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The World of Chinese 2013年第4期 80-83,5页

作者： Wai ka-fai Yau Nai-hoi Ryker Chan Yu Xi

Staff writer Terence Hsieh critiques Johnnie To’s latest blockbuster,a world of crooked cops and crafty criminals

关键词：古天乐

一种新的求解带约束的有限极大极小问题的精确罚函数

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应用数学和力学 2012年第2期33卷 250-264页

作者：马骋李迅姚家晖张连生香港理工大学应用数学系上海大学数学系上海200444

提出了一种新的精确光滑罚函数求解带约束的极大极小问题.仅仅添加一个额外的变量,利用这个精确光滑罚函数,将带约束的极大极小问题转化为无约束优化问题.证明了在合理的假设条件下,当罚参数充分大,罚问题的极小值点就是原问题的极小值... 详细信息

提出了一种新的精确光滑罚函数求解带约束的极大极小问题.仅仅添加一个额外的变量,利用这个精确光滑罚函数,将带约束的极大极小问题转化为无约束优化问题.证明了在合理的假设条件下,当罚参数充分大,罚问题的极小值点就是原问题的极小值点.进一步,研究了局部精确性质.数值结果表明这种罚函数算法是求解带约束有限极大极小问题的一种有效算法.

关键词：带约束的极大极小问题约束优化问题罚函数

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Cellular & Molecular Immunology 2021年第4期18卷 1005-1015页

作者： Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan ka fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina lnstitute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Liver Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SARChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Life Science Hong Kong University of Science and TechnologyHong Kong SARChina Department of Surgery The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong Kong SARChina Department of Clinical Oncology The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Oncogenes and Related Genes Stem Cell Research CenterRen Ji HospitalSchool of MedicineShanghai Cancer InstituteShanghai Jiao Tong UniversityShanghaiChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SARChina Clinical Trial Unit The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Cancer Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer *** a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely ***,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive *** an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)*** of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,***,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic ***,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation *** summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic *** findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention.

关键词： Cell cycle related kinase liver metastasis liver immune microenvironment myeloid-derived suppressor cell natural killer T cell

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针灸治疗网球肘疗效的系统评价

针灸治疗网球肘疗效的系统评价

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

第七届中医/中西医结合循证医学方法研讨会

作者： Marcus Gadau Wing-fai Yeung 柳华 Chris Zaslawski Yuan-Sheng Tan Fu-Chun Wang Sergio Bangrazia ka-fai Chung Zhao-Xiang Bian 张世平香港浸会大学中医药学院香港大学精神科川北医学院第二临床医学院南充市中心医院神经科 College of Traditional Chinese Medicine University of Technology Sydney World Federation of Acupuncture and Moxibustion Societies Changchun University of Traditional Chinese Medicine

针灸广泛应用于网球肘(肱骨外上髁炎,LEP)的治疗,然而,不同的研究结论差异较大。本研究旨在运用循证医学方法,对有关针灸治疗LEP的随机对照试验进行了系统评价,以探讨针灸对LEP的疗效和副作用。本研究广泛检索中英文数据库以获取合格文... 详细信息

针灸广泛应用于网球肘(肱骨外上髁炎,LEP)的治疗,然而,不同的研究结论差异较大。本研究旨在运用循证医学方法,对有关针灸治疗LEP的随机对照试验进行了系统评价,以探讨针灸对LEP的疗效和副作用。本研究广泛检索中英文数据库以获取合格文献,针刺临床试验干预措施报告的标准(STRICTA)被用来衡量针灸临床实施质量,Jadad评分修订版用来评估纳入研究的方法学质量。总共19个比较针灸和假针刺或者传统治疗对LEP的RCT研究纳入本系统评价,仅有5个研究Jadad评分在3分或以上,其余14个研究具有较低的方法学质量。分析结果表明,相对于假针刺或者超声治疗,针灸疗效更好;然而,由于纳入研究的方法学质量低,目前证据不足以支持针灸在治疗LEP中,疗效比局麻药注射、局部糖皮质激素注射和非甾体类消炎药更好,虽然分析发现针刺加灸法似乎比单用针刺疗效好,然而这些研究低的方法学质量减弱了证据的可靠性。在未来的研究中,需要改进研究方法学质量,以便得出针灸对LEP疗效的真实可靠结论。

关键词：针灸网球肘肱骨外上髁炎系统评价 Meta分析

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S Y Yau Kwok-fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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太赫兹3D打印透镜综述

微波学报 2020年第1期36卷 32-37页

作者：陈志豪吴耿波陈家辉屈世伟香港城市大学电机工程系香港999077 香港城市大学太赫兹及毫米波国家重点实验室香港999077 电子科技大学电子科学与工程学院成都611731

太赫兹波由于其独特的电磁特性可应用于超高速率无线通信、生物化学物质检测以及高分辨率成像等领域。但由于太赫兹波的物理波长小,传统适用于低频的加工工艺难以满足其加工精度的要求;而微纳米加工工艺又具有加工复杂、成本高等缺点。3... 详细信息

太赫兹波由于其独特的电磁特性可应用于超高速率无线通信、生物化学物质检测以及高分辨率成像等领域。但由于太赫兹波的物理波长小,传统适用于低频的加工工艺难以满足其加工精度的要求;而微纳米加工工艺又具有加工复杂、成本高等缺点。3D打印技术的发展为太赫兹器件的加工提供了新的选择和更多的设计灵活度。文章介绍了香港城市大学太赫兹与毫米波国家重点实验室在3D打印太赫兹透镜方面的最新研究动态和实验研究新成果,包括基于3D打印的太赫兹高增益圆极化透镜、近场聚焦圆极化透镜、贝塞尔波束生成透镜的设计,高精度3D打印方法的探索以及太赫兹天线测试方法等。太赫兹3D打印透镜天线具有低成本、低损耗、能快速成型等特点,可应用于不同的太赫兹场景中。

关键词：太赫兹 3D打印透镜圆极化贝塞尔波束

Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

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Cellular & Molecular Immunology 2022年第7期19卷 834-847页

作者： Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan ka fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng school of Biomedical Sciences The Chinese University of Hong KongHong Kong SAR 999077China Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong SAR 999077China Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Surgery The Chinese University of Hong KongHong Kong SAR 999077China Department of Medicine and Therapeutics The Chinese University of Hong Kong.Hong Kong SAR 999077China State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong Kong SAR 999077China Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 639798Singapore Institute of Precision Medicine The First Affliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of *** cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains *** high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor *** analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD ***,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC ***,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell ***,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and *** study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic.

关键词： Cancer microenvironment Cancer models Tumour immunology

A new prognostic histopathologic classification of nasopharyngeal carcinoma

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Chinese Journal of Cancer 2016年第6期35卷 30-45页

作者： Hai-Yun Wang Yih-Leong Chang ka-fai to Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Department of Molecular Diagnostics Sun Yat-sen University Cancer Center Department of Pathology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Anatomical and Cellular Pathology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Department of Pathology Singapore General Hospital Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center Department of Pathology Sun Yat-sen University Cancer Center Division of Epidemiology Department of Health Research and PolicyStanford University School of Medicine Health Sciences Practice ExponentInc. Department of Otolaryngology National Taiwan University HospitalNational Taiwan University College of Medicine Department of Clinical Oncology Hong Kong Cancer Institute and Sir YK Pao Centre for CancerFaculty of MedicineThe Chinese University of Hong Kong Division of Radiation Oncology National Cancer CenterSingapore Department of Radiation Oncology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology The Affiliated Hospital of Bengbu Medical College Department of Pathology Cancer Institute and HospitalChinese Academy of Medical Sciences Department of Radiation Oncology Guangxi Medical University Department of Pathology Hunan Provincial Cancer Hospital Department of Radiation Oncology Sun Yat-sen University Cancer Center Department of Pathology Fujian Provincial Cancer Hospital Department of Pathology The First Affiliated HospitalSun Yat-sen University Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Pathology The Third Affiliated HospitalSun Yat-sen University Department of Experiment Research Sun Yat-sen University Cancer Center Department of Medical Epidemiology and Biostatistics Karolinska Institutet Departments of Mi

Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic *** study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment ***:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from *** efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed *** used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis.

关键词： Nasopharyngeal carcinoma Pathologic classification Prognosis

沉积物中多环芳烃在海岸带水域自然环境中的衰减研究

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台湾海峡 2001年第2期20卷 171-176页

作者：张勇庄一廷张杰 ka-fai Poon Michael H W Lam 洪华生 Rudolf S S Wu 厦门大学海洋环境科学教育部重点实验室厦门大学环境科学研究中心福建厦门361005 福建省福州市环境监测中心站福建福州351000 香港城市大学生物及化学系海洋污染与观测中心

本文在现场情况下 ,研究了自然条件下受污染海岸带沉积物中的 7种多环芳烃(PolynuclearAromaticHydrocarbons ,简称PAHs)的解吸动力学行为 .结果表明 ,7种PAHs的解吸动力学行为可以用二元模型描述 .文中并将所得数据与文献报道的数据进... 详细信息

本文在现场情况下 ,研究了自然条件下受污染海岸带沉积物中的 7种多环芳烃(PolynuclearAromaticHydrocarbons ,简称PAHs)的解吸动力学行为 .结果表明 ,7种PAHs的解吸动力学行为可以用二元模型描述 .文中并将所得数据与文献报道的数据进行了比较 .

关键词：多环芳烃解吸动力学行为污染沉积物环境衰减海岸带自然环境

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香港地区肿瘤护理的发展历程

中国护理管理 2022年第7期22卷 980-985页

作者：麦素珊黄嘉辉李剑洪苏帼慧麦玮智车锡英唐华根香港医院管理局新界东联网医院临床肿瘤科香港特别行政区999077 香港威尔斯亲王医院临床肿瘤科中国香港香港中文大学那打素护理学院中国香港香港医院管理局总办公室中国香港

回顾了香港地区肿瘤专科护士的角色、培训、教育、实践和服务的发展历程。重点介绍了过去20多年香港地区肿瘤护理的发展和转型。反映了肿瘤科护士在癌症控制和癌症护理质量方面所做的重要贡献。提出了未来香港地区肿瘤护理的培训和实践... 详细信息

回顾了香港地区肿瘤专科护士的角色、培训、教育、实践和服务的发展历程。重点介绍了过去20多年香港地区肿瘤护理的发展和转型。反映了肿瘤科护士在癌症控制和癌症护理质量方面所做的重要贡献。提出了未来香港地区肿瘤护理的培训和实践的具体方向,及对未来护理实践发展至关重要的方向和所需要发挥的作用,这需要临床、学术和专业机构不断努力以实现这一目标。

关键词：肿瘤护理护理角色护理实践护士诊所高级培训专科教育香港特别行政区