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Ruxolitinib attenuates secondary injury after traumatic spinal cord injury

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Neural Regeneration Research 2022年第9期17卷 2029-2035页

作者： zhan-Yang Qian Ren-Yi kong sheng zhang Bin-yu wang Jie Chang jiang Cao Chao-Qin Wu Zi-Yan Huang Ao Duan Hai-Jun Li Lei Yang xiao-jian Cao Spine Center Zhongda Hospital of Southeast UniversityNanjingJiangsu ProvinceChina Medical School Southeast UniversityNanjingJiangsu ProvinceChina Department of Orthopedics First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Orthopedics Hospital Affiliated 5 to Nantong University(Taizhou People’s Hospital)TaizhouJiangsu ProvinceChina Taizhou Clinical Medical School of Nanjing Medical University Taizhou People’s HospitalTaizhouJiangsu ProvinceChina

Excessive inflammation post-traumatic spinal cord injury(SCI)induces microglial activation,which leads to prolonged neurological ***,the mechanism underlying microglial activation-induced neuroinflammation remains poorly ***(RUX),a selective inhibitor of JAK1/2,was recently reported to inhibit inflammatory storms caused by SARS-CoV-2 in the ***,its role in disrupting inflammation post-SCI has not been *** this study,microglia were treated with RUX for 24 hours and then activated with interferon-γfor 6 *** results showed that interferon-γ-induced phosphorylation of JAK and STAT in microglia was inhibited,and the mRNA expression levels of pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,interleukin-6,and cell proliferation marker Ki67 were *** further in vivo experiments,a mouse model of spinal cord injury was treated intragastrically with RUX for 3 successive days,and the findings suggest that RUX can inhibit microglial proliferation by inhibiting the interferon-γ/JAK/STAT ***,microglia treated with RUX centripetally migrated toward injured foci,remaining limited and compacted within the glial scar,which resulted in axon preservation and less ***,the protein expression levels of tumor necrosis factor-α,interleukin-1β,and interleukin-6 were *** neuromotor function of SCI mice also *** findings suggest that RUX can inhibit neuroinflammation through inhibiting the interferon-γ/JAK/STAT pathway,thereby reducing secondary injury after SCI and producing neuroprotective effects.

关键词： functional recovery glial scar inflammation interferon-γ JAK/STAT signaling microglia Ruxolitinib spinal cord injury

生物活性炭内吸附与生物降解协同去除有机污染物

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环境科学 2007年第4期28卷 777-780页

作者：孔令宇张晓健王占生清华大学环境科学与工程系北京100084

本研究建立了一个确定BAC内2种机理去除有机物分配比例的试验方法．该方法以BAC进出水中溶解性有机碳（DOC）与可生物降解有机碳（BDOC）浓度变化作为评价参数，并利用此方法确定了臭氧投加量对2种去除机理的影响．臭氧化可以使BDOC浓... 详细信息

本研究建立了一个确定BAC内2种机理去除有机物分配比例的试验方法．该方法以BAC进出水中溶解性有机碳（DOC）与可生物降解有机碳（BDOC）浓度变化作为评价参数，并利用此方法确定了臭氧投加量对2种去除机理的影响．臭氧化可以使BDOC浓度增加，臭氧投量为2～8mg／L时，BDOC增加0．12—0．54mg／L；BAC过滤使出水BDOC浓度降低为0．23-0．31mg／L．随着臭氧投量增加（2—8mg／L），在BAC内生物降解作用去除有机物比例从46％增加到89％．

关键词：臭氧-生物活性炭臭氧投加量吸附作用生物降解溶解性有机碳可生物降解有机碳

臭氧-生物活性炭组合工艺中最佳臭氧投加剂量的确定

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环境科学 2006年第7期27卷 1345-1347页

作者：孔令宇张晓健王占生清华大学环境科学与工程系北京100084

在水处理过程中投加臭氧，可提高饮用水的可生物降解性．臭氧氧化后继的生物过滤，可以减少水中可生物降解有机物数量，提高饮用水的生物稳定性．试验表明，臭氧投加量2～8mg／L可使AOC—P17，AOC-NOX和BDOC分别增加20．9％～85．5％，4... 详细信息

在水处理过程中投加臭氧，可提高饮用水的可生物降解性．臭氧氧化后继的生物过滤，可以减少水中可生物降解有机物数量，提高饮用水的生物稳定性．试验表明，臭氧投加量2～8mg／L可使AOC—P17，AOC-NOX和BDOC分别增加20．9％～85．5％，42．1％～158．2％和21．4％～84．4％．臭氧投加量为3mg／L时，AOC和BDOC增加得最多，即3mg／L的臭氧投量为最佳投加剂量．生物活性炭滤柱（BAC）出水AOC浓度（乙酸碳）均低于50μg／L，在35．9～46．6μg／L之间，属于生物稳定性水质．

关键词：臭氧-生物活性炭臭氧化臭氧投加量生物稳定性可生物同化有机碳可生物降解溶解性有机碳

臭氧—生物活性炭与单独活性炭工艺处理效果比较

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中国给水排水 2006年第11期22卷 49-51页

作者：孔令宇张晓健王占生清华大学环境科学与工程系北京100084

为有效去除水中有机物,明确是否应在活性炭前投加臭氧,比较了臭氧-生物活性炭（O3-BAC）和单独活性炭（GAC）过滤对CODMn、UV254和TOC的去除效果以及两套系统对提高水质生物稳定性的作用.研究发现,O3-BAC对CODMn、UV254和TOC的平均去除... 详细信息

为有效去除水中有机物,明确是否应在活性炭前投加臭氧,比较了臭氧-生物活性炭（O3-BAC）和单独活性炭（GAC）过滤对CODMn、UV254和TOC的去除效果以及两套系统对提高水质生物稳定性的作用.研究发现,O3-BAC对CODMn、UV254和TOC的平均去除率比GAC分别高10.3%、11.1%、7.1%,对AOC的去除率＞80%,出水AOC浓度为25.9～46.4μg乙酸碳/L,属生物稳定性水质;单独GAC柱对AOC的去除率在40%左右,出水AOC浓度为85.8～117.6μg乙酸碳/L,有时不能满足水质生物稳定性的要求.可见在活性炭前投加臭氧,可以强化活性炭对有机物的去除作用,延长活性炭的使用周期,增强活性炭滤池的生物降解能力.

关键词：臭氧-生物活性炭颗粒活性炭有机污染物生物稳定性

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng xiao-Wei Liu Yi-Peng Jing Gang wang Hao-Tong zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai yue Wu Yan Cai Shu-yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-yuan Chen jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin xiao kong Xu kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-sheng Tao yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang jian wang Jia-Ning wang jian-ling wang jian-Ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang yue-Fei wang You-Fen wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu yu-Zhong Wu xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong yu Hui yuan Hai-Bo yuan Hai-Long yuan Wei-Min yuan Chao Zhai En-Peng zhang Hua-Wei zhang jian-Nan zhang Li-Pin zhang Wei zhang Yong zhang Yan-Xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-Li Luo Hao-Tong zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-Ping Li Yao-Quan Chu jian-Rong Shi Gang wang jian-Nan zhang Zhong-Rui Bai xiao-Yan Chen Feng-Fei wang Yan-Xin Guo jian-Jun Chen Bing Du xiao kong Ya-Juan Lei Yin-Bi Li Yi-Han Song yue Wu Yan-Xia zhang Xin-Lin Zhou Fang Zuo Peng Du Lin He Wen Hou Yi-Qiao Dong jian Li Guang-Wei Li Shuang Li Jing Song yuan Tian Meng-Xin wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua jiang Xiang jiang Zi-Bo jiang Ge Jin Ai-Hua Li Qi Li Yin-Dun Mao Zheng-Hong Tang Qing-sheng Tao Liang-Ping Tu Da-Qing wang Dan wang jian-Ping wang Lei wang Shou-Guan wang Shu-Qing wang Ya-Nan wang You wang yue-Fei wang Ming-Zhi Wei Xiang-Xiang Xue xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu De-Hua Yang Shi-Hai Yang Zheng-Qiu Yao Yong yu Hui yuan Chao Zhai En-Peng zhang Jing zhang Li-Ping zhang Weizhang Yong zhang Zhen-Chao zhang Ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu yue Huang Guang-Cheng xiao Qing-Cui Bu Jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei Jia Fang-Jun Lu Xiang Ma Lian Tao Wei zhang Li Chen Li-Ming Song Ti-Pei Li yu-Peng Xu Xue-Lei Cao Yong Chen Cong-zhan Liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong yuan-yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-yu Ge yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua jiang Wei-Chun jiang Jing Jin Yong-Jie Jin ling-Da kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li Wei Li Xian Li xiao-Bo Li Xu-Fang Li Yang-Guo Li Zheng-Wei Li xiao-Hua Liang Jing-yuan Liao Bai-sheng Liu Guo-Qing Liu Hong-Wei Liu xiao-Jing Liu Yi-Nong Liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng Yi Nang jian-Yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-Ying Song Liang Sun Ying Tan You-Li Tuo Chen wang Guo-Feng wang Juan wang ling-Jun wang Weng-Shuai wang yu-Sa wang Xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo xiao Shao-Lin Xiong He Xu Jia-Wei Yang sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi Qian-Qing Yin yuan You Ai-Mei zhang Cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang Yong-Jie zhang yuan-Hang zhang yue zhang Zhao zhang Zhi zhang Zi-Liang zhang Hai-sheng Zhao xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou jian-Feng Zhou yu-Xuan Zhu Ren-Lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan Hong-tao Yang yue-yi Deng Wei Li Ya-ni He Zhao-hui Ni Yong-li zhan Shan Lin Zhi-yong Guo Jun Zhu Jing-ai Fang Xu-sheng Liu Li-hua wang Rong wang Nian-song wang xiao-hong Cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru jiang Hong-yu Chen Wen-hu Liu Hong-li Lin Meng Liang Lu Ma Ming Chen Li-qun Song jian Chen Qing Zhu Chang-ying Xing yun Li Ji-ning Gao Rong-shan Li Ying Li Hao zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(P<0.001)greater reduction in urine protein *** with the losartan potassium 100 mg group,the SYKFT plus losartan potassium 100 mg group had a 9.77%±2.52%(P=0.001)greater reduction in urine *** a superiority threshold of 15%,neither was statistically ***,serum creatinine and serum albumin from the baseline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

Expert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma(2022 version)

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Journal of Clinical and Translational Hepatology 2023年第7期11卷 1553-1564页

作者： Han wang Jun Chen Xin zhang Xia sheng xiao-Yan Chang Jie Chen Min-Shan Chen Hui Dong Guang-Jie Duan He-Ping Hu Zhi-Yong Huang Wei-Dong Jia xiao-Qing jiang Dong Kuang Shan-Shan Li Zeng-Shan Li Chang-Li Lu Shu-Kui Qin Xue-Shan Qiu Li-Juan Qu Chun-Kui Shao Feng Shen Guo-Ming Shi Su-sheng Shi yu-Jun Shi Hui-Chuan Sun xiao-Dong Teng Bin wang zhan-Bo wang Tian-Fu Wen Jia-Mei Yang Qiao-Qiao Yang sheng-Long Ye Hong-Fang Yin Zhen-Gang yuan Jing-Ping yun Feng-Lin Zang Hong-Qi zhang Li-Hong zhang Jing-Min Zhao jian Zhou Wei-Xun Zhou Jia Fan xiao-Ping Chen Wan Yee Lau yuan Ji Wen-Ming Cong Chinese Society of Liver Cancer of Chinese Anti-Cancer Association Digestive Disease Group of Chinese Society of Pathology,Chinese Medical Association Chinese Society of Pathology of Chinese Anti-Cancer Association Hepatic Surgery Group of Chinese Society of Surgery,Chinese Medical Association Biliary Tract Tumor Committee of China Anti-Cancer Association Chinese Society of Clinical Oncology IDepartment of Pathology Eastern Hepatobilary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology the Affiliated Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsuChina Department of Pathology Zhongshan HospitalFudan UniversityShanghaiChina Department of Pathology Minhang HospitalFudan Uni-versityShanghaiChina Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sci-ences and Peking Union Medical CollegeBeijingChina Department of Liver Surgery Sun Yat-Sen University Cancer CenterGuangzhouGuangdongChina Department of Pathology The First Affiliated HospitalArmy Medical UniversityChongqingChina Department of Hepatobiliary Medicine Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghaiChina Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWu-hanHubeiChina Department of General Surgery The First Affliated Hospital of USTCDivision of Life Science and Medi-cineUniversity of Science and Technology of ChinaHefeiAnhuiChina Department of Biliary Surgery I Eastern Hepatobil-iary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Pathology The First Afiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenanChina Department of Pathology Xijing Hospi-talAir Force Medical UniversityXi'anShaanxiChina Department of Pathology West China HospitalSichuan UniversityChengduSichuanChina Cancer Center of Jinling Hospital Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Pathology The First Affiliated HospitalChina Medical UniversityShenyangLiaoningChina Department of Pathology The 900 Hospital of the Chinese People's Liberation Army Joint Logistics TeamFuzhouFujianChina Department of Pathology The Third Affiliated HospitalSun Yat-Sen UniversityGuangz

Intrahepatic cholangiocarcinoma(iCCA)can originate from the large bile duct group(segment bile ducts and area bile ducts),small bile duct group(septal bile ducts and interlobular bile ducts),and terminal bile duct group(bile ductules and canals of Hering)of the intrahepatic biliary tree,which can be histopathological corresponding to large duct type iCCA,small duct type iCCA and iCCA with ductal plate malformation pattern,and cholangiolocarcinoma,*** challenge in pathological diagnosis of above subtypes of iCCA falls in the distinction of cellular morphologies,tissue structures,growth patterns,invasive behaviors,immunophenotypes,molecular mutations,and surgical *** these reasons,this expert consensus provides nine recommendations as a reference for standardizing and refining the diagnosis of pathological subtypes of iCCA,mainly based on the 5th edition of the World Health Organization Classification of Tumours of the Digestive System.

关键词： Intrahepatic cholangiocarcinoma Pathology Histological type Immunohistochemistry Molecular variation