检索结果-南通市图书馆

Human C-C chemokine receptor 3 monoclonal antibody inhibits pulmonary inflammation in allergic mice

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第11期28卷 1791-1796页

作者： kai wang~2,hua-hao shen~2,Wen LI,hua-qiong huaNGdepartment of respiratory Medicine,the second affiliated hospital,medical school of zhejiang university,hangzhou 310009,China department of respiratory Medicine the Second Affiliated Hospital Medical School of Zhejiang University Hangzhou China

Aim:To evaluate the effect of C-C chemokine receptor 3 (CCR3) blockade onpulmonary inflammation and mucus production in allergic ***:Weused the synthetic peptide of the CCR3 NH2-terminal as the immunizing antigenand generated murine monoclonal antibody against the human *** addition,the generated antibody was administered to mice sensitized and challenged *** inflammatory cells in bronchoalveolar lavage,cytokine levels,pulmonary histopathology,and mucus secretion were ***:TheWestern blotting analysis indicated that the generated antibody bound to *** allergic mice treated with the antihuman CCR3 antibody exhib-ited a significant reduction of pulmonary inflammation accompanied with the al-teration of ***:The antibody we generated was specific *** inhibition of airway inflammation and mucus overproduction by theantibody suggested that the blockade of CCR3 is an appealing therapeutical tar-get for *** present research may provide an experimental basis for thefurther study of this agent.

关键词： asthma C-C chemokine interleukin-4 lungs inflammation

PPARγ agonist modulates GATA-3 and T-bet mRNA transcripts and inhibits allergic airway inflammation in a murine model

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

PPARγ agonist modulates GATA-3 and T-bet mRNA transcripts a...

PPARγ agonist modulates GATA-3 and T-bet mRNA transcripts and inhibits allergic airway inflammation in a murine model

浙江省中西医结合呼吸病诊治进展暨第六次学术年会

作者： hua-qiong huaNG~1 Feng XU~1 kai wang~1 Wen LI~1 Jing-lu chen~2 Gen-sheng ZHANG~1 hua-hao shen~1 department of respiratory Disease,second hospital of medical school of zhejiang university~1hangzhou,310009 the second hospital of Ningbo~2,Ningbo,315000,China.

Background:Asthmatic airway inflammation is mediated by allergen-specific Th2 *** of PPARγis found to inhibit the airway inflammation in asthmatic models,however,the mechanism(s) underlying the action of PPARγactivation in allergic airway inflammation has not been revealed clearly. Methods:To investigate the role of PPARγactivation in allergic airway inflammation and to determine whether PPARγactivation could modulate the balance of Th1/Th2 response,we examined the effects of PPARγactivation on allergic airway inflammation,the levels of GATA-3 and T-bet mRNA transcripts in a murine asthmatic ***:Our data showed that treatment with Rosiglitazone significantly reduced eosinophilia and mucous overproduction in the ***,PPARγactivation significantly down-regulated the levels of GATA-3 mRNA transcript,but increased the expression of T-bet. Conclusions:Our data suggest that PPARγactivation inhibits allergic airway inflammation in asthmatic mice by down-regulating allergen-induced predominate Th2 responses,but enhancing Th1 response, modulating the balance of Th2/Th1 responses.

关键词： asthma GATA-3 PPARγ T-bet

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

PPARγ agonist modulates GATA-3 and T-bet mRNA transcripts a...

PPARγ agonist modulates GATA-3 and T-bet mRNA transcripts and inhibits allergic airway inflammation in a murine model

浙江省医学会呼吸系病分会成立三十周年庆典活动暨2008年呼吸病学学术年会

作者： hua-qiong huang Feng Xu kai wang Wen Li Jing-lu chen Gen-sheng ZHANG hua-hao shen department of respiratory Disease second hospital of medical school of zhejiang university

Introduction Peroxisome proliferator activated receptors(PPARs)are members of the nuclear hormone receptor ***,there are three subtypes of PPARs,PPARα、PPARγand PPARδ. During the p

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

PPARγ agonist modulates GATA-3 and T-bet mRNA transcripts a...

Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma

浙江省医学会呼吸系病分会成立三十周年庆典活动暨2008年呼吸病学学术年会

作者： hua-qiong huang,Feng Xu,kai wang,Wen Li,Jing-lu chen,Gen-sheng ZHANG, hua-hao shen department of respiratory Disease,second hospital of medical school of zhejiang university

Introduction Peroxisome proliferator activated receptors(PPARs)are members of the nuclear hormone receptor ***,there are three subtypes of PPARs,PPARα、PPARγand PPARδ. During the past decade,many researches have sh...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of zhejiang university-Science B(Biomedicine & Biotechnology) 2011年第10期12卷 828-834页

作者： kai wang Min ZHANG Ying-ying QIAN Zhe-vuan DING jun-hui LV hua-hao shen department of respiratory Medicine the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China school of Medicine Zhejiang University Hangzhou 310058 China

Objective： Mitogen-activated protein kinases （MAPKs） are correlated with a more malignant phenotype in many cancers. This study was designed to evaluate the predictive value of the expression of MAPK phosphatase-1 （MKP-1） and phosphorylated extracellular signal-regulated kinase 1/2 （p-ERKl/2）, as the key regulatory mechanism of the MAPKs, in lung squamous cell carcinoma （SCC）. Methods： We assessed the expressions of MKP-1 and p-ERK1/2 in twenty subjects at different differentiation degree of SCC and five normal lungs by immunohistochemistry and real-time reverse transcriptase polymerase chain reaction （RT-PCR） analysis. Results： Immunohistochemistry and real-time RT-PCR assay showed that the expression of MKP-1 was gradually decreased as tissue type went from normal lung tissues to increasingly undifferentiated carcinoma, and it was negatively correlated with tumor differentiation （P〈0.01）. However, the expression of p-ERK1/2 or ERKl/2 was gradually increased as tissue type went from normal lung tissues to increasingly undifferentiated carcinoma, and it was positively correlated with tumor differentiation （P〈0.01）. Conclusions： Our data indicates the relevance of MKP-1 and p-ERK1/2 in SCC as a potential positive and negative prognostic factor. The imbalanced expression of MKP-1 and p-ERKl/2 may play a role in the development of SCC and these two molecules may be new targets for the therapy and prognosis of SCC.

关键词： Mitogen-activated protein kinase phosphatase-1 (MKP-1) Extracellular signal-regulated kinase (ERK) Lung squamous cell carcinoma (SCC) Prognostic factor

维普期刊数据库

CEPC Technical Design Report

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen hua-Xing chen Huirun chen Jinhui chen Ji-Yuan chen kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen Xiang chen Xiaoyu chen Xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen chunhui chen Hok Chuen cheng huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu kaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang university HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China university of Geosciences Beijing China university of Geosciences WuhanHubei China university of Mining and Technology XuzhouJiangsu China West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Airborne fine particulate matter induced pulmonary inflammation as well as oxidative stress in neonate rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese medical Journal 2010年第20期123卷 2895-2900页

作者： DING Li-ren wang kai Baher Fahmy shen hua-hao Cormier Stephania department of respiratory Medicine Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China) WANG Kai(Department of Respiratory MedicineSecond Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China department of Pharmacology and Experimental Therapeutics Louisiana State University Health Sciences Center (New Orleans)LA70112USA

Background Airborne fine particulate matter （PM） can induce pulmonary inflammation which may adversely affect human health, but very few reports about its effect on the neonate rats are available. This study aimed to observe the potential impact and toxicity of fine PMs on the airway in neonate *** Pulmonary inflammation, cytotoxicity, histopathology, and antioxidants as well as oxidant products were assessed 24 hours after intratracheal instillation of fine PM consecutively for 3 days. Cytotoxicity of fine PM was measured in Hep-2 *** Rats treated with high dose fine PM developed significant pulmonary inflammation characterized by neutrophiland macrophage infiltration. The inflammatory process was related to elevated level of TNF-α and prooxidant/antioxidant imbalance in the lung. Cytotoxicity studies performed in human epithelial cells indicated that high dose fine PM significantly reduced cell *** The study demonstrated acute exposure to fine PM induced airway inflammation as well as increased oxidative stress in addition to its direct toxic effect on airway epithelium cells.

关键词： inflammation particle size oxidative stress lung

维普期刊数据库

Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

在线全文

学校读者我要写书评

暂无评论

Chinese medical Journal 2013年第12期126卷 2276-2280页

作者： ZHENG Ying CAI Guang-yan chen Xiang-mei FU Ping chen Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan wang Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying wang Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning chen Nan SU Zhen MEI Chang-lin Zhao Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan chen Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin wang Nian-song LI Hai-ying XI chun-sheng hao Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan wang Rong ZHANG Jing-hong wang Jian-qin LOU Tan-qi Shao Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU chun-hua chen Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian zhong Liang-bao department of Nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China Nephrology Institute of the Chinese People's Liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China department of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China department of Nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China department of Nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China department of Nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China department of Nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China department of Nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China department of Nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China department of Nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China department of Nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China department of Nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China department of Nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China department of Nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China department of Nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China department of Nephrology Daping Hospital Third Military Medi

Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in China （except Hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

收治新型冠状病毒感染者医疗机构的终末消毒及效果评价中国专家共识

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国感染控制杂志 2023年第2期22卷 233-238页

作者：高晓东班海群陈文森高洁顾健胡国庆李春辉李六亿李诗雨刘运喜倪晓平乔甫任南沈瑾王绍鑫吴安华张浩军张流波朱仁义邹妮胡必杰复旦大学附属中山医院感染管理科上海200032 上海交通大学医学院附属仁济医院上海200127 江苏省人民医院感染管理处江苏南京210029 西安交通大学医学部公共卫生学院流行病与卫生统计学系陕西西安710048 上海市儿童医院上海交通大学医学院附属儿童医院感控办上海200062 江苏省疾病预防控制中心江苏南京210009 浙江省疾病预防控制中心浙江杭州310057 中南大学湘雅医院医院感染控制中心湖南长沙410008 北京大学第一医院感染管理-疾病预防控制处北京100034 四川大学华西医院医院感染管理部四川成都610041 解放军总医院第一医学中心疾病预防控制科北京100853 杭州市疾病预防控制中心消媒所浙江杭州310021 中国疾病预防控制中心环境与健康相关产品安全所北京100021 上海市卫生健康委员会监督所上海200031 甘肃省第二人民医院甘肃兰州730099 上海市疾病预防控制中心消毒与感染控制科上海200336 上海市第一人民医院医院感染与疾病预防控制办公室上海201620 复旦大学附属中山医院感染病科上海200032

为科学指导收治新型冠状病毒感染者医疗机构的感染防控工作,科学做好终末消毒,有效避免不同类型患者间的交叉传播,特组织国内部分感染控制及消毒领域专家共同制定本共识。本共识适用于所有可能收治新冠病毒感染者的医疗机构终末消毒,指... 详细信息

为科学指导收治新型冠状病毒感染者医疗机构的感染防控工作,科学做好终末消毒,有效避免不同类型患者间的交叉传播,特组织国内部分感染控制及消毒领域专家共同制定本共识。本共识适用于所有可能收治新冠病毒感染者的医疗机构终末消毒,指导工作人员严格进行环境物体表面、诊疗器械、空调管路等的终末消毒及效果评价,重点针对消毒原则、消毒产品、个人防护、消毒方案及消毒效果评价给予工作上的指导。

关键词：新型冠状病毒医疗机构终末消毒效果评价

维普期刊数据库