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组织科学中的可重复性检验与理论发展: 以批判实在论为视角

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实证社会科学 2018年第1期 47-80页

作者： Eric W.K.Tsang kai man kwan 谢恩[译] 不详西安交通大学管理学院

在此文中我们从批判实在视角评估了可重复性检验在理论发展中所扮演的角色。我们首先概述了批判实在论,而后将之运用于回应可重复性检验并不适用于社会科学的观点。之后我们将可重复性分为6类和2个维度。最后,我们详尽论证了可重复性检... 详细信息

在此文中我们从批判实在视角评估了可重复性检验在理论发展中所扮演的角色。我们首先概述了批判实在论,而后将之运用于回应可重复性检验并不适用于社会科学的观点。之后我们将可重复性分为6类和2个维度。最后,我们详尽论证了可重复性检验在社会科学研究中的重要性,并提出了一个可与组织科学其他分散模式整合的知识积累多焦点模式。

关键词：批判实在论可重复性知识积累社会科学研究模式整合扮演的角色视角重要性

组织科学中的可重复性检验与理论发展:以批判实在论为视角

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组织科学中的可重复性检验与理论发展:以批判实在论为视角

Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence

作者： Eric W.K.Tsang kai man kwan 谢恩西安交通大学管理学院

在此文中我们从批判实在视角评估了可重复性检验在理论发展中所扮演的角色。我们首先概述了批判实在论,而后将之运用于回应可重复性检验并不适用于社会科学的观点。之后我们将可重复性分为6类和2个维度。最后,我们详尽论证了可重复性检...

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Engineering 2022年第3期8卷 57-64页

作者： Jiang Liu Chung Mau Lo kwan man Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 102218China Department of Surgery HKU-Shenzhen Hospital&LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China

Hepatic malignancy is a major indication for liver transplantation;however,post-tra ns plant cancer recurrence is an emerging clinical challenge affecting long-term ***-tra ns plant tumor biology,staging,and post-transplant immunosuppression regimens have been elucidated as risk factors for recurrent liver ***,increasing evidence indicates that hepatic ischemia and reperfusion(IR)injury to allografts are crucial to providing a favorable immunologic microenvironment for cancer cell invasiveness and metastasis after liver *** association of severe graft injury in marginal grafts,such as small-for-size or fatty grafts,with lower recurrence-free survival rates in living donor liver transplantations,substantiates the correlation between hepatic IR injury and cancer *** has been demonstrated to trigger intrahepatic immunological microenvironment remodeling,including pro-inflammatory responses exacerbating graft injury and anti-inflammatory responses promoting tissue ***,the role of regional immunity in post-transplant cancer recurrence is not comprehensively *** review describes the up-to-date evidence of the intrahepatic humoral microenvironment and regional regulatory immunological microenvironment induced by IR injury,as well as their roles in cancer recurrence after liver transplantation.A comprehensive understanding of regional immunity will provide novel precise diagnostic,therapeutic,and prognostic strategies for post-transplant cancer recurrence.

关键词： Liver transplantation Liver cancer Recurrence Immunology

Recent progress on the Dirichlet divisor problem and the mean square of the Riemann zeta-function

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Science China Mathematics 2010年第9期53卷 2561-2572页

作者： TSANG kai-man Department of Mathematics The University of Hong Kong

Let Δ(x) and E(t) denote respectively the remainder terms in the Dirichlet divisor problem and the mean square formula for the Riemann zeta-function on the critical *** article is a survey of recent developments on the research of these famous error terms in number *** include upper bounds,Ω-results,sign changes,moments and distribution,etc.A few open problems are also discussed.

关键词： divisor problems Riemann’s zeta-function mean values

Features of Ciguatera Fish Poisoning Cases in Hong Kong 2004-2007

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Biomedical and Environmental Sciences 2008年第6期21卷 521-527页

作者： CHUN-kwan WONG PATRICIA HUNG KELLIE L. H. LEE TINA MOK THOMAS CHUNG kai-man KAM Biotoxin Laboratory Public Health Laboratory Services Branch Centre for Health Protection Department of Health Shek Kip Mei Kowloon Food and Environmental Hygiene Department Queensway Government Offices

Ohjective To review the clinical features and laboratory investigations of ciguatera patients in Hong Kong between 2004 and 2007 in order to show the timely sampling of implicated fish from ciguatera victims and application of validated mouse bioassay for confirming suspected clinical cases of ciguatera. Methods Diagnosis of the ciguatera victims was based on history of coral fish consumption and clinical presentations stated in official guidelines for clinical diagnosis of ciguatera fish poisoning in Hong Kong. Food remnants of coral fish samples were collected swiftly from ciguatera victims between 2004 and 2007 for ciguatoxins （CTXs） analysis. Results Major clinical symptoms in ciguatera patients included gastrointestinal and neurological effects including limb numbness and diarrhoea, which developed at 0.5 to 15 hours after consumption of fish. In most cases, neurological symptoms were more common than gastrointestinal symptoms. A broad range of attack rate （10%-100%） was observed in each ciguatera outbreak. Validated mouse bioassay on ether extracts of the food remnant samples confirmed that all were CTXs-positive （〈0.5 - 4.3 MU/20 mg ether extract） and directly linked to the corresponding ciguatera cases. Conclusion Consistency between clinical and laboratory analysis for ciguatera poisoning illustrates the application of laboratory mouse bioassay in a timely fashion for confirming ciguatera poisoning cases and implementing effective public health measures. With further improvement in laboratory techniques, features of ciguatera fish poisoning cases can be better defined, Further studies are needed to determine the risk of each class of CTXs （Pacific-, Indian- and Caribbean-CTXs） in Hong Kong.

关键词： Ciguatera poisoning Ciguatoxin Food remnants Hong Kong Mouse bioassay

A diagnostic and screening strategy with neutrophil counts in patients with suspected aortic dissection in a certain time window

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World Journal of Emergency Medicine 2023年第4期14卷 307-311页

作者： Hon Chun kai man Siu Department of Accident&Emergency Tseung Kwan O HospitalHong KongChina Department of Accident&Emergency United Christian HospitalHospitalHong KongChina

Aortic dissection(AD)is a potentially devastating cardiovascular disease ***,given the low incidence of AD(2.5 to 3.5 cases per 100,000person-years),the diagnosis of this disease remains relatively difficult in emergency settings.[1,2]Computed tomography aortogram(CTA)is the most commonly used diagnostic tool,which is an invasive investigation with renal impairment and is cost *** are lots of patients at low or moderate risk of AD,which may be no need for CTA *** a result,validated clinical strategies beyond clinical judgment are needed to manage patients with suspected AD.

关键词： patients dissection diagnosis

Waring-Goldbach Problem for Unlike Powers

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Acta Mathematica Sinica,English Series 2007年第2期23卷 265-280页

作者： Xiu Min REN kai man TSANG Department of Mathematics Shandong University Department of Mathematics The University of Hong Kong

In this paper, it is proved that with at most O（N65/66） exceptions, all even positive integers up to N are expressible in the form p^2 2＋p^3 3＋p^4 4＋p^5 5. This improves a recent result O（N19193/19200＋ε） due... 详细信息

关键词： Waring-Goldbach problem circle method exceptional set

A green light-enhanced cytosolic protein delivery platform based on BODIPY-protein interactions

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Nano Research 2023年第1期16卷 1042-1051页

作者： Yang Zhou Yifan Gao Li Pang Weirong Kang kwan man Weiping Wang State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Dr.Li Dak-Sum Research Centre The University of Hong KongHong KongChina Department of Surgery School of Clinical MedicineHKU-SZH&LKS Faculty of MedicineThe University of Hong KongHong KongChina

Development of cytosolic protein delivery platforms brings new possibilities for various incurable *** based on polymer/protein self-assembly have shown their potential in protein ***,versatile photocontrolled platforms based on self-assembly for protein delivery are seldom ***,we report a boron-dipyrromethene(BODIPY)-modified polyamidoamine(PAMAM)with excellent photo-controllability and efficiency for the cytosolic delivery of various *** serum stability was achieved by coating hyaluronic acid and human serum albumin on the surface of BODIPY-modified PAMAM/protein *** nanoparticles under green light irradiation allowed efficient intracellular delivery of multiple cargo proteins with different charges and molecular weights and promoted endosome *** study provides valuable guidance for the development of BODIPY derivative-based protein delivery systems and advances the research in intracellular protein delivery.

关键词： photoresponsive nanoparticles intracellular delivery protein delivery polyamidoamine(PAMAM) boron-dipyrromethene(BODIPY)

Development of An ICR Mouse Bioassay for Toxicity Evaluation in Neurotoxic Poisoning Toxins-Contaminated Shellfish

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Biomedical and Environmental Sciences 2013年第5期26卷 346-364页

作者： WONG Chun kwan HUNG Patricia KAM kai man Biotoxin Laboratory Microbiology DivisionPublic Health Laboratory Services BranchCentre for Health ProtectionDepartment of HealthShek Kip MeiKowloon

Objective To develop an ICR （female） mouse bioassay （MBA） for toxicity confirmation and evaluation of neurotoxins （brevetoxins）-contaminated shellfish. Methods Brevetoxins （BTX-B） as a causative agent of neurotoxic shellfish poisoning （NSP） under different shellfish matrices were intraperitoneally injected at different doses into mice to study their toxic effects and to differentiate the range of lethal and sublethal dosages. Their sensitivity and specificity were analyzed with 2 competitive ELISA kits for quantitative determination of standard BTX-B and dihydroBTX-B under different shellfish matrix-diluent combinations. Detection rates of MBA and two antibody-based assays for BTX-B from field NSP-positive shellfish samples were compared. Results BTX-B could be detected in shellfish tissues at concentration of 50-400 μg/100 g under shellfish matrix-Tween-saline media, which were appropriate to identify toxic shellfish at or above the regulatory limit （80 μg/100 g shellfish tissues）. The LD 50 identified was 455 g/kg for BTX-B under general shellfish matrices （excluding oyster matrices） dissolved in Tween-saline. The presence of shellfish matrices, of oyster matrices in particular, retarded the occurrence of death and toxicity presentation in mice. Two antibody-based assays, even in the presence of different shellfish matrix-diluent combinations, showed acceptable results in quantifying BTX-B and dihydroBTX-B well below the regulatory limit. Conclusion The two ELISA analyses agree favorably （correlation coefficient, r 0.96; Student＇s t-tests, P〉0.05） with the developed bioassay.

关键词： Antibody-based assay Brevetoxin ICR female mice LD 50 Mouse bioassay Neurotoxic shellfish poisoning