检索结果-南通市图书馆

PM2RA: A Framework for Detecting and Quantifying Relationship Alterations in microbial Community

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2021年第1期19卷 154-167页

作者： Zhi Liu kai mi Zhenjiang Zech Xu Qiankun Zhang Xingyin Liu State Key Laboratory of Reproductive Medicine Center of Global HealthNanjing Medical UniversityNanjing 211166China Department of Pathogen Biology-microbiology Division Key Laboratory of Pathogen Biology of Jiangsu ProvinceNanjing Medical UniversityNanjing 211166China Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical UniversityNanjing 211166China School of Food and Technology State Key Laboratory of Food Science and TechnologyNanchang UniversityNanchang 330031China Key Laboratory of Holistic Integrative Enterology Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210003China

The dysbiosis of gut microbiota is associated with the pathogenesis of human ***,observing shifts in the microbe abundance cannot fully reveal underlying *** the relationship alterations(RAs)in the microbiome between health and disease statuses provides additional hints about the pathogenesis of human diseases,but no methods were designed to detect and quantify the RAs between different conditions ***,we present profile monitoring for microbial relationship alteration(PM2 RA),an analysis framework to identify and quantify the microbial *** performance of PM2 RA was evaluated with synthetic data,and it showed higher specificity and sensitivity than the co-occurrence-based *** of real microbial datasets showed that PM2 RA was robust for quantifying microbial RAs across different datasets in several *** applying PM2 RA,we identified several novel or previously reported microbes implicated in multiple ***2 RA is now implemented as a web-based application available at http://***2 ***/.

关键词： microbiome microbial relationship alteration Profile monitoring Network Human disease microbial community

Analysis of infections in the first 3-month after living donor liver transplantation

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第16期18卷 1975-1980页

作者： Chuan Li Tian-Fu Wen kai mi Chuan Wang Lu-Nan Yan Bo Li Division of Liver Transplantation West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To identify factors related to serious postoperative bacterial and fungal infections in the first 3 mo after living donor liver transplantation(LDLT).METHODS:In the present study,the data of 207 patients from 2004 to 2011 were *** pre-,intra-and post-operative factors were statistically *** transplantations were approved by the ethics committee of West China Hospital,Sichuan *** with definitely preoperative infections and infections within 48 h after transplantation were excluded from current *** potential risk factors were analyzed using univariate *** significant at a P minant bacterial pathogen,whereas Candida albicans was the most common fungal *** was the most common infection site for both bacterial and fungal *** age older than 45 years,preoperative hyponatremia,intensive care unit stay longer than 9 d,postoperative bile leak and severe hyperglycemia were independent risk factors for postoperative bacterial *** red blood cells transfusion and postoperative bacterial infection may be related to postoperative fungal ***:Predictive risk factors for bacterial and fungal infections were indentified in current ***-,intra-and post-operative factors can cause postoperative bacterial and fungal infections after LDLT.

关键词： Bacterial infection Fungal infection Living donor liver transplantation

SARS-CoV-2 encoded microRNAs are involved in the process of virus infection and host immune response

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2021年第3期35卷 216-227页

作者： Zhi Liu Jianwei Wang Yiyue Ge Yuyu Xu Mengchen Guo kai mi Rui Xu Yang Pei Qiankun Zhang Xiaoting Luan Zhibin Hu Ying Chi Xingyin Liu State Key Laboratory of Reproductive Medicine Center of Global HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Pathogen Biology-microbiology Division Key Laboratory of Pathogen of Jiangsu ProvinceSchool of Basic Medical ScienceNanjing Medical UniversityNanjingJiangsu 211166China National Health Commission Key Laboratory of Enteric Pathogenic microbiology Jiangsu Provincial Center for Diseases Control and PreventionNanjingJiangsu 210009China Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical UniversityNanjingJiangsu 211166China

The outbreak of COVID-19 caused by SARS-CoV-2 is spreading worldwide,with the pathogenesis mostly *** virus and host-derived microRNA(miRNA)play essential roles in the pathology of virus *** study aims to uncover the mechanism for SARS-CoV-2 pathogenicity from the perspective of *** scanned the SARS-CoV-2 genome for putative miRNA genes and miRNA targets and conducted in vivo experiments to validate the virus-encoded miRNAs and their regulatory role on the putative *** of such virus-encoded miRNAs,MR147-3p,was overexpressed that resulted in significantly decreased transcript levels of all of the predicted targets in human,i.e.,EXOC7,RAD9A,and TFE3 in the virus-infected *** analysis showed that the immune response and cytoskeleton organization are two of the most notable biological processes regulated by the infection-modulated ***,the genomic mutation of SARS-CoV-2 contributed to the changed miRNA repository and targets,suggesting a possible role of miRNAs in the attenuated phenotype of SARS-CoV-2 during its *** study provided a comprehensive view of the miRNA-involved regulatory system during SARS-CoV-2 infection,indicating possible antiviral therapeutics against SARS-CoV-2 through intervening miRNA regulation.

关键词： COVID-19 SARS-CoV-2 virus-encoded miRNA host miRNA virus infection immune response

尿石素A预处理对肝缺血再灌注损伤大鼠模型的保护作用

在线全文

学校读者我要写书评

暂无评论

临床肝胆病杂志 2020年第8期36卷 1783-1787页

作者：米凯黄锐核工业四一六医院(成都医学院第二附属医院)普外科成都610500 四川省人民医院肝胆外科成都610007

目的探讨尿石素A(Uro-A)对肝缺血再灌注损伤(HIRI)大鼠模型的保护作用。方法将40只SD大鼠随机分为假手术组、模型组、Uro-A低剂量组(1 mg/kg)和Uro-A高剂量组(3 mg/kg),每组10只。造模前Uro-A低剂量和高剂量组每天灌胃药物1次,持续5 d... 详细信息

目的探讨尿石素A(Uro-A)对肝缺血再灌注损伤(HIRI)大鼠模型的保护作用。方法将40只SD大鼠随机分为假手术组、模型组、Uro-A低剂量组(1 mg/kg)和Uro-A高剂量组(3 mg/kg),每组10只。造模前Uro-A低剂量和高剂量组每天灌胃药物1次,持续5 d。动物麻醉后造模,恢复血流后6 h检测血清中ALT、AST与乳酸脱氢酶(LDH)的含量,ELISA法检测肝组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、过氧化氢酶(CAT)、IL-1β、IL-6和TNFα含量,观察肝脏病理损伤与肝细胞凋亡情况,Western Blot法检测肝脏中内质网分子伴侣葡萄糖调节蛋白78(GRP78)、下游应激转录因子(CHOP)和凋亡蛋白家族(Caspase-12)的表达水平。计量资料多组间比较采用单因素方差分析,进一步两两比较采用LSD-t检验。结果Uro-A高剂量组ALT、AST、LDH、MDA、CAT、IL-1β、IL-6、TNFα、CHOP、GRP78、Caspase-12水平及凋亡率均较模型组降低,SOD含量较模型组升高,差异均有统计学意义(P值均<0.05)。模型组肝脏结构破坏严重,阳性率90%,Uro-A高剂量组肝脏结构完好,未见明显组织增生与炎性细胞增多,阴性率80%。与Uro-A高剂量组相比,Uro-A低剂量组ALT、AST、LDH水平和细胞凋亡率均显著升高(P值均<0.05)。结论Uro-A预处理可降低大鼠肝脏缺血再灌注造成的损伤,减少氧化损伤与炎症因子的释放,其机制与通过抑制内质网应激通路减少肝细胞的凋亡有关。

关键词：肝疾病再灌注损伤尿石素A 大鼠,Sprague-Dawley

乙醛脱氢酶2型与乙醛在肿瘤发生发展中的作用

在线全文

学校读者我要写书评

暂无评论

中国肿瘤 2019年第1期28卷 39-45页

作者：李凯咪邓炯上海交通大学医学院病理生理系上海200025

乙醛脱氢酶2型(aldehyde dehydrogenase 2 family,ALDH2)是一种线粒体酶,其主要作用是将乙醛(acetaldehyde,ACE)代谢成乙酸,以供后续参与生物体的能量代谢与生物合成。在人群中,ALDH2活性位点存在高频率变异,致使该人群对酒精不耐受,易... 详细信息

乙醛脱氢酶2型(aldehyde dehydrogenase 2 family,ALDH2)是一种线粒体酶,其主要作用是将乙醛(acetaldehyde,ACE)代谢成乙酸,以供后续参与生物体的能量代谢与生物合成。在人群中,ALDH2活性位点存在高频率变异,致使该人群对酒精不耐受,易患急性酒精中毒等饮酒相关疾病。越来越多的证据显示,ALDH2基因的多样性在肿瘤的发生、生长、转移和抗药性中也发挥着重要作用。文章回顾了ALDH2以及其底物ACE在肿瘤研究中的最新进展,阐述了可调控其活性的药物及调控机制,并预测ALDH2可能成为癌症预后的标志物和癌症治疗的新靶点。

关键词：乙醛脱氢酶2型乙醛肿瘤

在线全文

学校读者我要写书评

暂无评论

肝右动脉假性动脉瘤位于胆囊腔内一例

中华肝胆外科杂志 2021年第5期27卷 385-386页

作者：王明郑振江米凯成都市第三人民医院西南交通大学附属医院重庆医科大学附属成都第二临床医学院肝胆胰外科成都610031 四川大学华西医院胰腺外科成都610041 核工业四一六医院成都医学院第二附属医院普外科成都610051

患者女性,54岁,既往有慢性结石性胆囊炎反复发作病史,因"反复右上腹疼痛5年余,加重半个月"入院。影像学检查提示慢性结石性胆囊炎急性发作,肝右动脉假性动脉瘤形成并破入胆囊腔内。择期手术行肝右动脉假性动脉瘤切除术、胆囊切除术。术... 详细信息

患者女性,54岁,既往有慢性结石性胆囊炎反复发作病史,因"反复右上腹疼痛5年余,加重半个月"入院。影像学检查提示慢性结石性胆囊炎急性发作,肝右动脉假性动脉瘤形成并破入胆囊腔内。择期手术行肝右动脉假性动脉瘤切除术、胆囊切除术。术后病理证实肝右动脉假性动脉瘤形成,胆囊慢性炎、急性病变伴灶状坏死。

关键词：肝右动脉假性动脉瘤胆囊腔急性病变灶状坏死慢性结石性胆囊炎择期手术慢性炎

在线全文

学校读者我要写书评

暂无评论

竞争情报在企业危机预警中的应用

情报科学 2008年第2期26卷 192-196页

作者：史尚元糜凯北京师范大学图书馆北京100875

从竞争情报与危机预警的概念入手,探讨了竞争情报和企业危机预警的契合之处,从竞争情报在企业危机预警中的作用、企业危机预警中竞争情报的战略价值、企业危机预警中竞争情报工作的原则和企业危机预警中竞争情报工作应关注的问题这四个... 详细信息

从竞争情报与危机预警的概念入手,探讨了竞争情报和企业危机预警的契合之处,从竞争情报在企业危机预警中的作用、企业危机预警中竞争情报的战略价值、企业危机预警中竞争情报工作的原则和企业危机预警中竞争情报工作应关注的问题这四个方面对竞争情报在企业危机预警中的应用进行了分析。

关键词：竞争情报危机预警危机情报

在线全文

学校读者我要写书评

暂无评论

羧甲基改性糊料在活性染料印花中的应用研究

印染助剂 2014年第6期31卷 33-38页

作者：米凯吴华汪青中原工学院纺织学院河南郑州450007 杭州万事利丝绸科技有限公司浙江杭州310021

通过稳态剪切扫描试验,研究了羧甲基取代度对多糖类印花色浆流变性能的影响;并进行平网印花,探讨了糊料流变性与印制性能之间的关系.研究结果表明：羧甲基纤维素取代度对色浆流变性能的影响明显,取代度为1.35的羧甲基纤维素糊料的色浆... 详细信息

通过稳态剪切扫描试验,研究了羧甲基取代度对多糖类印花色浆流变性能的影响;并进行平网印花,探讨了糊料流变性与印制性能之间的关系.研究结果表明：羧甲基纤维素取代度对色浆流变性能的影响明显,取代度为1.35的羧甲基纤维素糊料的色浆粘度明显高于取代度为1.49的羧甲基纤维素.随取代度的增加,纯羧甲基纤维素糊料的色浆粘度虽然逐渐变小,但得色量增加,印透性变好.色浆所含原糊中羧甲基纤维素含量为15%时,印制花纹较为清晰,得色量高,印花后织物手感柔软.取代度为0.76-0.84时,纯羧甲基淀粉糊的色浆粘度变化不大,但得色量降低,印透性变大.

关键词：活性染料色浆流变性能印制性能

在线全文

学校读者我要写书评

暂无评论

组织工程在医学中的应用

中国医学科学院学报 2001年第2期23卷 189-192页

作者：宓开鸿李继承浙江大学医学院细胞生物学与组织工程学研究所杭州310031

组织工程学是一门新学科，它以工程学和生命科学为原理，研制生物结构，为解决组织和器官缺损所致的功能障碍或丧失的治疗问题提供广阔的前景。近几十年来的研究取得很大成功，并且应用于临床。本文根据各组织器官胚层发育的来源，综述... 详细信息

组织工程学是一门新学科，它以工程学和生命科学为原理，研制生物结构，为解决组织和器官缺损所致的功能障碍或丧失的治疗问题提供广阔的前景。近几十年来的研究取得很大成功，并且应用于临床。本文根据各组织器官胚层发育的来源，综述组织工程学在医学中的应用进展。

关键词：组织工程学中胚层组织工程医学应用内胚层组织工程