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Monkeypox awareness,knowledge,and attitude among undergraduate preclinical and clinical students at a Malaysian dental school:An emerging outbreak during the COVID-19 era

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Asian Pacific Journal of Tropical Medicine 2022年第10期15卷 461-467页

作者： Galvin Sim siang Lin Wen Wu Tan Daryl Zhun Kit chan kai Shen Ooi Hasnah Hashim Department of Dental Materials Faculty of DentistryAsian Institute of MedicineScience and Technology(AIMST)University08100BedongKedahMalaysia Department of Dental Public Health Faculty of DentistryAsian Institute of MedicineScience and Technology(AIMST)University08100BedongKedahMalaysia Department of Paediatrics Faculty of MedicineUniversiti Kebangsaan Malaysia Medical Centre56000Kuala LumpurMalaysia

Objective:To evaluate the awareness,knowledge,and attitude on monkeypox viral infection among preclinical and clinical dental students in ***:A cross-sectional study was conducted among 229 preclinical and clinical dental students via an online self-reported *** questionnaire included 3 items on awareness,15 items on knowledge,9 items on attitude and 2 open-ended *** were presented as frequencies and ***-square test was used to compare knowledge and awareness scores between preclinical and clinical dental students and content analysis was performed for open-ended ***:Preclinical and clinical dental students were aware of the existence of monkeypox(89.5%and 94.4%,respectively),that the disease emerged in non-endemic countries(81.0%and 87.1%,respectively)and that it was declared a public health emergency of international concern by the World Health Organization(73.3%and 79.0%,respectively).Clinical dental students’overall knowledge level was significantly higher than preclinical dental students(P=0.014).Both preclinical(95.2%)and clinical(96.8%)dental students demonstrated positive attitudes toward monkeypox with no significant difference(P=0.736)noted between *** themes emerged from the open-ended questions:(1)reimplementation of nationwide lockdown,(2)impact on the economy and health,and(3)disruption to the educational *** also anticipated their face-to-face learning to be reduced should there be a new ***:Both preclinical and clinical dental students showed comparable awareness and attitudes,while the latter demonstrated greater satisfactory knowledge toward the re-emergence of monkeypox during the COVID-19 ***,efforts to improve dental students’understanding of this alarming outbreak are required,to safeguard their health and minimise transmission.

关键词： Communicable disease Monkeypox virus Public health Tropical disease Zoonoses

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如何构建新型农业组织命运共同体:演进机制与知识基础——天虹丝绸纵向案例研究

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南开管理评论 2024年第3期27卷 82-93,105,I0015,I0016页

作者：曾宪聚曾凯曾梓萱欧阳桃花深圳大学管理学院澳门大学工商管理学院中国澳门北京航空航天大学经济管理学院

如何构建新型农业组织命运共同体是能否有效推动农业现代化转型的关键问题。本文通过蚕丝制造企业翘楚——天虹丝绸的纵向案例研究,系统分析了该新型农业组织共同体的演进过程、合作机制与知识基础。研究主要有三点发现:第一,新型农业... 详细信息

如何构建新型农业组织命运共同体是能否有效推动农业现代化转型的关键问题。本文通过蚕丝制造企业翘楚——天虹丝绸的纵向案例研究,系统分析了该新型农业组织共同体的演进过程、合作机制与知识基础。研究主要有三点发现:第一,新型农业组织共同体的演进经历了从“利益共同体”到“事业共同体”再成为“命运共同体”的三个阶段,这一发现奠定了新型农业组织共同体演进的理论基础。第二,企业与农户、共育户、家庭农场主等核心利益相关方不同的合作机制推动了新型农业组织共同体的演化。意义建构机制推动命运共同体高级形态的跃升,是对从利益嵌入机制和关系渗透机制出发构建新型农业组织的一种补充和超越。第三,组织知识、产业知识和乡土知识的整合影响了合作机制构建与运行。此外厘清了新型农业组织命运共同体演进过程中的底层知识逻辑。研究为构建新型农业组织命运共同体以推动乡村振兴背景下传统农业的现代化转型与新质生产力的加快形成提供了路径选项与理论启发。

关键词：新型农业组织共同体演进合作机制意义建构知识基础

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Occam’s razor or Hickam’s dictum-COVID-19 is not a textbook aetiology of acute pancreatitis:A modified Naranjo Score appraisal

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World Journal of Gastroenterology 2023年第13期29卷 2050-2063页

作者： Thomas Zheng Jie Teng Branden Qi Yu Chua Puay Khim Lim kai siang.chan Vishal G Shelat Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore Surgical Science Training Centre Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND Acute pancreatitis(AP)is a disease spectrum ranging from mild to severe *** the coronavirus disease 2019(COVID-19)pandemic,numerous reports of AP have been published,with most authors concluding a causal relationship between COVID-19 and *** case reports or small case series are unable to accurately determine the cause-effect relationship between COVID-19 and *** To establish whether COVID-19 is a cause of AP using the modified Naranjo scoring *** A systematic review was conducted on PubMed,World of Science and Embase for articles reporting COVID-19 and AP from inception to August *** criteria were cases of AP which were not reported to be due to COVID-19 infection,age<18 years old,review articles and retrospective cohort *** original 10-item Naranjo scoring system(total score 13)was devised to approximate the likelihood of a clinical presentation to be secondary to an adverse drug *** modified the original scoring system into a 8-item modified Naranjo scoring system(total score 9)to determine the cause-effect relationship between COVID-19 and AP.A cumulative score was decided for each case presented in the included *** of the modified Naranjo scoring system is as follows:≤3:Doubtful,4-6:Possible,≥7:Probable *** The initial search resulted in 909 articles,with 740 articles after removal of duplicates.A total of 67 articles were included in the final analysis,with 76 patients which had AP reported to be due to *** mean age was 47.8(range 18-94)*** of patients(73.3%)had≤7 d between onset of COVID-19 infection and diagnosis of *** were only 45(59.2%)patients who had adequate investigations to rule out common aetiologies(gallstones,choledocholithiasis,alcohol,hypertriglyceridemia,hypercalcemia and trauma)of *** G4 testing was conducted in 9(13.5%)patients to rule out autoimmune *** 5(6.6%)patients underwent endoscopic ultra

关键词： COVID-19 Infections Pancreatic diseases Pancreatitis Post-acute COVID-19 syndrome

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Isolated gallbladder tuberculosis mimicking acute cholecystitis:A case report

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World Journal of Gastrointestinal Surgery 2020年第3期12卷 123-128页

作者： kai siang.chan Vishal G Shelat Cher Heng Tan Yee Lin Tang Sameer P Junnarkar Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore Department of Diagnostic Radiology Tan Tock Seng HospitalSingapore 308433Singapore Department of Pathology Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND Isolated tuberculosis of the gallbladder is extremely rare due to its intrinsic resistance to tuberculous *** are reports of gallbladder tuberculosis mimicking cholecystitis or ***,these presentations were *** diagnosis of gallbladder tuberculosis warrants the need for investigation of additional sites of inoculation and contact tracing of all tuberculosis *** tuberculosis is a rare entity but should be suspected in patients from endemic regions with risk factors such as underlying immunosuppression or history of *** SUMMARY We present a case of gallbladder tuberculosis presenting as acute cholecystitis.A 44-year-old Filipino lady presented with a 11-d history of right hypochondrium and epigastric pain which worsened after meals with no significant past medical *** underwent laparoscopic cholecystectomy on the presumptive diagnosis of acute cholecystitis and diagnosed as gallbladder tuberculosis after histopathological *** patient did not have features of pulmonary or systemic tuberculosis nor was she *** recovered *** was subsequently discharged and followed-up at a hospital in her home country due to financial and social *** Clinicians should have a high index of suspicion for patients in endemic regions presenting with cholecystitis.

关键词： Cholecystectomy Cholecystitis Gallbladder Extra-pulmonary tuberculosis Case report

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《六祖坛经》成“经”与禅宗经典观念的创新

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华东师范大学学报（哲学社会科学版） 2024年第3期56卷 93-101,177,178页

作者：圣凯清华大学哲学系北京100084

《坛经》的形成是不断增补的过程,其编辑体例存在模仿翻译佛经的现象。但是,称为“坛经”之初,慧能的本意或许是借鉴唐代佛教、道教的仪轨文本称呼。授无相戒与说法是两种不同的宗教行事,前者具有内部传承的特征,后者则是公开的。因此,... 详细信息

《坛经》的形成是不断增补的过程,其编辑体例存在模仿翻译佛经的现象。但是,称为“坛经”之初,慧能的本意或许是借鉴唐代佛教、道教的仪轨文本称呼。授无相戒与说法是两种不同的宗教行事,前者具有内部传承的特征,后者则是公开的。因此,《坛经》才会有《施法坛经》和《六祖法宝记》两种不同的称呼。《坛经》成“经”后,慧能、神会等用《坛经》统摄教法传播、正法亲证、师资相传。神会门人采取“秘本”式登记管理维持《坛经》的内部传承,遭到佛教界批判。可以说,《坛经》成为“经”是佛教中国化最重要的事件之一,也是中国佛教之南方转向和唐宋转型的标志性事件。

关键词：《坛经》惠能正法师资相传

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Challenges to quantitative applications of Landsat observations for the urban thermal environment

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Journal of Environmental Sciences 2017年第9期29卷 80-88页

作者： Feng Chen Song Yang kai Yin Paul chan School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 519082China Institute of Earth Climate and Environment System Sun Yat-sen UniversityOuangzhou 510275China Fujian Key Laboratory of Sensing and Computing.for Smart City Xiarnen UniversityXiarnen 361005China Institute of Remote Sensing and Digital Earth Chinese Academy of SciencesBeijing 10094China Climate Decision LLC BethesdaMDUSA

Since the launch of its first satellite in 1972, the Landsat program has operated continuously for more than forty years. A large data archive collected by the Landsat program significantly benefits both the academic community and society. Thermal imagery from Landsat sensors, provided with relatively high spatial resolution, is suitable for monitoring urban thermal environment. Growing use of Landsat data in monitoring urban thermal environment is demonstrated by increasing publications on this subject, especially over the last decade. Urban thermal environment is usually delineated by land surface temperature（LST）. However, the quantitative and accurate estimation of LST from Landsat data is still a challenge, especially for urban areas. This paper will discuss the main challenges for urban LST retrieval, including urban surface emissivity, atmospheric correction, radiometric calibration, and validation. In addition, we will discuss general challenges confronting the continuity of quantitative applications of Landsat observations. These challenges arise mainly from the scan line corrector failure of the Landsat 7 ETM ＋ and channel differences among sensors. Based on these investigations, the concerns are to：（1） show general users the limitation and possible uncertainty of the retrieved urban LST from the single thermal channel of Landsat sensors;（2） emphasize efforts which should be done for the quantitative applications of Landsat data; and（3） understand the potential challenges for the continuity of Landsat observation（i.e., thermal infrared） for global change monitoring, while several climate data record programs being in progress.

关键词： Remote sensing Radiometric calibration SLC-off Surface temperature Data consistency

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TRANSFECTION AND CELL FUSION BY FEMTOSECOND LASERS

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Journal of Innovative Optical Health Sciences 2011年第2期4卷 113-125页

作者： HAO HE SIU kai KONG KAM TAI chan Department of Electronic Engineering The Chinese University of Hong Kong ShatinN.T.Hong Kong Department of Biochemistry The Chinese University of Hong Kong ShatinN.T.Hong Kong

Biophotonics is an exciting and fast-expanding frontier which involves the fusion of advanced photonics and *** has not only created many novel methodologies for biomedical research,but also achieved many significant results as an *** to femtosecond(fs)laser technologies,important progresses have been made regarding the manipulation,imaging,and engineering of biological samples ranging from single molecules to tissues in the last 20 *** ultrashort pulses at near-infrared band provide many advantages:high nonlinear efficiency,low absorption by biological samples,high spatial and temporal resolution and confinement,and low *** are noninvasive and easy to *** the mechanism of how fs laser pulses interact with cells remains unclear,experimental results have shown that they could open up the cell membrane and hence made optical transfection and optical cell fusion *** this review,some of the seminal works on transfection and cell fusion by fs lasers are *** ideas behind and the experimental details will be described together with a highlight on their ***,the thermal effect is analyzed based on multiphoton excitation and plasma formation in an aqueous environment to explain the nontoxic characteristic of fs laser ***,some applications of fs laser induced transfection and cellcell fusion with potential major impact in biomedical sciences are proposed.

关键词： Biophotonics transfection cell fusion femtosecond laser

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Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson's disease,with insights into Pink1 knockout models

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Zoological Research 2023年第3期44卷 559-576页

作者： Zhangting Wang See-Wing chan Hui Zhao kai-Kei Miu Wai-Yee chan School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics School of Biomedical SciencesThe Chinese University of Hong KongHong Kong SARChina Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesThe Chinese University of Hong KongHong Kong SARChina

Parkinson’s disease(PD)relates to defective mitochondrial quality control in the dopaminergic motor *** studies have revealed that PINK1 and Parkin mutations are indicative of a heightened propensity to PD onset,pinpointing mitophagy and inflammation as the culprit pathways involved in neuronal loss in the substantia nigra(SNpc).In a reciprocal manner,LRRK2 functions in the regulation of basal flux and inflammatory responses responsible for PINK1/Parkin-dependent mitophagy *** intervention in these diseasemodifying pathways may facilitate the development of novel PD therapeutics,despite the current lack of an established drug evaluation *** such,we reviewed the feasibility of employing the versatile global Pink1knockout(KO)rat model as a self-sufficient,spontaneous PD model for investigating both disease etiology and drug *** rats retain clinical features encompassing basal mitophagic flux changes with PD *** demonstrate the versatility of this PD rat model based on the incorporation of additional experimental insults to recapitulate the proinflammatory responses observed in PD patients.

关键词： Parkinson’s disease Mitophagy Inflammatory response Genetic model Pink1 KO rats

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Laparoscopic liver resection: western versus eastern experience

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Chinese Journal of Cancer Research 2014年第3期26卷 243-244页

作者： Fiona KM chan kai Chi Cheng Department of Surgery Kwong Wah Hospital

Hepatocellular carcinoma （HCC） is the most common primary liver tumor. It is the seventh world＇s most common cancer and rank second of all cancer deaths （I）. It incurs a global health burden, with 782,451 new cases diagnosed worldwide in the year 2012 and a morality of 745,517： a high incidence to morality ratio of 1.05. Majority of patients resides in the developing world and often presented late resulting in poor prognosis. Early detection is thus crucial for capturing early disease whereby curative resection can offer the best survival outcome （2）.

关键词： HCC western versus eastern experience

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氯代多氟醚基磺酸对稀有鮈鲫肝脏组织损伤及其毒理学机制研究

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生态毒理学报 2024年第3期19卷 274-286页

作者：徐婵宋杰玉李进杨鸿波滕春丽马凯谢锋贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室贵阳561113 贵州省分析测试研究院贵阳550014 贵州健安德科技有限公司贵阳550016 茅台学院食品科学与工程系仁怀564507

6:2氯代多氟醚基磺酸(F-53B)作为全氟辛烷磺酸(perfluorooctane sulfonate,PFOS)的替代品,已在金属电镀行业使用了40多年,这种普遍使用导致其在环境、野生动物和人体中广泛检出,且有研究表明F-53B具有肝细胞毒性作用,但其脂毒性机制尚... 详细信息

6:2氯代多氟醚基磺酸(F-53B)作为全氟辛烷磺酸(perfluorooctane sulfonate,PFOS)的替代品,已在金属电镀行业使用了40多年,这种普遍使用导致其在环境、野生动物和人体中广泛检出,且有研究表明F-53B具有肝细胞毒性作用,但其脂毒性机制尚不明确。将5月龄稀有鮈鲫暴露于0、10和200μg·L^(-1)28 d,以蛋白质组学作为研究手段,探究F-53B对稀有鮈鲫肝脏的脂毒性效应机制。在28 d暴露后,200μg·L^(-1)处理组观察到明显的血脂异常,肝脏蛋白组分析表明与脂质代谢相关的途径受到显著影响,与对照组相比,其中10μg·L^(-1)组与脂质代谢相关的上调蛋白有19个,下调的有4个,200μg·L^(-1)组上调蛋白有15个,下调蛋白9个,共同上调蛋白12个,下调蛋白2个,涉及脂肪酸降解、脂肪酸氧化、转运途径中酶的上调。同时PPAR信号通路参与了F-53B诱导的脂质代谢紊乱,表现为对PPAR的3种亚型的蛋白表达均产生激活作用,导致成骨/成脂分化失衡。这表明F-53B可破坏PPAR信号通路,破坏稀有鮈鲫的脂质稳态,结果可为F-53B脂毒作用机制研究提供新的思路。

关键词：全氟辛烷磺酸 6:2氯代多氟醚基磺酸稀有鮈鲫脂毒性蛋白组学过氧化物酶体增殖物激活受体

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