs per individual,representing an approximately seven-fold increase compared to calls of clinically validated *** validation of 24 randomly selected CNVs showed one false positive,i.e.,a false discovery rate(FDR)of 4.17%.A robustness test on lowercoverage data revealed a 100%sensitivity for CNVs larger than 300 kb(the current threshold for College of American Pathologists)down to 10×*** CNVs larger than 50 kb,sensitivities were 100%for coverages deeper than 20×,97%for 15×,and 95%for 10×.We developed a WGS-based CNV pipeline,including this newly developed CNV caller JAX-CNV,and found it capable of detecting CMA-reported CNVs at a sensitivity of 100%with about a FDR of 4%.We propose that JAX-CNV could be further examined in a multi-institutional study to justify the transition of first-tier genetic testing from CMAs to ***-CNV is available at https://***/TheJacksonLaboratory/JAX-CNV.

关键词： Copy number variant Chromosomal microarray assay Whole-genome sequencing JAX-CNV Genetic testing

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