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Cancer Communications 2022年第4期42卷 355-359页

作者： kah Yee Goh kah weng lau Terence You De Cheng Su Chin Tham Chwee Teck Lim Narayanan Gopalakrishna Iyer Su Bin Lim Darren Wan-Teck Lim Division of Medical Oncology National Cancer Centre SingaporeSingapore 169610 Department of Pathology National University HospitalSingapore 119074 A*STAR ProteosInstitute of Molecular and Cell BiologySingapore 138673 Department of Biomedical Engineering Mechanobiology InstituteNational University of SingaporeT-LabSingapore 117411 Institute for Health Innovation and Technology(iHealthtech) National University of SingaporeMD6Singapore 117599 Department of Head and Neck Surgery National Cancer Centre Singapore11 Hospital CrescentSingapore 169610 Office of Academic and Clinical Development Duke-NUS Medical SchoolSingapore 169857 Department of Biochemistry and Molecular Biology Ajou University School of MedicineYeongtong-GuSuwon 16499South Korea

Dear Editor,Head and neck squamous cell carcinoma(HNSCC)is the sixth most common cancer globally[1,2].Despite the improvement in treatment modalities,up to 50%of HNSCC patients still develop recurrent/metastatic(R/M)disease[3],and platinum-based chemotherapy with cetuximab and/or pembrolizumab has become the standard of care[4].However,R/M HNSCC is challenging to treat,the prognosis is poor,and there is an unmet need for new therapeutic targets.

关键词： chemotherapy cetuximab treatment

Enhancing memristor performance with 2D SnO_(x)/SnS_(2) heterostructure forneuromorphic computing

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Science China Materials 2025年第2期68卷 581-589页

作者： Yangwu Wu Sifan Li Yun Ji Zhengjin weng Houying Xing Lester Arauz Travis Hu Jinhua Hong kah-Wee Ang Song Liu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Joint International Research Laboratory of Information Display and Visualization School of Electronic Science and EngineeringSoutheast UniversityNanjing 210096China Department of Mechanical Engineering California State UniversityLos Angeles5151 State University DrLos AngelesCA 90032USA College of Materials Science and Engineering Hunan UniversityChangsha 410082China Shenzhen Research Institute Hunan UniversityShenzhen 518000China

Layered metal dichalcogenides (LMDs) neuromorphic memristor devices offer a promising alternative toconventional von Neumann architectures, addressing speedand energy efficiency constraints. However, challenges remainin controlling resistive switching and operating voltage incrystalline LMD memristors due to environmental stabilization issues, which hinder neural network hardware development. Herein, we introduce an optimization method formemristor operation by controlling oxidation through ozonetreatment, creating a SnO_(x)/SnS_(2) resistive layer. These optimized memristors demonstrate low switching voltages (~1 V),rapid switching speeds (~20 ns), high switching ratios (10^(2)),and the ability to emulate synaptic weight plasticity. Crosssectional transmission electron microscopy and energy-dispersive X-ray spectroscopy identified defects and Ti conductive filaments in the resistive switching layer, contributingto uniform switching and minimized operating variation. Thedevice achieved 90% accuracy in MNIST handwritten recognition, and hardware-based image convolution was successfully implemented, showcasing the potential of SnO_(x)/SnS_(2)memristors for neuromorphic applications.

关键词： SnO_(x)/SnS_(2) oxidation layered metal dichalcogenides convolutional image processing neuromorphic computing

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Molecular Layer Deposition of Crosslinked Polymeric Lithicone for Superior Lithium Metal Anodes

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Energy Material Advances 2021年第1期2021卷 62-77页

作者： Xiangbo Meng kah Chun lau Hua Zhou Sujan Kumar Ghosh Mourad Benamara Min Zou Department of Mechanical Engineering University of ArkansasFayettevilleAR 72701USA Department of Physics and Astronomy California State University NorthridgeCA 91330USA Advanced Photon Source Argonne National LaboratoryLemontIL 60439USA Institute for Nanoscience and Engineering University of ArkansasFayettevilleAR 72701USA

In this work,we for the first time developed a novel lithium-containing crosslinked polymeric material,a lithicone that enables excellent protection effects over lithium(Li)metal *** new lithicone was synthesized via an accurately controllable molecular layer deposition(MLD)process,in which lithium tert-butoxide(LTB)and glycerol(GL)were used as *** resultant LiGL lithicone was analyzed using a suite of ***,we found that the LiGL thichicone could serve as an exceptional polymeric protection film over Li metal *** experimental data revealed that the Li electrodes coated by this LiGL lithicone can achieve a superior cycling stability,accounting for an extremely long cyclability of>13,600 Listripping/plating cycles and having no failures so far in Li/Li symmetric cells at a current density of 5 mA/cm^(2)and an areal capacity of 1 mAh/cm^(2).We found that,with a sufficient protection by this LiGL coating,Li electrodes could realize long-term stable cyclability with little formation of Li dendrites and solid electrolyte *** novel LiGL represents a facile and effective solution to the existing issues of Li anodes and potentially paves a technically feasible route for lithium metal batteries.

关键词： lithium stripping exceptional

Mass and charge transport relevant to the formation of toroidal lithium peroxide nanoparticles in an aprotic lithium-oxygen battery： An experimental and theoretical modeling study

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Nano Research 2017年第12期10卷 4327-4336页

作者： Xiangyi Luo Rachid Amine kah Chun lau Jun Lu Chun Zhan Larry A. Curtiss Said AI Hallaj Brian P. Chaplin Khalil Amine Chemical Sciences and Engineering Division Argonne National Laboratory 9700 South Cass Avenue Lemont IL 60439 USA Materials Science Division Argonne National Laboratory 9700 South Cass Avenue Lemont IL 60439 USA Department of Chemical Engineering University of Illinois at Chicago 810 S. Clinton Chicago IL 60607 USA Department of Physics and Astronomy California State University Northridge 18111 Nordhoff Street Northridge CA 91330 USA

The discharge and charge mechanisms of rechargeable Li-O2 batteries have been the subject of extensive investigation recently. However, they are not fully understood yet. Here we report a systematic study of the morphological transition of Li2O2 from a single crystalline structure to a toroid like particle during the discharge-charge cycle, with the help of a theoretical model to explain the evolution of the Li2O2 at different stages of this process. The model suggests that the transition starts in the first monolayer of Li2O2, and is subsequently followed by a transition from particle growth to film growth if the applied current exceeds the exchange current for the oxygen reduction reaction in a Li-O2 cell. Furthermore, a sustainable mass transport of the diffusive active species （e.g., O2 and Li＋） and evolution of the underlying interfaces are critical to dictate desirable oxygen reduction （discharge） and evolution （charge） reactions in the oorous carbon electrode of a Li-O2 cell.

关键词： rechargeable Li-O2 battery electrocatalyst nanocomposite lithium peroxide

Characterization of La-promoted Ni/Al_2O_3 catalysts for hydrogen production from glycerol dry reforming

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Journal of Energy Chemistry 2014年第1期23卷 15-21页

作者： kah weng Siew Hua Chyn Lee Jolius Gimbun Chin Kui Cheng Centre of Excellence for Advanced Research in Fluid Flow Universiti Malaysia PahangLebuhraya Tun Razak26300 GambangKuantan PahangMalaysia Faculty of Chemical & Natural Resources Engineering Universiti Malaysia PahangLebuhraya Tun Razak26300 GambangKuantan PahangMalaysia

In the current paper, dry(CO2)-reforming of glycerol, a new reforming route, was carried out over alumina(Al2O3)-supported, non-promoted and lanthanum-promoted nickel(Ni) catalysts. Both sets of catalysts were synthesized via a wet co-impregnation procedure. Physicochemical characterization of the catalysts showed that the promoted catalyst possessed smaller metal crystallite size, hence higher metal dispersion compared to the virgin Ni/Al2O3catalyst. This was also corroborated by the surface images captured by the FESEM analysis. From temperature-programmed calcination analysis, the derivative weight profiles revealed two peaks, which represent a water elimination peak at a temperature range of 373 to 473 K followed by nickel nitrate decomposition from 473 to 573 K. In addition, BET surface area measurements gave 85.0 m2 g-1for the non-promoted Ni catalyst, whilst the promoted catalysts showed an average of 1% to 6% improvement depending on the La loadings. Significantly, reaction studies at 873 K showed that glycerol dry reforming successfully produced H2. The 2%La-Ni/Al2O3catalyst, which possessed the largest BET surface area, gave an optimum H2generation(9.70%) at a glycerol conversion of 24.5%.

关键词： Ni catalysts dry reforming lanthanide promotion reaction kinetics

CO_2 reforming of glycerol over La-Ni/Al_2O_3 catalyst:A longevity evaluative study

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Journal of Energy Chemistry 2015年第3期24卷 366-373页

作者： kah weng Siew Hua Chyn Lee Maksudur R.Khan Jolius Gimbun Chin Kui Cheng Faculty of Chemical & Natural Resources Engineering Universiti Malaysia Pahang Centre of Excellence for Advanced Research in Fluid Flow Universiti Malaysia Pahang Rare Earth Research Centre Universiti Malaysia Pahang

This paper reports on the longevity of glycerol-dry（CO2） reforming over the lanthanum（La） promoted Ni/Al2O3 *** XRD results showed that the Ni particle was well-dispersed in the presence of La *** addition,via the NH3-TPD analysis,it was found that the La promoter has reduced the acidity of Ni catalyst which may have explained the mitigation of carbon *** was determined that the 3.0 wt% La-promoted Ni/Al2O3 catalyst possessed the largest BET specific surface area of 97 m2 ***,it yielded the best catalytic longevity performance with conversion attained more than 90%,even after 72 h of reaction ***,it can be confirmed that the presence of CO2 during the glycerol dry reforming was essential in reducing carbon deposition,most likely via gasification *** has ensured a stability of catalytic activity for a long reaction period（72 h）.

关键词： CO2reforming glycerol lanthanum longevity syngas

Catalytic performance of cement clinker supported nickel catalyst in glycerol dry reforming

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Journal of Energy Chemistry 2014年第5期23卷 645-656页

作者： Hua Chyn Lee kah weng Siew Maksudur R.Khan Sim Yee Chin Jolius Gimbun Chin Kui Cheng Faculty of Chemical & Natural Resources Engineering Universiti Malaysia Pahang Lebuhraya Tun Razak 26300 Gambang Kuantan Pahang Malaysia Centre of Excellence for Advanced Research in Fluid Flow Universiti Malaysia Pahang Lebuhraya Tun Razak 26300 Gambang Kuantan Pahang Malaysia

The paper reports the development of cement clinker-supported nickel （with metal loadings of 5 wt%, 10 wt%, 15 wt% and 20 wt%） catalysts for glycerol dry （CO2） reforming reaction. XRF results showed that CaO constituted 62.0% of cement clinker. The physicochemical characterization of the catalysts revealed 32-folds increment of BET surface area （SBET） with the addition of nickel metal into the cement clinker, which was also corroborated by FESEM images. Significantly, XRD results suggested different types of Ni oxides formation with Ni loading, whilst Ca3SiO5 and Ca2Al0.67Mn0.33FeO5 were the main crystallite species for pure cement clinker. Temperature-programmed reduction analysis yielded three domains of H2 reduction peaks, viz. centered at approximately 750 K referred to as type-Ⅰ peaks, another peaks at 820 K denoted as type-Ⅱ peaks and the highest reduction peaks, type-Ⅲ recorded at above 1000 K. 20 wt% Ni was found to be the best loading with the highest XG and H2 yield, whilst the lowest methanation activity. Syngas with lower H2/CO ratios （0.6 to 1.5） were readily produced from glycerol dry reforming at CO2-to-Glycerol feed ratio （CGR） of unity. Nonetheless, carbon deposit comprised of whisker type （Cv） and graphitic-like type （Cc） species were found to be in majority on 20 wt%Ni/CC catalysts.

关键词： cement clinker dry reforming glycerol nickel catalyst syngas

Systematic review of the outcomes of surgical resection for intermediate and advanced Barcelona Clinic Liver Cancer stage hepatocellular carcinoma:A critical appraisal of the evidence

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World Journal of Hepatology 2018年第6期10卷 433-447页

作者： Ye Xin Koh Hwee Leong Tan weng Kit Lye Juinn Huar Kam Adrian kah Heng Chiow Siong San Tan Su Pin Choo Alexander Yaw Fui Chung Brian Kim Poh Goh Department of Hepatopancreatobiliary and Transplant Surgery Singapore General HospitalSingapore 169608Singapore Center for Quantitative Medicine Duke-NUS Graduate Medical SchoolSingapore 169857Singapore Department of General Surgery Hepatopancreatobiliary ServiceChangi General HospitalSingapore 529889Singapore Department of Medical Oncology National Cancer Centre SingaporeSingapore 169610Singapore Duke-NUS Graduate Medical School Singapore 169857Singapore

AIM To perform a systematic review to determine the survival outcomes after curative resection of intermediate and advanced hepatocellular carcinomas(HCC).METHODS A systematic review of the published literature was performed using the PubM ed database from 1 st January 1999 to 31 st Dec 2014 to identify studies that reported outcomes of liver resection as the primary curative treatment for Barcelona Clinic Liver Cancer(BCLC) stage B or C HCC. The primary end point was to determine the overall survival(OS) and disease free survival(DFS) of liver resection of HCC in BCLC stage B or C in patients with adequate liver reserve(i.e., Child's A or B status). The secondary end points were to assess the morbidity and mortality of liver resection in large HCC(defined as lesions larger than 10 cm in diameter) and to compare the OS and DFS after surgical resection of solitary vs multifocal *** We identified 74 articles which met the inclusion criteria and were analyzed in this systematic review. Analysis of the resection outcomes of the included studies were grouped according to(1) BCLC stage B or C HCC,(2) Size of HCC and(3) multifocal tumors. The median 5-year OS of BCLC stage B was 38.7%(range 10.0-57.0); while the median 5-year OS of BCLC stage C was 20.0%(range 0.0-42.0). The collective median 5-year OS of both stages was 27.9%(0.0-57.0). In examining the morbidity and mortality following liver resection in large HCC, the pooled RR for morbidity [RR(95%CI) = 1.00(0.76-1.31)] and mortality [RR(95%CI) = 1.15(0.73-1.80)] were not significant. Within the spectrum of BCLC B and C lesions, tumors greater than 10 cm were reported to have median 5-year OS of 33.0% and multifocal lesions 54.0%.CONCLUSION Indication for surgical resection should be extended to BCLC stage B lesions in selected patients. Further studies are needed to stratify stage C lesions for resection.

关键词： Barcelona Clinic Liver Cancer Hepatocellular carcinoma Hepatectomy Milan criteria

HM30181A,a potent P-glycoprotein inhibitor,potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model

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Cancer Biology & Medicine 2020年第4期17卷 986-1001页

作者： Wu Zeng Betty Yuen Kwan Law Vincent Kam Wai Wong Denise So Bik Chan Simon Wing Fai Mok Joyce Jia Ying Gao Rebecca Ka Yan Ho Xu Liang Jia Hao Li Ming Tsung Lee weng Li Yoon Michael P Smolinski Johnson Yiu Nam lau Christopher Wai Kei Lam Manson Fok State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina At he nex Hong Kong Irmo vative Limited Hong Kong China Faculty of Medici ne Macao Un iversity of Science and TechnologyMacaoChina Athenex Inc. New York 14203USA

Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma,owing to the presence of the blood-brain barrier and the activity of P-gp,which pumps its substrate back into the systemic *** aim of the present study was to develop an intravenous formulation of HM30181 A(HM)to inhibit P-gp in the brain to effectively deliver paclitaxel(PTX)for the treatment of malignant ***:Two formulations of solubilized HM were designed on the basis of different solid dispersion strategies:i)spray-drying[polyvinlypyrrolidone(PVP)-HM]and ii)solvent evaporation[HP-β-cyclodextrin(cyclodextrin)-HM].The P-gp inhibition of these 2 formulations was assessed on the basis of rhodamine 123 uptake in cancer *** and brain pharmacokinetic parameters were also determined,and the antitumor effect of cyclodextrin-HM with PTX was evaluated in an orthotopic glioma xenograft mouse ***:Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro,cyclodextrin-HM had a higher maximum tolerated dose in mice than did *** study of cyclodextrin-HM revealed a plasma concentration plateau at 20 mg/kg,and the mice began to lose weight at doses above this ***-HM(10 mg/kg)administered with PTX at 10 mg/kg showed optimal antitumor activity in a mouse model,according to both tumor volume measurement and survival time(P<0.05).Conclusions:In a mouse orthotopic brain tumor model,the intravenous co-administration of cyclodextrin-HM with PTX showed potent antitumor effects and therefore may have potential for glioma therapy in humans.

关键词： HM30181A glioma pharmacokinetics paclitaxel P-glycoprotein

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一种活性粘土专利产品的体外和体内抗菌效果

国外畜牧学（猪与禽） 2012年第2期32卷 18-20页

作者：万建美 G.Benzoni A.Guyonvarch Ng kah weng d.Marzin

越来越多的国家禁止抗生素生长促进剂的使用，使得养殖业面临肠道微生物病原过度增殖的风险更高，这些病原会导致肠道功能紊乱、垫料潮湿、死亡率增加和以及生产性能改变。

关键词：抗菌效果专利产品活性粘土抗生素生长促进剂微生物病原体内体外功能紊乱