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不同提取工艺桔梗多糖的理化性质分析及其对奥沙利铂体内分布的影响

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食品工业科技 2024年第18期45卷 326-333页

作者：孙济民吴亚运梁敏杰赵瑞芝王岩广东药科大学中药学院广东广州510000 广州中医药大学第二临床医学院广东广州510000

目的:探究不同提取工艺桔梗多糖(PGP)的理化性质,不同提取工艺所得的PGP对奥沙利铂(OXA)体内分布的影响。方法:本研究采用了热水提取(HW)、醋酸辅助提取(CA)、氨水辅助提取(ka)、超声辅助提取(UA)制备桔梗多糖,通过红外光谱、紫外光谱... 详细信息

目的:探究不同提取工艺桔梗多糖(PGP)的理化性质,不同提取工艺所得的PGP对奥沙利铂(OXA)体内分布的影响。方法:本研究采用了热水提取(HW)、醋酸辅助提取(CA)、氨水辅助提取(ka)、超声辅助提取(UA)制备桔梗多糖,通过红外光谱、紫外光谱、凝胶色谱、高效液相色谱等方法测定多糖的理化性质;建立OXA电感耦合等离子体-质谱(ICP-MS)体内分析方法,考察OXA单用组、OXA联用PGP-HW组、OXA联用PGP-CA组、OXA联用PGP-ka组、OXA联用PGP-UA组SD大鼠体内奥沙利铂分布的变化;使用Western Blot方法来测定肺组织中Oct-2和Pg-P蛋白的表达水平,考察PGP改变OXA体内分布的机制。结果:四种桔梗多糖在理化性质方面呈现出明显的区别。其中,PGP-ka的得率最高;四种桔梗多糖红外图谱均具备典型的多糖特征吸收峰;在分子量组成上,它们主要由7 kDa和3790 kDa两个分子量构成,但各自的分子量分布比例有所不同。此外,这四种桔梗多糖都含有甘露糖(Man)、鼠李糖(Rha)、半乳糖醛酸(GalA)、葡萄糖(Glu)、半乳糖(Gal)以及阿拉伯糖(Ara),但比例存在差异;四种多糖粒径主要集中在300 nm左右,且具有良好的溶液稳定性;与OXA单用组比,OXA联用PGP-CA组、OXA联用PGP-ka组分别增加肺组织OXA含量为36.93%和35.12%,且OXA联用PGP-ka组显著(Pka组能显著增加OXA在肺组织分布水平,其机制可能与增加肺组织中Oct-2的表达量有关。

关键词：提取工艺桔梗多糖奥沙利铂多糖构效关系体内分布

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Fabrication and magnetic properties of NiFe_2O_4 nanorods

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Rare Metals 2010年第4期29卷 385-389页

作者： wu Yue SHI Changhong YANG Wei National Key Laboratory for Electronic Measurement Technology North University of China Taiyuan 030051 China School of Mechanical andElectronic Engineering North University of China Taiyuan 030051 China The Quartermaster Institute of the General Logistics Department of the PLA Beijing 100010 China

NiFe2O4 nanorods have been successfully synthesized via thermal treatment of the rod-like precursor fabricated by Ni-doped （x-FeOOH, which was enwrapped by the complex of citric acid and Niz~. The morphology evolution during the calcination of the precursor nanorods was investigated with transmission electron microscopy （TEM）, and the phase and the magnetic properties of samples were analyzed through X-ray diffraction （XRD） and vibrating sample magnetometer （VSM）. The results indicated that the diameter of the NiFe204 nanorods obtained ranged between 30 and 50 nm, and the length ranged between 2 and 3 um. As the calcination temperature was up to 600℃, the coercivity, saturation magnetization, and remanent magnetization of the samples were 36.1 ka.m^-1, 27.2 ***^-1, and 5.3 ***^-1, respectively. The NiFe2O4 nanorods prepared have higher shape anisotropy and superior magnetic properties than those with irregular shapes.

关键词： inorganic compounds nickel ferrite nanorods electron microscopy magnetic properties

Magnetron sputtering deposition of [FePt/Ag]_n multilayers for perpendicular recording

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Rare Metals 2006年第1期25卷 47-50页

作者： WANG Fang XU Xiaohong wu Haishun School of Chemistry and Materials Science Shanxi Normal University Linfen 041004 China

[FePt/Ag]n multilayers were deposited on glass substrates by RF magnetron sputtering and ex situ annealed at 550℃ for 30 min. The effects of inserted Ag layer thickness and the number of bilayer repetitions （n） on the structure and magnetic properties of the multilayers were investigated. It was found that the difference between in-plane and out-of-plane coercivities varied with an increase of inserted Ag layer thickness in the [FePt 2 nm/Ag x nm]10 multilayers. The ratio of out-of-plane coercivity to in-plane coercivity reached the maximum value with the Ag layer thickness of 5 nm, indicating that the Ag layer thickness plays an important role in obtaining perpendicular orientation. For the [FePt 2 nm/Ag 5 um]n multilayers, perpendicular orientation is also influenced by n. The maximum value of the ratio of out-of-plane coercivity to in-plane coercivity appeared when n was given as 8. It was found that the [FePt 2 nm/Ag 5 nm]8 had a high perpendicular coercivity of 520 ka/m and a low in-plane one of 88 ka/m, which shows a strong perpendicular anisotropy.

关键词： [FePt/Ag]n multilayer perpendicular orientation magnetron sputtering coercivity

A meta-analysis of soluble suppression of tumorigenicity 2 （sST2） and clinical outcomes in pulmonary hypertension

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Journal of Geriatric Cardiology 2017年第12期14卷 766-771页

作者： King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK wu Mei DONG Guang-Ping LI ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse Department of Medicine and Therapeutics Faculty of Medicine Chinese University ofHong Kong Hong Kong China Li ka Shing Institute of Health Sciences Faculty of Medicine Chinese University ofHong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China Department of Anaesthesia and Intensive Care State Key Laboratory of Digestive Disease LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong China The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Department of Cardiology Qilu Hospital Shandong University Jinan China Research Center of Ion Channelopathy Institute of Cardiology Union Hospital Tongii Medical College Huazhong University of Science and Technology Wuhan China JC School of Public Health and Primary Care The Chinese University ofHong Kong Hong Kong China State Key Laboratory of digestive disease LKS Institute of Health Sciences Chinese University ofHong Kong Hong Kong China

Suppression of Tumorigenicity 2 （ST2） is a member of the interleukin （IL）-1 receptor family The ST2 receptor exists in two isoforms - ST2 ligand （ST2L） and soluble ST2 （sST2）.ST2L is a membrane receptor and sST2 is a trun- cated receptor which is soluble in the blood, allowing it to be detected in serum. IL-33 is a member of the IL-1 family of ligand and is the fimctional ligand of ST2L receptor. It binds to the ST2L, thereby mediating its immune function.

关键词： Mortality Poor outcomes Pulmonary hypertension Soluble suppression of tumorigenicity 2 SST2

从应对新冠肺炎疫情看非盟公共卫生治理的成就与问题

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西亚非洲 2022年第6期 27-48,156,157页

作者：吴卡金丽琴浙江师范大学法政学院浙江师范大学非洲法律与社会发展研究中心

新冠肺炎疫情对非洲公共卫生治理体系构成巨大考验。非盟作为全非性国际组织,积极采取一系列应急策略,即推出《非洲大陆新冠肺炎疫情应对联合战略》且进行动态调整,指导与协调成员国抗击疫情;依托非洲疾控中心,形成大陆与区域卫生协同机... 详细信息

新冠肺炎疫情对非洲公共卫生治理体系构成巨大考验。非盟作为全非性国际组织,积极采取一系列应急策略,即推出《非洲大陆新冠肺炎疫情应对联合战略》且进行动态调整,指导与协调成员国抗击疫情;依托非洲疾控中心,形成大陆与区域卫生协同机制;推动成立非洲药品管理局,促进非洲获得高质、安全、有效的医疗产品,为非洲制药业发展创造有利环境;创建“非洲疫苗采购信托基金”等机制,深化与国际组织对非疫情防控机制的专项合作。总体看,在应对新冠肺炎疫情过程中,非盟在本土医药生产、区域卫生协同治理及法律监管应急能力提升等方面作出了显著贡献。与此同时,非盟也面临公共卫生治理效能有待提高、公共卫生系统运行能力不足、国际援助不力等挑战。如何有效防范和应对突发性公共卫生事件,同时平衡经济社会发展与疫情防控之间的关系,将是非盟迫切需要解决的问题。未来,非盟若要在公共卫生治理领域发挥更大作用,对内需推进机制改革,优化政策设计,增强卫生系统防御能力;对外则需优化国际卫生合作模式,从整体上探索更优、更适合非洲大陆的公共卫生治理体制机制。

关键词：非盟新冠肺炎疫情公共卫生治理非洲疾控中心

Neoadjuvant chemotherapy plus intensity-modulated radiotherapy versus concurrent chemoradiotherapy plus adjuvant chemotherapy for the treatment of locoregionally advanced nasopharyngeal carcinoma:a retrospective controlled study

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Chinese Journal of Cancer 2016年第1期35卷 46-54页

作者： Wen-Ze Qiu Pei-Yu Huang Jun-Li Shi Hai-Qun Xia Chong Zhao ka-Jia Cao Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer Center Department of Radiation Oncology The Second Hospital of Tianjin Medical University

Background:In the era of intensity-modulated radiotherapy(IMRT),the role of neoadjuvant chemotherapy(NAC)for locoregionally advanced nasopharyngeal carcinoma(NPC)is *** aim of this study was to compare the efficacy of NAC plus IMRT and concurrent chemoradiotherapy(CCRT)plus adjuvant chemotherapy(AC)on locoregionally advanced ***:Between January 2004 and December 2008,240 cases of locoregionally advanced NPC confirmed by pathologic assessment in Sun Yat-sen University Cancer Center were *** the 240 patients,117 received NAC followed by IMRT,and 123 were treated with CCRT plus *** NAC+IMRT group received a regimen that included cisplatin and 5-fluorouracil(5-FU).The CCRT+AC group received cisplatin concurrently with radiotherapy,and subsequently received adjuvant cisplatin and *** survival rates were assessed by kaplan-Meier analysis,and the survival curves were compared using a log-rank *** analysis was conducted using the Cox proportional hazard regression ***:The 5-year overall survival(OS),locoregional relapse-free survival(LRRFS),distant metastasis-free survival(DMFS),and disease-free survival(DFS)were 78.0,87.9,79.0,and 69.8%,respectively,for the NAC+IMRT group and78.7,84.8,76.2,and 65.6%,respectively,for the CCRT+AC *** were no significant differences in survival between the two *** multivariate analysis,age(50 years)and overall stage(Ⅲvs.Ⅳ)were found to be independent predictors for OS and DFS;furthermore,the overall stage was a significant prognostic factor for *** with the CCRT+AC protocol,the NAC+IMRT protocol significantly reduced the occurrence rates of grade 3-4 nausea-vomiting(6.5 vs.1.5%,P=0.023)and leukopenia(9.7 vs.0.8%,P=0.006).Conclusions:The treatment outcomes of the NAC+IMRT and CCRT+AC groups were *** metastasis remained the predominant mode of treatment failure.

关键词：《癌症》期刊英文

Last glacial terrestrial vegetation record of leaf wax n-alkanols in the northern South China Sea:Contrast to scenarios from longchain n-alkanes

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Acta Oceanologica Sinica 2022年第8期41卷 22-30页

作者： Shengyi Mao Guodong Jia Xiaowei Zhu Nengyou wu Daidai wu Hongxiang Guan Lihua Liu CAS Key Laboratory of Gas Hydrate Guangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhou 510640China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Key Laboratory of Gas Hydrate of Ministry of Natural Resources Qingdao Institute of Marine GeologyQingdao 266237China Laboratory for Marine Mineral Resources Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

Long-chain n-alkanols and n-alkanes in core sediments from the northern South China Sea(SCS)were measured to make a comparison during terrestrial vegetation reconstruction from~42 ka to~7 *** results showed that terrestrial vegetation record from long-chain n-alkanes matched well with previous studies in nearby cores,showing that more C_(4)plants developed during the Last Glacial Maximum(LGM)and C_(3)plants dominated in the interglacial ***,these scenarios were not revealed by terrestrial vegetation reconstruction using long-chain n-alkanols,which showed C_(3)plant expansion during the *** discrepancy during the interglacial period could be attributed to the aerobic degradation of functionalized long-chain n-alkanols in the oxygen-rich bottom water,resulting in poor preservation of terrestrial vegetation *** the other hand,the different advantages of functionalized n-alkanols and non-functional n-alkanes to record local and distal vegetation signals,respectively,may offer a potential explanation for the contradiction during the LGM when the SCS was characterized by low-oxygen deep ***,large variations on n-alkyl lipid compositions in C_(3)/C_(4)plants could play a part in modulating sedimentary long-chain n-alkanols and n-alkanes toward different vegetation signals,thereby suggesting that caution must be taken in respect to the terrestrial vegetation reconstruction using long-chain n-alkanes and long-chain n-alkanols.

关键词： South China Sea long-chain n-alkanols long-chain n-alkanes Last Glacial Maximum terrestrial vegetation record

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始新世以来亚洲内陆干旱区的古气候定量重建

第四纪研究 2024年第5期44卷 1262-1272页

作者：贾云霞吴海斌张文超庞红丽山西师范大学地理科学学院山西太原030031 中国科学院地质与地球物理研究所中国科学院新生代地质与环境重点实验室北京100029 中国地质大学(北京)地球科学与资源学院北京100083 上海海事大学经济管理学院上海201306

亚洲内陆干旱化的形成与发展是新生代最引人瞩目的事件之一,与全球变冷、青藏高原隆升、东亚环境格局演化等一系列问题密切相关。目前,干旱化的起始时间、演化过程、驱动机制等方面均存在较大的争议。古气候的定量化研究有助于解答以上... 详细信息

亚洲内陆干旱化的形成与发展是新生代最引人瞩目的事件之一,与全球变冷、青藏高原隆升、东亚环境格局演化等一系列问题密切相关。目前,干旱化的起始时间、演化过程、驱动机制等方面均存在较大的争议。古气候的定量化研究有助于解答以上问题。本研究收集中国西北地区已经发表的、具有古地磁定年的3条孢粉序列,并且将孢粉百分比转换为植物功能型得分;之后,建立植物功能型-气候数据集的现代类比法模型,进而定量重建始新世以来古气候要素(年均降水、年均温度)的变化历史。留一法的交叉验证结果显示,该模型对于重建年均降水和年均温度均具有较高的可靠性。气候要素的定量重建结果显示,始新世以来年均降水从约948 mm下降至约84 mm,年均温度介于1~10℃之间。具体而言,40~23 Ma阶段,气候温暖湿润,年均降水和年均温度分别介于386~948 mm和2.00~9.44℃之间;23~8 Ma阶段,年均降水略有下降,介于187~953 mm之间,年均温度介于-1.11~8.52℃之间,其中17~12 Ma和10~9 Ma阶段年均降水明显增加,整体上超过400 mm;约8 Ma之后,气候逐渐冷干,年均降水介于84~434 mm之间,年均温度介于-2.84~8.85℃之间。与已有的古环境记录对比,本研究认为西北地区约23 Ma之后的干旱化过程主要受控于青藏高原的隆升和全球变冷的影响。

关键词：亚洲内陆定量重建干旱化新生代孢粉植物功能型

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Stephanorhinus kirchbergensis (Rhinocerotidae,Mammalia) from the Rhino Cave in Shennongjia,Hubei

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Chinese Science Bulletin 2010年第12期55卷 1157-1168页

作者： TONG HaoWen wu XianZhu Key Laboratory of Evolutionary Systematics of Vertebrates Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences 100044 Beijing China Chongqing Normal University Chongqing 400047 China

The Rhino Cave,a Paleolithic site in Shennongjia,is the highest altitude locality of rhinoceros in the Middle-South part of China,and it is also the southernmost and the richest locality in Stephanorhinus kirchbergensis fossils which include cranium,mandibles,isolated teeth and *** materials can be referred to the species Stephanorhinus kirchbergensis according to the following characters:incisorless,mandibular symphysis contracted,occiput high,subaural channel closed,with nasal and frontal horns,nasal septum partially ossified,premolars hypsodont and cheekteeth with smooth enamel surface,etc.;except its relatively shorter limb *** China,all the Pleistocene non-Coelodonta tandem-horned rhinoceroses were assigned to the genus dicerorhinus in the past *** today's viewpoint,most of them should be included in the genus Stephanorhinus,because dicerorhinus is quite different from Stephanorhinus in the following characters:smaller body size,generally unossified nasal septum,subaural channel open and with reduced incisors,*** is the first knowledge of Stephanorhinus kirchbergensis associated with Ailuropoda-Stegodon fauna,the typical Pleistocene mammalian fauna in South China.

关键词：神农架犀牛哺乳类哺乳动物群犀科湖北旧石器遗址表面光滑