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Neurological consequences of human calmodulin mutations

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Neural Regeneration Research 2024年第5期19卷 943-944页

作者： helene H.Jensen Anders Olsen Medical Biotechnology Department of Chemistry and BiosciencesAalborg UniversityAalborgDenmark

When calcium ions enter the cytosol,it is a stimulatory signal for cellular *** calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction *** this way,calmodulin affects cellular processes such as fertilization,muscle contraction,neuronal firing,and *** is,calmodulin is involved in(nearly)everything!The significance of calmodulin is emphasized by the fact that we all carry three different genes(CALM1,2,3)on different chromosomes that encode the exact same calmodulin protein,and these are all expressed in all cell ***,throughout vertebrate evolution,the protein sequence has remained completely unchanged.

关键词： consequences unchanged calmodulin

Bacterial plant pathogens affect the locomotor behavior of the insect vector:a case study of Citrus volkameriana-Triozae erytreae-Candidatus Liberibacter asiaticus system

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Insect Science 2024年第3期31卷 901-910页

作者： Arnaud Ameline Alain Karkach Thomas Denoirjean Martial Grondin Florencia Molinari Patrick Turpin helene Delatte Bernard Reynaud UMR CNRS 7058 EDYSAN(Ecologie et Dynamique des Systemes Anthropises) Universite de Picardie Jules VerneAmiensCedexFrance UMR PVBMT(Peuplements végétaux et bioagresseurs en milieu tropical) Universitéde la RéunionSaint PierreLa RéunionFrance

Plant pathogens can alter the behavior of their insect vectors as well as their survival and *** African psyllid,Trioza erytreae,is one of the vectors of Huanglongbing,a citrus disease caused mainly by"Candidatus Liberibacter asiaticus"(CLas).The purpose of this study was to characterize the effects of CLas on the psyllid,*** using Citrus volkamerina plants as the study *** study focused more specifically on the CLas effects prior to and after its acquisition by the psyllid *** results did not support the hypothesis that CLas effects psyllid probing behavior prior to acquisition;few differences were observed between uninfected *** feeding on CLas-infected versus control *** the other hand,compared to psyllids that had completed their development on control plants,the ones that had completed their development on a CLas-infected plant exhibited changes in their behavior(greater velocity),physiology(smaller mass)and biochemistry(lower water and lipid content).Altogether,our results confirm the existence of a marked postacquisition effect on the vector locomotor behavior and a minor preacquisition effect of CLas on the vector behavior,which can be partially explained by physiological and biochemical changes.

关键词： electrical penetration graph Huanglongbing locomotory behavior lipid biomass probing behavior vector manipulation

Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells

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World Journal of Stem Cells 2024年第5期16卷 551-559页

作者： Amani Yehya Joseph Azar Mohamad Al-Fares helene Boeuf Wassim Abou-Kheir Dana Zeineddine Ola Hadadeh Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Inserm BiotisU1026University BordeauxBordeaux F-33000France Rammal Rammal Lab Physio-Toxicity Environmental TeamFaculty of SciencesLebanese UniversityNabatieh 0000Lebanon

BACKGROUND Embryonic stem cells(ESCs)serve as a crucial ex vivo model,representing epiblast cells derived from the inner cell mass of blastocyst-stage *** exhibit a unique combination of self-renewal potency,unlimited proliferation,and *** latter is evident by the ability of the isolated cells to differ-entiate spontaneously into multiple cell lineages,representing the three primary embryonic germ *** regulatory networks guide ESCs,directing their self-renewal and lineage-specific ***,or programmed cell death,emerges as a key event involved in sculpting and forming various organs and structures ensuring proper embryonic ***-ever,the molecular mechanisms underlying the dynamic interplay between diffe-rentiation and apoptosis remain poorly *** To investigate the regulatory impact of apoptosis on the early differentiation of ESCs into cardiac cells,using mouse ESC(mESC)models-mESC-B-cell lym-phoma 2(BCL-2),mESC-PIM-2,and mESC-metallothionein-1(MET-1)-which overexpress the anti-apoptotic genes Bcl-2,Pim-2,and Met-1,*** mESC-T2(wild-type),mESC-BCL-2,mESC-PIM-2,and mESC-MET-1 have been used to assess the effect of potentiated apoptotic signals on cardiac *** hanging drop method was adopted to generate embryoid bodies(EBs)and induce terminal differentiation of *** size of the generated EBs was measured in each condition compared to the wild *** the functional level,the percentage of cardiac differentiation was measured by calculating the number of beating cardiomyocytes in the manipulated mESCs compared to the *** the molecular level,quantitative reverse transcription-polymerase chain reaction was used to assess the mRNA expression of three cardiac markers:Troponin T,GATA4,and ***,troponin T protein expression was evaluated through immunofluorescence and western blot *** Our findings showed that the upregulation of Bcl-

关键词： Mouse embryonic stem cells Self-renewal Apoptosis Cardiac differentiation B-cell lymphoma 2 PIM-2 Metallothionein-1

Cardiac Malformations in Congenital Hypothyroidism: A Case Report

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Open Journal of Pediatrics 2024年第2期14卷 279-284页

作者： Suzanne Sap Gaelle Ntsoli Jocelyn Tony Ritha Mbono helene Kamo David Chelo Mother and Child Center of Chantal Biya Foundation Yaounde Cameroon University of Yaounde I Yaounde Cameroon Laquintinie Hospital University of Douala Douala Cameroon General Hospital of Garoua University of Garoua Garoua Cameroon

Introduction: Congenital hypothyroidism is the most common causes of preventable mental retardation. It is associated with other births defects like cardiac malformations. Descriptions in Sub Saharan Africa are rare, justifying the present report. Case Report: We reported the cases of 3 female patients, diagnosed with hypothyroidism, presenting in addition pulmonary stenosis. The diagnosis was late in all the patients and we noticed clinical improvement under levothyroxine. Conclusion: Association congenital hypothyroidism and cardiac defect is not rare. Our patients are female with no history of consanguinity, presenting congenital hypothyroidism with a gland in situ associated with pulmonary stenosis. Systematic screening of other births defects is thus recommended in affected patients.

关键词： Congenital Hypothyroidism Cardiac Malformations Children

Understanding intrarenal backflow: Intrarenal pressure during ureteroscopy and beyond

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Asian Journal of Urology 2024年第2期11卷 139-142页

作者： Palle J.S.Osther Susanne S.Osther Maria P.Hesselholt Sofia Byllov Søren K.Lildal Louise F.Øbro helene Jung Urological Research Center Department of UrologyVejle Hospital(a part of Lillebaelt Hospital)University Hospital of Southern DenmarkVejleDenmark Department of Regional Health Research University of Southern DenmarkOdenseDenmark

The number of ureterorenoscopic procedures for upper urinary tract stone management has increased dramatically during recent years worldwide[1].Developments in flexible ureteroscope and laser technology have made it possible to successfully address larger and more complex stone scenarios *** the other hand,this means that more and more patients are exposed to the potential adverse effects of ureteroscopy[2].In general,ureteroscopy is considered a safe ***,serious complications and even deaths do occur,and these events are most likely underreported[3,4].

关键词： beyond likely ureter

A Rare Cause of Leukocoria in Children: Persistent Hyperplastic Primary Vitreous

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Open Journal of Ophthalmology 2024年第1期14卷 63-68页

作者： Prudence Ada Assoumou Davy Alex Mouinga Abayi Yoan Mboussou Annick Kougou Ntoutoume helene Nyinko Aboughe Olive Matsanga Tatiana Harly Mba Aki Emmanuel Mve Mengome Owendo University Hospital Center Department of Surgery at the Faculty of Medicine of the University of Health Sciences Libreville Gabon Omar Bongo Ondimba Military Instructions Hospital Department of Surgery at the Faculty of Medicine of the University of Health Sciences Libreville Gabon Médivision Clinic Libreville Gabon Jeanne Ebori Foundation Mother and Child University Hospital Center Department of Surgery at the Faculty of Medicine of the University of Health Sciences Libreville Gabon

Introduction: Leukocoria, a whitish pupillary reflection, is a common warning sign of various pediatric ocular pathologies, including Persistent hyperplastic primary vitreous (PHVP). This case report describes the observation of a 3-year-old child with melanoderma, presenting with a white spot in the left eye since birth. Observation: Uncorrected distance visual acuity was 2/10 in the right eye and hand movements were perceived at 2 meters in the left eye. Examination of the anterior segment in the left eye revealed leukocoria and microphthalmia. The fundus examination was normal in the right eye but revealed a white mass extending from the center of the optic disc towards the temporal region in the left eye. Ocular imaging, including ocular ultrasound and optical coherence tomography, confirmed the diagnosis of PHVP, illustrated by a residual white mass at the center of the optic disc in the left eye. Conclusion: PHVP should be considered in the presence of leukocoria in a child, with urgent exclusion of retinoblastoma. This observation underscores the importance of early diagnosis for appropriate management. .

关键词： PHVP Leukocoria Amblyopia Ocular Imaging Childhood

State-of-the-Art in Electrophilic Trifluoromethylthiolation Reagents

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Chinese Journal of Chemistry 2016年第5期34卷 445-454页

作者： helene Chachignon Dominique Cahard Normandie UniversitY CNRS UMR 6014 COBRA et FR 3038 Universite de Rouen INSA Rouen. 1 rue Tesniere 76821 Mont Saint-Aignan Cedex France

The trifluoromethylthio group （SCF3） is a fluorine chemotype that has experienced a strong acceleration of in- terest in the recent years. It is particularly true of the construction of new fluorinated architectures by electrophilic trifluoromethylthiolation. The spread of knowledge was already very active in this research domain in the sixties; however, gaseous and highly toxic trifluoromethanesulfenyl chloride （CF3SC1） was the only reagent available at that time. Nowadays, one really can speak of a revival in the field thanks to the rapid development of a wide pano- ply of reagents that are stable and easy to handle. This review provides a historical perspective of the development of shelf-stable electrophilic trifluoromethylthiolation reagents.

关键词： fluorine sulfur electrophilic addition synthetic methods

Salt Stress in Arabidopsis： Lipid Transfer Protein AZI1 and Its Control by Mitogen-Activated Protein Kinase MPK3

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Molecular Plant 2014年第4期7卷 722-738页

作者： Andrea Pitzschke Sneha Datta helene Persak Department of Applied Genetics and Cell Biology University of Natural Resources and Life Sciences Muthgasse 18 1190 Vienna Austria

A plant＇s capability to cope with environmental challenges largely relies on signal transmission through mitogen-activated protein kinase （MAPK） cascades. In Arabidopsis thaliana, MPK3 is particularly strongly associated with numerous abiotic and biotic stress responses. Identification of MPK3 substrates is a milestone towards improving stress resistance in plants. Here, we characterize AZI1, a lipid transfer protein （LTP）-related hybrid proline-rich protein （HyPRP）, as a novel target of MPK3. AZI1 is phosphorylated by MPK3 in vitro. As documented by co-immunoprecipitation and bimolecular fluorescence complementation experiments, AZI1 interacts with MPK3 to form protein complexes in planta. Furthermore, null mutants of azil are hypersensitive to salt stress, while AZIl-overexpressing lines are markedly more tolerant. AZI1 overexpression in the mpk3 genetic background partially alleviates the salt-hypersensitive phenotype of this mutant, but functional MPK3 appears to be required for the full extent of AZIl-conferred robustness. Notably, this robustness does not come at the expense of normal development. Immunoblot and RT-PCR data point to a role of MPK3 as positive regulator of AZI1 abundance.

关键词： salt stress Arabidopsis MAPK MPK3 lipid transfer protein AZI1 phosphorylation in vivo interaction.

The Nature of “Natural Disasters”: Survivors’ Explanations of Earthquake Damage

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International Journal of Disaster Risk Science 2019年第3期10卷 293-305页

作者： Alessandro Massazza Chris R.Brewin helene Joffe Department of Clinical Educational and Health PsychologyUniversity College London

The distinction between natural and human-made disasters is ingrained in everyday language. Disaster scientists have long been critical of this dichotomy. Nonetheless,virtually no attention has been paid to how disaster survivors conceptualize the causes of the disasters they experience. In this mixed-methods longitudinal study, 112 survivors of the2016–2017 Central Italy earthquakes completed questionnaires 3 and 16 months following the earthquakes, with the aim of assessing attributions of blame for the earthquake damage. In-depth interviews were also conducted with 52 participants at the 3-month mark to explore representations of causation for the earthquake damage. The distinction between disasters caused by nature and disasters caused by humans was not supported by survivors of the earthquake. In the longitudinal surveys, building firms and the State were assigned as much blame as nature for the earthquake damage, at both 3 months and 16 months after the *** this complexity, in the interviews, the causes of the earthquake damage, rather than being understood as purely natural, were perceived as a complex mosaic composed of political, technological, natural, and moral *** empirical work shows that disaster survivors combine both nature-based and human-based explanations of disasters, rather than subscribing to one or the other. These findings have practical implications for disaster risk reduction and response.

关键词： Amatrice Attributions Disaster causes Disaster survivors Human-made disasters Natural disasters 2016–2017 Central Italy earthquakes