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World Journal of Gastroenterology 2012年第21期18卷 2600-2608页

作者： Christian P Selinger Rupert WL leong Simon Lal Department of Gastroenterology Salford Royal HospitalSalford M6 8HD United Kingdom Gastroenterology and Liver Services Sydney Local Health Network Concord HospitalNSW 2139 Sydney Australia Faculty of Medicine The University of New South WalesNSW 2052 Sydney Australia

Inflammatory bowel disease (IBD) affects women of childbearing age and can influence fertility, pregnancy and decisions regarding breastfeeding. Women with IBD need to consider the possible course of disease during pregnancy, the benefits and risks associated with medications required for disease management during pregnancy and breastfeeding and the effects of mode of delivery on their disease. When indicated, aminosalicylates and thiopurines can be safely used during pregnancy. Infliximab and Adalimumab are considered probably safe during the first two trimesters. During the third trimester the placenta can be crossed and caution should be applied. Methotrexate is associated with severe teratogenicity due to its folate antagonism and is strictly contraindicated. Women with IBD tend to deliver earlier than healthy women, but can have a vaginal delivery in most cases. Caesarean sections are generally recommended for women with active perianal disease or after ileo-anal pouch surgery. While the impact of disease activity and medication has been addressed in several studies, there are minimal studies evaluating patients' perspective on these issues. Women's attitudes may influence their decision to have children and can positively or negatively influence the chance of conceiving, and their beliefs regarding therapies may impact on the course of their disease during pregnancy and/or breastfeeding. This review article outlines the impact of IBD and its treatment on pregnancy, and examines the available data on patients' views on this subject.

关键词： Pregnancy Breast-feeding Nursing Inflammatory bowel disease Crohn’s disease Ulcerative colitis

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INSIGHTS INTO IMAGES Mark leong Shares the Stories Behind His Stunning Photography

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城市漫步（GBA版） 2019年第6期 10-15页

作者： Matthew Bossons Mark leong 不详

A fifth-generation Chinese-American from sunshine-soaked California,Mark leong takes photos that are immediately *** images have been featured in a range of prestigious publications,including National Geographic,Time... 详细信息

关键词： striking Mark sunshine

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An Efficient Synthesis of Spiroquinoxalinones via Tandem Reactions

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Chinese Journal of Chemistry 2014年第12期32卷 1217-1220页

作者： Seh Yong leong Paul WSmith Bin Zou Novartis Institute for Tropical Diseases 10 Biopolis Road#05-01 Chromos138670 Singapore

A mild and efficient synthesis of spiroquinoxalinones via tandem condensation of chlorooxoindoline 1 with benzene-1,2-diamines 2 is *** a plausible mechanism for the reaction is proposed.

关键词： spiroquinoxalinone spirooxindole tandem reaction diamine mechanism

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Observing antimicrobial process with traceable gold nanodusters

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Nano Research 2021年第4期14卷 1026-1033页

作者： kaiyuan Zheng Magdiel I.Setyawati David Tai leong Jianping Xie Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4Singapore 117585Singapore School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Understanding the interaction of nanomaterials with biological systems has always been of high concern and *** emerging type of nanomaterials,ultrasmall metal nanoclusters(NCs,kage of bacterial contents,which can finally kill the *** Au NCs(or other metal NCs)provide a promising platform to study the antimicrobial mechanisms as well as other fundamentals on the interfacing of functional nanomaterials with the biological systems,further increasing their acceptance in various biomedical applications.

关键词： metal nanoclusters gold nancx^lusters antimicrobial agents luminescent probes bioimaging

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3-D Grid-Based Localization Technique in Mobile Sensor Networks

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Wireless Sensor Network 2010年第11期2卷 828-837页

作者： Jia Li Lei Sun wai Yee leong Peter H J Chong 不详

Considering the environmental protection, forest fire becomes a more and more serious problem and requires more concerns. This paper provides an efficient method for fire monitoring and detection in forests using wireless sensor network technology. The proposed technique estimates the location of a sensor node based on the current set of hop-count values, which are collected through the anchor nodes’ broadcast. Our algorithm incorporates two salient features;grid-based output and event-triggering mechanism, to improve the accuracy while reducing the power consumption. Through the computer simulation, the output region obtained from our algorithm can always cover the target node. In addition, the algorithm was implemented and tested with a set of Crossbow sensors. Experimental results demonstrated the high feasibility and worked well in real environment.

关键词： Wireless Mobile Sensor Networks Forest Fire Detection Localization Technique

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Structural Design Optimization Using Isogeometric Analysis: A Comprehensive Review

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Computer Modeling in Engineering & Sciences 2018年第12期117卷 455-507页

作者： Yingjun Wang Zhenpei Wang Zhaohui Xia leong Hien Poh National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing Engineering(South China University of Technology)Ministry of EducationSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou510641China Department of Civil and Environmental Engineering National University of Singapore 1 Engineering Drive 2E1A 07-03117576Singapore Center for Modeling Simulation and Imaging in Medicine(CeMSIM)Rensselaer Polytechnic InstituteTroyNY 12180USA.

Isogeometric analysis(IGA),an approach that integrates CAE into conventional CAD design tools,has been used in structural optimization for 10 years,with plenty of excellent research *** paper provides a comprehensive review on isogeometric shape and topology optimization,with a brief coverage of size *** isogeometric shape optimization,attention is focused on the parametrization methods,mesh updating schemes and shape sensitivity *** interesting observations,*** popularity of using direct(differential)method for shape sensitivity analysis and the possibility of developing a large scale,seamlessly integrated analysis-design platform,are discussed in the framework of isogeometric shape *** isogeometric topology optimization(ITO),we discuss different types of ITOs,*** using SIMP(Solid Isotropic Material with Penalization)method,ITO using level set method,ITO using moving morphable com-ponents(MMC),ITO with phase field model,etc.,their technical details and applications such as the spline filter,multi-resolution approach,multi-material problems and stress con-strained *** addition to the review in the last 10 years,the current developmental trend of isogeometric structural optimization is discussed.

关键词： Isogeometric analysis structural optimization shape optimization topology optimization sensitivity analysis.

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Epidemiological studies of migration and environmental risk factors in the inflammatory bowel diseases

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World Journal of Gastroenterology 2014年第5期20卷 1238-1247页

作者： Yanna Ko Rhys Butcher Rupert W leong Concord Hospital Gastroenterology and Liver Services and The University of New South Wales

Inflammatory bowel diseases(IBD)are idiopathic chronic diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk *** genotypes may manifest into clinical phenotypes under certain environmental influences and these may be best studied from migratory *** differences between first and second generation migrants may further highlight the contribution of environmental factors towards the development of *** are few opportunities that have been offered so *** aim to review the available migration studies on IBD,evaluate the known environmental factors associated with IBD,and explore modern migration patterns to identify new opportunities and candidate migrant groups in IBD migration research.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Epidemiology, Risk factor, Environment, Hygiene hypothesis

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Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?

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Regenerative Biomaterials 2016年第2期3卷 87-98页

作者： Hon Fai Chan Siying Ma kam W.leong Department of Biomedical Engineering Department of Systems BiologyColumbia UniversityNew YorkNY 10032USA

Translation of any inventions into products requires *** of drug/gene/cell delivery systems will eventually face manufacturing challenges,which require the establishment of standardized processes to produce biologically-relevant products of high quality without incurring prohibitive *** technologies present many advantages to improve the quality of drug/gene/cell delivery *** also offer the benefits of *** remains unclear is whether they can meet the scale-up *** this perspective,we discuss the advantages of microfluidic-assisted synthesis of nanoscale drug/gene delivery systems,formation of microscale drug/cell-encapsulated particles,generation of genetically engineered cells and fabrication of macroscale drug/cell-loaded micro-/*** also highlight the scale-up challenges one would face in adopting microfluidic technologies for the manufacturing of these therapeutic delivery systems.

关键词： microfluidics biomanufacturing nanoparticle microencapsulation microfiber

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Size prediction of κ-carrageenan droplets formed in co-flowing immiscible liquid

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Particuology 2011年第6期9卷 637-643页

作者： Jun-Yee leong Tek-kaun Lim Ravindra Pogaku Eng-Seng Chan Centre of Materials and Minerals School of Engineering and Information Technology Universiti Malaysia Sabah School of Engineering Monash University

The formation of K-carrageenan droplets in channel emulsification was experimentally investigated. The dispersed phase was vertically injected into co-flowing immiscible palm oil in the direction of gravity. This study focused on predicting K-carrageenan drop size using force balance analysis. The force balance model considers the interracial tension to be the solitary attaching force, while a combination of the drag force from the co-flowing palm oil and the body force of the extruding K-carrageenan liquid act as the detaching forces. The conventional model gave poor predictions for droplet size, with an average relative deviation of 23%. This large deviation could be attributed to necking phenomena and an underestimation of the drag force generated on the shear-thinning K-carrageenan solution. By incorporating correction factors, the average relative deviation of the force balance model dronned to 4%.

关键词： K-Carrageenan Droplet Channel emulsification Co-flowing Dripping Bioencapsulation

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CRL： Efficient Concurrent Regeneration Codes with Local Reconstruction in Geo-Distributed Storage Systems

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Journal of Computer Science & Technology 2018年第6期33卷 1140-1151页

作者： Quan-Qing Xu Wei-Ya Xi Khai leong Yong Chao Jin Institute of High Performance Computing Agency for Science Technology and Research Singapore 138632 Singapore Data Storage Institute Agency for Science Technology and Research Singapore 138632 Singapore Institute for Infocomm Research Agency for Science Technology and Research Singapore 138632 Singapore

As a typical erasure coding choice, Reed-Solomon （RS） codes have such high repair cost that there is a penaltyfor high reliability and storage efficiency, thereby they are not suitable in geo-distributed storage systems. We present anovel family of concurrent regeneration codes with local reconstruction （CRL） in this paper. The CRL codes enjoy threebenefits. Firstly, they are able to minimize the network bandwidth for node repair. Secondly, they can reduce the numberof accessed nodes by calculating parities from a subset of data chunks and using an implied parity chunk. Thirdly, they arefaster than existing erasure codes for reconstruction in geo-distributed storage systems. In addition, we demonstrate howthe CRL codes overcome the limitations of the Reed-Solomon codes. We also illustrate analytically that they are excellent inthe trade-off between chunk locality and minimum distance. Furthermore, we present theoretical analysis including latencyanalysis and reliability analysis for the CRL codes. By using quantity comparisons, we prove that CRL（6, 2, 2） is only0.657x of Azure LRC（6, 2, 2）, where there are six data chunks, two global parities, and two local parities, and CRL（10,4, 2） is only 0.656x of HDFS-Xorbas（10, 4, 2）, where there are 10 data chunks, four local parities, and two global paritiesrespectively, in terms of data reconstruction times. Our experimental results show the performance of CRL by conductingperformance evaluations in both two kinds of environments： 1） it is at least 57.25% and 66.85% more than its competitorsin terms of encoding and decoding throughputs in memory, and 2） it has at least 1.46x and 1.21x higher encoding anddecoding throughputs than its competitors in JBOD （Just a Bunch Of Disks）. We also illustrate that CRL is 28.79% and30.19% more than LRC on encoding and decoding throughputs in a geo-distributed environment.

关键词： concurrent regeneration code local reconstruction geo-distributed storage system

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