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Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function:implication of miRNAs and microvesicles

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Military Medical Research 2024年第1期11卷 1-18页

作者： zi-Sen Zhang Yi-Yan Liu Shuang-Shuang He Dai-Qin Bao Hong-Chen Wang Jie Zhang Xiao-Yong Peng Jia-Tao Zang Yu Zhu Yue Wu qing-Hui Li Tao Li Liang-Ming Liu State Key Laboratory of Trauma Burns and Combined InjuryDepartment of Shock and TransfusionResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon *** hypothesized that pericytes,a group of pluripotent cells that maintain vascular integrity and tension,are protective against sepsis via regulating vascular reactivity and *** We conducted a series of in vivo experiments using wild-type(WT),platelet-derived growth factor receptor-β(PDGFR-β)-Cre+mT/mG transgenic mice and Tie2-Cre+Cx43^(flox/flox)mice to examine the relative contribution of pericytes in sepsis,either induced by cecal ligation and puncture(CLP)or lipopolysaccharide(LPS)*** a separate set of experiments with Sprague-Dawley(SD)rats,pericytes were depleted using CP-673451,a selective PDGFR-βinhibitor,at a dosage of 40 mg/(kg·d)for 7 consecutive *** pericytes,vascular endothelial cells(VECs)and vascular smooth muscle cells(VSMCs)were used for mechanistic *** effects of pericytes and pericyte-derived microvesicles(PCMVs)and candidate miRNAs on vascular reactivity and barrier function were also *** CLP and LPS induced severe injury/loss of pericytes,vascular hyporeactivity and leakage(P<0.05).Transplantation with exogenous pericytes protected vascular reactivity and barrier function via microvessel colonization(P<0.05).Cx43 knockout in either pericytes or VECs reduced pericyte colonization in microvessels(P<0.05).Additionally,PCMVs transferred miR-145 and miR-132 to VSMCs and VECs,respectively,exerting a protective effect on vascular reactivity and barrier function after sepsis(P<0.05).miR-145 primarily improved the contractile response of VSMCs by activating the sphingosine kinase 2(Sphk2)/sphingosine-1-phosphate receptor(S1PR)1/phosphorylation of myosin light chain 20 pathway,whereas miR-132 effectively improved the barrier function of VECs by activating the Sphk2/S1PR2/zonula occludens-1 and vascular endothelial-cadherin *** Pericytes are protective a

关键词： Pericyte Vascular reactivity Vascular permeability Cx43 Microvesicle

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The construction and practice of humanistic care teaching model based on 5C care theory

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Nursing Communications 2024年第8期8卷 1-9页

作者： Xi-Peng liu qing-qing Li Yu-zi Zhong Fei-Fei Hong Yan Li Yi-Jing Wang School of Nursing Tianjin University of Traditional Chinese MedicineTianjin 301617China.

Objective:To construct a scientific and feasible teaching mode based on 5C caring theory and evaluate it,so as to provide a reference basis for future study about nursing humanistic quality ***:Based on the 5C caring theory,the teaching design and teaching content were revising and implementing in the intervention *** and after the implementation of the course,a questionnaire survey was conducted using the Caring Ability Inventory(CAI).The results of the surveys were collected,and the data were statistically analysis using ***:After the implementation of the course,the cognitive dimension,patience dimension,and humanistic caring ability scores of the nursing students in the intervention group improved compared with those before the implementation of the course(P0.05).Conclusion:The humanistic caring teaching model based on 5C caring theory has a positive effect on improving nursing students'humanistic caring *** the future nursing teaching,the modules with the characteristics of humanistic caring ability can be increased,and carry out the educational reform throughout the humanistic caring *** guiding nursing students to establish the awareness of humanistic caring,so as to lay a solid foundation for high-quality clinical nursing work.

关键词： 5C caring theory humanistic caring ability undergraduate nursing students teaching model

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Comparative Analysis of ARIMA and LSTM Model-Based Anomaly Detection for Unannotated Structural Health Monitoring Data in an Immersed Tunnel

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1797-1827页

作者： qing Ai Hao Tian Hui Wang qing Lang Xingchun Huang Xinghong Jiang Qiang Jing School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Key Laboratory of Road and Bridge Detection and Maintenance Technology of Zhejiang Province Hangzhou311305China Zhejiang Scientific Research Institute of Transport Hangzhou310023China State Key Laboratory of Coal Mine Dynamics and Control Chongqing UniversityChongqing400044China Hong kong-Zhuhai-Macao Bridge Authority Zhuhai519060China

Structural Health Monitoring(SHM)systems have become a crucial tool for the operational management of long *** immersed tunnels exposed to both traffic loads and the effects of the marine environment,efficiently identifying abnormal conditions from the extensive unannotated SHM data presents a significant *** study proposed amodel-based approach for anomaly detection and conducted validation and comparative analysis of two distinct temporal predictive models using SHM data from a real immersed ***,a dynamic predictive model-based anomaly detectionmethod is proposed,which utilizes a rolling time window for modeling to achieve dynamic *** the assumption of temporal data similarity,an interval prediction value deviation was employed to determine the abnormality of the ***,dynamic predictive models were constructed based on the Autoregressive Integrated Moving Average(ARIMA)and Long Short-Term Memory(LSTM)*** hyperparameters of these models were optimized and selected using monitoring data from the immersed tunnel,yielding viable static and dynamic predictive ***,the models were applied within the same segment of SHM data,to validate the effectiveness of the anomaly detection approach based on dynamic predictive modeling.A detailed comparative analysis discusses the discrepancies in temporal anomaly detection between the ARIMA-and LSTM-based *** results demonstrated that the dynamic predictive modelbased anomaly detection approach was effective for dealing with unannotated SHM *** a comparison between ARIMA and LSTM,it was found that ARIMA demonstrated higher modeling efficiency,rendering it suitable for short-term *** contrast,the LSTM model exhibited greater capacity to capture long-term performance trends and enhanced early warning capabilities,thereby resulting in superior overall performance.

关键词： Anomaly detection dynamic predictive model structural health monitoring immersed tunnel LSTM ARIMA

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东汉时期罗马和贵霜对西域归属汉朝的认知

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新疆大学学报（哲学社会科学版） 2024年第3期52卷 45-53页

作者：张子青新疆大学历史学院新疆乌鲁木齐830046

有汉一代,西域被正式纳入中国统一多民族国家的格局之中,与此同时“西域与中原地区是一个整体”的观念也开始形成。这一观念不仅体现在中央政权对西域管辖权的宣示和西域各民族对中央政权的认同,也体现在域外国家对西域归属中国的认知... 详细信息

有汉一代,西域被正式纳入中国统一多民族国家的格局之中,与此同时“西域与中原地区是一个整体”的观念也开始形成。这一观念不仅体现在中央政权对西域管辖权的宣示和西域各民族对中央政权的认同,也体现在域外国家对西域归属中国的认知。东汉时期,不论是罗马帝国的马其顿商团,还是迫使部分西域地方政权纳质的贵霜统治者,均将西域视作汉朝的一部分。这不仅与汉朝中央、西域地方政权对西域属于汉朝的认知形成呼应和对证,而且开辟了日后亚欧大陆诸多民族对西域与中原地区一体性认知的先例,进而从思想史的层面和世界史的视野佐证这一事实,即汉代以后历代中央政权经略西域的实质,是中国统一多民族国家对在汉代已属一体的中原地区与西域的不断整合,而非西方帝国历史经验中的“征服”。这一研究有助于我们进一步审视近代以来部分国外学者在新疆历史认知上的局限,以及长期流行的“中原地区—内亚”二元对立视角,重新看待中国统一多民族国家形态的特殊性和延续性。

关键词：东汉西域罗马贵霜

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冬季运行能量桩热力响应及系统性能监测与评价

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岩土工程学报 2024年第6期46卷 1309-1317页

作者：孔纲强陈玉杨庆三峡大学三峡库区地质灾害教育部重点实验室湖北宜昌443002 河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210024 大连理工大学海岸和近海工程国家重点实验室辽宁大连116024

以湖北宜昌地区25 m~2的建筑房间冬季供暖需求为应用场景,构建由能量桩、集分水器、热泵机组、循环水泵等组成的地源热泵系统,分析建筑房间实际冬季供暖需求条件下,能量桩系统持续或间歇运行对能量桩热力响应及系统性能的影响规律,并开... 详细信息

以湖北宜昌地区25 m~2的建筑房间冬季供暖需求为应用场景,构建由能量桩、集分水器、热泵机组、循环水泵等组成的地源热泵系统,分析建筑房间实际冬季供暖需求条件下,能量桩系统持续或间歇运行对能量桩热力响应及系统性能的影响规律,并开展传统钻孔埋管地源热泵系统试验和空气源热泵系统试验进行对比分析。着重探讨实际运行条件下能量桩热力响应特性与传统TPT或TRT试验条件下获得结果之间的异同点,监测能量桩系统的供暖效果、能效比(COP)。持续运行试验对应桩顶出现最大温度降低值3.78℃及最大约束拉应力0.70 MPa(约为完全约束应力上限值的57.5%),运行桩较非运行对角桩对应承台部位产生的实测应变值差值在顶部和底部分别为19.98,17.78με。实测能量桩系统COP约为3.03,较相关空气源热泵系统提高约12.2%~21.2%(规范参考COP为2.50~2.70)。能量桩系统较常规空气源热泵系统,能提前约2.5 h到达预设温度,具有更快的启动速度。

关键词：能量桩间歇运行热力响应特性能效比(COP) 现场试验

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Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

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Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-Hui Zhang Fei-Fei Zhang Zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na kong Min Wu Hai-Ou Liu Yan Liu Zhi Li qing-qing Cai Yang Wang Quan-Wei Wei Peng-Cheng Lin Yan Lin Wei Xu Cong-Jian Xu Yi-Yuan Yuan Shi-Min Zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

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Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 412-424,I0003-I0010页

作者： Shi-Chuan Tang Yong-Kang Diao kong-Ying Lin Chao Li Xiao Xu Lei Liang Jie kong qing-Jing Chen Xian-Ming Wang Fu-Bao Liu Wei-Min Gu Ya-Hao Zhou Ying-Jian Liang Hong-Zhi Liu Ming-Da Wang Lan-qing Yao Timothy M.Pawlik Feng Shen Wan Yee Lau Tian Yang Yong-Yi Zeng Department of Hepatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouChina Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalNavy Medical University(Second Military Medical University)ShanghaiChina Department of Hepatobiliary Surgery Affiliated Hospital of Nantong UniversityNantongChina Department of Hepatobiliary Surgery People’s Hospital of Zhejiang ProvincialPeople’s Hospital of Hangzhou Medical CollegeHangzhouChina Department of Hepatobiliary Heze Municiple HospitalHezeChina Department of General Surgery First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinanChina Department of Hepatobiliary Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiChina The First Department of General Surgery Fourth Hospital of HarbinHarbinChina Department of Hepatobiliary Surgery Pu’er People’s HospitalPu’erChina Department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Surgery Ohio State UniversityWexner Medical CenterColumbusOHUSA Faculty of Medicine The Chinese University of Hong KongHong KongChina Department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Fujian Medical UniversityFuzhouChina The Liver Disease Research Center of Fujian Province FuzhouChina

Background:The application of Pringle maneuver(PM)during hepatectomy reduces intraoperative blood loss and the need for perioperative transfusion,but its effect on long-term recurrence and survival for patients with hepatocellular carcinoma(HCC)remains *** sought to determine the association between the application of PM and post-hepatectomy oncologic outcomes for patients with ***:Patients who underwent curative hepatectomy for HCC at 9 Chinese hospitals from January 2010 to December 2018 were *** two propensity score methods[propensity score matching(PSM)and inverse probability of treatment weight(IPTW)],cumulative recurrence rate and cancer-specific mortality(CSM)were compared between the patients in the PM and non-PM *** competing-risks regression models were performed to adjust for the effect of non-cancer-specific mortality and other prognostic risk ***:Of the 2,798 included patients,2,404 and 394 did and did not adopt PM(the PM and non-PM groups),*** rates of intraoperative blood transfusion,postoperative 30-day mortality and morbidity were comparable between the two groups(all P>0.05).In the PSM cohort by the 1:3 ratio,compared to 382 patients in the non-PM group,1,146 patients in the PM group also had the higher cumulative 5-year recurrence rate and CSM(63.9%and 39.1%vs.55.3%and 31.6%,both P<0.05).Similar results were also yielded in the entire cohort and the IPTW *** competing-risks regression analyses demonstrated that no application of the PM was independently associated with lower recurrence rate and CSM based on various analytical cohorts[hazard ratio(HR),0.82 and 0.77 in the adjusted entire cohort,HR 0.80 and 0.73 in the PSM cohort,and HR 0.80 and 0.76 in the IPTW cohort,respectively].Conclusions:The findings suggested that no application of PM during hepatectomy for patients with HCC reduced the risk of postoperative recurrence and cancer-specific death by appr

关键词： Hepatocellular carcinoma(HCC) Pringle maneuver(PM) recurrence survival hepatectomy

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焊后局部热处理区域布置对厚壁圆筒环缝残余应力的影响

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金属热处理 2024年第9期49卷 221-225页

作者：刘姿孔为民中北大学创新创业学院山西太原030051

采用粘弹塑性有限元方法,研究了16MND5钢厚壁圆筒在不同局部热处理标准(B31.1、B31.3、ASME section NB、BS2633和AWS D10.10)加热条件下焊接残余等效应力、环向应力及轴向应力的变化及分布情况。综合分析了焊缝中心及其附近区域的焊接... 详细信息

采用粘弹塑性有限元方法,研究了16MND5钢厚壁圆筒在不同局部热处理标准(B31.1、B31.3、ASME section NB、BS2633和AWS D10.10)加热条件下焊接残余等效应力、环向应力及轴向应力的变化及分布情况。综合分析了焊缝中心及其附近区域的焊接残余应力、加热区边缘附加热处理应力,并讨论了加热宽度、保温宽度对焊后局部热处理效果的影响。结果表明,局部热处理后,加热区边缘不均匀加热引起一定的应力上升,保温区的存在可以缓解温度梯度,从而使加热区边缘的附加应力降低。对厚壁圆筒来说按AWS D10.10标准局部热处理时,焊缝中心可达到与整体热处理相当的效果,焊接残余应力消除效果最好。

关键词：厚壁圆筒 16MND5钢焊后局部热处理加热宽度保温宽度

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Plant diversity increases diversity and network complexity rather than alters community assembly processes of leaf-associated fungi in a subtropical forest

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Science China Life Sciences 2024年

作者： Jie Li Xing-Chun Li Hui-Yun Gan Yue Zhang zi-Xuan Guo Yu-Xuan Liu Yong-qing Lin Liang-Dong Guo State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences

Plant diversity significantly impacts ecosystem processes and functions, yet its influence on the community assembly of leaf fungi remains poorly understood. In this study, we investigated leaf epiphytic and endophytic fungal communities in a Chinese subtropical tree species richness experiment, ranging from 1 to 16 species, using amplicon sequencing to target the internal transcribed spacer 1 region of the rDNA. We found that the community assembly of epiphytic and endophytic fungi was predominantly governed by stochastic processes, with a higher contribution of dispersal limitation on epiphytic than on endophytic fungal communities but a higher contribution of selection on endophytic than on epiphytic fungal communities. The plant-epiphytic fungus interaction network was more complex(e.g., more highly connected and strongly nested but less specialized and modularized) than the plant-endophytic fungus interaction network. Additionally,tree species richness was positively correlated with the network complexity and diversity of epiphytic(α-, β-and γ-diversity) and endophytic(β-and γ-diversity) fungi, but was not associated with the contribution of the stochastic and deterministic processes on the community assembly of epiphytic and endophytic fungi. This study highlights that tree species diversity enhances the diversity and network complexity,rather than alters the ecological processes in community assembly of leaf-associated fungi.

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Prescribed Performance Tracking Control of Time-Delay Nonlinear Systems With Output Constraints

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1557-1565页

作者： Jin-Xi Zhang Kai-Di Xu qing-Guo Wang IEEE the State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110819China Institute of Artificial Intelligence and Future Networks Beijing Normal UniversityZhuhai 519087 Guangdong Key Laboratory of Artificial Intelligence and Multi-Modal Data Processing Beijing Normal University-Hong Kong Baptist University United International CollegeZhuhai 519087

The problem of prescribed performance tracking control for unknown time-delay nonlinear systems subject to output constraints is dealt with in this paper. In contrast with related works, only the most fundamental requirements, i.e., boundedness and the local Lipschitz condition, are assumed for the allowable time delays. Moreover, we focus on the case where the reference is unknown beforehand, which renders the standard prescribed performance control designs under output constraints infeasible. To conquer these challenges, a novel robust prescribed performance control approach is put forward in this ***, a reverse tuning function is skillfully constructed and automatically generates a performance envelop for the tracking error. In addition, a unified performance analysis framework based on proof by contradiction and the barrier function is established to reveal the inherent robustness of the control system against the time delays. It turns out that the system output tracks the reference with a preassigned settling time and good accuracy,without constraint violations. A comparative simulation on a two-stage chemical reactor is carried out to illustrate the above theoretical findings.

关键词： Nonlinear systems output constraints prescribed performance reference tracking time delays

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