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膝关节粘连：治疗和预防研究新进展

中国组织工程研究 2017年第36期21卷 5879-5885页

作者：吴海啸王鹏张超 Egiazaryan ka Ratyev AP Melnichenko SY Kuzin VV Skoroglyadov AV 俄罗斯联邦国立医科大学俄罗斯莫斯科1179972 俄罗斯联邦国立医科大学第一附属医院俄罗斯莫斯科1179972 河北省中医院河北省石家庄市050011 天津医科大学肿瘤医院国家肿瘤临床医学研究中心天津市“肿瘤防治”重点实验室天津市恶性肿瘤临床医学研究中心天津市300070

背景:膝关节粘连严重影响了患者术后的日常生活,而传统的治疗方式疗效有限。降低膝关节粘连发生率是提高手术预期疗效的关键,也是临床医学上需要急待解决的重要问题。目的:对膝关节粘连的各类研究文献进行分析,总结近10年的研究成果,为... 详细信息

背景:膝关节粘连严重影响了患者术后的日常生活,而传统的治疗方式疗效有限。降低膝关节粘连发生率是提高手术预期疗效的关键,也是临床医学上需要急待解决的重要问题。目的:对膝关节粘连的各类研究文献进行分析,总结近10年的研究成果,为防治膝关节粘连提供新的思路和方法。方法:由第一作者检索Pub Med数据库,查找2006至2016年的文献,英文检索词为"tissue adhesions,arthrofibrosis,joint stiffness,prevent,treatment",共检索到1 500余篇相关文献,59篇符合纳入标准。结果与结论:(1)近年来大量学者研究发现,创伤/手术引起膝关节出血、炎症反应,造成血管内皮细胞生长因子和白细胞介素6高表达,增加了成纤维细胞的活性,导致大量胶原蛋白沉积,发生粘连;(2)改进传统治疗方式和运用微创技术治疗膝关节粘连取得了一定的疗效,但仍存在再粘连风险;(3)关节腔内用药预防膝关节粘连在基础研究方面获得了显著成果,可成为预防膝关节粘连的一种有效方案,但临床可行性存在争议,需进一步深入研究,寻找疗效确切、不良反应小的药物。

关键词：组织构建组织工程组织粘连纤维化僵直伤口愈合血管内皮生长因子治疗预防

Parallelized volumetric fluorescence microscopy with a reconfigurable coded incoherent light-sheet array

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Light(Science & Applications) 2020年第1期9卷 1914-1924页

作者： Yu-Xuan Ren Jianglai wu Queenie T.K.Lai Hei Ming Lai dickson M.D.Siu wutian wu Kenneth K.Y.Wong Kevin K.Tsia Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong KongSAR 999077China Department of Physics University of CaliforniaBerkeleyCA 94720USA School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongSAR 999077China Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongHong KongSAR 999077China GHM Institute of CNS Regeneration Jinan University601 Huangpu Avenue WestGuangzhou 510632China Re-Stem Biotechnology Suzhou 215007China

Parallelized fluorescence imaging has been a long-standing pursuit that can address the unmet need for a comprehensive three-dimensional(3D)visualization of dynamical biological processes with minimal ***,the available approaches are limited to incomplete parallelization in only two dimensions or sparse sampling in three *** hereby develop a novel fluorescence imaging approach,called coded light-sheet array microscopy(CLAM),which allows complete parallelized 3D imaging without mechanical *** the concept of an“infinity mirror”,CLAM generates a light-sheet array with controllable sheet density and degree of ***,CLAM circumvents the common complications of multiple coherent light-sheet generation in terms of dedicated wavefront engineering and mechanical dithering/***,the encoding of multiplexed optical sections in CLAM allows the synchronous capture of all sectioned images within the imaged *** demonstrate the utility of CLAM in different imaging scenarios,including a light-scattering medium,an optically cleared tissue,and microparticles in fluidic *** can maximize the signal-to-noise ratio and the spatial duty cycle,and also provides a further reduction in photobleaching compared to the major scanning-based 3D imaging *** flexible implementation of CLAM regarding both hardware and software ensures compatibility with any light-sheet imaging modality and could thus be instrumental in a multitude of areas in biological research.

关键词： scattering light mirror

Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation

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Bioactive Materials 2023年第10期28卷 95-111页

作者： Pu Luo Ruoxuan Huang You wu Xingchen Liu Zhengjie Shan Li Gong Shudan Deng Haiwen Liu Jinghan Fang Shiyu wu Xiayi wu Quan Liu Zetao Chen Kelvin W.K.Yeung Wei Qiao Shoucheng Chen Zhuofan Chen Hospital of Stomatology Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of StomatologyGuangdong Research Center for Dental and Cranial Rehabilitation and Material EngineeringGuangzhou510055China Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative Region Instrumental Analysis Research Center Sun Yat-sen UniversityGuangzhou510275China Applied Oral Sciences and Community Dental Care Faculty of DentistryThe University of Hong KongHong Kong Special Administrative Region Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Traum1 The University of Hong Kong-Shenzhen HospitalShenzhen518058China

With the discovery of the pivotal role of macrophages in tissue regeneration through shaping the tissue immune microenvironment, various immunomodulatory strategies have been proposed to modify traditional biomaterials. Decellularized extracellular matrix (dECM) has been extensively used in the clinical treatment of tissue injury due to its favorable biocompatibility and similarity to the native tissue environment. However, most reported decellularization protocols may cause damage to the native structure of dECM, which undermines its inherent advantages and potential clinical applications. Here, we introduce a mechanically tunable dECM prepared by optimizing the freeze-thaw cycles. We demonstrated that the alteration in micromechanical properties of dECM resulting from the cyclic freeze-thaw process contributes to distinct macrophage-mediated host immune responses to the materials, which are recently recognized to play a pivotal role in determining the outcome of tissue regeneration. Our sequencing data further revealed that the immunomodulatory effect of dECM was induced via the mechnotrasduction pathways in macrophages. Next, we tested the dECM in a rat skin injury model and found an enhanced micromechanical property of dECM achieved with three freeze-thaw cycles significantly promoted the M2 polarization of macrophages, leading to superior wound healing. These findings suggest that the immunomodulatory property of dECM can be efficiently manipulated by tailoring its inherent micromechanical properties during the decellularization process. Therefore, our mechanics-immunomodulation-based strategy provides new insights into the development of advanced biomaterials for wound healing.

关键词： Wound healing Decellularized extracellular matrix Freeze-thaw treatment Multiscale mechanics Macrophage polarization Immunomodulation Mechanotransduction

Experience of Drug Abusers Participating in Community-Based Drug Rehabilitation Services Provided by the Counselling Centres for Psychotropic Substance Abusers (CCPSAs) in Hong Kong

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Health 2020年第8期12卷 1008-1028页

作者： Mimi Mei Ha Tiu Carmen ka Man Fung Wing Yan Fung Yin Yee Lai Chui Man Tse Tsz Hung Wong Tsz Kwan Wong Wing Yi Wong Mei Suet wu ka Man Yeung Lok Tung Yeung Yuk Ying Yu School of Nursing and Health Studies The Open University of Hong Kong HKSAR China

Despite the official statistics showing that the number of drug users has been declining, the problem of drug abuse remains serious in Hong Kong. This problem is evidenced by the trend of hidden and prolonged drug abuse. The recovery of drug abusers is an important process, because the misuse of drugs can cause many bio-psycho-social complications. Therefore, 11 Counselling Centres for Psychotropic Substance Abusers (CCPSAs) in different districts in Hong Kong play an important role on those drug abusers [1]. As a core community-based drug rehabilitation service in Hong Kong, studies about CCPSAs are limited. This study uses a descriptive qualitative approach to explore the experience of drug abusers participating in community-based drug rehabilitation services provided by CCPSAs. Five CCPSA users, who utilized the services for more than two months, participated in the semi-structured face-to-face interviews. Data collected were then analysed by thematic analysis, and five themes were generated: 1) receiving supportive counselling service in CCPSAs, 2) revealing variance towards nonmandatory services in CCPSAs, 3) encountering intrapersonal conflicts when participating in CCPSAs, 4) expanding social network through integration in group activities and 5) wishing to be a companion to other drug abusers. Findings of this study provide valuable insights towards services modification and the enhancement of drug rehabilitation and drug abusers’ wellbeing over the collaboration of healthcare workers, services providers and the media. However, this study has some limitations, and it presents suggestions for future research.

关键词： Drug Rehabilitation Services Counselling Centres Substances Abusers

Targeting PTP σ ameliorates morphological and behavioral outcomes after experimental ICH in mice

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Targeting PTP σ ameliorates morphological and behavioral ou...

张掖盆地晚更新世至中全新世气候变化:孢粉学和重矿物学证据

第十四届中国医师协会神经外科医师年会

作者： Haitao Sun Min Yao Hei Ming Lai Yin Stephen Chen Smaranda Ruxandra Badea Jiandong Huang Gilberto ka Kit Leung wutian wu Department of Neurosurgery Zhujiang HospitalSouthern Medical University School of Biomedical Sciences LKS Faculty of Medicinethe University of Hong Kong Department of Surgery LKS Faculty of Medicinethe University of Hong Kong State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong GHM Institute of CNS regeneration Jinan University

＜正＞Objective: To investigate effects of treatment with ISP targeting PTPσ on behavioral and morphological outcomes after experimental ICH in mice. Methods: Experimental ICH model in male mice was induced by intrastriatal injection of Collagenase IV. The functional neurological recovery were evaluated weekly until 8 weeks post-ICH using rotarod test and Cylinder test following daily ISP（10μM）

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西北地质 2024年第2期57卷 230-243页

作者：赵淼龚磊吴玺蔡五田张文卿安永会李康刘作鹏中国地质调查局水文地质环境地质调查中心河北保定071051 中国地质大学(北京)水资源与环境学院北京100083

为确定张掖盆地晚第四纪沉积地层时代和探讨其蕴含的古气候信息,笔者利用孢粉分析、重矿物分析、光释光测年等方法对研究区晚更新世以来气候变化特征进行了重建,并确认了当地全新世和晚更新世地层界限。结果表明:地层自下而上划分为4个... 详细信息

为确定张掖盆地晚第四纪沉积地层时代和探讨其蕴含的古气候信息,笔者利用孢粉分析、重矿物分析、光释光测年等方法对研究区晚更新世以来气候变化特征进行了重建,并确认了当地全新世和晚更新世地层界限。结果表明:地层自下而上划分为4个孢粉组合带和植被类型及气候特征:①深度为56.8~26.4 m,年龄为112.7~63.3 ka,属末次间冰期,粉组合为松–板栗–藜–菊–蒿,针阔叶混交林草原植被,为晚更新世温暖较湿润气候。②深度为26.4~2.6 m,年龄为63.3~11.8 ka,与末次冰期相当,孢粉组合为松–麻黄–藜–蒿,植被类型为针阔叶混交林草原植被,为晚更新世干燥寒冷气候。③深度为2.6~0.8 m,年龄为11.8~8.9 ka,全新世早期,孢粉组合为松–藜–蒿,稀树针阔叶混交林草原植被,较凉较干气候。④深度为0.8~0.15 m,年龄为8.9~7.8 ka,全新世早期向中期过渡期,孢粉组合为松–藜–菊–蒿,稀树针阔叶混交林草原植被,为温暖较干气候。孢粉组合所揭示的晚更新世—中全新世气候变化特征,对于揭示张掖盆地甚至西北干旱区的古气候变化具有重要意义。

关键词：张掖盆地古气候冰期孢粉分析重矿物

A high-resolution stalagmite O-C isotope record from Nanjing and its rapid response to climatic events

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Chinese Science Bulletin 2002年第2期47卷 139-143页

作者： wu Jiangying WANG Yongjin CHENG Hai CHEN Jun Earth Science Department Nanjing UniversityNanjing 210093China Geography College Nanjing normal UniversityNanjing 210097China Geology and Geophysics Department Minnesota University

Here we discussed rapid response of the cave temperature and vegetation to the four Dansgaard-Oeschger cold and warm cycles during 50-40 kaBP based on results of oxygen and carbon stable isotopic compositions from a stalagmite in Tangshan, Nanjing. It is found that the amount of C3 vegetation relative to C4-type declines during the D-O warm events, indicating the decrease of the effective mete-oric precipitation. Compared with O-isotope records of the Greenland ice core, the stalagmite record displays a very similar pattern to Greenland ice core record over the dec-ade-century time scale, suggesting that the changes of the East Asian monsoon climate are in accordance with the high-latitude polar climate in the short-term time scale. The age of the ice-rafted H5 event in the stalagmite record, how-ever, preceded that of Greenland ice cores by 2 ka. This out of phase between the remote areas cannot be yet proven be-cause the two time scales were determined from different dating methods.

关键词： Dansgaard-Oeschger cycle East Asian monsoon climate stalagmite.

Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats

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Neuroscience Bulletin 2013年第4期29卷 509-516页

作者： Qiuju Yuan Huanxing Su Kin Chiu wutian wu Zhi-Xiu Lin Department of Anatomy The University of Hong Kong School of Chinese Medicine Faculty of Science The Chinese University of Hong Kong State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences University of Macao State Key Laboratory of Brain and Cognitive Sciences Development and Growth Li Ka Shing Faculty of Medicine The University of Hong Kong Research Center of Reproduction Development and Growth Li Ka Shing Faculty of Medicine The University of Hong Kong GHM Institute of CNS Regeneration Jinan University

Conflicting findings exist regarding the link between functional recovery and the regrowth of spinal tracts across the lesion leading to the restoration of functional contacts. In the present study, we investigated whether functional locomotor recovery was attributable to anatomical regeneration at postnatal day 1 （PN1）, PN7, PN14 and in adult rats two months after transection injury at the tenth thoracic segment of the spinal cord. The Basso, Beattie, and Bresnahan scores showed that transection led to a failure of hindlimb locomotor function in PN14 and adult rats. However, PN1 and PN7 rats showed a significant level of stepping function after complete spinal cord transection. Unexpectedly, unlike the transected PN14 and adult rats in which the spinal cord underwent limited secondary degeneration and showed a scar at the lesion site, the rats transected at PN1 and PN7 showed massive secondary degeneration both anterograde and retrograde, leaving a 〉5-mm gap between the two stumps. Furthermore, retrograde tracing with fluorogold （FG） also showed that FG did not cross the transection site in PN1 and PN7rats as in PN14 and adult rats, and re-transection of the cord caused no apparent loss in locomotor performance in the rats transected at PN1. Thus, these three lines of evidence strongly indicated that the functional recovery after transection in neonatal rats is independent of regrowth of spinal tracts across the lesion site. Our results support the notion that the recovery of locomotor function in developing rats may be due to intrinsic adaptations in the spinal circuitry below the lesion that control hindlimb locomotor activity rather than the regrowth of spinal tracts across the lesion. The difference in secondary degeneration between neonatal and adult rats remains to be explored.

关键词： neonatal spinal cord injury regeneration functional recovery rat

Pollen-recorded climate changes between 13.0 and 7.0 ^(14)C ka BP in southern Ningxia,China

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Chinese Science Bulletin 2007年第8期52卷 1080-1088页

作者： SUN AiZhi MAYuZhen FENG ZhaoDong LI Fei wu HuiNing MOE Key Laboratory of Western China's Environmental Systems & College of Earth & Environment Sciences Lanzhou University Lanzhou 73000 China College of Resources and Technology Beijing Normal University Beijing 100875 China Department of Geology Baylor University Waco TX 76798 USA

A pollen record from Haiyuan section in the southern part of Ningxia revealed a detailed history of vegetation variation and associated climate changes during the period from^13.0 to^7.0 14 C ka BP.A steppe landscape under a moderately dry(and probably cool)condition(~12.7-~12.1 14 C ka BP)was replaced by a coniferous forest dominating the landscape under a generally wet climate from^12.1 to ~11.01 4C ka *** generally wet period,corresponding to the European B?lling/All?rod period,can be divided into three stages:a cool and wet stage between^12.1 and^11.4 14 C ka BP,a mild and rela- tively dry stage between^11.4 and^11.2 14 C ka BP,and a mild and wet stage between^11.2 and^11.0 14 C ka *** coniferous forest-dominated landscape was then deteriorated into steppe landscape (~11.0-~10.6 14 C ka BP)and further into a desert steppe landscape from^10.6 to^9.8 14 C ka BP,being correspondent to the European Younger Dryas *** a brief episode of a cool and wet climate (~9.8-~9.6 14 C ka BP),a relatively mild and dry condition prevailed during the early Holocene(~9.6- ~7.6 14 C ka BP)and then a warm and humid climate started the mid-Holocene(~7.6-~7.2 14 C ka BP).

关键词：中国宁夏南部花粉记录气候变化植被历史