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The role of protein phosphorylation in the regulation of class switch recombination

BIOCELL 2020年第4期44卷 545-558页

作者： kano tanabe RYUTARO KAJIHARA Department of Medical Technology Faculty of Health ScienceKumamoto Health Science UniversityKumamoto861-5598Japan Department of Biomedical Laboratory Sciences Faculty of Life SciencesKumamoto UniversityKumamoto862-0976Japan Center for Immunotherapy Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA

Antibody is an important part of adaptive immune system and is produced only by B *** are five main classes(IgM,IgD,IgG,IgA,IgE)and some subclasses in *** and IgD are produced by mature naïve B *** the other hand,IgG,IgA and IgE are produced by activated antigen-specific B cells via class switch recombination(CSR).CSR is the irreversible DNA rearrangement from upstream to downstream classes in immunoglobulin heavy chain ***-stimulations of CD40 ligand(CD40L)and cytokines are required for induction of CSR by activating several transcription *** signal transduction pathways involve many protein *** or dephosphorylation of cellular protein is an important kind of post-translational protein modification in intracellular signal *** the fact,more than one third of the intracellular proteins are said to be transiently phosphorylated in human.A protein kinase is an enzyme that catalyzes the addition of phosphate to substrate ***,a protein phosphatase catalyzes the removal of phosphate from the *** review focuses on the mechanism of CSR controlled by protein phosphorylation and *** provide the role of protein kinase and phosphatase in the regulation of class switch recombination.

关键词： Antibody Kinase Phosphatase Signal Transduction

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Biosorption of Chromium from Aqueous Solution Using Chitosan

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Journal of Chemistry and Chemical Engineering 2014年第11期8卷 1049-1058页

作者： Naoki kano Kunlhlro tanabe Meiling Pang Yanling Deng Hiroshi Imaizumi Department of Chemistry and Chemical Engineering Faculty of Engineering Niigata University Niigata 950-2181 Japan Graduate School of Science and Technology Niigata University Niigata 950-2181 Japan

Adsorption experiment from aqueous solutions containing known amount of Cr （chromium） using chitosan was explored to evaluate the efficiency of chitosan as sorbent for Cr. Some variable parameters such as pH, reaction time and chitosan dosage were optimized. Under the optimum experiment condition, the effect of common ions on the adsorption of Cr （i.e., Na^＋, K^＋, Mg^2＋, Ca^2＋ for Cr（Ⅲ）, and Cl^-, NO3^-, SO4^2- for Cr（Ⅵ）） was also investigated. Furthermore, the sorption mechanism of Cr by chitosan was investigated by applying Langmuir and Freundlich isotherm equations to the data obtained. In addition, to confirm the characteristics of the chitosan, the surface morphology of the biomass was determined by SEM （scanning electron microscope） and specific surface area analyzer （N2-BET （Brunaeur, Emmet and Teller））. Consequently, the following matters have been mainly clarified：（1） chitosan can be an efficient sorbent for Cr （both Cr（Ⅲ） and Cr（Ⅵ））; （2） the effect of common ions on the adsorption ofCr （Cr（Ⅲ） and Cr（Ⅵ）） was not significant under this experimental conditions; （3） adsorption isotherms using the chitosan can be generally described by Langmuir isotherm more satisfactorily for Cr. The adsorption may have occurred mainly by monolayer reaction; （4） the rates of adsorption were found to conform to pseudo-second order kinetics.

关键词： Biosorption chromium chitosan adsorption isotherms kinetics

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Control strategy and methods for continuous direct compression processes

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Asian Journal of Pharmaceutical Sciences 2021年第2期16卷 253-262页

作者： Yasuhiro Suzuki Hirokazu Sugiyama Manabu kano Ryutaro Shimono Gosuke Shimada Ryoichi Furukawa Eichi Mano Keiichi Motoyama Tatsuo Koide Yasuhiro Matsui Kazuki Kurasaki Issei Takayama Shunin Hikage Noriko Katori Masahiko Kikuchi Hiroshi Sakai Yoshihiro Matsuda Formulation Technology Research Laboratories Daiichi Sankyo Co.Ltd.Kanagawa 254-0014Japan Department of Chemical System Engineering The University of TokyoTokyo 113-8656Japan Department of Systems Science Kyoto UniversityKyoto 606-8501Japan CMC Sciences Department Regulatory Affairs DivisionR&D DivisionJanssen Pharmaceutical K.K.Tokyo 101-0065Japan EuroTechno Ltd. Kanagawa 223-0057Japan Pharmaceutical Research Department Mitsubishi Tanabe Pharma CorporationOsaka 532-8505Japan Chemical Products CMC Regulatory Affairs Area Japan DevelopmentMSD K.K.Tokyo 102-8667Japan Graduate School of Pharmaceutical Sciences Kumamoto UniversityKumamoto 862-0973Japan Division of Drugs National Institute of Health SciencesKawasaki 210-9501Japan Technology Research&Development Sumitomo Dainippon Pharma Co.Ltd.Osaka 564-0053Japan Formulation Development Department Chugai pharmaceutical Co.Ltd.Tokyo 115-8543Japan Office of New Drug IV Pharmaceuticals and Medical Devices AgencyShin-Kasumigaseki Bldg.Tokyo 100-0013Japan Office of Generic Drugs Pharmaceuticals and Medical Devices AgencyShin-Kasumigaseki Bldg.Tokyo 100-0013Japan KOKANDO Co. Ltd.Toyama 930-8580Japan Pharmaceuticals and Medical Devices Agency Shin-Kasumigaseki Bldg.Tokyo 100-0013Japan

We presented a control strategy for tablet manufacturing processes based on continuous direct *** work was conducted by the experts of pharmaceutical companies,machine suppliers,academia,and regulatory authority in *** different items in the process,the component ratio and blended powder content were selected as the items requiring the control method specific to continuous manufacturing different from the conventional batch *** control and management of the Loss in Weight(LIW)feeder were deemed the most important,and the Residence Time Distribution(RTD)model were regarded effective for setting the control range and for controlling of the LIW *** on these ideas,the concept of process control using RTD was summarized.

关键词： Continuous manufacturing Solid drug products Process control Residence time distribution Loss in weight feeder Regulatory science

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