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Exploration of nonpharmacological control in thorough QT/QTc studies

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Exploration of nonpharmacological control in thorough QT/QTc...

第三届中日双边药理学和临床药理学学术会议

作者： SAHASHI Kunihiko KUMAGAI Yuji FUJITA Tomoe IKEDA Yasuhiko HASUNUMA Tomoko IIJIMA Hajime kosuge kazuhito OHTANI Yoshio Kitasato University East Hospital Japan Kitasato University East Hospital Japan Kitasato University East Hospital Japan Kitasato University East Hospital Japan Kitasato Institute Japan Kitasato Institute Japan Kitasato Institute Japan Kitasato University East Hospital Japan

＜正＞AIM Drug induced QT prolongation is a risk factor of torsade de pointes,a lethal ventricular tachycar- *** ICH-E14 guideline concerning QT/QTc pro- longation reached step5 in USA and *** the guideline, use of a positive control is recommended to detect changes in QT ***,a pharmacological control such as moxifloxaein is used in a thorough QT/QTc study,how- ever Japanese authority suggests use of nonpharmacological *** studied the possibility of such controls. METHODS The study included 2 parts in healthy male *** part A,effects of standing for 5 min and valsalva maneuver were studied in 74 subjects,and in part B effects of hand grip with 30% of max load for 3 min was studied in 50 *** were recorded for 15 s and QT intervals were measured in lead Ⅱ on *** in- terval was corrected by 2 methods of Bazette （QTcB） and of Fridericia （QTcF）.RESULTS QT interval itself was shortened markedly by standing although corrected QTcs showed changes of opposite *** observed chan- ges were a prolongation in QTcB and a shortening in *** maneuver caused no significant changes. QTcB and QTcF decreased immediately after hand grip but they increased after 3 min’ hand *** Changes in QT by physiological loads may be affected by heart rate,a cautious interpretation is necessary in discus- sing the possibility of such loads as positive controls.

关键词： QT interval ICH-E14 positive control standing,hand grip

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太赫兹行波管用金刚石输能窗研究进展

材料导报 2024年第16期38卷 20-28页

作者：张鹏伟宋惠白慧萍易剑江南西村一仁云南大学材料与能源学院昆明650091 中国科学院宁波材料技术与工程研究所浙江宁波315201

太赫兹波处于电磁波谱中电子学与光子学之间的空隙区域,具有不同于低频微波和高频光学的独特属性,在无线通信、生物医学、公共安全等军事和民用领域具有广阔的应用前景。太赫兹技术重点是对太赫兹波的产生和传输进行研究,当前所面临问... 详细信息

太赫兹波处于电磁波谱中电子学与光子学之间的空隙区域,具有不同于低频微波和高频光学的独特属性,在无线通信、生物医学、公共安全等军事和民用领域具有广阔的应用前景。太赫兹技术重点是对太赫兹波的产生和传输进行研究,当前所面临问题是在不产生额外传输损耗下保证高效率传输太赫兹信号。太赫兹行波管输能窗是典型的结构与功能一体化器件,主要起着行波管内外信号传递的作用,同时要保证器件内部的真空度以及对太赫兹波表现出高度“透明”。本文通过对近年来的文献进行总结整理,综述了国内外太赫兹行波管的应用和研究进展,揭示了未来发展大功率、高效率和宽频带传输是实现太赫兹真空器件实际应用的重点,这将对输能窗材料本身以及超精密加工提出了巨大挑战。纵观近几年国内外输能窗材料的发展历程,笔者们认为,与传统输能窗材料相比,单晶金刚石强度高,导热好,微波损耗小,没有晶界,气密性好,是最理想的太赫兹行波管输能窗口材料,也是目前研究发展的主流趋势。

关键词：太赫兹输能窗金刚石介电性能

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高温高压合成掺杂金刚石研究进展

人工晶体学报 2024年第2期53卷 194-209页

作者：郝敬林邓丽芬王凯悦宋惠江南西村一仁太原科技大学材料科学与工程学院太原030024 中国科学院宁波材料技术与工程研究所海洋材料及相关技术重点实验室浙江省海洋材料与防护技术重点实验室宁波315201

金刚石具有超高热导率、宽禁带等优点,通过掺杂引入电子和空穴等缺陷,提升载流子浓度,可以使金刚石具有适合半导体应用的电导率,被称为第三代终极宽禁带半导体材料。本文首先介绍了金刚石单晶的高温高压合成方法,接着系统综述了基于高... 详细信息

金刚石具有超高热导率、宽禁带等优点,通过掺杂引入电子和空穴等缺陷,提升载流子浓度,可以使金刚石具有适合半导体应用的电导率,被称为第三代终极宽禁带半导体材料。本文首先介绍了金刚石单晶的高温高压合成方法,接着系统综述了基于高温高压法的金刚石掺杂研究现状和发展,然后分析了N、B、P和S等单元素掺杂及多元素共掺杂对金刚石晶体生长和电学性能的影响,并且对第一性原理计算研究金刚石掺杂进行了分析总结。高温高压退火可以有效改变金刚石中掺杂元素与空位等缺陷组合和分布状态,本文明晰了金刚石中含氮色心形成的原因及高温高压退火对色心的调控机制。最后对金刚石掺杂以及掺杂后金刚石的光学性能和电学性能研究前景进行了展望,指出可进一步探索多元素共掺杂的理论与实验方法,对提升掺杂金刚石性能具有重要意义。

关键词：金刚石高温高压掺杂含氮色心退火第一性原理计算

Quantification of Ride Comfort Using Musculoskeletal Mathematical Model Considering Vehicle Behavior

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2287-2306页

作者： Junya Tanehashi Szuchi Chang Takahiro Hirosei Masaki Izawa Aman Goyal Ayumi Takahashi kazuhito Misaji Graduate Student Graduate School of Industrial TechnologyNihon UniversityChiba275-8575Japan Hitachi Astemo Ltd.Tochigi321-3325Japan Former Graduate Student Graduate School of Industrial TechnologyNihon UniversityChiba275-8575Japan College of Industrial Technology Nihon UniversityChiba275-8575Japan

This research aims to quantify driver ride comfort due to changes in damper characteristics between comfort mode and sport mode,considering the vehicle’s inertial *** comfort of riding in an automobile has been evaluated in recent years on the basis of a subjective sensory evaluation given by the ***,reflecting driving sensations in design work to improve ride comfort is abstract in nature and difficult to express ***,we evaluated the human body’s effects while driving scientifically by quantifying the driver’s behavior while operating the steering wheel and the behavior of the automobile while in motion using physical *** this end,we collected driver and vehicle data using amotion capture system and vehicle CAN and IMU *** also constructed a three-dimensional musculoskeletal mathematical model to simulate driver movements and calculate the power and amount of energy per unit of time used for driving the joints and muscles of the human ***,we used comfort mode and sport mode to compare damper characteristics in terms of *** comfort mode,damper characteristics are soft and steering stability is mild,but vibration from the road is not easily transmitted to the driver making for a lighter load on the *** sport mode,on the other hand,damper characteristics are hard and steering stability is comparatively ***,vibration from the road is easily transmitted to the driver,whichmakes it easy for a load to be placed on the *** a result of this comparison,it was found that a load was most likely to be applied to the driver’s *** result in relation to the neck joint can therefore be treated as an objective measure for quantifying ride comfort.

关键词： Human engineering biomechanics driver’s sense of fatigue double lane change musculoskeletal mathematical model

Left- and Right-Handers May Unintentionally Apply Different Cognitive Strategies in Response to Situational Demands: Study Using the Block-Wise Proportion Congruency Effect

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Journal of Behavioral and Brain Science 2022年第1期12卷 10-21页

作者： kazuhito Yoshizaki Yurina Watanabe Department of Psychology Aichi Shukutoku University Nagakute Japan

We investigated the effects of handedness on developing latent cognitive response strategies according to situation variables. We used the findings of the block-wise Proportion Congruency (PC) effect in which the proportion of congruent trials in a given block modulates the compatibility effect in its block. The block-wise PC effect cannot be intentionally controlled. A Simon task with three different types of Proportion Congruency (PC) in a given block was used to measure the block-wise PC effects. This task was administered to 24 left-handed and 24 right-handed participants. The reaction time and error rates, consistent with previous studies, demonstrated that the block-wise PC effect was observed in left- and right-handers. Crucially, the block-wise PC effect was more pronounced in left- than right-handers, suggesting that left- and right-handers unintentionally apply different cognitive strategies in response to conflict resolution experiences.

关键词： Cognitive Control Handedness Block-Wise Proportion Congruency (PC) Effect

Roles of Thioredoxins in the Obligate Anaerobic Green Sulfur Photosynthetic Bacterium Chlorobaculum tepidum

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Molecular Plant 2009年第2期2卷 336-343页

作者： Naomi Hosoya-Matsuda kazuhito Inoue Toru Hisabori Department of Biological Sciences Kanagawa University Hiratsuka Kanagawa 259-1293 Japan Chemical Resources Laboratory Tokyo Institute of Technology Nagatsuta 4259-R1-8 Yokohama 226-8503 Japan

Thioredoxin is a small ubiquitous protein that is involved in the dithiol-disulfide exchange reaction, byway of two cysteine residues located on the molecule surface. In order to elucidate the role of thioredoxin in Chlorobaculum tepidurn, an anaerobic green sulfur bacterium that uses various inorganic sulfur compounds and H2S as electron donors under strict anaerobic conditions for growth, we applied the thioredoxin affinity chromatography method （Motohashi et al., 2001）. In this study, 37 cytoplasmic proteins were captured as thioredoxin target candidates, including proteins involved in sulfur assimilation. Furthermore, six of the candidate proteins were members of the reductive tricarboxylic acid cycle （pyruvate orthophosphate dikinase, pyruvate flavodoxin/ferredoxin oxidoreductase, ^-oxoglutarate synthase, citrate lyase, citrate synthase, malate dehydrogenase）. The redox sensitivity of three enzymes was then examined： citrate lyase, citrate synthase, and malate dehydrogenase, using their recombinant proteins. Based on the information relating to the target proteins, the significance of thioredoxin as a reductant for the metabolic pathway in the anaerobic photosynthetic bacteria is discussed.

关键词： Thioredoxin anaerobic green sulfur bacteria redox regulation reductive tricarboxylic acid cycle.

Using a Musculoskeletal Mathematical Model to Analyze Fatigue of the Muscles in the Lower Limbs during Different Motions

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Computer Modeling in Engineering & Sciences 2018年第2期114卷 191-207页

作者： Kaito Watanabe Masaki Izawa Ayumi Takahashi kazuhito Misaji College of Industrial Technology Nihon University

Under the aim of finding effective rehabilitation solutions,the difference between the extents of fatigue of each muscle used in different motions are *** research suggested methods for estimating muscle torque and muscle tension on the basis of a musculoskeletal *** a result,it has become possible to quantitatively identify the extent of fatigue in each muscle during ***,to evaluate muscle fatigue more quantitatively,driving power and angular momentum are focused *** on the driving torque of joints and the muscle torque calculated by using a three-dimensional musculoskeletal model,a method for calculating the driving power of joints and the angular momentum of a muscle is *** method is applied to analysis of different ***,fatigue of muscles is quantitatively analyzed on the basis of driving power and angular momentum.

关键词： Angular momentum driving power driving torque musculoskeletal model

A Spiral Graphene Framework Containing Highly Ordered Graphene Microtubes for Polymer Composites with Superior Through-Plane Thermal Conductivity

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Chinese Journal of Chemistry 2022年第3期40卷 329-336页

作者： Jinrui Gong Xue Tan Qilong Yuan Zhiduo Liu Junfeng Ying Le Lv Qingwei Yan Wubo Chu Chen Xue Jinhong Yu kazuhito Nishimura Nan Jiang Cheng-Te Lin Wen Dai Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and Engineering(NIMTE)Chinese Academy of SciencesNingboZhejiang 315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBejjing 100049China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)Beijing Key Lab of Nonophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing 100081China College of Materials Science and Engineering Hunan UniversityChangshaHunan 410082China Advanced Nano-processing Engineering Lob Mechanical Systems EngineeringKogakuin UniversityTokyo 192-0015Japan

As the power density of electronic devices increases,there has been an urgent demand to develop highly conductive polymer composites to address the accompanying thermal management *** to the ultra-high intrinsic thermal conductivity,graphene is considered a very promising filler to improve the thermal conductivity of ***,graphene-based polymer composites prepared by the conventional mixing method generally have limited thermal conductivity,even under high graphene loading,due to the failure to construct efficient heat transfer pathways in the polymer ***,a spiral graphene framework(SGF)containing continuous and highly ordered graphene microtubes was developed based on a modified CVD *** embedding into the epoxy(EP)matrix,the graphene microtubes can act as efficient heat pathways,endowing the SGF/EP composites with a high through-plane thermal conductivity of 1.35 W·m^(-1)·K^(-1) at an ultralow graphene loading of 0.86 wt%.This result gives a thermal conductivity enhancement per 1 wt%filler loading of 710%,significantly outperforming various graphene structures as *** addition,we demonstrated the practical application of the SGF/EP composite as a thermal interface material for efficient thermal man-agement of the light-emitting diode(LED).

关键词： Graphene Chemical vapor deposition Polymer Thermal conductivity Thermal management material

Current status and future perspectives for the treatment of resectable locally advanced esophagogastric junction cancer:A narrative review

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World Journal of Gastroenterology 2023年第24期29卷 3758-3769页

作者： Yoshiaki Shoji Kazuo Koyanagi Kohei Kanamori Kohei Tajima Mika Ogimi Kentaro Yatabe Miho Yamamoto Akihito Kazuno kazuhito Nabeshima Kenji Nakamura Takayuki Nishi Masaki Mori Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193Japan

Incidence rates for esophagogastric junction cancer are rising rapidly worldwide possibly due to the economic development and demographic ***,increased attention has been paid to the prevention,diagnosis,and the treatment of esophagogastric junction *** there are discrepancies in the treatment strategy between Asian and Western countries,surgery remains the mainstay of treatment for esophagogastric junction *** developments of perioperative multidisciplinary treatment may lead to better therapeutic effect,higher complete resection rate,and better control of the residual diseases,thus result in prolonged *** this review,we will focus on the treatment of locally advanced resectable esophagogastric junction cancer,and discuss the current status and future perspectives of the perioperative treatment including chemotherapy,radiation therapy,and immunotherapy,as well as the surgical *** understanding of the latest treatment strategy and future overlook may enable to standardize and individualize the treatment for esophagogastric junction cancer,thus leading to better prognosis for those patients.

关键词： Esophagogastric junction cancer Perioperative therapy Neoadjuvant therapy Surgery Multidisciplinary treatment