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Effects of vitamin E on stroke: a systematic review with meta- analysis and trial sequential analysis

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Stroke & Vascular Neurology 2021年第1期6卷 109-120页

作者： Hong Chuan Loh Renly Lim kai wei lee Chin Yik Ooi Deik Roy Chuan Irene Looi Yuen Kah Hay Nurzalina Abdul Karim Khan Clinical Research Center Hospital Seberang JayaMinistry of Health MalaysiaSeberang JayaMalaysia Clinical and Health Sciences University of South AustraliaAdelaideSouth AustraliaAustralia Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman-Kampus Bandar Sungai LongKajangMalaysia Medical Department Hospital Seberang JayaMinistry of Health MalaysiaSeberang JayaMalaysia School of Pharmaceutical Sciences Universiti Sains MalaysiaMindenMalaysia

There are several previous studies on the association of vitamin E with prevention of stroke but the findings remain *** have conducted a systematic review,meta-analysis together with trial sequential analysis of randomised controlled trials to evaluate the effect of vitamin E supplementation versus placebo/no vitamin E on the risk reduction of total,fatal,non-fatal,haemorrhagic and ischaemic *** studies were identified by searching online databases through Medline,PubMed and Cochrane Central Register of Controlled Trials.A total of 18 studies with 148016 participants were included in the *** was no significant difference in the prevention of total stroke(RR(relative risk)=0.98,95% CI 0.92-1.04,p=0.57),fatal stroke(RR=0.96,95% CI 0.77-1.20,p=0.73)and non-fatal stroke(RR=0.96,95% CI 0.88-1.05,p=0.35).Subgroup analyses were performed under each category(total stroke,fatal stroke and non-fatal stroke)and included the following subgroups(types of prevention,source and dosage of vitamin E and vitamin E alone vs control).The findings in all subgroup analyses were statistically *** stroke subtypes analysis,vitamin E showed significant risk reduction in ischaemic stroke(RR=0.92,95% CI 0.85-0.99,p=0.04)but not in haemorrhagic stroke(RR=1.17,95%CI 0.98-1.39,p=0.08).However,the trial sequential analysis demonstrated that more studies were needed to control random *** of this study include the following:trials design may not have provided sufficient power to detect a change in stroke outcomes,participants may have had different lifestyles or health issues,there were a limited number of studies available for subgroup analysis,studies were mostly done in developed countries,and the total sample size for all included studies was insufficient to obtain a meaningful result from *** conclusion,there is still a lack of statistically significant evidence of the effects of vitamin E on the risk reduction of str

关键词： vitamin prevention dosage

Prevalence of anxiety among gestational diabetes mellitus patients: A systematic review and meta-analysis

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World Journal of Meta-Analysis 2020年第3期8卷 275-284页

作者： kai wei lee Hong Chuan Loh Seng Choi Chong Siew Mooi Ching Navin Kumar Devaraj Maiza Tusimin Habibah Abdul Hamid Fan Kee Hoo Department of Family Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia Clinical Research Centre Hospital Seberang JayaMinistry of Health MalaysiaPerai 13700PenangMalaysia Department of Psychiatry Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia Department of Obstetrics and Gynaecology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia Department of Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia

BACKGROUND A diagnosis of gestational diabetes mellitus(GDM)negatively influences maternal mental *** is a lack of systematic review and meta-analysis on prevalence of anxiety among GDM *** To pool data from existing literature to determine the pooled estimates for the prevalence of anxiety among women diagnosed with *** We searched multiple databases including MEDLINE,Cinahl,PubMed and Scopus to identify studies published up to 31 October 2019 with data on the prevalence of anxiety among women diagnosed with *** were extracted from published *** were pooled using random-effects *** We reviewed 19 abstracts,retrieved 10 articles and included three studies incorporating 12744 GDM women from three *** pooled prevalence of anxiety was 29.5%(95%CI:6.9,52.0)among GDM *** Prevalence of anxiety among GDM women was *** suggest that epidemiological studies on anxiety should be conducted urgently as it merits clinical *** addition,it is important to identify factors associated with anxiety among women diagnosed with GDM.

关键词： Prevalence Anxiety Gestational diabetes Psychiatry Meta-analysis Systematic review

Prevalence and Factors Associated with Smartphone Addiction among Adolescents–A Nationwide Study in Malaysia

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International Journal of Mental Health Promotion 2023年第2期25卷 237-247页

作者： kai wei lee Siew Mooi Ching Norsiah Ali Chor Yau Ooi Shahnul Kamal Hj Sidek Azlin Amat Yusnita Yatim Zaiton Yahaya Nabihah Shamsuddin Idora Ibrahim Fauzia Abdul Majid Fazlin Suhana Othman Nik Suhaila Zakaria Artini Abidin Nor Hazlin Talib Dhashani Sivaratnam Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanKajangSelangor43000Malaysia Department of Family Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang43400Malaysia Klinik Kesihatan Masjid Tanah Ministry of Health MalaysiaMasjid Tanah78300Malaysia Department of Family Medicine Universiti Malaysia SarawakKota Samarahan94300Malaysia Klinik Kesihatan Tanjung Malim Ministry of Health MalaysiaTanjung Malim35900Malaysia Klinik Kesihatan Hiliran Ministry of Health MalaysiaKuala Terengganu20300Malaysia Klinik Kesihatan Bandar Pekan Ministry of Health MalaysiaPekan26600Malaysia Klinik Kesihatan Sandakan Ministry of Health MalaysiaSandakan90000Malaysia Klinik Kesihatan Serting Hilir Ministry of Health MalaysiaBandar Seri Jempol72120Malaysia Klinik Kesihatan Kuala Perlis Ministry of Health MalaysiaKuala Perlis02000Malaysia Klinik Kesihatan Kempas Ministry of Health MalaysiaJohor Bahru81200Malaysia Klinik Kesihatan Kuala Kedah Ministry of Health MalaysiaKuala Kedah06600Malaysia Klinik Kesihatan Bandar Gua Musang Ministry of Health MalaysiaGua Musang18300Malaysia Klinik Kesihatan Kepala Batas Ministry of Health MalaysiaKepala Batas13200Malaysia Klinik Kesihatan Kajang Ministry of Health MalaysiaKajang43000Malaysia Department of Ophthalmology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang43400Malaysia

Smartphone ownership among adolescents is getting common in this decade especially in Malaysia;Adolescent are strongly devoted to their smartphone and this may lead to smartphone *** have reported that smartphone addiction has become an emerging social and health problem especially among the youth in many countries however there is lack of study among adolescents in *** study aimed to examine the prevalence and factors associated with smartphone addiction among adolescents in *** was a cross-sectional study involving adolescents from 15 primary care clinics throughout the *** were assessed on their smartphone activities using the Malaysian short version of the Smartphone addiction scale(SAS-M-SV).Multiple logistic regression was used to determine the predictors of smartphone addiction among *** study was conducted among 921 adolescents with 49.6%male(n=457).The mean age of adolescents was 16.4±2.4 *** ethnicity distribution were 74.6%Malay,7.3%Chinese,4.7%Indian and 13.4%other *** prevalence of smartphone addiction was 37.1%(342/921);37.4%in male and 36.9%in *** on multiple logistic regression analysis,longer duration of smartphone use per week was associated with higher odds of smartphone addiction among adolescent(odd ratio=1.005%,95%confidence interval=1.000–1.009,p-value=0.039).Smartphone addiction is present in nearly four in ten adolescents in *** who spend longer duration in smartphone usage per week were associated with higher odds of having smartphone *** should be more alert and vigilant about this ***,parents should limit their children from spending too much of time with smartphone in order to prevent their children from getting smartphone addiction.

关键词： Addiction smartphone adolescents Malaysia internet

Rational design of perfectly oriented thermally activated delayed fluorescence emitter for efficient red electroluminescence

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Science China Materials 2021年第4期64卷 920-930页

作者： Xuan Zeng Yu-Hsin Huang Shaolong Gong Xuguang Yin wei-kai lee Xiao Xiao Yu Zhang weixuan Zeng Chen-Han Lu Chang-Cheng lee Xiu-Qin Dong Cheng Zhong Chung-Chih Wu Chuluo Yang Renmin Hospital of Wuhan University Department of ChemistryHubei Key Lab on Organic and Polymeric Optoelectronic MaterialsWuhan UniversityWuhan 430072 College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060 Department of Electrical Engineering Graduate Institute of Electronics Engineering and Graduate Institute of Photonics and OptoelectronicsTaiwan UniversityTaipei 10617

How to control the dipole orientation of organic emitters is a challenge in the field of organic light-emitting diodes(OLEDs).Herein,a linear thermally activated delayed fluorescence(TADF)molecule,PhNAI-PMSBA,bearing a 1,8-naphthalimide-acridine framework was designed by a doublesite long-axis extension strategy to actively control the dipole *** horizontal ratio of emitting dipole orientation of PhNAI-PMSBA reaches 95%,substantially higher than that of isotropic emitters(67%).This unique feature is associated with the intrinsically horizontal molecular orientation of PhNAI-PMSBA and the good agreement between its transition dipole moment direction and molecular long *** PhNAI-PMSBA-based OLED achieves an ultrahigh optical outcoupling efficiency of 43.2%and thus affords one of the highest red electroluminescence with an external quantum efficiency of 22.3%and the Commission International de l’Eclairage 1931 coordinates at around(0.60,0.40).

关键词： organic light-emitting diodes thermally activated delayed fluorescence dipole orientation outcoupling efficiency

Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien lee Cheng-Hui Lin Chi-Huan Wu Yung-Kuan Tsou kai-Feng Sung Sheng-Fu Wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

Prevalence,awareness and control of hypertension in Malaysia from 1980-2018:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2020年第4期8卷 320-344页

作者： Man Jun Soo Zhen Yee Chow Siew Mooi Ching Chun Han Tan kai wei lee Navin Kumar Devaraj Hani Syahida Salim Vasudevan Ramachandran Poh Ying Lim Dhashani Sivaratnam Fan Kee Hoo Ai Theng Cheong Yook Chin Chia Department of Family Medicine Universiti Putra MalaysiaSerdang 43400Malaysia Hospital Seberang Jaya Perai 13700Malaysia Malaysian Research Institute on Ageing Universiti Putra MalaysiaSerdang 43400Malaysia Department of Community Health Universiti Putra MalaysiaSerdang 43400Malaysia Department of Surgery Universiti Putra MalaysiaSerdang 43400Malaysia Department of Medicine Universiti Putra MalaysiaSerdang 43400Malaysia Department of Medical Sciences Sunway UniversityBandar Sunway 47500Malaysia

BACKGROUND Hypertension is a common public health problem worldwide and is a well-known risk factor for increased risk of cardiovascular diseases,contributing to high morbidity and ***,there has been no systematic review and meta-analysis of a multiethnic population such as that of *** To determine the trend in prevalence,awareness and control rate of hypertension in *** Systematic searches were conducted in six databases(PubMed,Scopus,Ovid,CINAHL,Malaysian Medical Repository and Malaysia Citation Index)for articles published between 1980 and *** authors reviewed the studies and performed quality assessment and data extraction *** estimates of hypertension prevalence,awareness and control rate were calculated using the DerSimonian-Laird random-effects *** and sensitivity analyses were *** We included 56 studies involving a total of 241796 *** overall pooled prevalence of hypertension aged≥18 years was 29.7%.The prevalence of hypertension was the lowest in the 1980s(16.2%,95%confidence interval(CI):13.4,19.0),increasing up to 36.8%(95%CI:6.1,67.5)in the 1990s,then decreasing to 28.7%(95%CI:21.7,35.8)in the 2000s and 26.8%(95%CI:21.3,32.3)in the *** prevalence of awareness was 51.4%(95%CI:46.6,56.3),while 33.3%(95%CI:28.4,38.2)of those on treatment had achieved control of their blood *** In Malaysia,three in ten adults aged≥18 years have hypertension,while four in ten adults aged≥30 years have *** out of ten people are aware of their hypertension status and only one-third of those under treatment achieved control of their *** efforts by policymakers and healthcare professionals to improve awareness and control of hypertension should be of high priority.

关键词： Prevalence Awareness Control Hypertension Blood pressure Malaysia Systematic review Meta-analysis

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li wei Yue Nam‑Young Kim Yang Li Guozhen Shen Jong‑Chul lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Defects‑Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 528-547页

作者： Jiaolong Liu Siyu Zhang Dan Qu Xuejiao Zhou Moxuan Yin Chenxuan Wang Xuelin Zhang Sichen Li Peijun Zhang Yuqi Zhou kai Tao Mengyang Li Bing wei Hongjing Wu Mengyang Li Bing wei Hongjing Wu School of Physics Xidian UniversityXi’an 710071People’s Republic of China School of Advanced Materials and Nanotechnology State Key Discipline Laboratory of Wide Band Gap Semiconductor TechnologyXidian UniversityXi’an 710071People’s Republic of China School of Microelectronics Xidian UniversityXi’an 710071People’s Republic of China School of Telecommunication Engineering Xidian UniversityXi’an 710071People’s Republic of China MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary School of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China The Ministry of Education Key Laboratory of Micro and Nano Systems forAerospace School of Mechanical EngineeringNorthwestern PolytechnicalUniversityXi’an 710072People’s Republic of China

Defects-rich heterointerfaces integrated with adjustable crystalline phases and atom vacancies,as well as veiled dielectric-responsive character,are instrumental in electromagnetic *** methods,however,constrain their delicate ***,an innovative alternative is proposed:carrageenan-assistant cations-regulated(CACR)strategy,which induces a series of sulfides nanoparticles rooted in situ on the surface of carbon *** unique configuration originates from strategic vacancy formation energy of sulfides and strong sulfides-carbon support interaction,benefiting the delicate construction of defects-rich heterostructures in M_(x)S_(y)/carbon composites(M-CAs).Impressively,these generated sulfur vacancies are firstly found to strengthen electron accumulation/consumption ability at heterointerfaces and,simultaneously,induct local asymmetry of electronic structure to evoke large dipole moment,ultimately leading to polarization coupling,i.e.,defect-type interfacial ***“Janus effect”(Janus effect means versatility,as in the Greek two-headed Janus)of interfacial sulfur vacancies is intuitively confirmed by both theoretical and experimental investigations for the first ***,the sulfur vacancies-rich heterostructured Co/Ni-CAs displays broad absorption bandwidth of 6.76 GHz at only 1.8 mm,compared to sulfur vacancies-free CAs without any dielectric *** defects-rich heterostructures,this one-pot CACR strategy may steer the design and development of advanced nanomaterials,boosting functionality across diverse application domains beyond electromagnetic response.

关键词： Defects-rich heterointerfaces Sulfides Polarization coupling Electromagnetic wave absorption