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Chiral N-phosphonyl imine chemistry:asymmetric additions of glycine enolate to diphenyl diamine-based phosphonyl imines

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Science China Chemistry 2010年第1期53卷 125-129页

作者： PINDI Suresh kattamuri padmanabha v. Department of Chemistry and Biochemistry Texas Tech University

Diphenyl diamine-based phosphonyl imines attached by the N-isopropyl group in the auxiliary hav. been synthesized in good yields under conv.nient reaction *** new chiral N-phosphonyl imines can react with glycine enolate smoothly to giv. chiral α-β diamino esters in good yields(72%-90%) and up to excellent diastereoselectiv.ty(>99:1 dr).By treatment with HBr,the chiral auxiliary can be readily *** absolute structure has been unambiguously determined by conv.rting a product to a known sample.

关键词： chiral N-phosphonyl imine chiral phosphoramide glycine enolate α-β diamino ester

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Brain targeted deliv.ry of paclitaxel using endogenous ligand

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Asian Journal of Pharmaceutical Sciences 2016年第3期11卷 427-438页

作者： Sanjeev.R.Acharya padmanabha R.v.Reddy Department of Pharmacognosy Nirma University Department of Pharmacy Institute of Pharmacy Nirma University

The objectiv. of the present inv.stigation was to formulate nanoparticles constructed using PLGA polymer for the effectiv. targeted deliv.ry to brain v.a nasal route. The PLGA nanoparticles were optimized using nov.l design of experiment technique by 23 full factorial design. Drug: polymer ratio（X1）, surfactant concentration（X2） and stirring speed（X3） were identified as critical process parameters, and its impact on particle size（Y1） and % entrapment efficiency（Y2） was studied. The optimized nanoparticle formulation was conjugated with glutathione as an endogenous ligand by using carbodiimide chemistry using(1-Ethyl-3-（3-dimethylaminopropyl）carbodiimide)（EDAC） as linker molecule. From Ellman's assay,it was found that a total of 691.27 ± 151 units of glutathione were conjugated upon each PLGA nanoparticle. The in v.tro release studies as well as ex v.v. studies rev.aled biphasic pattern of drug release with initial burst release followed by slow exponential release of drug ov.r a period of 24 h. The in v.v. biodistribution studies were conducted on rat following nasal administration of the nanoparticle formulation（conjugated and unconjugated）and were compared with plain paclitaxel suspension. The results clearly demonstrated that the brain targeting efficiency was enhanced with the glutathione conjugated formulation（387.474%） as compared to the unconjugated nanoparticle formulation（224.327%）. Further,the in v.tro in v.v. correlation studies rev.aled good relationship（R2> 0.95） as obtained from the lev. plot. Glutathione prov.s to be an efficient v.ctor for the successful transport of poor bioav.ilable drug to the brain.

关键词： Biodistribution Glutathione In v.tro in v.v. correlation (Iv.v.) PLGA nanoparticles

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An Efficient Long Short-Term Memory Model for Digital Cross-Language Summarization

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Computers, Materials & Continua 2023年第3期74卷 6389-6409页

作者： Y.C.A.padmanabha Reddy Shyam Sunder Reddy Kasireddy Nageswara Rao Sirisala Ramu Kuchipudi Purnachand Kollapudi Department of CSE B V Raju Institute of TechnologyNarsapurMedakT.S502313India Department of IT Vasavi College of EngineeringHyderabadT.S500089India Department of CSE K.S.R.M College of EngineeringKadapaA.P516003India Department of IT C.B.I.TGandipetHyderabadTelangana500075India

The rise of social networking enables the dev.lopment of multilingual Internet-accessible digital documents in sev.ral *** digital document needs to be ev.luated physically through the Cross-Language Text Summarization(CLTS)inv.lv.d in the disparate and generation of the source ***-language document processing is inv.lv.d in the generation of documents from disparate language sources toward targeted *** digital documents need to be processed with the contextual semantic data with the decoding *** paper presented a multilingual crosslanguage processing of the documents with the abstractiv. and summarising of the *** proposed model is represented as the Hidden Markov.Model LSTM Reinforcement Learning(HMMlstmRL).First,the dev.loped model uses the Hidden Markov.model for the computation of keywords in the cross-language words for the *** the second stage,bi-directional long-short-term memory networks are used for key word extraction in the cross-language ***,the proposed HMMlstmRL uses the v.ting concept in reinforcement learning for the identification and extraction of the *** performance of the proposed HMMlstmRL is 2%better than that of the conv.ntional bi-direction LSTM model.

关键词： Text summarization reinforcement learning hidden markov.model cross-language multilingual

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Biorthogonal Wav.let Based Algebraic Multigrid Preconditioners for Large Sparse Linear Systems

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Applied Mathematics 2011年第11期2卷 1378-1381页

作者： A. padmanabha Reddy Nagendrappa M. Bujurke 不详

In this article algebraic multigrid as preconditioners are designed, with biorthogonal wav.lets, as intergrid operators for the Krylov.subspace iterativ. methods. Construction of hierarchy of matrices in algebraic multigrid context is based on lowpass filter v.rsion of Wav.let Transform. The robustness and efficiency of this new approach is tested by applying it to large sparse, unsymmetric and ill-conditioned matrices from Tim Dav.s collection of sparse matrices. Proposed preconditioners hav. potential in reducing cputime, operator complexity and storage space of algebraic multigrid v.cycle and meet the desired accuracy of solution compared with that of orthogonal wav.lets.

关键词： Algebraic Multigrid Preconditioner Wav.let Transform Sparse Matrix Krylov Subspace Iterativ. Methods

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Role of angiogenesis and angiogenic factors in acute and chronic wound healing

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Plastic and Aesthetic Research 2015年第1期2卷 243-249页

作者： Thittamaranahalli Muguregowda Honnegowda Pramod Kumar Echalasara Gov.ndarama padmanabha Udupa Sudesh Kumar Udaya Kumar Pragna Rao Department of Plastic Surgery and Burns Kasturba Medical CollegeManipal 576104KarnatakaIndia Department of Plastic Surgery King Abdulaziz Specialist HospitalSakaka 42421Al-JoufSaudi Arabia Department of Biochemistry Kasturba Medical CollegeManipal 576104KarnatakaIndia Department of Surgery District Government HospitalUdupi 576108KarnatakaIndia

Angiogenesis plays a crucial role in wound healing by forming new blood v.ssels from preexisting v.ssels by inv.ding the wound clot and organizing into a microv.scular network throughout the granulation *** dynamic process is highly regulated by signals from both serum and the surrounding extracellular matrix *** endothelial growth factor,angiopoietin,fibroblast growth factor and transforming growth factor-beta are among the potent angiogenic cytokines in wound *** endothelial cell ECM receptors are critical for morphogenetic changes in blood v.ssels during wound *** particular integrin(αv.3)receptors for fibrin and fibronectin,appear to be required for wound angiogenesis:αv.3 is focally expressed at the tips of angiogenic capillary sprouts inv.ding the wound clot,and any functional inhibitors ofαv.3 such as monoclonal antibodies,cyclic RGD peptide antagonists,and peptidomimetics rapidly inhibit granulation tissue *** spite of clear knowledge about influence of many angiogenic factors on wound healing,little progress has been made in defining the source of these factors,the regulatory ev.nts inv.lv.d in wound angiogenesis and in the clinical use of angiogenic stimulants to promote repair.

关键词： Angiogenic factors endothelium extracellular matrix protein granulation tissue wound healing

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