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Cholangioscopy-assisted guidewire placement in a malignant biliary stricture: A case report

World Journal of Surgical Procedures 2020年第2期10卷 3-8页

作者： Grace E kim David yung-An Lo Internal Medicine University of Maryland Medical CenterBaltimoreMD 21201United States Department of Medicine The Ohio State University College of MedicineOhio Gastroenterology GroupIncColumbusOH 43214United States

BACKGROUND Cholangioscopy has been described in case reports and series to facilitate guidewire placement in difficult benign biliary ***,it has been infrequently used in difficult benign anastomotic liver transplant biliary strictures to visualize the stricture orifice for guidewire *** we describe a case of guidewire placement through a difficult malignant biliary stricture using single operator *** SUMMARY A 74-year-old female presented with jaundice and weight *** ultrasound and endoscopic retrograde cholangiopancreatography(ERCP)by other endoscopists demonstrated pancreatic adenocarcinoma with a dilated cystic duct(CD)and proximal common bile duct(CBD).The associated distal CBD stricture was dilated and stented with a plastic *** she subsequently developed cholangitis,prompting referral for a repeat *** stent was found to have migrated distally to the confluence of the dilated CD and CBD *** using multiple hydrophilic guidewires,the stricture could not be traversed due to preferential wire passage into the dilated *** DS(Boston Scientific Corp,Marlborough,MA,United States)was then used to visualize the orifices of the CD and CBD stenosis,enabling the guidewire to be placed directly through the stricture into the proximal CBD.A WallFlex covered metal stent(Boston Scientific Corp,Marlborough,MA,United States)was successfully placed,resulting in resolution of her *** To our knowledge,this is one of the first cases to describe successful cholangioscopic guidewire placement for malignant biliary strictures.

关键词： Cholangiopancreatoscopy Malignant biliary stricture Cholangioscopy Guidewire placement Obstructive jaundice Case report

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Preoperative CA 125 is significant indicator of curative resection in gastric cancer patients

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World Journal of Gastroenterology 2015年第4期21卷 1216-1221页

作者： Dae Hoon kim Hyo yung Yun Dong Hee Ryu Hye-Suk Han Joung-Ho Han Soon Man Yoon Sei Jin Youn Department of Surgery Chungbuk National University College of MedicineCheongju 361-763South Korea Internal Medicine Chungbuk National University College of MedicineCheongju 361-763South Korea

AIM: To investigate the correlation among tumor markers, curative resection, and recurrence in gastric ***: The patients with preoperative tumormakers [Carcinoembryonic antigen, Carbohydrate antigen(CA) 19-9, and CA 125] and elective gastrectomy between January 2000 and December 2009 at Chungbuk National University Hospital were enrolled in this study. We analyzed the relationship among the tumor makers, curative resection and recurrence, ***: Among the 679 patients with gastric cancer, curative resection was 93.6%(n = 636) and noncurative resection was 6.4%(n = 43). The independent risk factors for the non-curative resection were tumor location and the positivity of preoperative serum CA 19-9 and CA 125 levels. After curative resection, the independent prognostic risk factors for recurrence in curative resection were gender, stage, and preoperative increased serum CA 125 level(HR = 2.431, P =0.020), in a multivariate analysis. CONCLUSION: Preoperative CA 125 is a useful predictive biomarker for curative resection and prognostic biomarker for recurrence in gastric cancer patients.

关键词： Gastric Cancer Tumor Marker Carcinoembryonic antig

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CD24 expression predicts distant metastasis in extrahepatic bile duct cancer

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World Journal of Gastroenterology 2013年第9期19卷 1438-1443页

作者： Kyubo kim Hye Sook Min Eui Kyu Chie Jin-Young Jang Sun Whe kim Sae-Won Han Do-Youn Oh Seock-Ah Im Tae-You kim yung-Jue Bang Ja-June Jang Sung W Ha Department of Radiation Oncology Seoul National University College of Medicine Seoul 110-744 South Korea Department of Pathology Seoul National University College of Medicine Seoul 110-744 South Korea Institute of Radiation Medicine Medical Research Center Seoul National University Seoul 151-742 South Korea Department of Surgery Seoul National University College of Medicine Seoul 110-744 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-744 South Korea

AIM: To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Eighty-four patients with EHBD cancer who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled in this study. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes up to a median of 40 Gy (range: 40-56 Gy). All patients also received fluoropyrimidine chemotherapy for radiosensitization during radiotherapy. CD24 expression was assessed with immunohistochemical staining on tissue microarray. Clinicopathologic factors as well as CD24 expression were evaluated in multivariate analysis for clinical outcomes including loco-regional recurrence, distant metastasisfree and overall survival. RESULTS: CD24 was expressed in 36 patients (42.9%). CD24 expression was associated with distant metastasis, but not with loco-regional recurrence nor with overall survival. The 5-year distant metastasis-free survival rates were 55.1% and 29.0% in patients with negative and positive expression, respectively (P=0.0100). On multivariate analysis incorporating N stage, histologic differentiation and CD24 expression, N stage was the only significant factor predicting distant metastasis-free survival (P=0.0089), while CD24 expression had borderline significance (P=0.0733). In subgroup analysis, CD24 expression was significantly associated with 5-year distant metastasis-free survival in node-positive patients (38.4% with negative expression vs 0% with positive expression, P=0.0110), but not in nodenegative patients (62.0% with negative expression vs 64.0% with positive expression,P=0.8599). CONCLUSION: CD24 expression was a significant predictor of distant metastasis for patients undergoing curative resection followed by adjuvant chemoradiotherapy especially for node-positive EHBD cancer.

关键词： CD24 Tissue microarray Extrahepatic bile duct cancer Adjuvant chemoradiotherapy Distant metastasis

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Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans

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World Journal of Gastroenterology 2014年第26期20卷 8592-8598页

作者： Yong-Dae kim Dong-Hyuk Yim Sang-Yong Eom Sun In Moon Hyo-yung Yun Young-Jin Song Sei-Jin Youn Taisun Hyun Joo-Seung Park Byung Sik kim Jong-Young Lee Hee Kwan Won Heon kim Department of Preventive Medicine College of MedicineChungbuk National University Department of Surgery College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Food and Nutrition Chungbuk National University Department of Surgery College of MedicineEulji University Department of Surgery Asan Medical CenterCollege of MedicineUlsan University Center for Genome Science National Institute of Health Department of Internal Medicine Division of Endocrinology and MetabolismSchool of MedicineKonyang University

AIM: To evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase (PRKAA1) and the risk of gastric cancer.

关键词： AMP-activated protein kinase Gastric cancer PRKAA1 Single nucleotide polymorphism Case-control study

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ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population

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World Journal of Gastroenterology 2013年第35期19卷 5870-5876页

作者： Dong-Hyuk Yim Yan-Wei Zhang Sang-Yong Eom Sun In Moon Hyo-yung Yun Young-Jin Song Sei-Jin Youn Taisun Hyun Joo-Seung Park Byung Sik kim Jong-Young Lee Yong-Dae kim Heon kim Department of Preventive Medicine and Medical Research Institute College of Medicine Chungbuk National University Center for Disease Control and Prevention Department of Surgery College of Medicine Chungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Food and Nutrition Chungbuk National University Department of Surgery College of MedicineEulji University Department of Surgery Asan Medical Center College of Medicine Ulsan University Center for Genome Science National Institute of Health

AIM:To evaluate the association between the geneticpolymorphisms and haplotypes of the ITGA1 gene and the risk of gastric ***:The study subjects were 477 age-and sex-matched case-control *** was performed for 15 single nucleotide polymorphisms(SNPs)in *** associations between gastric cancer and these SNPs and haplotypes were analyzed with multivariate conditional logistic regression *** testing corrections were carried out following methodology for controlling the false discovery ***-based association tests were performed using the versatile gene-based association study(VEGAS)***:In the codominant model,the ORs for SNPs rs2432143(1.517;95%CI:1.144-2.011)and rs2447867(1.258;95%CI:1.051-1.505)were statistically *** the dominant model,polymorphisms of rs1862610 and rs2447867 were found to be significant risk factors,with ORs of 1.337(95%CI:1.029-1.737)and 1.412(95%CI:1.061-1.881),*** the recessive model,only the rs2432143 polymorphism was significant(OR=1.559,95%CI:1.150-2.114).The C-C type of ITGA1 haplotype block 2 was a significant protective factor against gastric cancer in the both codominant model(OR=0.602,95%CI:0.212-0.709,P=0.021)and the dominant model(OR=0.653,95%CI:0.483-0.884).The ITGA1 gene showed a significant gene-based association with gastric cancer in the VEGAS *** the dominant model,the A-T type of ITGA1 haplotype block 2 was a significant risk factor(OR=1.341,95%CI:1.034-1.741).SNP rs2447867 might be related to the severity of gastric epithelial injury due to inflammation and,thus,to the risk of developing gastric ***:ITGA1 gene SNPs rs1862610,rs2432143,and rs2447867 and the ITGA1 haplotype block that includes SNPs rs1862610 and rs2432143 were significantly associated with gastric cancer.

关键词： Integrin ITGA1 Gastric cancer Polymorphism Haplotype

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Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson’s disease

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Journal of Traditional Chinese Medicine 2019年第6期39卷 800-808页

作者： Liu Quanfeng Sang Heon kim yung-Wei Sung Sok Cheon Pak Wonwoong Lee Jongki Hong jaehwan Jang Kyoung Sang Cho Songhee Jeon Byung-Soo Koo Department of Oriental Medicine Dongguk UniversityGyeogju38066Republic of Korea Department of Oriental Neuropsychiatry Graduate School of Oriental MedicineDongguk UniversityGyeonggi-do 10326Republic of Korea College of Pharmacy Kyung Hee UniversitySeoul 02447Republic of Korea School of Biomedical Sciences Charles Sturt UniversityBathurstNew South Wales2795Australia Department of Biological Sciences Konkuk UniversitySeoul 05029Republic of Korea Department of Biomedical Sciences Center for Creative Biomedical Scientists at Chonnam National UniversityGwangju 61469Korea

OBJECTIVE:To examine the role of KSOP1009(a modified formulation of Suhexiang Wan essential oil)in an animal model of Parkinson's disease(PD)induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine(MPTP)***:Cell toxicity,apoptosis,and reactive oxygen species(ROS)levels were analyzed in the human neuroblastoma cell line SH-SY5 *** that,changes in animal behavior and tyrosine hydroxylase(TH)protein levels in the substantia nigra(SN)of MPTP-injected mice were *** different doses of KSOP1009(30,100,and 300 mg/kg,n=8 for each group)were administered daily for 7 d before MPTP injection and 14 d after MPTP injection,totaling 21 ***:MPP+,the active metabolite of MPTP,decreased the viability of SH-SY5 Y cells,whereas KSOP1009 alleviated MPP+-induced ***1009(10 and 50 mg/m L)reduced MPP+-induced ROS generation compared with the control *** with 1 m M MPP+increased the percentage of depolarized/live cells,whereas KSOP1009 intake at a dose of 10 mg/m L decreased the percentage of these *** mean latency to fall in the rotarod test was reduced in mice treated with MPTP compared with the control ***,mice receiving three different doses of KSOP1009 performed better than MPTP-treated ***-treated mice were more hesitant and took longer to traverse the balance beam than the control *** contrast,KSOP1009-treated mice performed significantly better than MPTPtreated ***,the KSOP1009-treated groups had a significantly higher number of TH-positive neurons in the lesioned SN and significantly higher expression of TH in the striatum than the MPTP-treated *** treatment strongly induced Jun-N-terminal kinase(JNK)activation,whereas KSOP1009 suppressed MPTP-induced JNK *** addition,KSOP1009 intake reversed the decrease in the phosphorylation levels of c AMP-response element-binding protein in the brain of MPTP-treated ***1009 also restored the decrease in dopaminergic

关键词： Parkinson disease 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mitochondria Reactive oxygen species Suhexiang Wan

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High-performance MoS_(2)/p^(+)-Si heterojunction field-effect transistors by interface modulation

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Nano Research 2022年第7期15卷 6500-6506页

作者： Yoonsok kim Taeyoung kim Eun Kyu kim Department of Physics and Research Institute of Natural Science Hanyang UniversitySeoul 04763Republic of Korea

Molybdenum disulfide(MoS_(2)),one of transition metal dichalcogenides,is a promising semiconductor material for electronic or optoelectronic devices due to its favorably electronic ***,in metal-oxide semiconductor field-effect transistor(MOSFET)structures using MoS_(2),electrical performances such as mobility and subthreshold swing are suppressed by the interface trap density between the channel and dielectric ***,the electrical stability of such structures is compromised due to interface traps and that can be analyzed such as current hysteresis and transient ***,we demonstrate MoS_(2) heterojunction field-effect transistors(HFET)by applying MoS_(2)/p^(+)-Si heterojunctions and achieve high performance characteristics,including a mobility of 636.19 cm^(2)/(V∙s),a subthreshold swing of 67.4 mV/dec,minimal hysteresis of 0.05 V,and minimized transient ***,the HFET devices with varying the channel length demonstrated degradation of electrical performance with increasing the overlap area of the channel and dielectric *** results regarding MoS_(2)/p^(+)-Si HFETs resulted in the structural optimization of high-performance electronic devices for practical applications.

关键词： molybdenum disulfide(MoS_(2)) transition metal dichalcogenide junction field-effect transistor dielectric layer interface trap

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Overexpression of Arabidopsis YUCCA6 in Potato Results in High-Auxin Developmental Phenotypes and Enhanced Resistance to Water Deficit

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Molecular Plant 2013年第2期6卷 337-349页

作者： Jeong Im kim Dongwon Baek Hyeong Cheol Park Hyun Jin Chun Dong-Ha Oh Min Kyung Lee Joon-yung Cha Woe-Yeon kim Min Chul kim Woo Sik Chung Hans J. Bohner Sang Yeol Lee Ray A. Bressan Shin-Woo Lee Dae-Jin Yun Department of Biochemistry Purdue University West Lafayette IN 47907 USA Division of Applied Life Science (BK21 and WCU Program) Plant Molecular Biology and Biotechnology Research Center Gyeongsang National UniversityJinju 660-701 Republic of Korea Department of Plant Biology University of Illinois at Urbana-Champaign Urbana IL USA Department of Agronomy and Medicinal Plant Resources Gyeongnam National University of Science and Technology Jinju 660-758 Korea Faculty of Science King Abdulaziz University Jeddah 21589 KSA Department of Horticulture Purdue University West Lafayette IN 47907 USA

Indole-3-acetic acid （IAA）, a major plant auxin, is produced in both tryptophan-dependent and tryptophan-independent pathways. A major pathway in Arabidopsis thaliana generates IAA in two reactions from tryptophan. Step one converts tryptophan to indole-3-pyruvic acid （IPA） by tryptophan aminotransferases followed by a rate-limiting step converting IPA to IAA catalyzed by YUCCA proteins. We identified eight putative StYUC （Solanum tuberosum YUCCA） genes whose deduced amino acid sequences share 50%-70% identity with those of Arabidopsis YUCCA proteins. All include canonical, conserved YUCCA sequences： FATGY motif, FMO signature sequence, and FAD-binding and NADP-binding sequences. In addition, five genes were found with -50% amino acid sequence identity to Arabidopsis trypto-phan aminotransferases. Transgenic potato （Solanum tuberosum cv. Jowon） constitutively overexpressing Arabidopsis AtYUC6 displayed high-auxin phenotypes such as narrow downward-curled leaves, increased height, erect stature, and longevity. Transgenic potato plants overexpressing AtYUC6 showed enhanced drought tolerance based on reduced water loss. The phenotype was correlated with reduced levels of reactive oxygen species in leaves. The results suggest a func-tional YUCCA pathway of auxin biosynthesis in potato that may be exploited to alter plant responses to the environment.

关键词： Solanum tuberosum potato Arabidopsis thaliana yuc6-1D YUCCA, StYUCCA, StTAA, auxin, drought.

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KOREAN-ENGLISH MACHINE TRANSLATION BASED ON IDIOM RECOGNITION

KOREAN-ENGLISH MACHINE TRANSLATION BASED ON IDIOM RECOGNITIO...

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计算机，通信，控制与电力工程国际会议

作者： Hagyu Lee yung Taek kim Department of Computer Engineering Seoul National University

ISBN: (纸本)0780312333

In machine translation,it is one of the most difficult problems to translate those expressions that cannot be translated compositionally from the translations of the *** cope with the problem,an idiom-based translation approach is intoduced in our Korean-English machine translation *** the idiom-based approach, such expressions are regarded as idioms and idiomatic expressions are translated through idiom recognition. Moreover,the idiom recognition is performed prior to parsing for the efficiency of *** paper descibes an overview of the idiom-based Korean-English machine translation concentrating on the idiom recognition.

关键词： KOREAN-ENGLISH MACHINE TRANSLATION BASED ON IDIOM RECOGNITION

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Evaluation of the k-nearest neighbor method for forecasting the influent characteristics of wastewater treatment plant

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Frontiers of Environmental Science & Engineering 2016年第2期10卷 299-310页

作者： Minsoo kim Yejin kim Hyosoo kim Wenhua PIAO Changwon kim Department of Civil and Environmental Engineering Pusan National University Busan 609-735 Republic of Korea Department of Civil and Environmental Engineering Catholic University of Pusan Busan 609-757 Republic of Korea EnvironSoft Co. Ltd. #511 Industry-University Co.Bld. Pusan Nationai University Busan 609-735 Republic of Korea

The k-nearest neighbor （k-NN） method was evaluated to predict the influent flow rate and four water qualities, namely chemical oxygen demand （COD）, suspended solid （SS）, total nitrogen （T-N） and total phosphorus （T-P） at a wastewater treatment plant （WWTP）. The search range and approach for determining the number of nearest neighbors （NNs） under dry and wet weather conditions were initially optimized based on the root mean square error （RMSE）. The optimum search range for considering data size was one year. The square root-based （SR） approach was superior to the distance factor-based （DF） approach in determining the appropriate number of NNs. However, the results for both approaches varied slightly depending on the water quality and the weather conditions. The influent flow rate was accurately predicted within one standard deviation of measured values. Influent water qualities were well predicted with the mean absolute percentage error （MAPE） under both wet and dry weather conditions. For the seven-day prediction, the difference in predictive accuracy was less than 5% in dry weather conditions and slightly worse in wet weather conditions. Overall, the k-NN method was verified to be useful for predicting WWTP influent characteristics.

关键词： influent wastewater prediction data-drivenmodel k-nearest neighbor method (k-NN)

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