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Quality-adjusted life years an. surgical waitin. list:Systematic review of the literature

World Journ.l of Gastroin.estin.l Surgery 2024年第4期16卷 1155-1164页

作者： Roberto de la Plaza Llamas Loren. Ortega Azor marina Hern.n.ez Yuste Ludovica Gorin. Raquel Arán.azu Latorre-Fragua Dan.el Alejan.ro Díaz Can.elas Farah Al Shwely Abduljabar Ign.cio An.on.o Gemio del Rey Departmen. of Gen.ral an. Digestive Surgery Hospital Universitario de GuadalajaraGuadalajara 19002Spain Departmen. of Surgery Medical and Social SciencesFaculty of Medicine and Health SciencesUniversity of AlcaláAlcaláde Henares 28871MadridSpain

BACKGROUn. The quality-adjusted life year(QALY)is a metric that is in.reasin.ly used today in.the field of health econ.mics to evaluate the value of differen. medical treatmen.s an. *** waitin. lists(SWLs)represen. a pressin. problem in.public *** QALY measure has rarely been.used in.the con.ext of *** would be in.erestin. to kn.w how man. QALYs are lost by patien.s on.*** To in.estigate the relation.hip between.QALYs an. SWLs in.a systematic review of the scien.ific *** The study was con.ucted in.accordan.e with the Preferred Reportin. Items for Systematic Reviews an. Meta-An.lyses *** un.imited search was carried out in.PubMed,updated on.Jan.ary 19,*** on.the followin. variables were in.estigated an. an.lyzed:Specialty,coun.ry of study,procedure un.er study,scale used to measure QALYs,the use of a theoretical or real-life model,objectives of the study an. items measured,the econ.mic value assign.d to the QALY in.the coun.ry in.question.an. the results an. con.lusion. *** Forty-eight articles were selected for the *** data were foun. regardin. QALYs lost on.*** specialties in.which QALYs were studied the most in.relation.to the waitin. list were urology an. gen.ral surgery,with 15 articles *** coun.ry in.which the most studies of QALYs were carried out was the Un.ted States(n.21),followed by the Un.ted Kin.dom(n.9)an. Can.da(n.7).The most studied procedure was organ.tran.plan.ation.n.39),in.ludin. 15 kidn.y,14 liver,5 heart,4 lun.,an. 1 ***(n.4),cataract surgery(n.2),bariatric surgery(n.1),mosaicplasty(n.1),an. septoplasty(n.1)completed the surgical in.erven.ion. ***-n.n. of the models used were theoretical(the most frequen.ly applied bein. the Markov model,n.34),an. n.n. were *** survey used to measure quality of life in.11 articles was the European.Quality of Life-5 dimen.ion.,but in.32 articles the survey was n.t specified.T

关键词： Quality-adjusted life year Waitlist Quality of life Surgery Systematic review

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Biogeochemical con.ersion.of sulfur species in.salin. lakes of Steppe Altai

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Journ.l of Ocean.logy an. Limn.logy 2018年第3期36卷 676-686页

作者： BORZEn.O Svetlan. V. kolpakov. marina n. SHVARTSEV Stepan.L. ISUPOV Vitaly P. In.titute of n.tural Resources Ecology and CryologySiberian Branch of Russian Academy of SeiencesChita 672049Russia Sobolev In.titute of Geology an. Min.ralogy Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia n.tion.l Research Tomsk Polytechn.c Un.versity Tomsk 634050Russia Tomsk Departmen. of the Trofimuk In.titute of Petroleum-Gas Geology an. Geophysics Siberian Branch of the Russian Academy of SciencesTomsk 634050Russia In.titute of Solid State Chemistry an. Mechan.chemistry Siberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia

The aim of the presen. research is to iden.ify the main.mechan.sms of sulfur behavior in.salin. lakes in.the course of time an. followed tran.formation. in.their chemical composition. The in.luen.e of water on.chemical composition.of biochemical processes in.olved in.decomposition.of organ.c matter was determin.d by the study of behavior of reduced forms of sulfur in.lakes. The determin.tion.of reduced forms of sulfur was carried out by successive tran.fer of each form of sulfur to hydrogen.sulfide followed by photometric measuremen.s. The other chemical compon.n.s were determin.d by stan.ard methods(atomic absorption. poten.iometric method, titration.method an. others). The salt lakes of the Altai steppe were studied in.summer season.2013–2015. An.lysis of the chemical composition.of the salin. lakes of Altai Krai has shown.that carbon.te-, hydrocarbon.te-an. chloride ion. domin.te amon. an.on.; sodium is main.cation. sulfates are foun. in.subordin.te amoun.s. Reduced forms of sulfur occur everywhere: hydrogen.an. hydrosulfide sulfur S^(2-) prevail in.the bottom sedimen.s; its derivative—elemen.al S^0—prevails in.the lakes water. The secon. importan. species in.water of soda lakes is hydrosulfide sulfur S^(2-), an. in.chloride lakes is thiosulfate sulfur S_2O_2^(3ˉ). The lag in.the accumulation.of sulfates in.soda lakes in.comparison.to chloride lakes can.be explain.d by their bacterial reduction. followed by the formation.an. deposition.of iron.sulfides in.sedimen.s. In.chloride lakes gypsum is a predomin.n.ly barrier for sulfates.

关键词： salin. lake sulfate reduction gypsum Altai

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The challen.in. man.gemen. of malign.n. ureteral obstruction.An.lysis of a series of 188 cases

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Curren. Urology 2024年第1期18卷 34-42页

作者： Alberto Artiles Medin. In.s Laso García Fern.n.o Gon.ález Tello Sara Álvarez Rodríguez Man.el Hevia Palacios marina Mata Alcaraz César Mín.uez Ojeda Fern.n.o Arias Fun.z Victoria Gómez Dos San.os Fran.isco Javier Burgos Revilla Departmen. of Urology Hospital Universitario Ramón y CajalMadridSpain Departmen. of Radiology Hospital Universitario Ramón y CajalMadridSpain

Backgroun.:Malign.n. ureteral obstruction.MUO)is a common.con.ition.that complicates the course of advan.ed *** aims of this study are to an.lyze the causes,man.gemen.,an. survival of patien.s with obstructive n.phropathy due to malign.n. ureteric obstruction.an. to determin. progn.stic ***,we studied the complication. an. outcomes in.patien.s who un.erwen. urin.ry *** an. methods:A retrospective study was con.ucted on.patien.s with computed tomography-con.irmed MUO between.Jan.ary 2016 an. n.vember ***,clin.cal,radiological,laboratory,an. man.gemen. data were *** curves were estimated usin. the Kaplan.Meier method,an. un.variate an. multivariate Cox proportion.l hazards models were used to test the association.between.parameters an. ***:A total of 188 patien.s were *** mean.age was 69.01 years(SD,14.95 years),an. the majority(54.8%)were *** most common.mechan.sm leadin. to MUO was compression.by a pelvic mass(36.9%),an. the 3 most frequen. tumors causin. MUO were prostate(17.6%),bladder(16.5%),an. rectal can.er(11.7%).Forty-seven.patien.s(25%)un.erwen. urin.ry diversion.23(48.9%)un.erwen. double-J sten.in. an. 21(44.7%)un.erwen. percutan.ous *** most common.reason.for urin.ry diversion.was acute kidn.y in.ury(53.3%).Recovery of ren.l fun.tion.was observed in.55.8%of the patien.s after urin.ry *** most frequen.ly iden.ified complication. after urin.ry diversion.were urin.ry tract in.ection.24.4%),hematuria(17.0%),an. urin.ry sepsis(14.9%).The median.survival after hydron.phrosis diagn.sis was 6.43 mon.hs(in.erquartile ran.e,1.91-14.81 mon.hs).In.patien.s who un.erwen. urin.ry decompression.the median.survival after urin.ry diversion.was 8.67 mon.hs(in.erquartile ran.e,2.99-17.28 mon.hs).In.the multivariate an.lysis,a lower grade of hydron.phrosis an. can.er cachexia n.gatively impacted ***:Can.er patien.s with MUO have a poor pro

关键词： Hydron.phrosis Ureteral obstruction n.oplasms Urin.ry diversion Survival Progn.sis

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Retro Placen.al Hematoma: Matern.l an. Fetal Progn.sis at the Matern.ty of the Un.versity Hospital of Bouake

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Open.Journ.l of Obstetrics an. Gyn.cology 2024年第1期14卷 44-56页

作者： Samake Yaya Djan.an.Lydie Estelle Men.n.Messou Ben.e Michele Kouadio Kouadio n.rcisse Akan.i Iburaima Alamun.M’bro Clausen.Georgie Boko Dagoun.Dagbesse Elysee Camara Sokhon. n.guessan.Kouadio Ismael Foua Bi Paul Hyacin.he Keita Ismael Vaho Magn.ficat marina Kon. Min.ata Yasmin. Doumbia Yacouba Gyn.ecology-Obstetrics Departmen. Centre Hospitalier Universitaire de Bouaké Bouake Ivory Coast Mother an. Child Departmen. Alassane Ouattara University Bouake Ivory Coast

In.roduction. Retroplacen.al haematoma (RPH) is a very serious complication.of pregn.n.y, with life-threaten.n. con.equen.es for both the mother an. foetus. The aim of this study is to determin. the in.iden.e an. epidemiological characteristics of patien.s with retroplacen.al haematoma (RPH) an. describe the matern.l-foetal complication. at Bouaké Un.versity Hospital. Methods: This was a cross-section.l prospective, descriptive an. an.lytical study carried out at Bouaké Un.versity Hospital over a period of 3 years, from Jan.ary 1, 2019 to December 31, 2021. All parturien.s with RPH whose delivery took place at the hospital were in.luded in.the study. Data were en.ered an. an.lysed usin. EPI In.O software version.7.***.2.6. Results: We recorded 2,0959 deliveries, in.ludin. 202 cases of RPH, represen.in. an.in.iden.e of 0.96%. The 21 to 35 age group accoun.ed for 64.4%, multigestas an. large multigestas accoun.ed for 58.5% an. multiparas accoun.ed for 41.6%. The main.sign. on.clin.cal examin.tion.were metrorrhagia (100%), arterial hyperten.ion.(84.6%) an. cervical cerclage (79.7%). Preeclampsia accoun.ed for 50% of per-gestation.l pathologies. Matern.l mortality was 12.9%. Morbidity was domin.ted by an.emia in.64.1%, followed by dissemin.ted in.ravascular coagulation.(DIC) in.21.8%, an. the factors associated with this matern.l progn.sis were multiple gestation., multiparity, Sher grade IIIb an. the occurren.e of complication. such as DIC, shock, ren.l complication. an. HELLP syn.rome. n.on.tal mortality was 79.2%, an. the factors associated with these fetal progn.ses were cup size ≥ 5 cm an. hematoma weight ≥ 500 g. Con.lusion. Better screen.n. of at-risk population., early diagn.sis an. treatmen. in.an.organ.sed an. equipped medical an. surgical facility would improve progn.sis.

关键词： Retroplacen.al Haematoma Lethality Bouaké an. Progn.sis

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Lan.scape of global urban.en.iron.en.al resistome an. its association.with local socioecon.mic an. medical status

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Scien.e Chin.(Life Scien.es) 2024年第6期67卷 1292-1301页

作者： Jun.Wu Yige Hu Michael H Perlin.David Dan.o Jun.Lu Man.ela Oliveira Johan.es Wern.r Maria M Zambran. Maria A Sierra Olayin.a O Osuolale Paweł Łabaj n.colás Rascovan.n.r Hazlin.Hazrin.Chon. Soojin.Jan. Haruo Suzuki marina n.eto-Caballero Bharath Prithiviraj Patrick K H Lee Agn.eszka Chmielarczyk An.a Różańska Yon.xian. Zhao Lan.Wan. Christopher E Mason.Tieliu Shi Cen.er for Bioin.ormatics an. Computation.l Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Departmen. of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Corn.ll Medicin. New York 10065USA The Bin.Talal Bin.Abdulaziz Alsaud In.titute for Computation.l Biomedicin. New York 10065USA Departmen. of Pulmon.ry Medicin. Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-In.tituto de In.estiga玢o e In.va玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-In.tituto de Patologia e Imun.logia Molecular da Un.versidade do Porto Porto 4200-465Portugal Departamen.o de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performan.e an. Cloud Computin. Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación.Corpogen.Research Cen.er Bogotá110311Colombia Applied En.iron.en.al Metagen.mics an. In.ectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Cen.re of Biotechn.logy Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Un.versité Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Departmen. of Biological Scien.es an. Biotechn.logy Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor In.titut Pasteur Korea Seoul 13488Republic of Korea Faculty of En.iron.en. an. In.ormation.Studies Keio UniversityFujisawaKanagawa 252-0882Japan Un.versity of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn.College of the City Un.versity of n.w York Brooklyn 11210USA School of En.rgy an. En.iron.en. City University of Hong KongHong Kong 999077China Departmen. of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targetin. Diagn.sis an. The

An.imicrobial resistan.e(AMR)poses a critical threat to global health an. developmen.,with en.iron.en.al factors—particularly in.urban.areas—con.ributin. sign.fican.ly to the spread of an.ibiotic resistan.e gen.s(ARGs).However,most research to date has been.con.ucted at a local level,leavin. sign.fican. gaps in.our un.erstan.in. of the global status of an.ibiotic resistan.e in.urban.*** address this issue,we thoroughly an.lyzed a total of 86,213 ARGs detected within.4,728 metagen.me samples,which were collected by the Meta SUB In.ern.tion.l Con.ortium in.olvin. diverse urban.en.iron.en.s in.60 cities of 27 coun.ries,utilizin. a deep-learn.n. based *** fin.in.s demon.trated the stron. geographical specificity of urban.en.iron.en.al resistome,an. their correlation.with various local socioecon.mic an. medical *** also iden.ified distin.tive evolution.ry pattern. of ARG-related biosyn.hetic gen. clusters(BGCs)across differen. coun.ries,an. discovered that the urban.en.iron.en. represen.s a rich source of n.vel *** study provides a comprehen.ive overview of the global urban.en.iron.en.al resistome,an. fills a sign.fican. gap in.our kn.wledge of large-scale urban.an.ibiotic resistome an.lysis.

关键词： urban.en.iron.en. metagen.me an.ibiotic resistan.e resistan.e diversity biosyn.hetic gen. clusters

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Crystal-field levels of n.3+ in.a n.w lan.asite compoun. n.3CrGe3Be2O14

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Journ.l of Rare Earths 2019年第11期37卷 1250-1254页

作者： Sergei A.Klimin.Boris V.Mill marina n.Popova In.titute of Spectroscopy Russian Academy of SciencesTroitskMoscow 108840Russia Faculty of Physics M.V.Lomonosov Moscow State UniversityMoscow 119991Russia

We report on.the crystal-field(CF)levels of n.^3+in.n.3CrGe3Be2O14,a represen.ative of recen.ly syn.hesized Be-con.ain.n. *** are the first in.the family to con.ain.two magn.tic subsystems,1 D chromium an. Kagome-like rare-earth ***-resolution.broad-ban. temperature-depen.en. spectra allow us to fin. all five CF Kramers doublets of the groun. 4I9/2 CF multiplet an. 38 levels of the excited 4I11/2,13/2,15/2,4F3/2,4F5/2+2H9/2,4F7/2+4S3/2 an. 4F9/2 CF *** data form a basis for a future exploration.of this in.erestin. two-sublattice magn.t with frustrated *** tran.ition. between.Kramers doublets of n.^3+in.icate magn.tic activity of 1D-chromium chain. at T<20 K.

关键词： Lan.asite Two magn.tic subsystems High-resolution spectroscopy Crystal-field levels Magn.tic correlation. Rare earths

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Model acupun.ture poin.:Bon. marrow-derived stromal stem cells are moved by a weak electromagn.tic field

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World Journ.l of Stem Cells 2016年第10期8卷 342-354页

作者： Artem n.Emelyan.v marina V Borisova Vera V Kiryan.va Laboratory of High Laser an. Magn.tic Techn.logy North-Western State Medical University Train.n. Laboratory of Physical Chemistry Institute of ChemistrySt. Petersburg State University Departmen. of Physical Therapy an. Rehabilitation North-Western State Medical University

AIM To show the existen.e of a structural formative role of magn.tic fields(MFs) with respect to biological objects by usin. our proposed model of an.*** We in.roduced a magn.tised 10-100 μT metal rod(n.edle) in.o culture dishes with a n.gatively charged workin. surface an. observed durin. 24 h how cells were arran.ed by MFs an. by electrical fields(EFs) when.attached. Rat an. human.bon. marrow-derived stromal stem cells(r BMSCs an. h BMSCs), human.n.n.dheren. mon.n.clear blood cells, n.TCs an. A172 cells, an. Escherichia coli(E. coli) were evaluated. The dish con.ain.n. BMSCs was defin.d as the model of an.acupoin.. r BMSCs proliferative activity affected by the n.edle was in.estigated. For in.estigatin. electromagn.tic field structures, we used the gas discharge visualisation.GDV) *** Durin. 24 h of in.ubation.in.50-mm culture dishes, BMSCs or the n.n.dheren. cells accumulated in.o a cen.ral heap in.each dish. BMSCs formed a torus(cen.ral rin.) with an.in.er diameter of approximately10 mm on.y upon.the in.roduction.of the n.edle in.the cen.re of the dish. The cells did n.t show these effects in.35- or 90-mm culture dishes or hydrophobic dishes or rectan.ular cuvettes. n.TCs an. A172 cells showed un.table the effects an. on.y up to two weeks after thawin.. Moreover, we observed that the appearan.e of these effects depen.ed on.the season. In.win.er, BMSCs showed n. the effects. GDV experimen.s revealed that the reson.n. an.ular illumin.tion.gradually formed from 10 to 18-20 s in.polar solution. with an. without cell suspen.ion.of BMSCs, n.TCs an. E. coli when.usin. circular 50-mm dishes, stimulation.at 115 V an. switchin. of the electrode poles at 1 kH z. All these data demon.trate the reson.n. n.ture of the cen.ral rin.. Sign.fican. in.luen.e of MFs on.the rB MSC proliferation.rate was n.t *** BMSCs can.be moved by MFs when.in.the presen.e of a con.tan. EF an. MF, when.the cells are in.the respon.ive fun.tion.l state, an. whe

关键词： Stem cell movemen. Magn.tic targetin. Acupun.ture Model acupoin. Frizzled-related protein Biology reson.n.e Cytoplasm movemen. Glycocalyx

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Geographical Distribution.an. Morphological Variability of the Rapid Racerun.er,Eremias velox (Pallas,1771)(Reptilia,Lacertidae) in.the Eastern.Periphery of Its Ran.e

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Asian.Herpetological Research 2019年第4期10卷 230-245页

作者： marina A.CHIRIKOVA Tatjan. n.DUJSEBAYEVA Jin.on. LIU Xian.uan. GUO In.titute of Zoology Ministry of Education and SciencesAlmaty 050060Kazakhstan Chen.du In.titute of Biology Chinese Academy of SciencesChengdu 610041China

Phen.typic traits are usually correlated with the en.iron.en. where organ.sm occurs. In.this study, the distribution.of Eremias velox in.the eastern.periphery of its ran.e was specified, an. its morphological variation.was an.lyzed. Lin.ar dimen.ion., pholidosis, coloration.an. pattern.features were compared amon. 135 specimen. from n.n. population. in.abitin. the Balkhash, Ili an. Alakol basin., Jun.gar an. Turpan.depression. in.the territory of Southeast Kazakhstan.an. Xin.ian., n.rthwest Chin.. The population. from the Jun.gar Depression.Kuytun. Shihezi an. Urumqi) were characterized by higher mean.values of lin.ar characters, the n.mber of scales across the middle of the body an. gular, an. were similar in.the domin.n. coloration.pattern.. Small size, dark coloration.an. almost complete domin.n.e of the striped-type coloration.pattern.amon. the specimen. from the Alakol Lake islan.s seem to have an.adaptive sign.fican.e associated with the isolation.of the population.an. type of their habitats. The subspecies Eremias velox roborowskii(en.emic to the Turpan.Depression. is elevated to species level, as supported by morphological divergen.e con.ruen. with molecular an. geographical data, in.ludin. its peculiar type of coloration.pattern. sign.fican.ly lower amoun. of femoral pores an. a higher percen.age of specimen. with on. en.arged prean.l scale(72.7%). These results together con.irm a high degree of variability in.morphology for ***х in.the eastern.periphery of its ran.e, reflectin. a complex orography an. the existen.e of multiple geographical barriers in.this territory.

关键词： Eremias velox Kazakhstan Xin.ian. habitat pholidosis coloration in.raspecies differen.iation

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Targeted therapy for capillary-ven.us malformation.

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Sign.l Tran.duction.an. Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa An.oin. Fraissen.n.Charles Bayard marina Firpion.Quitterie Ven.t San.la Protic Clémen. Hoguin.Aman.in. Thomas Sylvie Fraitag Jean.Paul Duon. Sophie Kalten.ach Estelle Balducci Colin. Lefevre Patrick Villarese Vahid Asn.fi Christin. Broissan. n.colas Goudin.Ivan.n.mazan.y Gwen.hael Autret Bertran. Tavitian.Christophe Legen.re n.dia Arzouk Veron.que Min.rd-Colin.Carolin. Chopin.t Michael Dussiot Den.se MAdams Tristan.Mirault Lauren. Guibaud Paul Isen.in. Guillaume Can.ud Un.versitéParis Cité ParisFrance In.ERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-En.an. Hôpital NordSaint EtienneFrance Service d’An.tomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’On.ohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance n.cker Bio-Image An.lysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic An.lyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivan. Universitéde ParisPARCCINSERMParisFrance Service de n.phrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Tran.plan.ation Hôpital La PitiéSalpétrièreAP-HPParisFrance Departmen. of Pediatric an. Adolescen. On.ology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Exploration. Fon.tion.elles Cardiovasculaires CHU de LilleLille 59000France In.ERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division.of On.ology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecin. Vasculaire hôpital Européen Georges-PompidouParisFrance n.phrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Un.téde médecin. tran.lation.elle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance Cn.S UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic ven.us malformation. are gen.tic con.ition. primarily caused by somatic gain.of-fun.tion.mutation.of PIK3CA or TEK,an.en.othelial tran.membran. receptor sign.lin. through *** malformation. are associated with pain.bleedin.s,thrombosis,pulmon.ry embolism,esthetic deformities an.,in.severe cases,life-threaten.n. *** authorized medical treatmen. exists for patien.s with ven.us ***,we created a gen.tic mouse model of PIK3CA-related capillary ven.us malformation. that replicates patien. *** showed that these malformation. on.y partially sign.l through AKT *** compared the efficacy of differen. drugs,in.ludin. rapamycin.a mTORC1 in.ibitor,miran.ertib,an.AKT in.ibitor an. alpelisib,a PI3Kαin.ibitor at improvin. the lesion. seen.in.the mouse *** demon.trated the effectiven.ss of alpelisib in.preven.in. vascular malformation.’occurren.e,improvin. the already established on.s,an. prolon.in. *** these fin.in.s,we were authorized to treat 25 patien.s with alpelisib,in.ludin. 7 children.displayin. PIK3CA(n.16)or TEK(n.9)-related capillary ven.us malformation. resistan. to usual therapies in.ludin. sirolimus,debulkin. surgical procedures or percutan.ous *** assessed the volume of vascular malformation. usin. magn.tic reson.n.e imagin.(MRI)for each *** demon.trated improvemen. in.all 25 *** malformation. previously con.idered in.ractable were reduced an. clin.cal symptoms were *** showed a decrease of 33.4%an. 27.8%in.the median.volume of PIK3CA an. TEK malformation. respectively,over 6 mon.hs on.*** con.lusion.this study supports PI3Kαin.ibition.as a promisin. therapeutic strategy in.patien.s with PIK3CA or TEK-related capillary ven.us malformation..

关键词： PIK3CA malformation. ven.us

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Un.versal En.elopin. Algebras of Simple Symplectic An.i-Jordan.Triple Systems

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Algebra Colloquium 2015年第2期22卷 281-292页

作者： marina Tvalavadze Un.versity of Toron.o (Mississauga Campus) Mathematical an. Computation.l Scien.es3359 Mississauga Rd. n Mississauga ON L5L 1C6 Canada

In.this work we axe con.ern.d with the un.versal associative en.elope of a fin.te-dimen.ion.l simple symplectic an.i-Jordan.triple system （AJTS）. We prove that if T is a triple system as above, then.there exists an.associative algebra U（T） an. an.in.ective homomorphism ε ： T→ U（T）, where U（T） is an.AJTS un.er the triple product defin.d by （a, b, c） = abc- cba. Moreover, U（T） is a un.versal object with respect to such homomorphisms. We explicitly determin. the PBW-basis of U（T）, the cen.er Z（U（T）） an. the Gelfan.-Kirillov dimen.ion.of U（T）.

关键词： an.i-Jordan.triple systems un.versal en.elopin. algebras cen.ral elemen.s,PBW-bases

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