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Therapeutic Mechanism of Kai Xin San on Alzheimer's Disease Based on Network Pharmacology and Experimental Validation

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Chinese Journal of Integrative Medicine 2023年第5期29卷 413-423页

作者： wang Kan YANG Rong CHEN Tuan-tuan QIN Mei-rong wang Ping kong ming-wang The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Hepatology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhenGuangdong Province(518033)China Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao SARChina Key Laboratory of Cosmetics Monitoring and Evaluation State Drug AdministrationShenzhen Institute for Drug ControlShenzhenGuangdong Province(518057)China The School of Basic Medical Sciences Hubei University of Chinese MedicineWuhan(430065)China

Objective: To explore the specific pharmacological molecular mechanisms of Kai Xin San(KXS)on treating Alzheimer’s disease(AD) based on network pharmacology and experimental validation. Methods:The chemical compounds of KXS and their corresponding targets were screened using the Encyclopedia of Traditional Chinese Medicine(ETCM) database. AD-related target proteins were obtained from MalaCards database and DisGeNET databases. Key compounds and targets were identified from the compound-targetdisease network and protein-protein interaction(PPI) network analysis. Functional enrichment analysis predicted the potential key signaling pathways involved in the treatment of AD with KXS. The binding affinities between key ingredients and targets were further verified using molecular docking. Finally, the predicted key signaling pathway was validated experimentally. Positioning navigation and space search experiments were conducted to evaluate the cognitive improvement effect of KXS on AD rats. Western blot was used to further examine and investigate the expression of the key target proteins related to the predicted pathway. Results: In total, 38active compounds and 469 corresponding targets of KXS were screened, and 264 target proteins associated with AD were identified. The compound-target-disease and PPI networks identified key active ingredients and protein targets. Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analysis suggested a potential effect of KXS in the treatment of AD via the amyloid beta(Aβ)-glycogen synthase kinase-3 beta(GSK3β)-Tau pathway. Molecular docking revealed a high binding affinity between the key ingredients and targets. In vivo,KXS treatment significantly improved cognitive deficits in AD rats induced by Aβ1-42, decreased the levels of Aβ, p-GSK3β, p-Tau and cyclin-dependent kinase 5, and increased the expressions of protein phosphatase 1alpha(PP1A) and PP2A(P<0.05 or P<0.01). Conclusion: KXS exerted neuroprotective effects by regulating the

关键词： Kai Xin San Alzheimer's disease Tau protein network pharmacology molecular docking experimental validation Chinese medicine

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Interactions Between Exogenous Bt Insecticidal Protein and Cotton Terpenoid Aldehydes

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Agricultural Sciences in China 2002年第6期1卷 642-647页

作者： ZHANG Yong-jun, GUO Yu-yuan, WU kong-ming and wang Wu-gang(Institute of Plant Protection , Chinese Academy of-Agricultural Sciences , Beijing 100094 , P. R . China) Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100094 P. R. China

The contents of terpenoid aldehydes in Bt transgenic cotton and their non-Bt parental varieties were analyzed by the HPLC method. Statistical analysis of variance showed that Bt insecticidal protein Bt-ICP expression has no negative effect on the synthesis of gossypol, total heliocides and total resistant terpenoids. The results of the combined dosage test of Bt-ICP and gossypol in vitro showed that there is no interaction between gossypol and Bt-ICP on the mortality of cotton bollworm larvae Helicoverpa armigera (Hubnner). It is indicated that the actions of Bt-ICP and gossypol on cotton bollworm are additive. Therefore, it is advantageous to combine Bt-ICP with cotton terpenoid aldehydes in controlling cotton bollworm.

关键词： Bt-ICP Terpenoid aldehydes Interaction

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Discussion on the Relationship Between Senescence Caused by Pi(Spleen)Deficiency and Mitochondrial Autophagy

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World Journal of Integrated Traditional and Western Medicine 2022年第2期8卷 20-24页

作者： JIN Tian-tian TANG Jie kong ming-wang SHI He-yuan Institute of Basic Theory of Traditional Chinese Medicine Hubei University of Traditional Chinese MedicineWuhan 430065China

The Pi(Spleen)is responsible for the formation and transportation,and it is in the *** is the source of qi and blood generation and transformation,so it has an essential *** the qi and blood are biochemically passive,the functions of the human body will age *** are for energy synthesis and have always been a hot topic in modern medical *** of their functions are similar to those of the Pi in Chinese *** Chinese medicine,strengthening the Pi is to enhance the Pi’s ability to transport and transform,and to speed up the Pi,which is similar to the ability of mitochondria to maintain the ability to remove damaged *** can speed up the body’s ability to absorb nutrients and delay aging.

关键词： Huangdi Neijing Delays aging Pi(Spleen)deficiency Mitochondrial autophagy

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基于机器视觉的四通阀自动钎焊定位系统

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中国机械工程 2016年第22期27卷 3043-3047页

作者：孔明贺楚红王英军黄玮中国计量大学杭州310018

为了提高四通阀焊接的速度和精度,提出了四通阀自动钎焊定位技术及系统。运用基于图像处理方法的计算机视觉技术,实现了对空调零件四通阀钎焊坐标的快速准确定位。采用近红外背光源进行照明,实现了对四通阀圆心坐标及侧面高度的自动检... 详细信息

为了提高四通阀焊接的速度和精度,提出了四通阀自动钎焊定位技术及系统。运用基于图像处理方法的计算机视觉技术,实现了对空调零件四通阀钎焊坐标的快速准确定位。采用近红外背光源进行照明,实现了对四通阀圆心坐标及侧面高度的自动检测。采用近红外背光源能使成像边缘更清晰易辨,具有环保节能、寿命长等优点。该系统主要通过阈值分割和PCA算法分别实现对四通阀铜柱圆轮廓提取和铜柱高度的水平投影,通过形状匹配和直线拟合获得圆心相对坐标和高度,实现对四通阀钎焊定位的检测。该系统具有速度快、准确率高、系统运行稳定等优点,在工业上的四通阀钎焊中具有较好的应用性和广阔的发展前景。

关键词：图像处理图像分析灰度直方图测量

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei Kang Zhou Xin Huang Xing Zhou Jie Xu Taoyi kong Junwei Lucas Bao Xiaoli Dong Yonggang wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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老年性痴呆中医药本体构建探讨

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时珍国医国药 2014年第8期25卷 1918-1919页

作者：蔡晓鸿孔明望王平湖北中医药大学老年医学研究所湖北武汉430065

目的把本体作为知识表达和共享的载体,将分散的老年性痴呆知识组织起来。方法采用本体理论和方法,以老年性痴呆为研究实例,运用本体构建软件protégé。结果建立老年性痴呆领域本体。结论构建老年性痴呆中医药本体是利用信息技术为老年... 详细信息

目的把本体作为知识表达和共享的载体,将分散的老年性痴呆知识组织起来。方法采用本体理论和方法,以老年性痴呆为研究实例,运用本体构建软件protégé。结果建立老年性痴呆领域本体。结论构建老年性痴呆中医药本体是利用信息技术为老年性痴呆研究服务的数据技术基础,领域本体库的构建将为对知识共享和疾病诊疗决策带来革新性的变化。

关键词：中医药本体老年性痴呆

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经方方药固有矢量结构模型与模糊靶向

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中华中医药杂志 2019年第8期34卷 3791-3793页

作者：叶清华孔明望湖北中医药大学

经方和各大医家所遣方剂结构严谨,用药精准,往往一药就顾及人体和疾病的多个方面,讲究药物之间的配合与叠加作用,纠偏的时候注重方剂本身结构的稳定和平衡,方剂功效的指向也十分明确,很多隐含的功效和机制并未探明,超出了设计者本身的估... 详细信息

经方和各大医家所遣方剂结构严谨,用药精准,往往一药就顾及人体和疾病的多个方面,讲究药物之间的配合与叠加作用,纠偏的时候注重方剂本身结构的稳定和平衡,方剂功效的指向也十分明确,很多隐含的功效和机制并未探明,超出了设计者本身的估计,基于这种特性和规律,用现代研究方法和解释系统诠释其科学内涵并相互验证。

关键词：稳定矢量结构模型多线程复现解释系统模糊算法模糊集合

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温胆汤改良方对阿尔茨海默病模型大鼠学习记忆功能的影响

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湖北中医杂志 2011年第4期33卷 3-4页

作者：孔明望王平湖北中医药大学老年医学研究所湖北武汉430065

目的探讨温胆汤改良方对学习记忆功能的影响。方法 15月龄Wistar大鼠60只,随机分成6组:正常组,假手术组(空白组),模型组,脑复康组,温胆汤改良方低、高剂量组。大鼠双侧前脑基底核(NBM)注射鹅膏覃氨酸(IBO)损毁前脑基底核造阿尔茨海默病(... 详细信息

目的探讨温胆汤改良方对学习记忆功能的影响。方法 15月龄Wistar大鼠60只,随机分成6组:正常组,假手术组(空白组),模型组,脑复康组,温胆汤改良方低、高剂量组。大鼠双侧前脑基底核(NBM)注射鹅膏覃氨酸(IBO)损毁前脑基底核造阿尔茨海默病(AD)模型。动物经治疗处理28天后,各组大鼠进行Morris水迷宫行为学试验。结果从行为学实验来看,脑复康组、温胆汤改良方低、高剂量组与其它三组比较有统计学差异(p<0.01)。但温胆汤高剂量组比脑复康组明显表现出更好的学习记忆能力(p<0.01)。结论温胆汤改良方能改善学习记忆,说明温胆汤改良方对中枢胆碱能损害具有较好的保护作用。

关键词：阿尔茨海默病温胆汤改良方实验研究 Morris水迷宫

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肾虚痰盛与老年性痴呆发病关系探讨

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山西中医 2011年第3期27卷 1-3页

作者：孔明望王平北京中医药大学湖北中医药大学

老年性痴呆是中枢神经系统退行性疾病,严重影响患者的生活质量,属中医善忘、痴呆等病证范畴。精气是大脑活动的物质基础。通过大量文献研究,结合临证体会,认为本病病位在脑,属本虚标实证,本虚为诸脏亏损,气血不足,肾精亏虚,标实为痰阻... 详细信息

老年性痴呆是中枢神经系统退行性疾病,严重影响患者的生活质量,属中医善忘、痴呆等病证范畴。精气是大脑活动的物质基础。通过大量文献研究,结合临证体会,认为本病病位在脑,属本虚标实证,本虚为诸脏亏损,气血不足,肾精亏虚,标实为痰阻血瘀。其中肾精亏虚,脑髓不足,脑失所养是发病基础;痰浊困阻,蒙蔽脑窍为发病的关键因素。补肾化痰是老年性痴呆的防治大法。

关键词：老年性痴呆肾虚痰浊阻滞发病机制

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Micro-strain regulation strategy to stabilize perovskite lattice based on the categories and impact of strain on perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 578-604页

作者： Caixia Li Wenwu Liu Shiji Da Lingbin kong Fen Ran State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology

Photovoltaic metal halide perovskite solar cells(PSCs) convert light to electricity more efficiently than crystalline silicon cells, and the cost of materials used to make them is lower than that of silicon *** efficiency is not a core issue affecting the application of perovskite solar cells in special *** present, stability is the major technical encounters that hinders its further commercial development. Microstrain in PSCs is currently a significant factor responsible for the device's instability. Strain-induced ion migration is widely believed to accelerate perovskite degradation even when external stimuli are ***, it is imperative to study strain to enhance the stability of PSCs. This paper reviews recent developments to understand strain's origin and effect mechanisms on performance of PSCs, including ion migration,failure behavior, defect formation, and its effect on photoelectric properties, stability, and ***, several well-known strain management strategies are systematically introduced based on the strain effect mechanism and strain engineering on the film, providing more clues for further preparation with increased stability. The manipulation of external physical strain applied from films to entire devices has been extensively studied. Furthermore, recommendations for future research directions and chemical approaches have been provided. It is emphasized that strain engineering plays a crucial role in improving the efficiency and longevity of PSCs. Tensile strain causes rapid degradation, while moderate compressive strain and external strain control could improve properties and stability. Efforts should focus on controlling compressive strain to mitigate residual tensile strain and introducing it in a controlled manner. Future research endeavors may focus on exploring these pathways to improve the efficiency and lifespan of PSCs.

关键词： Halide perovskite solar cells Strain origins Strain effects Strain management

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