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自动化控制在煤矿机电中的应用研究

模具制造 2024年第5期24卷 201-203页

作者：寇辉山东里能里彦矿业有限公司山东济宁273517

研究自动化控制在煤矿机电领域的应用,可以通过对煤矿机电系统进行分析和探讨,探索自动化控制技术在提高煤矿生产效率、降低事故风险和节约能源方面的潜力。在研究中,运用了系统仿真、数据分析和实地观察等方法,以及对现有研究成果的综... 详细信息

研究自动化控制在煤矿机电领域的应用,可以通过对煤矿机电系统进行分析和探讨,探索自动化控制技术在提高煤矿生产效率、降低事故风险和节约能源方面的潜力。在研究中,运用了系统仿真、数据分析和实地观察等方法,以及对现有研究成果的综述,总结了自动化控制在煤矿机电中的应用现状和未来发展方向。

关键词：自动化控制煤矿机电生产效率事故风险节约能源

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数字政府建设与企业非生产性支出——以在线政务服务为例

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兰州大学学报（社会科学版） 2024年第4期52卷 83-95页

作者：戴敏岳林峰寇恩惠上海财经大学公共经济与管理学院上海200433 北京大学经济学院北京100871 中央财经大学财政税务学院北京102206

加强数字政府建设对加快转变政府职能、建设法制政府和服务型政府有重要意义。基于全国私营企业调查和政府网站绩效评估数据,从政府网站在线政务服务视角切入,考察政府数字化建设对企业非生产性支出的影响。研究表明,地方政府在线政务... 详细信息

加强数字政府建设对加快转变政府职能、建设法制政府和服务型政府有重要意义。基于全国私营企业调查和政府网站绩效评估数据,从政府网站在线政务服务视角切入,考察政府数字化建设对企业非生产性支出的影响。研究表明,地方政府在线政务服务水平越高,企业非生产性支出的相对规模越小,说明数字政府建设有助于降低企业交易成本。异质性分析表明,数字政府建设对小规模企业与缺乏政治联系企业的影响更大,说明数字政府建设可以惠及广大市场主体。机制分析表明,数字政府建设降低企业交易成本的重要机制在于优化行政审批流程、强化政务部门服务意识,所以数字政府建设能助力构建服务型政府。未来应当继续推进数字政府建设,加快政府职能转变,持续提升政府公共服务能力,助力国家治理体系和治理能力现代化。

关键词：数字政府非生产性支出在线政务服务交易成本服务型政府

Template Syntheses and Crystal Structures of Hexaaza Macrocyclic Complexes with C-Methyl Substituents

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1259-1263页

作者： ZHANG Bing kou hui-Zhong CUI Ai-Li WANG Ru-Ji Department of Chemistry Tsinghua University Beijing 100084 China

Two new macrocyclic complexes with C-methyl substituents on the framework, namely, [CuL]（ClO4）2 （L = 5,12-dimethyl-1,8-dihydroxyethyl-1,3,6,8,10,13-hexaazacyclotetradecane） 1 and [NiL]（ClO4）2 2, have been synthesized and structurally characterized through X-ray diffraction analysis. Also, crystal structure of [CuL^1]（ClO4）2 （L^1 = 1,8-dimethyl- 1,3,6,8, [ 0,13- hexaazacyclotetradecane） 3 has been determined. Crystal data for 1： C14H32C12CuN6O10, Mr = 578.90, monoclinic, P2 1/n, α = 8.3529（11）, b = 10.8105（17）, c = 13.3709（17） ,A, β = 105.189（10）°, V= 1165.2（3） A3, Z = 2, Dc = 1.650 g/cm^3, F（000） = 602, λ（MoKct） = 0.71073 A,μ = 1.229 mm ^-1, R = 0.0474 and wR = 0.0895 for 2771 observed reflections （I 〉 2σ（Ⅰ））. Crystal data for 2： C14H32C12N6NiO10, Mr = 574.07, monoclinic, P2 1/c, a = 8.3636（12）, b = 12.997（2）, c = 10.764（2） A, β = 99.31（2）°, V = 1154.7（3） A^3, Z = 2, DC = 1.651 g/cm^3, F（000） = 600, λ（MoKa） = 0.71073 A,μ = 1. 134 mm^-1, R = 0.0380 and wR = 0.0796 for 2670 observed reflections （i 〉 2σ（Ⅰ））. Crystal data for 3： C 10H26Cl2CuN6O8, Mr = 492.81, monoclinic, P2 1/n, a = 8.4860（17）, b = 8.6320（17）, c = 12.662（3） ,A,β = 103.40（3）°, V = 902.2（3）A^3, Z = 2, Dc = 1.814 g/cm^3, F（000） = 510, λ（MoKa） = 0.71073A, μ = 1.562 mm^-1, R = 0.0505 and wR = 0.1061 for 1967 observed reflections （I〉 2σ（Ⅰ））. Complexes 1 and 2 are isostructural with the metal ions situated at the inversion center/Hydrogen bonds between O atoms of pendant and perchlorate anion give rise to a two-dimensional supramolecular layer. The Cu（Ⅱ） ions of compounds 1 and 3 adopt distorted axially-elongated octahedral coordinate geometry, and the nickel（Ⅱ） ion in complex 2 is four-coordinated with a square-planar configuration.

关键词： synthesis crystal structure macrocycle C-methyl substituent copper nickel synthesis crystal structure macrocycle C-methyl substituent copper nickel

男性解脲支原体感染对精液常规参数、精子功能形态及辅助生殖妊娠结局的影响

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检验医学与临床 2024年第5期21卷 654-657页

作者：寇卉石绒杨杰苏婧张洲西北妇女儿童医院生殖中心陕西西安710004

目的分析男性解脲支原体(Uu)感染对精液常规参数、精子功能形态及辅助生殖妊娠结局的影响。方法回顾性分析2020年1月至2020年12月在该院门诊接受精液分析的22 265例不育男性患者的病历资料。采用Uu试剂盒检测Uu感染情况,根据是否存在U... 详细信息

目的分析男性解脲支原体(Uu)感染对精液常规参数、精子功能形态及辅助生殖妊娠结局的影响。方法回顾性分析2020年1月至2020年12月在该院门诊接受精液分析的22 265例不育男性患者的病历资料。采用Uu试剂盒检测Uu感染情况,根据是否存在Uu感染分为Uu阴性组与Uu阳性组。采集两组精液样本,检测并比较两组精子密度、精液量、液化时间、精子存活率、精子活力(a-b)、直线速度(VSL)、曲线速度(VCL)、平均路径(VAP)、精子DNA碎片、精子核蛋白组型。随访至2023年5月,记录并比较两组受精率、流产率、早产率。结果 Uu阴性组共18 793例,Uu阳性组共3 472例,两组精液量比较,差异无统计学意义(P>0.05);Uu阳性组精子密度、精子活率均明显低于Uu阴性组,液化时间明显高于Uu阴性组,差异均有统计学意义(P0.05);Uu阳性组VSL水平明显低于Uu阴性组,差异有统计学意义(P0.05)。结论 Uu感染可导致男性患者精液密度、活力下降,增加液体液化时间及精子畸形率,影响精液前进运动能力及功能,但对辅助生殖妊娠结局影响较小。

关键词：男性解脲支原体精液功能形态生殖妊娠

性激素七项抗苗勒管激素联合检测诊断不孕症的准确率及临床意义

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山西医药杂志 2024年第17期53卷 1306-1309页

作者：石绒寇卉马勤利马琳枝西北妇女儿童医院生殖中心西安710004

目的探究性激素七项、抗苗勒管激素(AMH)联合检测诊断不孕症的准确率及指导临床的意义。方法回顾性分析病例资料,选择2021年1月至2022年1月在我院接受治疗的不孕患者2050例为研究对象,纳为不育组。同期选择健康妇女1800名为健康对照组,... 详细信息

目的探究性激素七项、抗苗勒管激素(AMH)联合检测诊断不孕症的准确率及指导临床的意义。方法回顾性分析病例资料,选择2021年1月至2022年1月在我院接受治疗的不孕患者2050例为研究对象,纳为不育组。同期选择健康妇女1800名为健康对照组,采集2组受检者月经期2~4 d静脉血,采用BECKMAN DXI-800全自动化学发光仪分析仪检测受检者血清黄体生成素(LH)、泌乳素(PRL)、睾酮(T)、孕酮(P)、卵泡刺激素(FSH)、雌二醇(E_(2))、促甲状腺激素(TSH)、AMH水平,采用受试者工作特征(ROC)曲线评估性激素七项、AMH诊断不孕症价值。随访1年,根据不孕症患者做助孕治疗受孕结果分为受孕成功组(1271例)、受孕失败组(779例),比较2组患者性激素及AMH水平变化。结果2组患者血清T、P、E2水平差异无统计学意义(P>0.05);不孕组患者血清LH、TSH、FSH、PRL水平高于健康对照组(P<0.05)。不孕组患者血清AMH水平低于健康对照组(P<0.05)。ROC曲线显示,LH、TSH、FSH、PRL、AMH、性激素指标诊断不孕症的曲线下面积(AUC)分别为0.768、0.778、0.745、0.671、0.715、0.816。性激素指标+AMH诊断不孕症的AUC为0.869。受孕失败组患者LH偏高、TSH偏高、FSH偏高、PRL偏高、AMH偏低比例高于受孕成功组,手术+激素治疗比例低于受孕成功组(P<0.05)。结论不孕症患者血清LH、TSH、FSH、PRL、AMH水平明显异常表达,在诊断不孕症患者方面具有一定价值,且联合诊断价值最佳,另外,在临床手术治疗的同时辅助激素治疗调控LH、TSH、FSH、PRL、AMH水平变化有助于提高受孕成功率,改善患者预后情况。

关键词：性腺甾类激素抗苗勒管激素不育,女性准确率

男性性激素与抗米勒管激素水平对体外受精-胚胎移植胚胎发育的影响

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中国性科学 2024年第3期33卷 32-36页

作者：石绒寇卉马勤利马琳枝张洲西北妇女儿童医院生殖中心西安710004

目的探讨男性性激素与抗米勒管激素(AMH)水平对体外受精-胚胎移植(IVF-ET)胚胎发育的影响。方法回顾性分析2015年5月至2021年8月于西北妇女儿童医院接受体外受精(IVF)/卵胞质内单精子注射(ICSI)助孕的189例男性患者的临床资料,根据受精... 详细信息

目的探讨男性性激素与抗米勒管激素(AMH)水平对体外受精-胚胎移植(IVF-ET)胚胎发育的影响。方法回顾性分析2015年5月至2021年8月于西北妇女儿童医院接受体外受精(IVF)/卵胞质内单精子注射(ICSI)助孕的189例男性患者的临床资料,根据受精卵受精72h后是否有优质胚胎将其分为优质胚胎组和无优胚胎组。对比两组临床资料,通过LASSO和Logistic回归模型探讨影响优质胚胎形成的相关因素,采用受试者工作特征(ROC)曲线评价及性激素水平对胚胎发育情况的预测价值,构建列线图模型并进行评价。结果无优胚胎组的睾酮(T)、雌二醇(E_(2))、AMH、精子密度、精子活动率、精子速度试验结果、生育力指数、活动力指数低于优质胚胎组(P<0.05)。多因素分析结果显示,E_(2)、T、AMH水平及精子速度试验结果、生育力指数均为患者胚胎发育的独立影响因素(P<0.05)。与E_(2)、T及AMH单独预测相比,三者联合的预测效能明显较高。构建的列线图模型具有较高的区分度、准确性和临床适用性。结论血清E_(2)、T、AMH水平异常变化与男性不育症患者无优胚胎形成密切相关,三者联合对IVF-ET胚胎发育具有较高的预测价值,可作为临床筛选高危人群的敏感指标。

关键词：抗米勒管激素性激素体外受精胚胎移植胚胎发育

Changes in proteins related to early nerve repair in a rat model of sciatic nerve injury

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Neural Regeneration Research 2021年第8期16卷 1622-1627页

作者： Yu-Song Yuan Fei Yu Ya-Jun Zhang Su-Ping Niu Hai-Lin Xu Yu-hui kou Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina National&Local Joint Engineering Research Center of Orthopedic Biomaterials Department of Bone&Joint SurgeryPeking University Shenzhen HospitalShenzhenGuangdong ProvinceChina National Center for Trauma Medicine BeijingChina Office of Academic Research Peking University People’s HospitalBeijingChina Diabetic Foot Treatment Center Peking University People’s HospitalBeijingChina

Peripheral nerves have a limited capacity for self-repair and those that are severely damaged or have significant defects are challenging to repair. Investigating the pathophysiology of peripheral nerve repair is important for the clinical treatment of peripheral nerve repair and regeneration. In this study, rat models of right sciatic nerve injury were established by a clamping method. Protein chip assay was performed to quantify the levels of neurotrophic, inflammation-related, chemotaxis-related and cell generation-related factors in the sciatic nerve within 7 days after injury. The results revealed that the expression levels of neurotrophic factors(ciliary neurotrophic factor) and inflammationrelated factors(intercellular cell adhesion molecule-1, interferon γ, interleukin-1α, interleukin-2, interleukin-4, interleukin-6, monocyte chemoattractant protein-1, prolactin R, receptor of advanced glycation end products and tumor necrosis factor-α), chemotaxis-related factors(cytokine-induced neutrophil chemoattractant-1, L-selectin and platelet-derived growth factor-AA) and cell generation-related factors(granulocyte-macrophage colony-stimulating factor) followed different trajectories. These findings will help clarify the pathophysiology of sciatic nerve injury repair and develop clinical treatments of peripheral nerve injury. This study was approved by the Ethics Committee of Peking University People's Hospital of China(approval No. 2015-50) on December 9, 2015.

关键词： animal model cell generation chemotaxis clamp injury inflammation injury neurotrophic factor peripheral nerve protein array repair sciatic nerve Wallerian degeneration

Brain functional remodeling caused by sciatic nerve transposition repair in rats identified by multiplemodel resting-state blood oxygenation level-dependent functional magnetic resonance imaging analysis

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Neural Regeneration Research 2022年第2期17卷 418-426页

作者： Yu-Song Yuan Hai-Lin Xu Zhong-Di Liu Yu-hui kou Bo Jin Pei-Xun Zhang Department of Trauma and Orthopedics Peking University People’s HospitalPeking UniversityBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina National Center for Trauma Medicine BeijingChina

Lower extremity nerve transposition repair has become an important treatment strategy for peripheral nerve injury;however, brain changes caused by this surgical procedure remain unclear. In this study, the distal stump of the right sciatic nerve in a rat model of sciatic nerve injury was connected to the proximal end of the left sciatic nerve using a chitin conduit. Neuroelectrophysiological test showed that the right lower limb displayed nerve conduction, and the structure of myelinated nerve fibers recovered greatly. Muscle wet weight of the anterior tibialis and gastrocnemius recovered as well. Multiple-model resting-state blood oxygenation level-dependent functional magnetic resonance imaging analysis revealed functional remodeling in multiple brain regions and the re-establishment of motor and sensory functions through a new reflex arc. These findings suggest that sciatic nerve transposition repair induces brain functional remodeling. The study was approved by the Ethics Committee of Peking University People's Hospital on December 9, 2015(approval No. 2015-50).

关键词： brain connectivity brain network fALFF MRI nerve transposition repair peripheral nerve injury ReHo remodeling

Identification of four differentially expressed genes associated with acute and chronic spinal cord injury based on bioinformatics data

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Neural Regeneration Research 2021年第5期16卷 865-870页

作者： Su-Ping Niu Ya-Jun Zhang Na Han Xiao-Feng Yin Dian-Ying Zhang Yu-hui kou Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Office of Academic Research Peking University People’s HospitalBeijingChina

Complex pathological changes occur during the development of spinal cord injury(SCI),and determining the underlying molecular events that occur during SCI is necessary for the development of promising molecular targets and therapeutic *** study was designed to explore differentially expressed genes(DEGs)associated with the acute and chronic stages of SCI using bioinformatics *** expression profiles(GSE45006,GSE93249,and GSE45550)were downloaded from the Gene Expression Omnibus ***-associated DEGs from rat samples were identified,and Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were *** addition,a protein-protein interaction network was *** 66 DEGs were identified in GSE45550 between 3–14 days after SCI,whereas 2418 DEGs were identified in GSE450061–56 days after ***,1263,195,and 75 overlapping DEGs were identified between these two expression profiles,3,7/8,and 14 days after SCI,***,16 overlapping DEGs were obtained in GSE450061–14 days after SCI,including Pank1,Hn1,Tmem150c,Rgd1309676,Lpl,Mdh1,Nnt,Loc100912219,Large1,Baiap2,Slc24a2,Fundc2,Mrps14,Slc16a7,Obfc1,and ***,3882 overlapping DEGs were identified in GSE932491–6 months after SCI,including 3316 protein-coding genes and 567 long non-coding RNA genes.A comparative analysis between GSE93249 and GSE45006 resulted in the enrichment of 1135 overlapping *** significant functions of these 1135 genes were correlated with the response to the immune effector process,the innate immune response,and cytokine ***,the biological processes and KEGG pathways of the overlapping DEGs were significantly enriched in immune system-related pathways,osteoclast differentiation,the nuclear factor-κB signaling pathway,and the chemokine signaling ***,an analysis of the overlapping DEGs associated with both acute and chronic SCI,assessed using the expressio

关键词： bioinformatics differential expression factor gene immune response injury pathways protein spinal cord