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Assessing the Diagnostic Accuracy of SD BIOLINE for Detection of Hepatitis C Virus:A Systematic Review and Meta-analysis

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Infectious Microbes & Diseases 2023年第2期5卷 76-82页

作者： Shu-Chang weng Jie Zhou Xiao-Ying Zhong Qing Xin Yue-Xue Mai Li-Qin Ji Ya-Ping Li Xun-Jie Cao Wen-Hui Yang Hao-kai Chen Xu-Guang Guo Department of Clinical Laboratory Medicine The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Clinical Medicine The Third Clinical School of Guangzhou Medical UniversityGuangzhouChina Department of Pediatrics The Pediatrics School of Guangzhou Medical UniversityGuangzhouChina Department of Clinical Medicine The Sixth Clinical School of Guangzhou Medical UniversityGuangzhouChina Guangdong University of Foreign Studies GuangzhouChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases King Med School of Laboratory MedicineGuangzhou Medical UniversityGuangzhouChina.

Hepatitis C virus(HCV)is a globally widespread ribonucleic acid virus that transmits through blood and sexual *** morbidity and mortality are particularly higher in economically underdeveloped ***,an economical and effective diagnostic method for detection of HCV is urgently *** this study,we evaluated the diagnostic accuracy of the SD BIOLINE rapid diagnostic test for HCV *** searched for studies related to SD BIOLINE and HCV in PubMed,Embase,Web of Science,and the Cochrane Library and then designed inclusion and exclusion *** extracting valid data,the included literature was evaluated with the quality assessment tool Quality Assessment of Diagnostic Accuracy *** our data analysis,the sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,diagnostic accuracy,summary receiver operating characteristic curve,funnel plot,box plot,and Fagan plot of the diagnosticmethod were *** articles with nine sets of data were finally *** sensitivity and specificity were 0.94 and 0.98,respectively,the positive likelihood ratio was 79.53,the negative likelihood ratio was 0.05,the diagnostic odds ratio was 1590.32,and the summary receiver operating characteristic curve was *** SD BIOLINE test has the advantages of high sensitivity,high specificity,low cost,and easy operation for diagnosing ***,we recommend using SD BIOLINE for rapid and effective screening of HCV,which is especially applicable for economically underdeveloped areas.

关键词： SD BIOLINE HCV rapid diagnosis

China artificial joint annual data report

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Chinese Medical Journal 2021年第6期134卷 752-753页

作者： Bin Feng Wei Zhu Yan-Yan Bian Xiao Chang kai-Yuan Cheng Xi-Sheng weng Department of Orthopaedics Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

To the Editor:Artificial joint replacement,the most effective treatment for end-stage arthropathy of the hip and knee joint caused by various reasons,has been popularly performed around the world.[1]It was reported the number of total hip replacement case in the United States in 2017 was 1.1 million and the number of total knee replacement case in 2018 was 1.3 million.[2]And the case number is increasing *** the biggest population in the world,there is a big volume of joint replacement procedures in ***,there is lack of artificial joint annual data report in China *** this study,we intended to collect the data of artificial joint replacement in the mainland of China within the recent 10 years,and make a preliminary artificial joint annual report.

关键词： artificial China. annually

Differences in Variation of Human Immunodeficiency Virus Type 1 Sequences from Henan and Shanghai Regions of China

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中国病毒学 2007年第3期22卷 212-217页

作者： Chun-yu YIN　 Hong-zhou LU　 Wei-ming JIANG　 Maria Pia De Pasquale　 Yue-kai HU　 Xiao-zhang PAN　 Xin-hua weng　 Richard T. D＇Aquila　 Yi-Wei TANG Department of Infectious Diseases Fudan University Huashan Hospital Shanghai 200040China Department of Infectious Diseases the Sixth People＇s Hospital Hangzhou 310014 China Division of Infectious Diseases Department of Medicine Tennessee 37232 USA Departments of Pathology Tennessee 37232 USA Microbiology and Immunology Vanderbilt University Medical Center Nashville Tennessee 37232 USA

Illegally paid blood donation was a risk factor for HIV acquisition exclusively in Henan and Hubei Provinces of China,and not in *** sequences in the gag and env genes of HIV-1 were compared between isolates from Henan and Shanghai regions of China to test whether an expected higher degree of a common source of infections from this unique blood donation transmission risk would be evident as decreased variation among Henan isolates in an exploratory cross-sectional *** 38 isolates studied,23 of 23(100%)from Henan and 8 of 15(54%)from Shanghai were subtype *** addition,fewer sequence differences were found in gp41 of subtype B isolates from Henan than from Shanghai *** studies with additional controls are therefore warranted to confirm the role of the degree of a common source of infections in differences in HIV variation across populations.

关键词：人类免疫缺陷病毒河南上海序列分析艾滋病病毒

Distributed Timestamp Synchronization for End Hopping

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China Communications 2011年第4期8卷 164-169页

作者：林楷贾春福翁臣 College of Information Technical Science Nankai University

End hopping is an active and effective technology for defending against adversaries in the network *** is a key technology of end ***,the common synchronization methods are insufficient for end *** on timestamp synchronization,this paper proposes a novel method of Distributed Timestamp Synchronization(DTS)to improve the capacity of *** uses a list of timestamp servers which are located all over the Internet to synchronize timestamp,and a list of clock offsets to adjust the synchronized *** can overcome the main deficiencies(request overwhelming and boundary failure)of timestamp *** show that DTS is a feasible synchronization technology for end hopping.

关键词： network security end hopping synchronization distributed timestamp synchronization

Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease:Current Progress and Challenges

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Engineering 2024年第9期40卷 51-60页

作者： Ernesto Saenz Nathally Espinosa Montagut Baohong Wang Christoph Stein-Thöringer kaicen Wang Honglei weng Matthias Ebert kai Markus Schneider Lanjuan Li Andreas Teufel Division of Hepatology Division of Clinical BioinformaticsDepartment of Medicine ⅡMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Clinical Cooperation Unit Healthy Metabolism Center for Preventive Medicine and Digital HealthMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany School of Medicine Universidad de Los AndesBogotá111711Colombia State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Internal MedicineⅠ University Clinic Tuebingen&CoE CMFI(Controlling Microbes to Fight Infections)Tuebingen 72074Germany Department of MedicineⅡ Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany DKFZ Hector Cancer Institute at the University Medical Center Mannheim 69120Germany Molecular Medicine Partnership Unit European Molecular Biology LaboratoryHeidelberg 69117Germany Department of MedicineⅢ University Hospital RWTH AachenAachen 52074Germany

The prevalence of metabolic-dysfunction-associated steatotic liver disease(MASLD)is alarmingly high;it is estimated to affect up to a quarter of the global population,making it the most common liver disorder *** is characterized by excessive hepatic fat accumulation and is commonly associated with comorbidities such as obesity,dyslipidemia,and insulin resistance;however,it can also manifest in lean ***,it is crucial to develop effective therapies for this complex ***,there are no approved medications for MASLD treatment,so there is a pressing need to investigate alternative *** research has characterized MASLD as a multifaceted disease,frequently linked to metabolic disorders that stem from dietary *** suggests that changes in the gut microbiome play a fundamental role in the development and progression of MASLD from simple steatosis to steatohepatitis and even hepatocellular carcinoma(HCC).In this review,we critically examine the literature on the emerging field of gut-microbiota-based therapies for MASLD and metabolicdysfunction-associated steatohepatitis(MASH),including interventions such as fecal microbiota transplantation(FMT),probiotics,prebiotics,short-chain fatty acids,antibiotics,metabolic pathway targeting,and immune checkpoint kinase blockade.

关键词： Microbiome Fecal microbiota transplantation Metabolic-dysfunction-associated steatotic liver disease Fatty liver

Midkine ameliorates LPS-induced apoptosis of airway smooth muscle cells via the Notch2 pathway

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Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 512-519页

作者： Qi-Feng Huang Bo Wang Yu-Qing weng Tang Deng Li-Hua Li Jin Qian Qi Li kai-Wen Lin Dong-Mei Sun Shuang-Qin Xu Hang-Fei Wang Xin-Xin Wu Yuan-Tian Sun Xiao-Ran Liu Emergency Department The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China Jiangdong Health Center Haikou 571126China Department of Pulmonary and Critical Care Medicines Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519050China College of Pharmacy Hainan Medical UniversityHaikou 570100China Shandong Heze Mudan People’s Hospital Heze 274007China Emergency and Trauma College Hainan Medical UniversityHaikou 570100China College of Basic Medicine and Life Sciences Hainan Medical UniversityHaikou 570100China Key Laboratory of Emergency and Trauma of Ministry of Education Haikou 570100China

Objective:To evaluate the effect of midkine on lipopolysaccharide(LPS)-induced airway smooth muscle cells(ASMCs).Methods:LPS-stimulated acute lung injury model was used to analyze the effect of midkine on ASMCs in *** midkine and midkine siRNA were used to investigate the role of Notch2 signaling *** proliferation was assessed using Cell Counting Kit-8 ***,apoptosis was measured by flow cytometry and protein and mRNA expression of midkine and Notch2 was assessed by Western blotting and qPCR,*** analysis was also ***:LPS increased the mRNA and protein expression of midkine and *** silencing reduced LPS-induced midkine and Notch2 *** addition,midkine silencing further reduced the viability and increased apoptosis of ASMCs induced by LPS,which was attenuated by recombinant ***:The midkine/Notch2 signaling pathway plays a regulatory role in ASMC proliferation and apoptosis in airway inflammation.

关键词： Acute lung injury Airway smooth muscle cells Midkine Notch2 Lipopolysaccharide

高功率微波等离子体环境下甲烷浓度对金刚石膜的影响

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化工学报 2018年第A2期69卷 505-511页

作者：罗凯汪建华余军火翁俊武汉工程大学湖北省等离子体化学与新材料重点实验室湖北武汉430073

在实验室自制的10 kW微波等离子体化学气相沉积装置中,分析了高功率微波等离子体环境中甲烷浓度对金刚石膜生长的影响。利用等离子体发射光谱诊断分析高功率微波等离子体放电环境的特征,同时利用SEM及Raman光谱对不同沉积条件下获得的... 详细信息

在实验室自制的10 kW微波等离子体化学气相沉积装置中,分析了高功率微波等离子体环境中甲烷浓度对金刚石膜生长的影响。利用等离子体发射光谱诊断分析高功率微波等离子体放电环境的特征,同时利用SEM及Raman光谱对不同沉积条件下获得的金刚石膜的形貌及质量进行表征,以确定高功率微波等离子体环境下金刚石膜生长的最优甲烷浓度范围。实验表明在保持微波功率为5000W,CH_4/H_2≤1%时,金刚石膜中二次形核现象明显,晶粒尺寸较小;CH_4/H_2≥2.5%时,金刚石膜可获得较大的晶粒,但易于产生孪晶体;CH_4/H_2=1.5%～2%时,可获得晶粒完整且质量较高的金刚石膜。

关键词：甲烷高微波功率微波等离子体化学气相沉积

焊接连接预制混凝土梁-板子结构抗连续倒塌性能研究

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建筑结构学报 2020年第10期41卷 121-128页

作者：李治翁运昊邓小芳钱凯广西大学土木建筑工程学院广西南宁530004 桂林理工大学土木与建筑工程学院广西桂林541004

通过试验与有限元分析研究焊接连接预制混凝土(PC)梁-板子结构的抗连续倒塌性能。在实验室制作1个焊接连接PC梁-板子结构缩尺模型,采用Pushdown加载方法并考虑工作荷载对结构倒塌过程的影响,研究该子结构在去除1个边柱工况下的抗力曲线... 详细信息

通过试验与有限元分析研究焊接连接预制混凝土(PC)梁-板子结构的抗连续倒塌性能。在实验室制作1个焊接连接PC梁-板子结构缩尺模型,采用Pushdown加载方法并考虑工作荷载对结构倒塌过程的影响,研究该子结构在去除1个边柱工况下的抗力曲线、梁板变形、钢筋应变及有效抗力机制。试验结果表明,尽管假设动力放大系数为2.0,试验模型在瞬间移除1个边柱工况下也不会发生连续倒塌,焊接连接PC试件的破坏首先发生于焊缝处栓钉断裂。为了解焊接连接PC子结构抗倒塌机理及各主要构件的抗力贡献,通过商业软件ANSYS/LSDYNA进行数值分析并开展拓展分析。通过对比试验及有限元模拟结果发现,采用LSDYNA软件可以准确模拟试件的破坏模态及受力特性。有限元分析结果表明:在受荷初始阶段,预制板及叠合层对抗倒塌承载力的贡献只占30%,抗力主要由预制梁发展梁机制承担;但是在后期大变形阶段,预制板及叠合层对抗倒塌承载力的贡献可高达80%,叠合层中的钢筋网发展拉膜作用是后期大变形阶段试件的主要抗力机制。

关键词：预制混凝土梁-板子结构焊接连接 Pushdown分析抗力机制连续倒塌

钢支撑加固RC框架抗连续倒塌试验与数值模拟研究

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振动与冲击 2022年第5期41卷 173-181页

作者：翁运昊李治邓小芳钱凯广西大学土木建筑工程学院南宁530004 桂林理工大学土木建筑工程学院广西桂林541004

为研究钢支撑对RC框架抗连续倒塌性能的加固效应,在实验室制作了2榀RC平面子框架试件,并对其中1榀框架通过钢支撑进行加固,采用pushdown加载方式研究钢支撑对RC框架破坏模式和抗倒塌承载能力的影响。试验结果表明:钢支撑可以提高峰值荷... 详细信息

为研究钢支撑对RC框架抗连续倒塌性能的加固效应,在实验室制作了2榀RC平面子框架试件,并对其中1榀框架通过钢支撑进行加固,采用pushdown加载方式研究钢支撑对RC框架破坏模式和抗倒塌承载能力的影响。试验结果表明:钢支撑可以提高峰值荷载超过122%,其承载能力随拉杆的断裂而突然下降;由于压杆在加载初期就发生严重的平面外屈曲破坏,故仅对试件的初始刚度有影响,对峰值荷载作用很小。为进一步量化拉杆与压杆的加固贡献,通过商用有限元软件LS-DYNA进行精细有限元分析。有限元结果进一步验证了试验结果:采用角钢加固RC框架,压杆在加载初期容易发生平面外屈曲,对结构抗力影响不大,抗力提升主要由拉杆提供;通过拓展分析发现:采用防屈曲支撑加固可以显著提升压杆对结构抗力贡献,如压杆使用方钢管混凝土截面比L形截面峰值荷载提升超过42.8%。

关键词：钢支撑 RC框架连续倒塌加固效应防屈曲支撑