Human C-C chemokine receptor 3 monoclonal antibody inhibits pulmonary inflammation in allergic mice
Human C-C chemokine receptor 3 monoclonal antibody inhibits pulmonary inflammation in allergic mice作者机构：Department of Respiratory Medicine the Second Affiliated Hospital Medical School of Zhejiang University Hangzhou China
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2007年第28卷第11期
页 面：1791-1796页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：the National Natural Science Foundation of China(№ 30570807) the Natural Science Foundation of Zhejiang Province,China(№ Z303761)
主 题：asthma C-C chemokine interleukin-4 lungs inflammation
摘 要：Aim:To evaluate the effect of C-C chemokine receptor 3 (CCR3) blockade onpulmonary inflammation and mucus production in allergic ***:Weused the synthetic peptide of the CCR3 NH2-terminal as the immunizing antigenand generated murine monoclonal antibody against the human *** addition,the generated antibody was administered to mice sensitized and challenged *** inflammatory cells in bronchoalveolar lavage,cytokine levels,pulmonary histopathology,and mucus secretion were ***:TheWestern blotting analysis indicated that the generated antibody bound to *** allergic mice treated with the antihuman CCR3 antibody exhib-ited a significant reduction of pulmonary inflammation accompanied with the al-teration of ***:The antibody we generated was specific *** inhibition of airway inflammation and mucus overproduction by theantibody suggested that the blockade of CCR3 is an appealing therapeutical tar-get for *** present research may provide an experimental basis for thefurther study of this agent.
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