检索结果-南通市图书馆

Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第12期11卷 3966-3982页

作者： Yancheng Tang Liming Wang Tao Yi Jun Xu Jigang Wang Jiang-Jiang Qin Qilei Chen Ka-Man Yip Yihang Pan Peng Hong Yingying Lu Han-ming {2. Hu-Biao Chen School of Chinese Medicine Hong Kong Baptist UniversityHong Kong SAR 999077China School of Biomedical Sciences Hunan UniversityChangsha 410082China department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Artemisinin Research Center China Academy of Chinese Medical SciencesBeijing 100700China The First Affiliated Hospital of Southern University of Science and Technology the Second Clinical Medical College of Jinan UniversityShenzhen People’s HospitalShenzhen 518020China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China epartment of Medical Research Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China department of Biomedical Science City University of Hong KongHong Kong SAR 999077China Faculty of Health Sciences University of MacaoMacao SAR 999078China

Mitochondria as a signaling platform play crucial roles in deciding cell *** classic anticancer agents are known to trigger cell death through induction of mitochondrial ***,one selective autophagy,is the key mitochondrial quality control that effectively removes damaged ***,the precise roles of mitophagy in tumorigenesis and anticancer agent treatment remain largely ***,we examined the functional implication of mitophagy in the anticancer properties of magnolol,a natural product isolated from herbal Magnolia ***,we found that magnolol induces mitochondrial depolarization,causes excessive mitochondrial fragmentation,and increases mitochondrial reactive oxygen species(mtROS).Second,magnolol induces PTEN-induced putative kinase protein 1(PINK1)-Parkin-mediated mitophagy through regulating two positive feedforward amplification ***,magnolol triggers cancer cell death and inhibits neuroblastoma tumor growth via the intrinsic apoptosis ***,magnolol prolongs the survival time of tumor-bearing ***,inhibition of mitophagy by PINK1/Parkin knockdown or using inhibitors targeting different autophagy/mitophagy stages significantly promotes magnolol-induced cell death and enhances magnolol's anticancer efficacy,both in vitro and in ***,our study demonstrates that magnolol can induce autophagy/mitophagy and apoptosis,whereas blockage of autophagy/mitophagy remarkably enhances the anticancer efficacy of magnolol,suggesting that targeting mitophagy may be a promising strategy to overcome chemoresistance and improve anticancer therapy.

关键词： PINK1-Parkin-mediated mitophagy Magnolol Combination therapy Apoptosis Tumor suppression

Diagnosis,treatment,and prevention of monkeypox in children:an experts'consensus statement

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2023年第3期19卷 231-242页

作者： Rong-Meng Jiang Yue-Jie Zheng Lei Zhou Lu-Zhao Feng Lin Ma Bao-Ping Xu Hong-Mei Xu Wei liu Zheng-De Xie Ji-Kui Deng Li-Juan Xiong Wan-Jun Luo Zhi-sheng liu Sai-Nan Shu Jian-She Wang Yi Jiang Yun-Xiao Shang Miao liu Li-Wei Gao Zhuang Wei Guang-Hua liu Gang liu Wei Xiang Yu-Xia Cui Gen Lu Min Lu Xiao-Xia Lu Run-ming Jin Yan Bai Le-Ping Ye Dong-Chi Zhao A-Dong shen Xiang Ma Qing-Hua Lu Feng-Xia Xue Jian-Bo Shao Tian-You Wang Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China department of Respiratory Shenzhen Children’s HospitalShenzhen 518038China Branch for Emerging Infectious Disease Public Health Emergency CenterChinese Center for Disease Control and PreventionBeijing 102206China School of Population Medicine&Public Health Chinese Academy of Medical Science/Peking Union Medical CollegeBeijing 100730China department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China department of Respiratory Beijing Children’s HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children’s Health(Beijing)Beijing 100045China department of Infectious Diseases Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Tianjin Children’s Hospital Children’s Hospital of Tianjin UniversityTianjin 300134China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China department of Infectious Diseases Shenzhen Children’s HospitalShenzhen 518038China department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Ofce of Infection Management Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Neurology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Pediatrics Tongji

Monkeypox is a zoonotic *** the first human monkeypox case was detected in 1970,it has been prevalent in some countries in central and western *** May 2.2.,monkeypox cases have been reported in more than 96 non-endemic countries and regions *** of September 14,2.2.,there have been more than 58,2.0 human monkeypox cases,and there is community *** cessation of smallpox vaccination in 1980,which had some cross-protection with monkeypox,resulted in a general lack of immunity to monkeypox,which caused global concern and *** of Sep-tember 14,2.2.,there are four monkeypox cases in china,including three in Taiwan province and one in Hong kong *** foreign studies have shown that children are vulnerable to monkeypox and are also at high risk for severe disease or *** order to improve pediatricians'understanding of monkeypox and achieve early detection,early diagno-sis,early treatment,and early disposal,we have organized national authoritative experts in pediatric infection,respiratory,dermatology,critical care medicine,infectious diseases,and public health and others to formulate this expert consensus,on the basis of the latest"Clinical management and infection prevention and control for monkeypox"released by The World Health Organization,the"guidelines for diagnosis and treatment of monkeypox(version 2.2.)"issued by National Health Commission of the People's Republic of china and other relevant *** the development of this consensus,multidisciplinary experts have repeatedly demonstrated the etiology,epidemiology,transmission,clinical manifestations,laboratory examinations,diagnosis,differential diagnosis,treatment,discharge criteria,prevention,disposal process,and key points of prevention and control of suspected and confirmed cases.

关键词： Children Consensus Diagnosis Monkeypox Prevention Treatment

Cavity Swelling in Three Ferritic-Martensitic Steels Irradiated by 196 MeV Kr Ions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2013年第12期30卷 83-86页

作者： LI Yuan-Fei shen Tie-Long GAO Xing YAO Cun-Feng WEI kong-Fang SUN Jian-Rong LI Bing-sheng ZHU Ya-Bin PANG Li-Long CUI ming-Huan CHANG Hai-Long WANG Ji ZHU Hui-Ping HU Bi-Tao WANG Zhi-Guang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 University of Chinese Academy of Sciences Beijing 100049 School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000

We report on cavity swelling at peak damage regions of three ferritic-martensitic(FM)steels(NHS,RAFM and T91)irradiated by 196 MeV Kr ions at different temperatures(450/550℃).Cavity configurations of the irradiated specimens are investigated by transmission electron microscopy with cross-section *** home-made reduced activation ferritic-martensitic(RAFM)and T91 steels irradiated at 450℃,both large size and bimodal size distribution of the cavity are found in their peak damage regions,whereas novel high silicon(NHS)steel exhibits good swelling resistance at different irradiation *** relativity of the cavity swelling in NHS,RAFM and T91 steels is discussed briefly.

关键词： martensitic ferritic steel

宝钢N_2.钢煤气冷却高压水回流系统节能改造

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

热能动力工程 2010年第1期25卷 69-71页

作者：余晓明申文军孔彪龙上海理工大学能源与动力工程学院上海200093 上海市通用机械技术研究所上海200431

以宝钢N2.钢煤气冷却高压水回流系统节能改造及自动回流装置性能检测系统为研究对象,通过对高压水循环控制系统的自动回流阀组动态特性分析证明,该装置将流量感应、止回、旁路控制及多级降压等控制功能集于一体,使复杂的旁通回流系统... 详细信息

以宝钢N2.钢煤气冷却高压水回流系统节能改造及自动回流装置性能检测系统为研究对象,通过对高压水循环控制系统的自动回流阀组动态特性分析证明,该装置将流量感应、止回、旁路控制及多级降压等控制功能集于一体,使复杂的旁通回流系统得到合理简化,且调节平缓,有效保证泵的正常工作流程,避免了大流量空排,达到了节能与安全运行。经高压供水系统动态特性分析及多项节能改造的应用实践证明,阀组完全达到了设计和现场运行工艺流程所要求的各项技术和经济性能指标。

关键词：煤气冷却高压水自动回流阀组动态测试自力驱动控制循环

美国城市化背景下的砂石资源管理体系及相关政策研究

在线全文

学校读者我要写书评

暂无评论

中国矿业 2015年第11期24卷 5-8,64页

作者：沈明沈镭张超曹植孔含笑中国科学院地理科学与资源研究所北京100101 中国科学院大学研究生院北京100049

目前中国处于城市化快速发展阶段,资源和生态日显珍贵,然而我国在砂石资源管理中仍然存在管理粗放和执行效力低等问题。本文以城市化为背景研究美国砂石资源管理体系及政策,力图为中国砂石资源政策改进提供借鉴。经分析认为,美国砂石资... 详细信息

目前中国处于城市化快速发展阶段,资源和生态日显珍贵,然而我国在砂石资源管理中仍然存在管理粗放和执行效力低等问题。本文以城市化为背景研究美国砂石资源管理体系及政策,力图为中国砂石资源政策改进提供借鉴。经分析认为,美国砂石资源管理有三大特点,即金字塔式、差异性管理和先环保后发展的政策理念。城市化与砂石资源开采矛盾主要体现在环境保护政策限制、土地利用冲突和社区冲突三方面。针对这三点,本文在总结美国典型州县砂石管理基础上提出了资源摸底、整合区划、制定供需计划等五点建议。此外,美国"金字塔式"管理体系、差异性和精细化管理模式等思想,对于提高砂石资源管理执行效力同样具有借鉴意义。

关键词：砂石资源城市化政策研究美国

Helium-Implantation-Induced Damage in NHS Steel Investigated by Slow-Positron Annihilation Spectroscopy

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2014年第3期31卷 111-114页

作者： LI Yuan-Fei shen Tie-Long GAO Xing GAO Ning YAO Cun-Feng SUN Jian-Rong WEI kong-Fang LI Bing-sheng ZHANG Peng CAO Xing-Zhong ZHU Ya-Bin PANG Li-Long CUI ming-Huan CHANG Hai-Long WANG Ji ZHU Hui-Ping WANG Dong SONG Peng shenG Yan-Bin ZHANG Hong-Peng HU Bi-Tao WANG Zhi-Guang Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 University of Chinese Academy of Sciences Beijing 100049 School of Nuclear Science and Technology Lanzhou University Lanzhou 730000 Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049

Evolutions of defects and helium contained defects produced by atomic displacement and helium deposition with helium implantation at different temperatures in novel high silicon （NHS） steel are investigated by a slow positron beam. Differences of the defect information among samples implanted by helium to a fluence of 1×1017 ions/cm2.at room temperature, 300°C, 450°C and 750°C are discussed. It is found that the mobility of vacancies and vacancy clusters, a recombination of vacancy-type defects and the formation of the He-V complex lead to the occurrence of these differences. At high temperature irradiations, a change of the diffusion mechanism of He atoms/He bubbles might be one of the reasons for the change of the S-parameter.

关键词： Positron annihilation spectroscopy

一种新的双偶氮染料掺杂聚合物薄膜的光致双折射及偏振全息的研究(英文)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

发光学报 2007年第2期28卷 160-166页

作者：刘重付申成贾艳孔洁珺刘益春卢然金明东北师范大学先进光电子功能材料中心吉林长春130024 吉林大学化学学院吉林长春130023

作为一种有可能作为永久信息存储的材料,合成出一种新的双偶氮材料(BA1)。当样品被波长为532.m的光激发时,几乎大部分BA1分子从反-反态转化到顺-顺态,产生了光致双折射。因此,研究了BA1分子掺杂的PMMA薄膜的光致双折射和透过信号与入射... 详细信息

作为一种有可能作为永久信息存储的材料,合成出一种新的双偶氮材料(BA1)。当样品被波长为532.m的光激发时,几乎大部分BA1分子从反-反态转化到顺-顺态,产生了光致双折射。因此,研究了BA1分子掺杂的PMMA薄膜的光致双折射和透过信号与入射光强度的关系。实验结果表明:透过信号强度随着泵浦光的增强而增强。通过偏振态互相平行(SS)和垂直(SP)的两束偏振光用来研究偏振全息存储,结果表明SP光栅形成的衍射信号要比SS光栅的衍射信号强很多。

关键词：光致双折射偏振全息 BA1 He—Ne激光

基于毫米波雷达获取料堆DEM的插值方法研究

在线全文

学校读者我要写书评

暂无评论

计量学报 2022年第12期43卷 1554-1560页

作者：孔德明曹帅沈阅周逸人燕山大学电气工程学院河北秦皇岛066004 河北燕大燕软信息系统有限公司河北秦皇岛066004

针对现有的全自动堆取料机技术的发展过程中存在料堆高程模型获取困难、测量装置环境适应性差、成本高和模型精度低的问题,提出利用77 GHz毫米波雷达、差分北斗和角度编码器的集成技术获取大型料堆表面的离散点云数据。推导出多传感数... 详细信息

针对现有的全自动堆取料机技术的发展过程中存在料堆高程模型获取困难、测量装置环境适应性差、成本高和模型精度低的问题,提出利用77 GHz毫米波雷达、差分北斗和角度编码器的集成技术获取大型料堆表面的离散点云数据。推导出多传感数据融合获取离散点云数据的公式,并提出采用量子化鸽群优化Kriging插值算法获取料堆的数字高程模型(DEM),采用交叉验证的方式对比分析了优选参数后改进的普通Kriging、普通Kriging、反距离加权、基于三角剖分的线性和自然邻域插值算法,改进后的Kriging插值算法均方根误差低于0.37 m,均方误差低于0.14 m,均方根误差相比普通Kriging插值算法降低了39.9%。在现场的测试过程中,该方法可不受天气和粉尘的影响得到料堆的DEM,能够满足堆取料机全自动项目对精度的需求。

关键词：计量学料堆 DEM 毫米波雷达点云数据量子化鸽群优化算法改进Kriging插值算法

室间隔缺损合并主动脉瓣脱垂与关闭不全的外科治疗

在线全文

学校读者我要写书评

暂无评论

中华胸心血管外科杂志 1994年第3期10卷 202-204页

作者：高晓明乔峻申康马拉提新疆医学院第一附属医院心脏外科

报告１０例室间隔缺损合并主动脉瓣关闭不全与脱垂的临床特点及治疗方法。发病率占同期室间隔缺损修补术的３．２％，其中８例行主动脉瓣成形术；１例主动脉瓣替换术；１例单纯室间隔缺损修补。手术效果满意。我们对发病机制，不同类型... 详细信息

报告１０例室间隔缺损合并主动脉瓣关闭不全与脱垂的临床特点及治疗方法。发病率占同期室间隔缺损修补术的３．２％，其中８例行主动脉瓣成形术；１例主动脉瓣替换术；１例单纯室间隔缺损修补。手术效果满意。我们对发病机制，不同类型的主动脉瓣病变采用不同的手术方法进行了分析和讨论。

关键词：室间隔缺损主动脉瓣成形术